-
2
-
-
56149121336
-
Complexities of assessing the disease burden attributable to Leishmaniasis
-
Bern, C., Maguire, J.H., and Alvar, J. (2008) Complexities of assessing the disease burden attributable to Leishmaniasis. PLoS Negl. Trop. Dis. 2, 1-8.
-
(2008)
PLoS Negl. Trop. Dis.
, vol.2
, pp. 1-8
-
-
Bern, C.1
Maguire, J.H.2
Alvar, J.3
-
3
-
-
84882489798
-
Leishmaniasis
-
Guerrant, R.L., Walker, D.H., and Weller, P.F., Eds. Churchill Livingstone Elsevier, Edinburgh
-
Jeronimo, S.M.B., de Queiroz Sousa, A., and Pearson, R.D. (2006) Leishmaniasis. In Tropical Infectious Diseases: Principles, Pathogens and Practice. Guerrant, R.L., Walker, D.H., and Weller, P.F., Eds. Churchill Livingstone Elsevier, Edinburgh. pp. 1095-1113.
-
(2006)
Tropical Infectious Diseases: Principles, Pathogens and Practice
, pp. 1095-1113
-
-
Jeronimo, S.M.B.1
De Queiroz Sousa, A.2
Pearson, R.D.3
-
4
-
-
33750845322
-
Leishmaniasis and poverty
-
Alvar, J., Yactayo, S., and Bern, C. (2006) Leishmaniasis and poverty. Trends Parasitol. 22, 552-557.
-
(2006)
Trends Parasitol.
, vol.22
, pp. 552-557
-
-
Alvar, J.1
Yactayo, S.2
Bern, C.3
-
5
-
-
65549147111
-
Current treatment and drug discovery against Leishmania spp. and Plasmodium spp.: A review
-
Cruz, A.K., De Toledo, J.S., Falade, M., Terrão, M.C., Kamchonwongpaisan, S., Kyle, D.E., and Uthaipibull, C. (2009) Current treatment and drug discovery against Leishmania spp. and Plasmodium spp.: a review. Curr. Drug Targets 10, 178-192.
-
(2009)
Curr. Drug Targets
, vol.10
, pp. 178-192
-
-
Cruz, A.K.1
De Toledo, J.S.2
Falade, M.3
Terrão, M.C.4
Kamchonwongpaisan, S.5
Kyle, D.E.6
Uthaipibull, C.7
-
6
-
-
68649102607
-
Pentavalent antimonials: New perspectives for old drugs
-
Frézard, F., Demicheli, C., and Ribeiro R.R. (2009) Pentavalent antimonials: new perspectives for old drugs. Molecules 14, 2317-2336
-
(2009)
Molecules
, vol.14
, pp. 2317-2336
-
-
Frézard, F.1
Demicheli, C.2
Ribeiro, R.R.3
-
7
-
-
0037170069
-
Leishmanicidal activity of some aliphatic diamines and amino-alcohols
-
Del Olmo, E.M., Alves, M., Lopéz, J.L., Inchaustti, A., Yaluff, G., and De Arias, A.R. (2002) Leishmanicidal activity of some aliphatic diamines and amino-alcohols. Bioorg. Med. Chem. Lett. 12, 659-662.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 659-662
-
-
Del Olmo, E.M.1
Alves, M.2
Lopéz, J.L.3
Inchaustti, A.4
Yaluff, G.5
De Arias, A.R.6
-
8
-
-
48749083910
-
Antileishmanial activity of aldonamides and N-acyl-diamine derivatives
-
Reis, R.C.N., Coimbra, E.S., Almeida, C.G., Júnior, W.V., De Almeida, A.C.F., Forezi, L.S.M., Almeida, M.V., and Le Hyaric, M. (2008) Antileishmanial activity of aldonamides and N-acyl-diamine derivatives. TheScientificWorldJOURNAL 8, 752-756.
-
(2008)
TheScientificWorldJOURNAL
, vol.8
, pp. 752-756
-
-
Reis, R.C.N.1
Coimbra, E.S.2
Almeida, C.G.3
Júnior, W.V.4
De Almeida, A.C.F.5
Forezi, L.S.M.6
Almeida, M.V.7
Le Hyaric, M.8
-
9
-
-
58049159779
-
Preparation and antileishmanial activity of lipophilic N-alkyl diamines
-
Costa, C.F., Coimbra, E.S., Braga, F.G., Reis, R.C.N., Silva, A.D., and De Almeida, M.V. (2009) Preparation and antileishmanial activity of lipophilic N-alkyl diamines. Biomed. Pharmacother. 63, 40-42.
-
(2009)
Biomed. Pharmacother.
, vol.63
, pp. 40-42
-
-
Costa, C.F.1
Coimbra, E.S.2
Braga, F.G.3
Reis, R.C.N.4
Silva, A.D.5
De Almeida, M.V.6
-
10
-
-
1642575101
-
Diamine derivatives with antiparasitic activities
-
Labadie, G.R., Choi, S.R., and Avery, M.A. (2004) Diamine derivatives with antiparasitic activities. Bioorg. Med. Chem. Lett. 14, 615-619.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 615-619
-
-
Labadie, G.R.1
Choi, S.R.2
Avery, M.A.3
-
11
-
-
37549032505
-
Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2- cyclohexanediamine derivatives
-
Rebollo, O., del Olmo, E., Ruiz, G., López-Pérez, J.L., Giménez, A., and San Feliciano, A. (2008) Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2- cyclohexanediamine derivatives. Bioorg. Med. Chem. Lett. 18, 184-187.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 184-187
-
-
Rebollo, O.1
Del Olmo, E.2
Ruiz, G.3
López-Pérez, J.L.4
Giménez, A.5
San Feliciano, A.6
-
12
-
-
38749149982
-
Validation of spermidine synthase as a drug target in African trypanosomes
-
Taylor, M.C., Kaur, H., Blessington, B., Kelly, J.M., and Wilkinson, S.R. (2008) Validation of spermidine synthase as a drug target in African trypanosomes. Biochem. J. 15, 563-569.
-
(2008)
Biochem. J.
, vol.15
, pp. 563-569
-
-
Taylor, M.C.1
Kaur, H.2
Blessington, B.3
Kelly, J.M.4
Wilkinson, S.R.5
-
13
-
-
34547654456
-
Targeting the polyamine biosynthetic enzymes: A promising approach to therapy of African sleeping sickness, Chagas disease, and leishmaniases
-
Heby, O., Persson, L., and Rentala, M. (2007) Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas disease, and leishmaniases. Amino Acids 33, 359-366.
-
(2007)
Amino Acids
, vol.33
, pp. 359-366
-
-
Heby, O.1
Persson, L.2
Rentala, M.3
-
14
-
-
63449136128
-
Trypanothione reductase from Leishmania infantum: Cloning, expression, purification, crystallization and preliminary X-ray data analysis
-
Baiocco, P., Franceshini, S., Ilari, A., and Colotti, G. (2009) Trypanothione reductase from Leishmania infantum: cloning, expression, purification, crystallization and preliminary X-ray data analysis. Protein Pept. Lett. 16, 196-200.
-
(2009)
Protein Pept. Lett.
, vol.16
, pp. 196-200
-
-
Baiocco, P.1
Franceshini, S.2
Ilari, A.3
Colotti, G.4
-
15
-
-
43349083951
-
Cloning and expression of trypanothione reductase from a New World Leishmania species
-
Castro-Pinto, D.B., Genestra, M., Menezes, G.B., Wagahabi, M., Gonçalves, A., De Nigris Del Cistia, C., Sant'Anna, C.M., Leon, L.L., and Mendonça-Lima, L. (2008) Cloning and expression of trypanothione reductase from a New World Leishmania species. Arch. Microbiol. 189, 375-384.
-
(2008)
Arch. Microbiol.
, vol.189
, pp. 375-384
-
-
Castro-Pinto, D.B.1
Genestra, M.2
Menezes, G.B.3
Wagahabi, M.4
Gonçalves, A.5
De Nigris Del Cistia, C.6
Sant'Anna, C.M.7
Leon, L.L.8
Mendonça-Lima, L.9
-
16
-
-
25444520813
-
Alterations in membrane fluidity, lipid metabolism, mitochondrial activity, and lipophosphoglycan expression in pentamidine-resistant Leishmania
-
Basselin, M. and Robert-Gero, M. (1998) Alterations in membrane fluidity, lipid metabolism, mitochondrial activity, and lipophosphoglycan expression in pentamidine-resistant Leishmania. Parasitol. Res. 84, 78-83.
-
(1998)
Parasitol. Res.
, vol.84
, pp. 78-83
-
-
Basselin, M.1
Robert-Gero, M.2
-
17
-
-
77956642330
-
Preparation of 8-azabicyclo[3.2.1]octane derivatives for use in pharmaceutical compositions as opioid receptor antagonists PCT
-
Int. Appl. WO 2007103187 A2 20070913
-
Long, D., Church, T.J., Jacobsen, J.R., Jiang, L., Saito, DR., and Stergiades, I. (2007) Preparation of 8-azabicyclo[3.2.1]octane derivatives for use in pharmaceutical compositions as opioid receptor antagonists PCT. Int. Appl. WO 2007103187 A2 20070913.
-
(2007)
-
-
Long, D.1
Church, T.J.2
Jacobsen, J.R.3
Jiang, L.4
Saito, D.R.5
Stergiades, I.6
-
18
-
-
12444273714
-
Synthesis and structure - Activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis
-
DOI 10.1021/jm0205550
-
Aranapakam, V., Davis, J.M., Grosu, G.T., Baker, J., Ellingboe, J., Zask, A., Levin, J.I., Sandanayaka, V.P., Du, M., Skotnicki, J.S., DiJoseph, J.F., Sung, A., Sharr, M.A., Killar, L.M., Walter, T., Jin, G., Cowling, R., Tillett, J., Zhao, W., McDevitt, J., and Xu, Z. (2003) Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis. J. Med. Chem. 46, 2376-2396. (Pubitemid 36637922)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.12
, pp. 2376-2396
-
-
Aranapakam, V.1
Davis, J.M.2
Grosu, G.T.3
Baker, J.4
Ellingboe, J.5
Zask, A.6
Levin, J.I.7
Sandanayaka, V.P.8
Du, M.9
Skotnicki, J.S.10
Dijoseph, J.F.11
Sung, A.12
Sharr, M.A.13
Killar, L.M.14
Walter, T.15
Jin, G.16
Cowling, R.17
Tillett, J.18
Zhao, W.19
McDevitt, J.20
Xu, Z.B.21
more..
-
19
-
-
0022486710
-
Derivatives of 2-N-arylalkylamino-2-methyl-1-propanol with antiarrhythmic activity
-
Eckstein, M., Zajaczkowska, J., Krupinska, J., and Michna, M. (1986) Derivatives of 2-N-arylalkylamino-2-methyl-1-propanol with antiarrhythmic activity. Pol. J. Pharmacol. Pharm. 38, 215-220.
-
(1986)
Pol. J. Pharmacol. Pharm.
, vol.38
, pp. 215-220
-
-
Eckstein, M.1
Zajaczkowska, J.2
Krupinska, J.3
Michna, M.4
-
20
-
-
0023794281
-
β-Adrenergic antagonists: N-alkyl and N-amidoethyl(arylalkoxy) propanolamines related to propranolol
-
Mauleon, D., Pujol, M., and Rosell, G. (1988) β-Adrenergic antagonists: N-alkyl and N-amidoethyl(arylalkoxy)propanolamines related to propranolol. Eur. J. Med. Chem. 23, 421-426.
-
(1988)
Eur. J. Med. Chem.
, vol.23
, pp. 421-426
-
-
Mauleon, D.1
Pujol, M.2
Rosell, G.3
-
21
-
-
77952322249
-
Relationship between structure and antibacterial activity of lipophilic N-acyldiamines
-
Almeida, C.G., Darbois, G.D., Amaral, L.M., Diniz, C.G., and Le Hyaric, M. (2010) Relationship between structure and antibacterial activity of lipophilic N-acyldiamines. Biomed. Pharmacother. 64, 287-290.
-
(2010)
Biomed. Pharmacother.
, vol.64
, pp. 287-290
-
-
Almeida, C.G.1
Darbois, G.D.2
Amaral, L.M.3
Diniz, C.G.4
Le Hyaric, M.5
-
22
-
-
84878757166
-
-
note
-
13C NMR: 5a (139.1; 129.0-128.5; 126.6; 73.7; 72.4; 69.3; 61.2; 52.0; 36.4); 5b (138.9; 129.0-128.5; 126.4; 73.6; 72.4; 68.9; 63.1; 52.2; 49.0; 36.2; 30.9); 5c (138.9; 129.0-127.5; 126.4; 73.7; 72.4; 69.9; 68.6; 53.6; 44.4; 36.3; 23.1); 5d (138.9; 129.0-128.5; 126.4; 73.2; 72.5; 67.9; 59.5; 58.4; 57.5; 36.3); 7a (173.9; 138.9; 129.0-128.5; 126.4; 73.5; 72.4; 68.7; 51.8; 48.9; 38.8; 36.9; 36.3; 31.8-22.7; 14.2); 7b (174.1; 138.9; 129.0-128.5; 126.5; 73.4; 72.5; 68.4; 51.8; 38.5; 36.9; 36.3; 32.0-22.8; 14.2); 7c (174.1; 13.8; 129.0-128.5; 126.4; 76.7; 72.5; 68.3; 51.8; 48.9; 38.5; 36.8; 36.3; 32.0-22.8; 14.2); 9a (139.0; 129.0-128.5; 126.5; 73.7; 72.5; 68.8; 52.1; 50.0; 36.4; 31.9-22.8; 14.2); 9b (139.0; 129.0-128.5; 126.4; 73.3; 72.4; 69.5; 58.1; 55.8; 36.4; 32.0-22.8; 14.2).
-
-
-
-
23
-
-
34047230705
-
Synthesis and biological evaluation of some 6-substituted purines
-
Braga, F.G., Coimbra, E.S., Matos, M.O., Carmo, A.M.L., Cancio, M.D., and Da Silva, A.D. (2007) Synthesis and biological evaluation of some 6-substituted purines. Eur. J. Med. Chem. 42, 530-537.
-
(2007)
Eur. J. Med. Chem.
, vol.42
, pp. 530-537
-
-
Braga, F.G.1
Coimbra, E.S.2
Matos, M.O.3
Carmo, A.M.L.4
Cancio, M.D.5
Da Silva, A.D.6
-
24
-
-
0036150927
-
Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH3 (edelfosine) and amphotericin B
-
Escobar, P., Sangeeta, M., Marques, C., and Croft, S.L. (2002) Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH3 (edelfosine) and amphotericin B. Acta Trop. 81, 151-157.
-
(2002)
Acta Trop.
, vol.81
, pp. 151-157
-
-
Escobar, P.1
Sangeeta, M.2
Marques, C.3
Croft, S.L.4
-
25
-
-
33745196673
-
Current scenario of drug development for leishmaniasis
-
Croft, S.L., Seifert, K., and Yardley, V. (2006) Current scenario of drug development for leishmaniasis. Indian J. Med. Res. 123, 399-410.
-
(2006)
Indian J. Med. Res.
, vol.123
, pp. 399-410
-
-
Croft, S.L.1
Seifert, K.2
Yardley, V.3
-
26
-
-
26844461073
-
Chemotherapy of trypanosomiases and leishmaniasis
-
Croft, S.L., Barrett, M.P., and Urbina, J.A. (2005) Chemotherapy of trypanosomiases and leishmaniasis. Trends Parasitol. 21, 508-512.
-
(2005)
Trends Parasitol.
, vol.21
, pp. 508-512
-
-
Croft, S.L.1
Barrett, M.P.2
Urbina, J.A.3
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