Obstructive sleep apnea syndrome is associated with deficits in verbal but not visual memory

American Journal of Respiratory and Critical Care Medicine

Volumn 182, Issue 1, 2010, Pages 98-103

  Twigg, Gillian L ^a   Papaioannou, Ioannis ^a   Jackson, Melinda ^b   Ghiassi, Ramesh ^c   Shaikh, Zarrin ^a   Jaye, Jay ^a   Graham, Kim S ^d   Simonds, Anita K ^a   Morrell, Mary J ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c CHARING CROSS HOSPITAL   (United Kingdom)

^d CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Cognitive function; Hypoxia; Sleep disordered breathing; Sleepiness

Indexed keywords

ADULT; AGED; APNEA HYPOPNEA INDEX; ARTICLE; ATTENTION; COGNITION; COMPARATIVE STUDY; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; DISEASE SEVERITY; EDUCATION; EPISODIC MEMORY; EPWORTH SLEEPINESS SCALE; FEMALE; HOSPITAL ANXIETY AND DEPRESSION SCALE; HUMAN; LINEAR REGRESSION ANALYSIS; LOGICAL MEMORY TEST; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; MENTAL PERFORMANCE; MENTAL TEST; OXFORD SLEEP RESISTANCE TEST; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANK SUM TEST; RECALL; REGRESSION ANALYSIS; REM SLEEP; SEMANTIC MEMORY; SEMANTICS; SLEEP APNEA SYNDROME; SLEEP PARAMETERS; SOMNOLENCE; TASK PERFORMANCE; VERBAL MEMORY; VISUAL MEMORY; WORKING MEMORY; CASE CONTROL STUDY; LEARNING; PATTERN RECOGNITION; POLYSOMNOGRAPHY;

ADULT; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; MEMORY DISORDERS; MENTAL RECALL; PATTERN RECOGNITION, VISUAL; POLYSOMNOGRAPHY; SLEEP APNEA, OBSTRUCTIVE; VERBAL LEARNING;

EID: 77955900446     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200901-0065OC     Document Type: Article

References (33)

1. Ferini-Strambi L, Baietto C, Di Gioia MR, Castaldi P, Castronovo C, Zucconi M, Cappa SF. Cognitive dysfunction in patients with obstructive sleep apnea (OSA): partial reversibility after continuous positive airway pressure (CPAP). Brain Res Bull 2003;61:87-92.
2. Naegele B, Launois SH, Mazza S, Feuerstein C, Pepin JL, Levy P. Which memory processes are affected in patients with obstructive sleep apnea? An evaluation of 3 types of memory. Sleep 2006;29:533-544.
3. Naegele B, Thouvard V, Pepin JL, Levy P, Bonnet C, Perret JE, Pellat J, Feuerstein C. Deficits of cognitive executive functions in patients with sleep apnea syndrome. Sleep 1995;18:43-52.
4. Quan SF, Wright R, Baldwin CM, Kaemingk KL, Goodwin JL, Kuo TF, Kaszniak A, Boland LL, Caccappolo E, Bootzin RR. Obstructive sleep apnea-hypopnea and neurocognitive functioning in the Sleep Heart Health Study. Sleep Med 2006;7:498-507.
5. Redline S, Strauss ME, Adams N, Winters M, Roebuck T, Spry K, Rosenberg C, Adams K. Neuropsychological function in mild sleep-disordered breathing. Sleep 1997;20:160-167. (Pubitemid 27194754)
6. Adams N, Strauss M, Schluchter M, Redline S. Relation of measures of sleep-disordered breathing to neuropsychological functioning. Am J Respir Crit Care Med 2001;163:1626-1631.
7. Steffens DC, Otey E, Alexopoulos GS, Butters MA, Cuthbert B, Ganguli M, Geda YE, Hendrie HC, Krishnan RR, Kumar A, et al. Perspectives on depression, mild cognitive impairment, and cognitive decline. Arch Gen Psychiatry 2006;63:130-138.
8. Salorio CF, White DA, Piccirillo J, Duntley SP, Uhles ML. Learning, memory, and executive control in individuals with obstructive sleep apnea syndrome. J Clin Exp Neuropsychol 2002;24:93-100. (Pubitemid 34412141)
9. Dempsey JA, Veasey SC, Morgan BJ, O'Donnell CP. Pathophysiology of sleep apnea. Physiol Rev 2010;90:47-112.
10. Cheshire K, Engleman H, Deary I, Shapiro C, Douglas NJ. Factors impairing daytime performance in patients with sleep apnea/hypopnea syndrome. Arch Intern Med 1992;152:538-541.
11. Greenberg GD, Watson RK, Deptula D. Neuropsychological dysfunction in sleep apnea. Sleep 1987;10:254-262.
12. Lee MM, Strauss ME, Adams N, Redline S. Executive functions in persons with sleep apnea. Sleep Breath 1999;3:13-16.
13. Kim HC, Young T, Matthews CG, Weber SM, Woodward AR, Palta M. Sleep-disordered breathing and neuropsychological deficits: a population-based study. Am J Respir Crit Care Med 1997;156:1813-1819. (Pubitemid 28011787)
14. Bedard MA, Montplaisir J, Richer F, Rouleau I, Malo J. Obstructive sleep apnea syndrome: pathogenesis of neuropsychological deficits. J Clin Exp Neuropsychol 1991;13:950-964.
15. Rouleau I, Decary A, Chicoine AJ, Montplaisir J. Procedural skill learning in obstructive sleep apnea syndrome. Sleep 2002;25:401-411.
16. Twigg G, Papaioannou I, Simonds AK, Morrell MJ. Cognitive defects in patients with moderate to severe obstructive sleep apnoea [abstract]. Thorax 2006;61:ii2.
17. Twigg G, Papaioannou I, Simonds AK, Morrell MJ. Effect of intermittent hypoxia on cognitive function in patients with obstructive sleep apnoea [abstract]. J Sleep Res 2006;15:44.
18. Johns MW. A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale. Sleep 1991;14:540-545.
19. Bennett LS, Stradling JR, Davies RJ. A behavioural test to assess daytime sleepiness in obstructive sleep apnoea. J Sleep Res 1997;6:142-145.
20. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983;67:361-370.
21. Reschtschaffen A, Kales A. A manual of standardised terminology, techniques and scoring system for sleep stages in human subjects. Washington DC: U.S. Public Health Service, U.S. Government Printing Office; 1968.
22. Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep 1992;15:173-184.
23. Weschler D. Weschler memory scale. London: The Psychological Corporation; 1998.
24. Verstraeten E, Cluydts R, Pevernagie D, Hoffmann G. Executive function in sleep apnea: controlling for attentional capacity in assessing executive attention. Sleep 2004;27:685-693.
25. Bernard FA, Desgranges B, Eustache F, Baron JC. Neural correlates of age-related verbal episodic memory decline: a PET study with combined subtraction/correlation analysis. Neurobiol Aging 2007;28:1568-1576.
26. Gozal D, Daniel JM, Dohanich GP. Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat. J Neurosci 2001;21:2442-2450. (Pubitemid 32240541)
27. Kheirandish L, Gozal D, Pequignot JM, Pequignot J, Row BW. Intermittent hypoxia during development induces long-term alterations in spatial working memory, monoamines, and dendritic branching in rat frontal cortex. Pediatr Res 2005;58:594-599.
28. Macey PM, Henderson LA, Macey KE, Alger JR, Frysinger RC, Woo MA, Harper RK, Yan-Go FL, Harper RM. Brain morphology associated with obstructive sleep apnea. Am J Respir Crit Care Med 2002;166:1382-1387.
29. Morrell MJ, McRobbie DW, Quest RA, Cummin AR, Ghiassi R, Corfield DR. Changes in brain morphology associated with obstructive sleep apnea. Sleep Med 2003;4:451-454.
30. Morrell MJ, Twigg G. Neural consequences of sleep disordered breathing: the role of intermittent hypoxia. Adv Exp Med Biol 2006;588:75-88.
31. O'Donoghue FJ, Briellmann RS, Rochford PD, Abbott DF, Pell GS, Chan CH, Tarquinio N, Jackson GD, Pierce RJ. Cerebral structural changes in severe obstructive sleep apnea. Am J Respir Crit Care Med 2005;171:1185-1190.
32. Yoo SS, Hu PT, Gujar N, Jolesz FA, Walker MP. A deficit in the ability to form new human memories without sleep. Nat Neurosci 2007;10:385-392. (Pubitemid 46310470)
33. Tartar JL, Ward CP, McKenna JT, Thakkar M, Arrigoni E, McCarley RW, Brown RE, Strecker RE. Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation. Eur J Neurosci 2006;23:2739-2748.