Lymphatic vessel density and VEGF-C expression are significantly different among benign and malignant thyroid lesions

Endocrine Pathology

Volumn 21, Issue 2, 2010, Pages 101-107

  Garcia, Eduardo Anselmo ^a   Simões, Kleber ^a   Wakamatsu, Alda ^a   Ressio, Rodrigo Albergaria ^a   Alves, Venâncio Avancini Ferreira ^a   Longatto Filho, Adhemar ^a,b   Camargo, Roberto Souza ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF MINHO   (Portugal)

Author keywords

Lymphatic vessel density; Thyroid; Thyroid cancer; Tumor lymphangiogenesis; Vascular endothelial growth factor; VEGF C

Indexed keywords

MONOCLONAL ANTIBODY D2-40; VASCULOTROPIN C; DIAGNOSTIC AGENT; MONOCLONAL ANTIBODY; TUMOR MARKER;

ADULT; ARTICLE; BENIGN TUMOR; CANCER INVASION; CLINICAL EVALUATION; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHANGIOGENESIS; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX DIFFERENCE; THYROID ADENOMA; THYROID CANCER; THYROID FOLLICULAR CARCINOMA; THYROID PAPILLARY CARCINOMA; TUMOR LOCALIZATION; ADENOCARCINOMA; ADENOMA; BIOSYNTHESIS; LYMPH VESSEL; METABOLISM; MIDDLE AGED; PATHOLOGY; THYROID TUMOR;

ADENOCARCINOMA, FOLLICULAR; ADENOCARCINOMA, PAPILLARY; ADENOMA; ADULT; ANTIBODIES, MONOCLONAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC VESSELS; MALE; MIDDLE AGED; THYROID NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 77955899229     PISSN: 10463976     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12022-010-9116-9     Document Type: Article

References (32)

1. Stacker SA, Achen MG, Jussila L, Baldwin ME, Alitalo K. Lymphangiogenesis and cancer metastasis. Nat Rev Cancer 2:573-83, 2002.
2. Reis-Fillho JS, Schmitt FC. Lymphangiogenesis in tumors: what do we know? Microsc Res Techn 60:171-80, 2003.
3. Schacht V, Dadras SS, Johnson LA, Jackson DG, Hong YK, Detmar M. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol 166:913-21, 2005.
4. Gombos Z, Xiamowei X, Chu CS, Zhang PJ, Acs G. Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix. Clin Cancer Res 11:8364-71, 2005.
5. Kahn HJ, Marks A. A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors. Lab Invest 82:1255-7, 2002.
6. Van der Auwera I, Cao Y, Tille JC, et al. First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours. Br J Cancer 95:1611-25, 2006.
7. Afonso J, Santos LL, Amaro T, Lobo F, Longatto-Filho A. The aggressiveness of urothelial carcinoma depends to a large extent on lymphovascular invasion. Histopathology 55:514-24, 2009
8. Beasley NJ, Prevo R, Banerji S, et al. Intratumoral lymphangio-genesis and lymph node metastasis in head and neck cancer. Cancer Res 62:1315-20, 2002.
9. Alitalo K, Carmeliet P. Molecular mechanisms of lymphangio-genesis in health and disease. Cancer Cell 1:219-27, 2002.
10. Byrne AM, Bouchier-Hayes DJ, Harmey JH. Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J Cell Mol Med 9(4): 777-94, 2005.
11. Yamazaki Y, Morita T. Molecular and functional diversity of vascular endothelial growth factors. Mol Divers. 10(4):515-27, 2006.
12. Karkkainen MJ, Haiko P, Sainio K, et al. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol 5:74-80, 2004.
13. Roskoski, R.J. Vascular endothelial growth factor (VEGF) signaling in tumor progression. Critical Reviews in Oncology Hematology 62:179-213, 2007.
14. Duff SE, Li C, Jeziorska M, Kumar S, Saunders MP, Sherlock D, O'Dwyer ST, Jayson GC. Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy. Br J Cancer 89:426-30, 2003.
15. Jussila L, Alitalo K. Vascular growth factors and lymphangio-genesis. Physiol Rev 82:673-700, 2002.
16. (http://www.cancer.gov/cancertopics/types/thyroid assessed 12 September, 2009)
17. Camargo RS, Maeda MYS, DI Loreto C, Shirata NK, Garcia EA, Longatto Filho A. Is AgNOR and DNA ploidy analysis useful for evaluating thyroid neoplasms? Analytical and Quantitative Cytology and Histology 27, 2005.
18. Kondo T, Ezzat S, Asa SL. Pathogenetic mechanisms in thyroid follicular-cell neoplasias. Nature Reviews Cancer 6:292-306, 2006.
19. Lang BHH, Lo CY, Chan WF, Lam KY, Wan KY. prognostic factors in papillary and follicular thyroid carcinoma: their implications for cancer staging. Annals of Surgical Oncology 14:730-38, 2007.
20. Camargo RS, Scafuri AG, de Tolosa EM, Ferreira EA. DNA image cytometric analysis of differentiated thyroid adenocarcino-ma specimens. Am J Surg 164(6): 640-5, 1992.
21. Giorgadze TA, Baloch ZW, Pasha T, Zhang PJ, LiVolsi VA: Lymphatic and blood vessel density in the follicular patterned lesions of thyroid. Modern Pathology 18:1424-31, 2005.
22. Longatto-Filho A, Pinheiro C, Ferreira L, Scapulatempo C, Alves VA, Baltazar F, Schmitt F. Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers. Virchows Arch 452(2):133-8, 2008.
23. Torre GNL, Buley I, Wass JAH, Turner HE. Angiogenesis and lymphangiogenesis in thyroid proliferative lesions: relationship to type and tumor behavior. Endocrine-Related Cancer 13:931-44, 2006.
24. IARC WHO Classification of Tumours. Pathology and Genetics of Tumours of Endocrine Organs 3ed 8:8, 2004.
25. Longatto-Filho A, Pinheiro C, Pereira SM, Etlinger D, Moreira MA, Jubé LF, Queiroz GS, Baltazar F, Schmitt FC. Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix. Gynecol Oncol 107(1):45-51, 2007.
26. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogen-esis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 324:1-8, 1991.
27. Fassnacht M, Kreissl MC, Weismann D, Allolio B. New targets and therapeutic approaches for endocrine malignancies. Pharmacol Ther 123:117-41, 2009
28. Camargo RS Cirurgia da glândula tireóide. In: Goffi. Técnica Cirúrgica-bases anatômicas, fisiopatológicas e técnica cirúrgica. 4ed São Paulo Atheneu, pp 297-305, 1996.
29. Schlumberger MJ. Papillary and follicular thyroid carcinoma. New England Journal of Medicine 29:297-306, 1998.
30. Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 7:296:1883-6, 2002.
31. Kurahara H,Takao S,Maemura K,Shinchi H,Natsugoe S, Aikou T. Impact of vascular endothelial growth factor-C and-D expression in human pancreatic cancer: its relationship to lymph node metastasis. Clin Cancer Res 10:8413-20, 2004.
32. Bono P, Wasenius VM, Heikkila P, Lundin J, Jackson DG, Joensuu H. High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer. Clin Cancer Res 10:7144-9, 2004.