Inhibition of mycobacterial replication by pyrimidines possessing various C-5 functionalities and related 2′-deoxynucleoside analogues using in vitro and in vivo models

Journal of Medicinal Chemistry

Volumn 53, Issue 16, 2010, Pages 6180-6187

  Srivastav, Naveen C ^a   Rai, Dinesh ^a   Tse, Christopher ^a   Agrawal, B ^a   Kunimoto, Dennis Y ^a   Kumar, Rakesh ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2' DEOXYNUCLEOSIDE; 5 (2 PHENYLETHYNYL)URACIL; 5 (2 PYRIDYLETHYNYL) 2' DEOXYCYTIDINE; 5 (2 PYRIDYLETHYNYL) 2' DEOXYURIDINE; 5 (2 PYRIDYLETHYNYL)URACIL; 5 (4 N PENTYLPHENYLETHYNYL)URACIL; 5 (4 N PROPYLPHENYLETHYNYL)URACIL; 5 DECYNYL URACIL; 5 DODECYNYL URACIL; 5 HEPTYNYL URACIL; 5 PENTYNYL URACIL; 5 TETRADECYNYL URACIL; 5 TRIDECYNYL URACIL; 6 DECYL 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE; 6 OCTYL 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE; 6 PENTYL 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE; 6 PROPYL 2,3 DIHYDROFURO[2,3 D]PYRIMIDIN 2 ONE; ANTIMYCOBACTERIAL AGENT; CYCLOSERINE; ISONIAZID; PYRIMIDINE DERIVATIVE; RIFAMPICIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; TUBERCULOSIS;

ALKYNES; ANIMALS; ANTITUBERCULAR AGENTS; CELL LINE, TUMOR; DEOXYCYTIDINE; DEOXYRIBONUCLEOSIDES; HUMANS; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; PYRIDINES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBERCULOSIS; URACIL;

EID: 77955857278     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100568q     Document Type: Article

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