Studies on acyclic pyrimidines as inhibitors of mycobacteria

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 5, 2007, Pages 2045-2053

  Srivastav, Naveen C ^a   Manning, Tracey ^a   Kunimoto, Dennis Y ^a   Kumar, Rakesh ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Anti mycobacterial agent; Heterocycle; Pyrimidine; Tuberculosis

Indexed keywords

1 (2 HYDROXYETHOXY)METHYL 5 (1 AZIDO 2 AZIDOVINYL) DERIVATIVE; 1 (2 HYDROXYETHOXY)METHYL 5 (1 AZIDO 2 HALOETHYL) DERIVATIVE; 1 [[2 HYDROXY 1 (HYDROXYMETHYL)ETHOXY]METHYL] 5 DECYNYLURACIL; 1 [[2 HYDROXY 1 (HYDROXYMETHYL)ETHOXY]METHYL] 5 DODECYNYLURACIL; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIUM CULTURE; CULTURE MEDIUM; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM AVIUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM; PYRIMIDINES; SPECIES SPECIFICITY;

CORYNEBACTERINEAE; MYCOBACTERIUM AVIUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 33846646012     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.12.032     Document Type: Article

References (24)

1. Pilheu J.A. Int. J. Tuberc. Lung Dis. 2 (1998) 696-703
2. Raviglione M.C., Snider D.E., and Kochi A. J. Am. Med. Assoc. 273 (1995) 220-226
3. Willcox P.A. Curr. Opin. Pulm. Med. 6 (2000) 198-202
4. Méndez A.P., Raviglione M.C., Laszlo A., Binkin N., Rieder H.L., Bustreo F., Cohn D.L., Weezenbeek C.S.B.L.-van., Kim S.J., Chaulet P., and Nunn P. N. Eng. J. Med. 338 (1998) 1641-1649
5. Pozniak A. J. HIV Ther. 7 (2002) 13-16
6. Inderlied C.B., Kemper C.A., and Bermudez L.E. Clin. Microbiol. Rev. 6 (1993) 266-310
7. Falkinham III J.O. Clin. Microbiol. Rev. 9 (1996) 177-215
8. Dautzenberg B. Res. Microbiol. 145 (1994) 197-206
9. Ellner J.J., Goldberger M.J., and Parenti D.M. J. Infect. Dis. 163 (1991) 1326-1335
10. Johar M., Manning T., Kunimoto D.Y., and Kumar R. Bioorg. Med. Chem. 13 (2005) 6663-6671
11. Hansch C., Leo A., Unger S.H., Kim K.H., Nikaitani D., and Lien E.J. J. Med. Chem. 16 (1973) 1207-1216
12. Srivastav N.C., Manning T., Kunimoto D.Y., and Kumar R. Med. Chem. 2 (2006) 287-293
13. Rai D., Johar M., Manning T., Agrawal B., Kunimoto D.Y., and Kumar R. J. Med. Chem. 48 (2005) 7012-7017
14. Chu C.K., and Cutler S.J. J. Heterocyc. Chem. 23 (1986) 289-319
15. Freeman S., and Gardiner J.M. Mol. Biotechnol. 5 (1996) 125-137
16. de Miranda P., Good S.S., Krasny H.C., Connor J.D., Laskin O.L., and Lietman P.S. Am. J. Med. 73 (1982) 215-220
17. Balzarini J., Morin K.W., Knaus E.E., Wiebe L.I., and De Clercq E. Gene Ther. 2 (1995) 317-322
18. Balzarini J., Sienaert R., Liekens S., Van Kuilenburg A., Carangio A., Esnouf R., De Clercq E., and McGuigan C. Mol. Pharmacol. 61 (2002) 1140-1145
19. Kumar R., Sharma N., Nath M., Saffran H., and Tyrrell D.L.J. J. Med. Chem. 44 (2001) 4225-4229
20. Kumar R., Nath M., and Tyrrell D.L.J. J. Med. Chem. 45 (2002) 2032-2040
21. Kumar R., Semaine W., Johar M., Tyrrell D.L.J., and Agrawal B. J. Med. Chem. 49 (2006) 2049-2054
22. De Clercq E. Methods Find Exp. Clin. Pharmacol. 2 (1980) 253-267
23. Kulikowski T. Pharm. World Sci. 16 (1994) 127-138
24. Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry III C.E., Tekala F., Badcock K., Bashman D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., Mclean J., Moule S., Murphy L., Oliver K., Osborne J., Quail M.A., Rajandream M.-A., Rogers J., Rutter S., Seeger K., Skelton J., Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S., and Barrell B.G. Nature 393 (1998) 537-544