Both systemic and mucosal LCMV immunization generate robust viral-specific IgG in mucosal secretions, but elicit pooor LCMV-specific IgA

Viral Immunology

Volumn 23, Issue 4, 2010, Pages 377-384

  Rajini, Bheemreddy ^a   Zeng, Junwei ^a   Suvas, Pratima Krishna ^a   Dech, Heather M ^a   Onami, Thandi M ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS VACCINE; UNCLASSIFIED DRUG; VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARENAVIRUS INFECTION; ARTICLE; CONTROLLED STUDY; FEMALE; HUMORAL IMMUNITY; IMMUNOLOGICAL MEMORY; LUNG LAVAGE; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; MUCOSAL IMMUNITY; NASAL LAVAGE; NONHUMAN; NOSE SECRETION; VAGINA SECRETION; VIRUS ENTRY;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, VIRAL; ANTIBODY SPECIFICITY; FEMALE; IMMUNITY, MUCOSAL; IMMUNIZATION; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INJECTIONS, INTRAPERITONEAL; LUNG; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MUCOUS MEMBRANE; NASAL MUCOSA; VAGINA;

HUMAN IMMUNODEFICIENCY VIRUS 1; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MUS;

EID: 77955855299     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.2010.0012     Document Type: Article

References (44)

1. Ahmed R, Salmi A, Butler LD, Chiller JM, and Oldstone MB: Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J Exp Med 1984;160:521-540.
2. Armstrong C, and Lillie RD: Experimental lymphocytic choriomeningitis of monkeys and mice produced by a virus encountered in studies of the 1933 St. Louis encephalitis epidemic. Pub Health Rep 1934;49:1019-1027.
3. Bergthaler A, Flatz L, Verschoor A, et al.: 2009. Impaired antibody response causes persistence of prototypic T cellcontained virus. PLoS Biol 7:e1000080.
4. Bergthaler A, Gerber NU, Merkler D, Horvath E, de la Torre JC, and Pinschewer DD: Envelope exchange for the generation of live-attenuated arenavirus vaccines. PLoS Pathog 2006;2:e51.
5. Buchmeier MJ, Bowen MD, and Peters CJ: Arenaviridae: The Viruses and Their Replication, 4th ed, Vol.2. Lippincott Williams and Wilkins, Philadelphia.
6. Cerutti A: The regulation of IgA class switching. Nat Rev Immunol 2008;8:421-434.
7. Chen HD, Fraire AE, Joris I, Brehm MA, Welsh RM, and Selin LK: Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung. Nat Immunol 2001;2:1067-1076.
8. Crotty S, Kersh EN, Cannons J, Schwartzberg PL, and Ahmed R: SAP is required for generating long-term humoral immunity. Nature 2003;421:282-287.
9. Djavani M, Yin C, Xia L, Lukashevich IS, Pauza CD, and Salvato MS: Murine immune responses to mucosally delivered Salmonella expressing Lassa fever virus nucleoprotein. Vaccine 2000;18:1543-1554.
10. Dullaers M, Li D, Xue Y, et al.: A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts. Immunity 2009;30: 120-129.
11. Fayad R, Zhang H, Quinn D, Huang Y, and Qiao L: Oral administration with papillomavirus pseudovirus encoding IL-2 fully restores mucosal and systemic immune responses to vaccinations in aged mice. J Immunol 2004;173:2692-2698.
12. Flatz L, Hegazy AN, Bergthaler A, et al.: Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8(+) T cell immunity. Nat Med 2010;16:339-345.
13. Haase AT: Perils at mucosal front lines for HIV and SIV and their hosts. Nat Rev Immunol 2005;5:783-792.
14. Joo HM, He Y, and Sangster MY: Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia. Proc Natl Acad Sci USA 2008;105: 3485-3490.
15. Joo HM, He Y, Sundararajan A, Huan L, and Sangster MY: Quantitative analysis of influenza virus-specific B cell memory generated by different routes of inactivated virus vaccination. Vaccine 2010;28:2186-2194.
16. Kaufman DR, Liu J, Carville A, Mansfield KG, Havenga MJ, Goudsmit J, and Barouch DH: Trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccination. J Immunol 2008;181:4188-4198.
17. Khanolkar A, Fuller MJ, and Zajac AJ: CD4 T cell-dependent CD8 T cell maturation. J Immunol 2004;172:2834-2844.
18. Li Q, Skinner PJ, Ha SJ, et al.: Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection. Science 2009;323:1726-1729.
19. Masopust D, Vezys V, Usherwood EJ, et al.: Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin. J Immunol 2004;172:4875-4882.
20. Massacand JC, Kaiser P, Ernst B, Tardivel A, Burki K, Schneider P, and Harris NL: Intestinal bacteria condition dendritic cells to promote IgA production. PLoS One 2008;3: e2588.
21. Mestecky J, Jackson S, Moldoveanu Z, et al.: Paucity of antigen-specific IgA responses in sera and external secretions of HIV-type 1-infected individuals. AIDS Res Hum Retroviruses 2004;20:972-988.
22. Mestecky J, Moldoveanu Z, and Russell MW: Immunologic uniqueness of the genital tract: challenge for vaccine development. Am J Reprod Immunol 2005;53:208-214.
23. Moskophidis D, Moskophidis M, and Lohler J: Virus-specific IgD in acute viral infection of mice. J Immunol 1997;158: 1254-1261.
24. Murali-Krishna K, Altman JD, Suresh M, et al.: Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 1998;8:177-187.
25. Neutra MR, and Kozlowski PA: Mucosal vaccines: the promise and the challenge. Nat Rev Immunol 2006;6:148-158.
26. Pal R, Venzon D, Santra S, et al.: Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels. J Virol 2006;80:3732-3742.
27. Pepper M, Linehan JL, Pagan AJ, Zell T, Dileepan T, Cleary PP, and Jenkins MK: Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat Immunol 2010;11:83-89.
28. Pinschewer DD, Perez M, Jeetendra E, et al.: Kinetics of protective antibodies are determined by the viral surface antigen. J Clin Invest 2004;114:988-993.
29. Rai SK, Micales BK, Wu MS, Cheung DS, Pugh TD, Lyons GE, and Salvato MS: Timed appearance of lymphocytic choriomeningitis virus after gastric inoculation of mice. Am J Pathol 1997;151:633-639.
30. Rodas, JD, Lukashevich IS, Zapata JC, et al.: Mucosal arenavirus infection of primates can protect them from lethal hemorrhagic fever. J Med Virol 2004;72:424-435.
31. Royce RA, Sena A, Cates W Jr, and Cohen MS: Sexual transmission of HIV. N Engl J Med 1997;336:1072-1078.
32. Sangster MY, Topham DJ, D'Costa S, Cardin RD, Marion TN, Myers LK, and Doherty PC: Analysis of the virus-specific and nonspecific B cell response to a persistent B-lymphotropic gammaherpesvirus. J Immunol 2000;164:1820-1828.
33. Schafer F, Kewenig S, Stolte N, et al.: Lack of simian immunodeficiency virus (SIV) specific IgA response in the intestine of SIV infected rhesus macaques. Gut 2002;50:608-614.
34. Sheinbergas MM, Verikene VV, Maslinskas VY, and Lyubetsky VB: Specific immunofluorescent IgG, IgM, and IgA antibodies in lymphocytic choriomeningitis. Acta Virol 1978; 22:218-224.
35. Slifka MK, Antia R, Whitmire JK, and Ahmed R: Humoral immunity due to long-lived plasma cells. Immunity 1998;8: 363-372.
36. Stavnezer J, and Kang J: The surprising discovery that TGF beta specifically induces the IgA class switch. J Immunol 2009;182:5-7.
37. Stevceva L, Alvarez X, Lackner AA, et al.: Both mucosal and systemic routes of immunization with the live, attenuated NYVAC/simian immunodeficiency virus SIV(gpe) recombinant vaccine result in gag-specific CD8(+) T-cell responses in mucosal tissues of macaques. J Virol 2002;76:11659-11676.
38. Suvas PK, Dech HM, Sambira F, Zeng J, and Onami TM: Systemic and mucosal infection program protective memory CD8 T cells in the vaginal mucosa. J Immunol 2007;179: 8122-8127.
39. Suzich JA, Ghim SJ, Palmer-Hill FJ, et al.: Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas. Proc Natl Acad Sci USA 1995;92:11553-11557.
40. Tezuka H, Abe Y, Iwata M, et al.: Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature 2007;448:929-933.
41. Tsuji M, Komatsu N, Kawamoto S, et al.: Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science 2009;323:1488-1492.
42. Xu W, Santini PA, Sullivan JS, et al.: HIV-1 evades virusspecific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits. Nat Immunol 2009;10:1008-1017.
43. Yin C, Djavani M, Schenkel AR, Schmidt DS, Pauza CD, and Salvato MS: Dissemination of lymphocytic choriomeningitis virus from the gastric mucosa requires G protein-coupled signaling. J Virol 1998;72:8613-8619.
44. Zeng J, Joo HM, Rajini B, Wrammert JP, Sangster MY, and Onami TM: The generation of influenza-specific humoral responses is impaired in ST6Gal I-deficient mice. J Immunol 2009;182:4721-4727.