Treatment with the Iron Chelator, Deferoxamine Mesylate, Alters Serum Markers of Oxidative Stress in Stroke Patients

Translational Stroke Research

Volumn 1, Issue 1, 2010, Pages 35-39

  Selim, Magdy ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Deferoxamine; Iron; Oxidative stress; Stroke

Indexed keywords

DEFEROXAMINE MESYLATE; HYDROPEROXIDE; LIPID PEROXIDE;

AGED; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; DRUG EFFECT; FEMALE; HUMAN; MALE; NEUROPROTECTION; OXIDATIVE STRESS; PRIORITY JOURNAL; STROKE;

EID: 77955852226     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-009-0001-0     Document Type: Article

References (25)

1. Kondo Y, Asanuma M, Nishibayashi S, Iwata E, Ogawa N (1997) Late-onset lipid peroxidation and neuronal cell death following transient forebrain ischemia in rat brain. Brain Res 772(12): 37-44.
2. Ishimaru H, Ishikawa K, Ohe Y, Takahashi A, Tatemoto K, Maruyama Y (1996) Activation of iron handling system within the gerbil hippocampus after cerebral ischemia. Brain Res 726(1-2): 23-30.
3. Palmer C, Menzies S, Roberts R, Pavlick G, Connor J (1999) Changes in iron histochemistry after hypoxic-ischemic brain injury in the neonatal rat. J Neurosci Res 56: 60-71.
4. Huang FP, Xi G, Keep RF, Hua Y, Nemoianu A, Hoff JT (2002) Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. J Neurosurg 96: 287-293.
5. Koeppen AH, Dickson AC, McEvoy JA (1995) The cellular reactions to experimental intracerebral hemorrhage. J Neurol Sci 134(Supl): 102-112.
6. Bishop G, Robinson S (2001) Quantitative analysis of cell death and ferritin expression in response to cortical iron: implications for hypoxia-ischemia and stroke. Brain Res 907(1-2): 175-187.
7. Winterbourn C (1995) Toxicity of iron and hydrogen peroxide: the Fenton reaction. Toxicol Lett 82: 969-974.
8. Palmer C, Roberts R, Bero C (1994) Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats. Stroke 25: 1039-1045.
9. Patt A, Horesh R, Berger M, Harken A, Repine E (1990) Iron depletion or chelation reduces ischemia/reperfusion-induced edema in gerbil brains. J Pediatr Surg 25: 224-228.
10. Prass K, Ruscher K, Karsch M, Isaev N, Megow D, Priller J, Scharff A, Dirnagl U, Meisel A (2002) Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro. J Cereb Blood Flow Metab 22: 520-525.
11. Soloniuk D, Perkins E, Wilson J (1992) Use of allopurinol and deferoxamine in cellular protection during ischemia. Surg Neurol 38(2): 110-113.
12. Regan RF, Rogers B (2003) Delayed treatment of hemoglobin neurotoxicity. J Neurotrauma 20: 111-120.
13. Sangchot P, Sharma S, Chetsawang B, Porter J, Govitrapong P, Ebadi M (2002) Deferoxamine attenuates iron-induced oxidative stress and prevents mitochondrial aggregation and alpha-synuclein translocation in SK-N-SH cells in culture. Dev Neurosci 24(2-3): 143-153.
14. waf1/cip1, and erythropoietin. J Neurosci 19(22): 9821-9830.
15. Cesarone MR, Belcaro G, Carratelli M, Cornelli U, De Sanctis MT, Incandela L, Barsotti A, Terranova R, Nicolaides A (1999) A simple test to monitor oxidative stress. Int Angiol 18(2): 127-130.
16. Rice-Evans C, Miller N (1994) Total antioxidant status in plasma and body fluids. Meth Enzymol 234: 279-475.
17. Love S (1999) Oxidative stress in brain ischemia. Brain Pathol 9(1): 119-131.
18. Wu J, Hua Y, Keep RF, Schallert T, Hoff JT, Xi G (2002) Oxidative brain injury from extravasated erythrocytes after intracerebral hemorrhage. Brain Res 953(1-2): 45-52.
19. Nanetti L, Taffi R, Vignini A, Moroni C, Raffaelli F, Bacchetti T, Silvestrini M, Provinciali L, Mazzanti L (2007) Reactive oxygen species plasmatic levels in ischemic stroke. Mol Cell Biochem 303(1-2): 19-25.
20. Aygul R, Demircan B, Erdem F, Ulvi H, Yildirim A, Demirbas F (2005) Plasma values of oxidants and antioxidants in acute brain hemorrhage: role of free radicals in the development of brain injury. Biol Trace Elem Res 108(1-3): 43-52.
21. Hershko C, Weatherall D (1988) Iron chelating therapy. Crit Rev Clin Lab Sci 26: 303-346.
22. Yokel RA, Lidums V, Ungerstedt U (1991) Aluminum mobilization by desferrioxamine assessed by microdialysis of the blood, liver and brain. Toxicology 66(3): 313-324.
23. Amaro S, Soy D, Obach V, Cervera A, Planas AM, Chamorro A (2007) A pilot study of dual treatment with recombinant tissue plasminogen activator and uric acid in acute ischemic stroke. Stroke 38(7): 2173-2175.
24. Miller NJ, Johnston JD, Collis CS, Rice-Evans C (1997) Serum total antioxidant activity after myocardial infarction. Ann Clin Biochem 34(Pt 1): 85-90.
25. Altamura C, Squitti R, Pasqualetti P, Gaudino C, Palazzo P, Tibuzzi F, Lupoi D, Cortesi M, Rossini PM, Vernieri F (2009) Ceruloplasmin/transferrin system is related to clinical status in acute stroke. Stroke 40(4): 1282-1288.