Metabolomic analysis of normal and sickle cell erythrocytes;Analyse métabolomique des globules rouges normaux et drépanocytaires

Transfusion Clinique et Biologique

Volumn 17, Issue 3, 2010, Pages 148-150

  Darghouth, D ^a,b   Koehl, B ^a,b   Junot, C ^c   Romeo P H ^a,b  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^b INSERM   (France)

^c CEA SACLAY   (France)

Author keywords

Biomarkers; Metablome; Metabolic pathways; Red blood cells; Sickle cell disease

Indexed keywords

ASCORBIC ACID; GLUTATHIONE; NITRIC OXIDE; UREA;

ARTICLE; CELL ISOLATION; CELL METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; ERYTHROCYTE DISORDER; FOLLOW UP; GLYCOLYSIS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLOMICS; SICKLE CELL; SICKLE CELL ANEMIA; UREA CYCLE;

EID: 77955851315     PISSN: 12467820     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tracli.2010.06.011     Document Type: Article

References (4)

1. Nicholson J.K. Global systems biology, personalized medicine and molecular epidemiology. Mol Syst Biol 2006, 2:52.
2. Sana T.R., Waddell K., Fischer S.M. A sample extraction and chromatographic strategy for increasing LC/MS detection coverage of the erythrocyte metabolome. J Chromatogr B Analyt Technol Biomed Life Sci 2008, 871:314-321.
3. Zhang Y., Jiye A., Wang G., Huang Q., Yan B., Zha W. Organic solvent extraction and metabonomic profiling of the metabolites in erythrocytes. J Chromatogr B Analyt Technol Biomed Life Sci 2009, 877:1751-1757.
4. Nishino T., Yachie-Kinoshita A., Hirayama A., Soga T., Suematsu M., Tomita M., et al. In silico modeling and metabolome analysis of long-stored erythrocytes to improve blood storage methods. J Biotechnol 2009, 144:212-223.