In silico modeling and metabolome analysis of long-stored erythrocytes to improve blood storage methods

Journal of Biotechnology

Volumn 144, Issue 3, 2009, Pages 212-223

  Nishino, Taiko ^a   Yachie Kinoshita, Ayako ^a   Hirayama, Akiyoshi ^a   Soga, Tomoyoshi ^a   Suematsu, Makoto ^a   Tomita, Masaru ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Blood storage; Cellular modeling; Erythrocyte metabolism; Metabolic simulation; Metabolome analysis

Indexed keywords

CELL VIABILITY; CELLULAR MODELING; CHEMICAL FACTORS; DYNAMIC SYSTEMS; ENZYMATIC REACTION; ERYTHROCYTE METABOLISM; IN-SILICO; MATHEMATICAL MODELING; METABOLIC INTERMEDIATES; METABOLIC NETWORK; METABOLIC SIMULATION; METABOLOME ANALYSIS; OXYGEN DELIVERY; PHOSPHATE SOLUTIONS; SYSTEMATIC ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY;

BIOCHEMISTRY; BLOOD; CAPILLARY ELECTROPHORESIS; CONFORMAL MAPPING; DYNAMICAL SYSTEMS; MASS SPECTROMETERS; MASS SPECTROMETRY; MATHEMATICAL MODELS; METABOLITES; OXYGEN; SIMULATORS;

METABOLISM;

2,3 DIPHOSPHOGLYCERIC ACID; ADENINE; ADENOSINE TRIPHOSPHATE; MANNITOL; PHOSPHATE;

ARTICLE; BLOOD STORAGE; COMPUTER MODEL; COMPUTER PREDICTION; CONTROLLED STUDY; ERYTHROCYTE METABOLISM; ERYTHROCYTE PRESERVATION; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; METABOLOMICS; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; STORAGE TEMPERATURE;

2,3-DIPHOSPHOGLYCERATE; ADENOSINE TRIPHOSPHATE; BLOOD PRESERVATION; COLD TEMPERATURE; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; ELECTROPHORESIS, CAPILLARY; ERYTHROCYTES; GLYCOLYSIS; HUMANS; MASS SPECTROMETRY; METABOLOME; MODELS, BIOLOGICAL; SOLUTIONS; TIME FACTORS;

EID: 70449530590     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2009.08.010     Document Type: Article

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