Combined effect of CYP1B1 codon 432 polymorphism and N-acetyltransferase 2 slow acetylator phenotypes in relation to breast cancer in the Turkish population

Anticancer Research

Volumn 30, Issue 7, 2010, Pages 2885-2889

  Özbek, Yasemin K ^a   Öztürk, Tülin ^c   Tüzüner, Bora M ^a   Calay, Zerrin ^b   Ilvan, Sennur ^b   Seyhan, Fatih M ^a   Kisakesen, Halil I ^a   Öztürk, Oǧuz ^a   Isbir, Turgay ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c Bagcilar Education and Research Hospital ^*  (Turkey)

Author keywords

Breast cancer; Cytochrome P450 1B1; Heterocyclic arylamines; N acetyltransferase 2; Oestrogen metabolism

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE; CYTOCHROME P450 1B1;

ACETYLATOR PHENOTYPE; ADULT; AGED; ALLELE; ARTICLE; BREAST CANCER; CANCER PATIENT; CODON; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MISSENSE MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; ARYLAMINE N-ACETYLTRANSFERASE; BREAST NEOPLASMS; CASE-CONTROL STUDIES; CODON; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; MIDDLE AGED; MUTATION; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; TURKEY; YOUNG ADULT;

EID: 77955811177     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Gadducci A, Biglia N, Sismondi P and Genazzani AR: Breast Cancer and sex steroids: Critical review of epidemiological, experimental and clinical investigations on etiopathogenesis, chemoprevention and endocrine treatment of breast cancer. Gyn End 20: 343-360, 2005. (Pubitemid 40978807)
2. Kumaraguruparan R, Mohan KVPC and Nagini S: Xenobiotic-metabolising enzymes in patients with adenocarcinoma of the breast: Correlation with clinical stage and menopausal status. The Breast 15: 58-68, 2006.
3. Sissung TM, Price DK, Sparreboom A and Figg WD: Pharmacogenetics and Regulation of Human Cytochrome P450 1B1: Implications in Hormone-Mediated Tumor Metabolism and a Novel Target for Therapeutic Intervention. Mol Cancer Res 4: 135-150, 2006.
4. Perez CB, Valdiglesias V, Pásaro E, Méndez J and Laffon B: Genetic Polymorphism in Cytochrome 1B1 in a Spanish Population. Basic & Clin Pharmacology & Toxicology 101: 70-72, 2007.
5. Cavalieri EL, Stack DE, Devanesan PD , Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML , Gooden JK, Ramanathan R, Cerny RL and Rogan EG: Molecular Origin Of Cancer: Catechol Estrogen-3,4- Quinones As Endogenous Tumor initiators. Proc Natl Acad Sci USA 94: 10937-10942. 1997.
6. Meyer UA: Polymorphism of Human Acetyltransferases. Env Health Pers 102: 213-216 1994.
7. Sabbagh A and Darlu P: Inferring haplotypes at the NAT2 locus: the computational approach. BMC Genetics 6: 30, 2005.
8. Sabbagh A, Langaney A, Darlu P, Gerard N, Krishnamoorthy R and Poloni ES: Worldwide distribution of NAT 2 diversity: Implications for NAT 2 evolutionary history. BMC Genetics 9: 21, 2008. (Pubitemid 351552575)
9. Ozturk O, Kagnici OF, Ozturk T, Durak H, Tuzuner BM, Kisakesen HI, Cakalir C and Isbir T: 192R Allele of Paraoxanase 1 (PON1) Gene as a New Marker for Susceptibility to Bladder Cancer. Anticancer Research 29: 4041-4046, 2009.
10. Wright DK and Manos MM: Sample preparation from paraffin-embedded tissues. In: PCR Protocols, A Guide to Methods and Applications. U.K. Inis MA, Gelfand DH, Sninsky JJ, White TJ (eds.). Academic Press, pp. 153-158, 1990.
11. Miller SA, Dykes DD and Polesky HS: Simple salting-out procedure for extracting DNA from human nucleated cells. Nucleic Acid Res 16: 1215, 1988.
12. Zheng W, Xie D, Jin F, Cheng J, Dai Q, Wen W, Shu X and Gao Y: Genetic Polymorphism of Cytochrome P450-1B1 and Risk of Breast Cancer. Cancer Epid Biom & Prev 9: 147-150, 2000. (Pubitemid 30111936)
13. Deitz AC, Zheng W, Leff MA, Gross M, Wen W, Doll MA, Xiao GH, Folsom AR and Hein DW: N-Acetyltransferase-2 Genetic Polymorphism, Well-done Meat Intake, and Breast Cancer Risk among Postmenopausal Women. Cancer Epid Biom & Prev 9: 905-910, 2000.
14. Hein DW, Doll MA, Fretland AJ, Leff MA, Webb SJ, Xiao GH, Devanaboyina U, Nangju NA and Feng Y: Molecular Genetics and Epidemiology of the NAT 1 and NAT 2 Acetylation Polymorphisms. Cancer Epid Biom & Prev 9: 29-42, 2000. (Pubitemid 30062907)
15. Ochs-Balcom HM, Wiesner G and Elston RC: A Meta-Analysis of the Association of N-Acetyltransferase 2 Gene (NAT2) Variants with Breast Cancer. Am J Epidemiol 166: 246-254, 2007. (Pubitemid 47216806)
16. Alberg AJ, Daudt A, Huang HY, Hoffman SC, Comstock GW, Helzlsouer KJ, Strickland PT and Bell DA: N-acetyltransferase 2 (NAT2) genotypes,cigarette smoking, and the risk of breast cancer. Cancer Detect Prev 25: 187-197, 2004.
17. Huang CS, Chern HD, Shen CY, Hsu SM and Chang KJ: Association between Nacetyltransferase 2 (NAT2) genetic polymorphism and development of breast cancer in post-menopausal Chinese women in Taiwan, an area of great increase in breast cancer incidence. Int J Cancer 82: 175-179, 1999.
18. Sillanpaa P, Hirvonen A, Kataja V, Kataja V, Eskelinen M, Kosma VM, Uusitupa M, Vainio H and Mitrunen K: NAT2 slow acetylator genotype as an important modifier of breast cancer risk. Int J Cancer 114: 579-584, 2005. (Pubitemid 40349616)
19. Hunter DJ, Hankinson SE, Hough H, Gertig DM, Garcia-Closas M, Spiegelman D, Manson JE, Colditz GA, Willett WC, Speizer FE and Kelsey K: A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer. Carcinogenesis 18: 2127-2132, 1997.
20. Millikan RC, Pittman GS, Newman B, Tse CK, Selmin O, Rockhill B, Savitz D, Moorman PG and Bell DA: Cigarette smoking, N acetyltransferases 1 and 2, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 7: 371-378, 1998. (Pubitemid 28354124)
21. McFadyen MC, Rooney PH, Melvin WT and Murray G: Quantitative analysis of the Ah receptor/cytochrome P450 CYP1B1/CYP1A1 signalling pathway. Biochem Pharmacol 65: 1663-1674, 2003.
22. Cavalieri E, Frenkel K, Liehr JG, Rogan E and Roy D: Estrogens as endogenous genotoxic agents-DNA adducts and mutations. J Natl Cancer Inst Monogr 27: 75-93, 2000.
23. Hanna IH, Dawling S, Roodi N, Guengerich FP and Parl FF: Cytochrome P450 1B1 (CYP1B1) Pharmacogenetics: Association of Polymorphisms with Functional Differences in Estrogen Hydroxylation Activity. Cancer Research 60: 3440-3444, 2000. (Pubitemid 30482162)
24. Liehr JG and Roy D: Free radical generation by redox cycling of estrogens. Free Radical Biol Med 8: 415-423, 1990. (Pubitemid 20186989)
25. Huang Z, Fasco MJ, Figge HL, Keyomarsi K and Kaminsky LS: Expression of cytochromes P450 in human breast tissue and tumors. Drug Metab Dispos 24: 899-905, 1996. (Pubitemid 26274749)
26. Sillanpaa P, Heikinhemo L, Kataja V, Eskelinen M, Komsa V, Uusitupa M, Vainio H, Metsola K and Hirvonen A: CYP 1A1 and CYP 1B1 genetic polymorphisms, smoking and breast cancer in a Finnish Caucasian population. Breast Cancer Res Treat 104: 287-297, 2007. (Pubitemid 47231273)