Oxidant-NO dependent gene regulation in dogs with type I diabetes: Impact on cardiac function and metabolism

Cardiovascular Diabetology

Volumn 9, Issue , 2010, Pages

  Ojaimi, Caroline ^a   Kinugawa, Shintaro ^a   Recchia, Fabio A ^a   Hintze, Thomas H ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; MESSENGER RNA; NITRIC OXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RNA; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SUPEROXIDE DISMUTASE; OXIDIZING AGENT;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DNA MICROARRAY; DOG; DOWN REGULATION; GENE CONTROL; GENE EXPRESSION PROFILING; GLUTATHIONE METABOLISM; HEART FUNCTION; HEART MUSCLE METABOLISM; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; OXIDATIVE STRESS; ANIMAL; CORONARY ARTERY BLOOD FLOW; DISEASE MODEL; EXPERIMENTAL DIABETES MELLITUS; GENETICS; HEART; HEART MUSCLE; HEMODYNAMICS; METABOLISM; PHYSIOLOGY; VASODILATATION;

ANIMALS; CORONARY CIRCULATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; DOGS; GENE EXPRESSION PROFILING; HEART; HEMODYNAMICS; MYOCARDIUM; NITRIC OXIDE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDANTS; VASODILATION;

EID: 77955807021     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-9-43     Document Type: Article

References (51)

1. Scoppola A, Montecchi FR, Menzinger G, Lala A. Urinary mevalonate excretion rate in type 2 diabetes: role of metabolic control. Atherosclerosis 2001, 156:357-61. 10.1016/S0021-9150(00)00660-2, 11395032.
2. Unwin N, Setel P, Rashid S, Mugusi F, Mbanya JC, Kitange H, Hayes L, Edwards R, Aspray T, Alberti KG. Noncommunicable diseases in sub-Saharan Africa: where do they feature in the health research agenda?. Bull World Health Organ 2001, 79:947-953. 2566676, 11693977.
3. Caballero AE, Arora S, Saouaf R, Lim SC, Smakowski P, Park JY, King GL, LoGerfo FW, Horton ES, Veves A. Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes 1999, 48:1856-1862. 10.2337/diabetes.48.9.1856, 10480619.
4. Kassab E, McFarlane SI, Sower JR. Vascular complications in diabetes and their prevention. Vasc Med 2001, 6:249-55. 10.1177/1358836X0100600409, 11958392.
5. Betteridge DJ. Diabetic dyslipidaemia: treatment implications. J Intern Med Suppl 1994, 736:47-52.
6. Regensteiner JG, Sippel J, McFarling ET, Wolfel EE, Hiatt WR. Effects of non-insulin-dependent diabetes on oxygen consumption during treadmill exercise. Med Sci Sports Exerc 1995, 27:875-81.
7. Franssila-Kallunki A, Groop L. Factors associated with basal metabolic rate in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1992, 35:962-6. 10.1007/BF00401426, 1451954.
8. Avesani CM, Cuppari L, Silva AC, Sigulem DM, Cendoroglo M, Sesso R, Draibe SA. Resting energy expenditure in pre-dialysis diabetic patients. Nephrol Dial Transplant 2001, 16:556-565. 10.1093/ndt/16.3.556, 11239031.
9. Diederich D, Skopec J, Diederich A, Dai FX. Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: role of free radicals. Am J Physiol 1994, 266:H1153-1161.
10. Kiff RJ, Gardiner SM, Compton AM, Bennett T. The effects of endothelin-1 and NG-nitro-L-arginine methyl ester on regional haemodynamics in conscious rats with streptozotocin-induced diabetes mellitus. Br J Pharmacol 1991, 103:1321-1326. 1908389, 1884094.
11. Zhao G, Zhang X, Smith CJ, Xu X, Ochoa M, Greenhouse D, Vogel T, Curran C, Hintze TH. Reduced coronary NO production in conscious dogs after the development of alloxan-induced diabetes. Am J Physiol 1999, 277:H268-278.
12. Zhao G, Zhang X, Xu X, Wolin MS, Hintze TH. Depressed modulation of oxygen consumption by endogenous nitric oxide in cardiac muscle from diabetic dogs. Am J Physiol Heart Circ Physiol 2000, 279:H520-527.
13. Flarsheim CE, Grupp IL, Matlib MA. Mitochondrial dysfunction accompanies diastolic dysfunction in diabetic rat heart. Am J Physiol Heart Circ Physiol 1996, 271:H192-202.
14. Kuo TH, Moore KH, Giacomelli F, Wiener J. Defective oxidative metabolism of heart mitochondria from genetically diabetic mice. Diabetes 1983, 32:781-787. 10.2337/diabetes.32.9.781, 6414861.
15. Mokhtar N, Lavoie J-P, Rousseau-Migneron R, Nadeau A. Physical training reverses defect in mitochondrial energy production in heart of chronically diabetic rats. Diabetes 1993, 42:682-687. 10.2337/diabetes.42.5.682, 8482425.
16. Tanaga Y, Konno N, Kako KJ. Mitochondrial dysfunction observed in situ in cardiomyocytes of rats in experimental diabetes. Cardiovasc Res 1992, 26:409-414. 10.1093/cvr/26.4.409, 1638575.
17. Linke A, Zhao G, Recchia FA, Williams J, Xu X, Hintze TH. Shift in metabolic substrate uptake by the heart during development of alloxan-induced diabetes. Am J Physiol Heart Circ Physiol 2003, 285:H1007-1014.
18. Sun G. Application of DNA microarrays in the study of human obesity and type 2 diabetes. OMICS 2007, 11:25-40. 10.1089/omi.2006.0003, 17411394.
19. Ojaimi C, Qanud K, Hintze TH, Recchia FA. Altered expression of a limited number of genes contributes to cardiac decompensation during chronic ventricular tachypacing in dogs. Physiol Genomics 2007, 29:76-83.
20. Ojaimi C, Li W, Kinugawa S, Post H, Csiszar A, Pacher P, Kaley G, Hintze TH. Transcriptional basis for exercise limitation in male eNOS-knockout mice with age: heart failure and the fetal phenotype. Am J Physiol Heart Circ Physiol 2005, 289:H1399-407. 10.1152/ajpheart.00170.2005, 15879487.
21. Savabi F. Mitochondrial creatine phosphokinase deficiency in diabetic rat heart. Biochem Biophys Res Commun 1988, 154:469-475. 10.1016/0006-291X(88)90710-3, 3395342.
22. Fuller W, Shattock MJ. Phospholemman and the cardiac sodium pump: protein kinase C, take a bow. Circ Res 2006, 99:1290-1292. 10.1161/01.RES.0000253090.54488.81, 17158344.
23. Searls YM, Loganathan R, Smirnova IV, Stehno-Bitte L. Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered with type 1 diabetes due to the direct effects of hyperglycemia. Cardiovasc Diabetol 2010, 9:8. 10.1186/1475-2840-9-8, 2829469, 20122173.
24. Hamed S, Brenner B, Aharon A, Daoud D, Roguin A. Nitric oxide and superoxide dismutase modulate endothelial progenitor cell function in type 2 diabetes mellitus. Cardiovasc Diabetol 2009, 8:56. 10.1186/1475-2840-8-56, 2773759, 19878539.
25. Bakker SJ, IJzerman RG, Teerlink T, Westerhoff HV, Gans RO, Heine RJ. Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure?. Atherosclerosis 2000, 148:17-21. 10.1016/S0021-9150(99)00329-9, 10580166.
26. Kristal BS, Koopmans SJ, Jackson CT, Ikeno Y, Park BJ, Yu BP. Oxidant-mediated repression of mitochondrial transcription in diabetic rats. Free Radic Biol Med 1997, 22:813-22. 10.1016/S0891-5849(96)00429-7, 9119250.
27. Wallace DC. Mitochondrial diseases in man and mouse. Science 1999, 283:1482-1488. 10.1126/science.283.5407.1482, 10066162.
28. Aggarwal BB, Quintanilha AT, Cammack R, Packer L. Damage to mitochondrial electron transport and energy coupling by visible light. Biochim Biophys Acta 1978, 502:367-382. 10.1016/0005-2728(78)90057-9, 656406.
29. Forsberg L, de Faire U, Morgenstern R. Oxidative stress, human genetic variation, and disease. Arch Biochem Biophys 2001, 389:84-93. 10.1006/abbi.2001.2295, 11370676.
30. Berliner A, Heinecke JW. The role of oxidized lipoproteins in atherogenesis. Free Radic Biol Med 1996, 20:707-727. 10.1016/0891-5849(95)02173-6, 8721615.
31. Pradhan D, Weiser M, Lumley-Sapanski K, Frazier D, Kemper S, Williamson P, Schlegel RA. Peroxidation-induced perturbations of erythrocyte lipid organization. Biochim Biophys Acta 1990, 1023:398-404. 10.1016/0005-2736(90)90132-8, 2334731.
32. Sevanian A, Mukkassah-Kelley SF, Montestruque S. The influence of phospholipase A2 and glutathione peroxidase on the elimination of membrane lipid peroxides. Biochim Biophys Acta 1983, 223:441-452.
33. Thomas JP, Ursini MF, Girotti AW. Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides. J Biol Chem 1990, 265:454-461.
34. Fisher AB, Dodia C, Manevich Y, Chen JW, Feinstein SI. Phospholipid hydroperoxides are substrates for non-selenium glutathione peroxidase. J Biol Chem 1999, 274:21326-21334. 10.1074/jbc.274.30.21326, 10409692.
35. Hurst R, Bao Y, Jemth P, Mannervik B, Williamson G. Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases. Biochem J 1998, 332:97-100. 1219456, 9576856.
36. Raes M, Michiels C, Remacle J. Comparative study of the enzymatic defense systems against oxygen-derived free radicals: the key role of glutathione peroxidase. Free Radic Biol Med 1987, 3:3-7. 10.1016/0891-5849(87)90032-3, 3623187.
37. Arthur JR. The glutathione peroxidases. Cell Mol Life Sci 2000, 57:1825-1835. 10.1007/PL00000664, 11215509.
38. Sies H. Glutathione and its role in cellular functions. Free Radic Biol Med 1999, 27:916-921. 10.1016/S0891-5849(99)00177-X, 10569624.
39. Forgione MA, Cap A, Liao R, Moldovan NI, Eberhardt RT, Lim CC, Jones J, Goldschmidt-Clermont PJ, Loscalzo J. Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure. Circulation 2002, 106:1154-1158. 10.1161/01.CIR.0000026820.87824.6A, 12196344.
40. Loeper J, Goy L, Rozensztazn O B, Moisson P. Lipid peroxidation and protective enzymes during myocardial infarction. Clin Chim Acta 1991, 196:119-125. 10.1016/0009-8981(91)90064-J, 2029778.
41. Espinola-Klein C, Rupprecht HJ, Bickel C, Schnabel R, Genth-Zotz S, Torzewski M, Lackner K, Munzel T, Blankenberg S, . AtheroGene Investigators Glutathione peroxidase-1 activity, atherosclerotic burden, and cardiovascular prognosis. Am J Cardiol 2007, 99:808-12. 10.1016/j.amjcard.2006.10.041, 17350371, AtheroGene Investigators.
42. Meister A. Methods for the selective modification of glutathione metabolism and study of glutathione transport. Methods Enzymol 1985, 113:571-585. full_text, 2868397.
43. Richmann PG, Meister A. Regulation of g-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione. J Biol Chem 1975, 250:1422-1426.
44. Murakami K, Kondo T, Otsuka Y, Fujiwara Y, Shimada M, Kawakami Y. Impairment of glutathione metabolism in erythrocytes from patients with diabetes mellitus. Metabolism 1989, 38:753-758. 10.1016/0026-0495(89)90061-9, 2569661.
45. Flögel U, Gödecke A, Klotz LO, Schrader J. Role of myoglobin in the antioxidant defense of the heart. FASEB J 2004, 18:1156-8.
46. Flögel U, Laussmann T, Gödecke A, Abanador N, Schäfers M, Fingas CD, Metzger S, Levkau B, Jacoby C, Schrader J. Lack of myoglobin causes a switch in cardiac substrate selection. Circ Res 2005, 96:e68-75. 10.1161/01.RES.0000165481.36288.d2, 15817884.
47. Li W, Jue T, Edwards J, Wang X, Hintze TH. Changes in NO bioavailability regulate cardiac O2 consumption: control by intramitochondrial SOD2 and intracellular myoglobin. Am J Physiol Heart Circ Physiol 2004, 286:H47-54. 10.1152/ajpheart.00730.2003, 12919935.
48. Suematsu N, Ojaimi C, Kinugawa S, Wang Z, Xu X, Koller A, Recchia FA, Hintze TH. Hyperhomocysteinemia alters cardiac substrate metabolism by impairing nitric oxide bioavailability through oxidative stress. Circulation 2007, 115:255-262. 10.1161/CIRCULATIONAHA.106.652693, 17200441.
49. Williams JG, Ojaimi C, Qanud K, Zhang S, Xu X, Recchia FA, Hintze TH. Coronary nitric oxide production controls cardiac substrate metabolism during pregnancy in the dog. Am J Physiol Heart Circ Physiol 2008, 294:H2516-2523. 10.1152/ajpheart.01196.2007, 18424630.
50. Czechowski T, Bari RP, Stitt M, Scheible WR, Udvardi MK. Real-time RT-PCR profiling of over 1400 Arabidopsis transcription factors: unprecedented sensitivity reveals novel root- and shoot-specific genes. Plant J 2004, 38:366-379. 10.1111/j.1365-313X.2004.02051.x, 15078338.
51. Lee JM, Stetten D. Studies in alloxan metabolism. I. The distribution and excretion of injected alloxan. J Biol Chem 1952, 197:205-214.