메뉴 건너뛰기




Volumn 107, Issue 3, 2010, Pages 730-736

Toxic effect of cyclophosphamide on sperm morphology, testicular histology and blood oxidant-antioxidant balance, and protective roles of lycopene and ellagic acid

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CATALASE; CYCLOPHOSPHAMIDE; ELLAGIC ACID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LYCOPENE; MALONALDEHYDE; OXIDIZING AGENT; SUPEROXIDE DISMUTASE;

EID: 77955786918     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2010.00571.x     Document Type: Article
Times cited : (91)

References (41)
  • 2
    • 28744447446 scopus 로고    scopus 로고
    • Chemoprotective effect of lipoic acid against cyclophosphamide-induced changes in the rat sperm
    • Selvakumar E, Prahalathan C, Sudharsan PT, Varalakshmi P. Chemoprotective effect of lipoic acid against cyclophosphamide-induced changes in the rat sperm. Toxicology 2006 217 : 71 8.
    • (2006) Toxicology , vol.217 , pp. 71-78
    • Selvakumar, E.1    Prahalathan, C.2    Sudharsan, P.T.3    Varalakshmi, P.4
  • 3
    • 34547470062 scopus 로고    scopus 로고
    • Chronic cyclophosphamide exposure alters the profile of rat sperm nuclear matrix proteins
    • Codrington AM, Hales BF, Robaire B. Chronic cyclophosphamide exposure alters the profile of rat sperm nuclear matrix proteins. Biol Reprod 2007 77 : 303 11.
    • (2007) Biol Reprod , vol.77 , pp. 303-311
    • Codrington, A.M.1    Hales, B.F.2    Robaire, B.3
  • 4
    • 69049116501 scopus 로고    scopus 로고
    • Potential chemoprotective effect of melatonin in cyclophosphamide- and cisplatin-induced testicular damage in rats
    • Ibey YÖ, Özbek E, imek A, Ötüntemur A, ekmen M, Somay A. Potential chemoprotective effect of melatonin in cyclophosphamide- and cisplatin-induced testicular damage in rats. Fertil Steril 2009 92 : 1124 32.
    • (2009) Fertil Steril , vol.92 , pp. 1124-1132
    • Ibey, Y.Ö.1    Özbek, E.2    Imek, A.3    Ötüntemur, A.4    Ekmen, M.5    Somay, A.6
  • 5
    • 17644392112 scopus 로고    scopus 로고
    • Beneficial effects of DL - Lipoic acid on cyclophosphamide-induced oxidative stress in mitochondrial fractions of rat testis
    • Selvakumar E, Prahalathan C, Mythili Y, Varalakshmi P. Beneficial effects of DL - lipoic acid on cyclophosphamide-induced oxidative stress in mitochondrial fractions of rat testis. Chem Biol Interact 2005 152 : 59 66.
    • (2005) Chem Biol Interact , vol.152 , pp. 59-66
    • Selvakumar, E.1    Prahalathan, C.2    Mythili, Y.3    Varalakshmi, P.4
  • 6
    • 20944439997 scopus 로고    scopus 로고
    • Mitigation of oxidative stress in cyclophosphamide-challenged hepatic tissue by DL - Lipoic acid
    • Selvakumar E, Prahalathan C, Mythili Y, Varalakshmi P. Mitigation of oxidative stress in cyclophosphamide-challenged hepatic tissue by DL - lipoic acid. Mol Cell Biochem 2005 272 : 179 85.
    • (2005) Mol Cell Biochem , vol.272 , pp. 179-185
    • Selvakumar, E.1    Prahalathan, C.2    Mythili, Y.3    Varalakshmi, P.4
  • 7
    • 45749118021 scopus 로고    scopus 로고
    • Chemoprotective effects of hesperidin against genotoxicity induced by cyclophosphamide in mice bone marrow cells
    • Ahmadi A, Hosseinimehr SJ, Naghshvar F, Hajir E, Ghahremani M. Chemoprotective effects of hesperidin against genotoxicity induced by cyclophosphamide in mice bone marrow cells. Arch Pharm Res 2008 31 : 794 7.
    • (2008) Arch Pharm Res , vol.31 , pp. 794-797
    • Ahmadi, A.1    Hosseinimehr, S.J.2    Naghshvar, F.3    Hajir, E.4    Ghahremani, M.5
  • 8
    • 34547829492 scopus 로고    scopus 로고
    • Molecular mechanisms of sperm capacitation: Progesterone-induced secondary calcium oscillations reflect the attainment of a capacitated state
    • Aitken RJ, McLaughlin EA. Molecular mechanisms of sperm capacitation: progesterone-induced secondary calcium oscillations reflect the attainment of a capacitated state. Soc Reprod Fertil Suppl 2007 63 : 273 93.
    • (2007) Soc Reprod Fertil Suppl , vol.63 , pp. 273-293
    • Aitken, R.J.1    McLaughlin, E.A.2
  • 9
    • 37349018261 scopus 로고    scopus 로고
    • Clinical relevance of oxidative stress in male factor infertility: An update
    • Agarwal A, Makker K, Sharma R. Clinical relevance of oxidative stress in male factor infertility: an update. Am J Reprod Immunol 2008 59 : 2 11.
    • (2008) Am J Reprod Immunol , vol.59 , pp. 2-11
    • Agarwal, A.1    Makker, K.2    Sharma, R.3
  • 11
    • 0142216401 scopus 로고    scopus 로고
    • Antioxidant activity of carotenoids
    • Stahl W, Sies H. Antioxidant activity of carotenoids. Mol Aspects Med 2003 24 : 345 51.
    • (2003) Mol Aspects Med , vol.24 , pp. 345-351
    • Stahl, W.1    Sies, H.2
  • 13
    • 34848855545 scopus 로고    scopus 로고
    • Ellagic acid prevents cisplatin-induced oxidative stress in liver and heart tissue of rats
    • DOI 10.1111/j.1742-7843.2007.00129.x
    • Yüce A, Ateahin A, eribai AO, Aksakal M. Ellagic acid prevents cisplatin-induced oxidative stress in liver and heart tissue of rats. Basic Clin Pharmacol Toxicol 2007 101 : 345 9. (Pubitemid 47512388)
    • (2007) Basic and Clinical Pharmacology and Toxicology , vol.101 , Issue.5 , pp. 345-349
    • Yuce, A.1    Atessahin, A.2    Ceribasi, A.O.3    Aksakal, M.4
  • 14
    • 3242769077 scopus 로고    scopus 로고
    • Antioxidant activity and phenolic content of selected fruit seeds
    • Soong Y-Y, Barlow PJ. Antioxidant activity and phenolic content of selected fruit seeds. Food Chem 2004 88 : 411 7.
    • (2004) Food Chem , vol.88 , pp. 411-417
    • Soong, Y.-Y.1    Barlow, P.J.2
  • 15
    • 29344471441 scopus 로고    scopus 로고
    • Quantification of gallic acid and ellagic acid from longan (Dimocarpus longan Lour.) seed and mango (Mangifera indica L.) kernel and their effects on antioxidant activity
    • Soong Y-Y, Barlow PJ. Quantification of gallic acid and ellagic acid from longan (Dimocarpus longan Lour.) seed and mango (Mangifera indica L.) kernel and their effects on antioxidant activity. Food Chem 2006 97 : 524 30.
    • (2006) Food Chem , vol.97 , pp. 524-530
    • Soong, Y.-Y.1    Barlow, P.J.2
  • 16
    • 14744279197 scopus 로고    scopus 로고
    • Flavonoids from Punica granatum-potential antiperoxidative agents
    • Sudheesh S, Vijayalakshmi NR. Flavonoids from Punica granatum-potential antiperoxidative agents. Fitoterapia 2005 76 : 181 6.
    • (2005) Fitoterapia , vol.76 , pp. 181-186
    • Sudheesh, S.1    Vijayalakshmi, N.R.2
  • 17
    • 55949087619 scopus 로고    scopus 로고
    • Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats
    • Pari L, Sivasankari R. Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats. Fundam Clin Pharmacol 2008 22 : 395 401.
    • (2008) Fundam Clin Pharmacol , vol.22 , pp. 395-401
    • Pari, L.1    Sivasankari, R.2
  • 18
    • 68549113154 scopus 로고    scopus 로고
    • Lycopene, an antioxidant carotenoid, attenuates testicular injury caused by ischemiareperfusion in rats
    • Hekimolu A, Kurer Z, Aral F, Baba F, ahna E, Atessahin A. Lycopene, an antioxidant carotenoid, attenuates testicular injury caused by ischemiareperfusion in rats. Tohoku J Exp Med 2009 218 : 141 7.
    • (2009) Tohoku J Exp Med , vol.218 , pp. 141-147
    • Hekimolu, A.1    Kurer, Z.2    Aral, F.3    Baba, F.4    Ahna, E.5    Atessahin, A.6
  • 19
    • 43549105129 scopus 로고    scopus 로고
    • Improvement of cisplatin-induced injuries to sperm quality, the oxidant-antioxidant system, and the histologic structure of the rat testis by ellagic acid
    • Türk G, Ateahin A, Sönmez M, eribai AO, Yüce A. Improvement of cisplatin-induced injuries to sperm quality, the oxidant-antioxidant system, and the histologic structure of the rat testis by ellagic acid. Fertil Steril 2008 89 (5S 1474 81.
    • (2008) Fertil Steril , vol.89 , Issue.5 , pp. 1474-1481
    • Türk, G.1    Ateahin, A.2    Sönmez, M.3    Eribai, A.O.4    Yüce, A.5
  • 20
    • 77955804192 scopus 로고    scopus 로고
    • Antiperoxidative and antiapoptotic effects of lycopene and ellagic acid on cyclophosphamide-induced testicular lipid peroxidation and apoptosis
    • in press)
    • Türk G, eribai AO, Sakin F, Sönmez M. Ateahin A. Antiperoxidative and antiapoptotic effects of lycopene and ellagic acid on cyclophosphamide-induced testicular lipid peroxidation and apoptosis. Reprod Fertil Dev 2009 (in press).
    • (2009) Reprod Fertil Dev
    • Türk, G.1    Eribai, A.O.2    Sakin, F.3    Sönmez, M.4    Ateahin, A.5
  • 21
    • 33846554727 scopus 로고    scopus 로고
    • Lycopene protects against cyclosporine A-induced testicular toxicity in rats
    • Türk G, Ateahin A, Sönmez M, Yüce A, eribai AO. Lycopene protects against cyclosporine A-induced testicular toxicity in rats. Theriogenology 2007 67 : 778 85.
    • (2007) Theriogenology , vol.67 , pp. 778-785
    • Türk, G.1    Ateahin, A.2    Sönmez, M.3    Yüce, A.4    Eribai, A.O.5
  • 22
    • 0018079943 scopus 로고
    • Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method
    • Satoh K. Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chim Acta 1978 90 : 37 43.
    • (1978) Clin Chim Acta , vol.90 , pp. 37-43
    • Satoh, K.1
  • 25
    • 0021288878 scopus 로고
    • Superoxide dismutase assay
    • Flohe L, Otting F. Superoxide dismutase assay. Methods Enzymol 1984 195 : 93 104.
    • (1984) Methods Enzymol , vol.195 , pp. 93-104
    • Flohe, L.1    Otting, F.2
  • 27
    • 0014893015 scopus 로고
    • Testicular biopsy score count a method for registration of spermatogenesis in human normal values and results in 335 hypogonadal males
    • Johnsen SG. Testicular biopsy score count a method for registration of spermatogenesis in human normal values and results in 335 hypogonadal males. Hormones 1970 1 : 2 25.
    • (1970) Hormones , vol.1 , pp. 2-25
    • Johnsen, S.G.1
  • 28
    • 43849092492 scopus 로고    scopus 로고
    • Astaxanthin inhibits cytotoxic and genotoxic effects of cyclophosphamide in mice germ cells
    • Tripathi DN, Jena GB. Astaxanthin inhibits cytotoxic and genotoxic effects of cyclophosphamide in mice germ cells. Toxicology 2008 248 : 96 103.
    • (2008) Toxicology , vol.248 , pp. 96-103
    • Tripathi, D.N.1    Jena, G.B.2
  • 29
    • 0036827741 scopus 로고    scopus 로고
    • Protective role of -tocopherol-succinate (provitamin-E) in cyclophosphamide induced testicular gametogenic and steroidogenic disorders: A correlative approach to oxidative stress
    • Ghosh D, Das UB, Misro M. Protective role of -tocopherol-succinate (provitamin-E) in cyclophosphamide induced testicular gametogenic and steroidogenic disorders: a correlative approach to oxidative stress. Free Radic Res 2002 36 : 1209 18.
    • (2002) Free Radic Res , vol.36 , pp. 1209-1218
    • Ghosh, D.1    Das, U.B.2    Misro, M.3
  • 30
    • 33646271593 scopus 로고    scopus 로고
    • Cyclophosphamide treatment causes impairment of sperm and its fertilizing ability in mice
    • Elangovan N, Chiou T-J, Tzeng W-F, Chu S-T. Cyclophosphamide treatment causes impairment of sperm and its fertilizing ability in mice. Toxicology 2006 222 : 60 70.
    • (2006) Toxicology , vol.222 , pp. 60-70
    • Elangovan, N.1    Chiou, T.-J.2    Tzeng, W.-F.3    Chu, S.-T.4
  • 31
    • 34447345951 scopus 로고    scopus 로고
    • Effects of the chemotherapeutic agents for non-hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), on the male rat reproductive system and progeny outcome
    • Vaisheva F, Delbes G, Hales BF, Robaire B. Effects of the chemotherapeutic agents for non-hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), on the male rat reproductive system and progeny outcome. J Androl 2007 28 : 578 87.
    • (2007) J Androl , vol.28 , pp. 578-587
    • Vaisheva, F.1    Delbes, G.2    Hales, B.F.3    Robaire, B.4
  • 33
    • 0034676493 scopus 로고    scopus 로고
    • Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology
    • Mates JM. Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 2000 153 : 83 104.
    • (2000) Toxicology , vol.153 , pp. 83-104
    • Mates, J.M.1
  • 35
    • 0141921796 scopus 로고    scopus 로고
    • Activities of xanthine oxidoreductase and antioxidant enzymes in different tissues of diabetic rats
    • Alicigüzel Y, Özen I, Aslan M, Karayalin U. Activities of xanthine oxidoreductase and antioxidant enzymes in different tissues of diabetic rats. J Lab Clin Med 2003 142 : 172 7.
    • (2003) J Lab Clin Med , vol.142 , pp. 172-177
    • Alicigüzel, Y.1    Özen, I.2    Aslan, M.3    Karayalin, U.4
  • 36
    • 0024464691 scopus 로고
    • Lycopene as the most efficient biological carotenoid singlet oxygen quencher
    • DiMascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989 274 : 532 8.
    • (1989) Arch Biochem Biophys , vol.274 , pp. 532-538
    • Dimascio, P.1    Kaiser, S.2    Sies, H.3
  • 37
    • 0000043582 scopus 로고    scopus 로고
    • International life sciences institute North America food component reports
    • Clydesdale FM. International life sciences institute North America food component reports. Crit Rev Food Sci Nutr 1999 39 : 203 316.
    • (1999) Crit Rev Food Sci Nutr , vol.39 , pp. 203-316
    • Clydesdale, F.M.1
  • 39
    • 47649128995 scopus 로고    scopus 로고
    • Amelioration of cyclosporine A-induced renal, hepatic and cardiac damages by ellagic acid in rats
    • Yüce A, Ateahin A, eribai AO. Amelioration of cyclosporine A-induced renal, hepatic and cardiac damages by ellagic acid in rats. Basic Clin Pharmacol Toxicol 2008 103 : 186 91.
    • (2008) Basic Clin Pharmacol Toxicol , vol.103 , pp. 186-191
    • Yüce, A.1    Ateahin, A.2    Eribai, A.O.3
  • 40
    • 30044444945 scopus 로고    scopus 로고
    • Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats
    • Ateahin A, Karahan, Türk G, Gür S, Yilmaz S, eribai AO. Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats. Reprod Toxicol 2006 21 : 42 7.
    • (2006) Reprod Toxicol , vol.21 , pp. 42-47
    • Ateahin, A.1    Karahan2    Türk, G.3    Gür, S.4    Yilmaz, S.5    Eribai, A.O.6
  • 41
    • 33645754253 scopus 로고    scopus 로고
    • Lycopene prevents adriamycin-induced testicular toxicity in rats
    • Ateahin A, Türk G, Karahan, Yilmaz S, eribai AO, Bulmu Ö. Lycopene prevents adriamycin-induced testicular toxicity in rats. Fertil Steril 2006 85 (Suppl 1 1216 22.
    • (2006) Fertil Steril , vol.85 , Issue.1 , pp. 1216-1222
    • Ateahin, A.1    Türk, G.2    Karahan3    Yilmaz, S.4    Eribai, A.O.5    Bulmu, Ö.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.