Induction of the vascular endothelial growth factor pathway in the brain of adults with fatal falciparum malaria is a non-specific response to severe disease

Histopathology

Volumn 57, Issue 2, 2010, Pages 282-294

  Medana, Isabelle M ^a   Day, Nicholas P J ^b,c   Roberts, Rachel ^a   Sachanonta, Navakanit ^c   Turley, Helen ^a   Pongponratn, Emsri ^c   Hien, Tran Tinh ^d   White, Nicholas J ^b,c   Turner, Gareth D H ^a,b,c  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b CHURCHILL HOSPITAL   (United Kingdom)

^c MAHIDOL UNIVERSITY   (Thailand)

^d CHO QUAN HOSPITAL   (Viet Nam)

Author keywords

cerebral; hypoxia; immunohistochemistry; malaria; pathophysiology; Plasmodium falciparum

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; PROTEIN KINASE R; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ACUTE KIDNEY FAILURE; ANEMIA; ARTICLE; AUTOPSY; BLOOD VESSEL OCCLUSION; BRAIN STEM; BRAIN TISSUE; CELL NUCLEUS; CONTROLLED STUDY; CORRELATION ANALYSIS; DIENCEPHALON; DISEASE SEVERITY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOGLYCEMIA; HYPOXIA; IMMUNOHISTOCHEMISTRY; LUNG EDEMA; MALARIA CONTROL; MALARIA FALCIPARUM; NEUROPATHOLOGY; NONHUMAN; OUTCOME ASSESSMENT; PARASITEMIA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SHOCK; TEMPORAL CORTEX; TISSUE SECTION;

ADULT; BRAIN; CASE-CONTROL STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; MALARIA, CEREBRAL; MALARIA, FALCIPARUM; MICROVESSELS; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

PLASMODIUM FALCIPARUM;

EID: 77955777236     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2010.03619.x     Document Type: Article

References (30)

1. White NJ, Ho M. The pathophysiology of malaria. Adv. Parasitol. 1992 31 83 173.
2. Newton CR, Hien TT, White N. Cerebral malaria. J. Neurol. Neurosurg. Psychiatry 2000 69 433 441.
3. World Health Organization CDC. Severe falciparum malaria. Trans. R. Soc. Trop. Med. Hyg. 2000 94 (Suppl. 1 S1 S90.
4. Pongponratn E, Turner GD, Day NP et al. An ultrastructural study of the brain in fatal Plasmodium falciparum malaria. Am. J. Trop. Med. Hyg. 2003 69 345 359.
5. Silamut K, Phu NH, Whitty C et al. A quantitative analysis of the microvascular sequestration of malaria parasites in the human brain. Am. J. Pathol. 1999 155 395 410.
6. Turner GD, Morrison H, Jones M et al. An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration. Am. J. Pathol. 1994 145 1057 1069.
7. Medana IM, Turner GD. Human cerebral malaria and the blood-brain barrier. Int. J. Parasitol. 2006 36 569 582.
8. Medana IM, Day NP, Hien TT et al. Cerebral calpain in fatal falciparum malaria. Neuropathol. Appl. Neurobiol. 2007 33 179 192.
9. Greenberg DA, Jin K. From angiogenesis to neuropathology. Nature 2005 438 954 959.
10. Armah HB, Wilson NO, Sarfo BY et al. Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children. Malar. J. 2007 6 147.
11. Casals-Pascual C, Idro R, Gicheru N et al. High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria. Proc. Natl. Acad. Sci. USA 2008 105 2634 2639.
12. Jain V, Armah HB, Tongren JE et al. Plasma IP-10, apoptotic and angiogenic factors associated with fatal cerebral malaria in India. Malar. J. 2008 7 83.
13. Yeo TW, Lampah DA, Gitawati R et al. Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria. Proc. Natl. Acad. Sci. USA 2008 105 17097 17102.
14. Deininger MH, Winkler S, Kremsner PG, Meyermann R, Schluesener HJ. Angiogenic proteins in brains of patients who died with cerebral malaria. J. Neuroimmunol. 2003 142 101 111.
15. Sachanonta N, Medana IM, Roberts R et al. Host vascular endothelial growth factor is trophic for Plasmodium falciparum-infected red blood cells. Asian Pac. J. Allergy Immunol. 2008 26 37 45.
16. Hien TT, Day NP, Nguyen HP et al. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. N. Engl. J. Med. 1996 335 76 83.
17. Campo L, Turley H, Han C et al. Angiogenin is up-regulated in the nucleus and cytoplasm in human primary breast carcinoma and is associated with markers of hypoxia but not survival. J. Pathol. 2005 205 585 591.
18. Giatromanolaki A, Koukourakis MI, Sivridis E et al. DEC1 (STRA13) protein expression relates to hypoxia-inducible factor 1-alpha and carbonic anhydrase-9 overexpression in nonα-SMAll cell lung cancer. J. Pathol. 2003 200 222 228.
19. Day NP, Phu NH, Mai NT et al. The pathophysiologic and prognostic significance of acidosis in severe adult malaria. Crit. Care Med. 2000 28 1833 1840.
20. Schmid-Brunclik N, Burgi-Taboada C, Antoniou X, Gassmann M, Ogunshola OO. Astrocyte responses to injury: VEGF simultaneously modulates cell death and proliferation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008 295 R864 R873.
21. Guo S, Bragina O, Xu Y et al. Glucose up-regulates HIF-1 alpha expression in primary cortical neurons in response to hypoxia through maintaining cellular redox status. J. Neurochem. 2008 105 1849 1860.
22. Dondorp AM, Ince C, Charunwatthana P et al. Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria. J. Infect. Dis. 2008 197 79 84.
23. Zhou J, Kohl R, Herr B, Frank R, Brune B. Calpain mediates a von Hippel-Lindau protein-independent destruction of hypoxia-inducible factor-1alpha. Mol. Biol. Cell 2006 17 1549 1558.
24. Rapella A, Negrioli A, Melillo G, Pastorino S, Varesio L, Bosco MC. Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma. Int. J. Cancer 2002 99 658 664.
25. Medana IM, Hien TT, Day NP et al. The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria. J. Infect. Dis. 2002 185 650 656.
26. Jin KL, Mao XO, Greenberg DA. Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc. Natl. Acad. Sci. USA 2000 97 10242 10247.
27. Talks KL, Turley H, Gatter KC et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 2000 157 411 421.
28. Turley H, Scott PA, Watts VM, Bicknell R, Harris AL, Gatter KC. Expression of VEGF in routinely fixed material using a new monoclonal antibody VG1. J. Pathol. 1998 186 313 318.
29. Stewart M, Turley H, Cook N et al. The angiogenic receptor KDR is widely distributed in human tissues and tumours and relocates intracellularly on phosphorylation. An immunohistochemical study. Histopathology 2003 43 33 39.
30. Medana IM, Day NP, Hien TT, White NJ, Turner GD. Erythropoietin and its receptors in the brainstem of adults with fatal falciparum malaria. Malar. J. 2009 8 261.