Cyclosporin A induces hyperpermeability of the blood-brain barrier by inhibiting autocrine adrenomedullin-mediated up-regulation of endothelial barrier function

European Journal of Pharmacology

Volumn 644, Issue 1-3, 2010, Pages 5-9

  Dohgu, Shinya ^a   Sumi, Noriko ^a   Nishioku, Tsuyoshi ^a   Takata, Fuyuko ^a,b   Watanabe, Takuya ^a   Naito, Mikihiko ^c   Shuto, Hideki ^a   Yamauchi, Atsushi ^a   Kataoka, Yasufumi ^a,b  

^a FUKUOKA UNIVERSITY   (Japan)

^b PharmaCo Cell Co Ltd   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Adenylyl cyclase; Adrenomedullin; Blood brain barrier; CAMP; Cyclosporin A; Permeability

Indexed keywords

ADENYLATE CYCLASE; ADRENOMEDULLIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOSPORIN A;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; BLOOD BRAIN BARRIER; BRAIN CELL; CELL LEVEL; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ELECTRIC RESISTANCE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME INHIBITION; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ADENYLATE CYCLASE; ADRENOMEDULLIN; ANIMALS; AUTOCRINE COMMUNICATION; BLOOD-BRAIN BARRIER; BRAIN; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; IMMUNOSUPPRESSIVE AGENTS; MICE; MICE, INBRED BALB C; PERMEABILITY; UP-REGULATION;

EID: 77955773133     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.05.035     Document Type: Article

References (25)

1. Banafshe H.R., Ghazi-Khansari M., Mehr S.E., Dehpour A.R. Cyclosporine attenuates the adenylyl cyclase superactivation induced by chronic cannabinoid treatment. Eur. J. Pharmacol. 2007, 557:20-22.
2. Banks W.A., Robinson S.M., Wolf K.M., Bess J.W., Arthur L.O. Binding, internalization, and membrane incorporation of human immunodeficiency virus-1 at the blood-brain barrier is differentially regulated. Neuroscience 2004, 128:143-153.
3. Chan G.C.K., Tonegawa S., Storm D.R. Hippocampal neurons express a calcineurin-activated adenylyl cyclase. J. Neurosci. 2005, 25:9913-9918.
4. Dehouck M.-P., Jolliet-Riant P., Brée F., Fruchart J.-C., Cecchelli R., Tillement J.-P. Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo models. J. Neurochem. 1992, 58:1790-1797.
5. Dohgu S., Kataoka Y., Ikesue H., Naito M., Tsuruo T., Oishi R., Sawada Y. Involvement of glial cells in cyclosporine-increased permeability of brain endothelial cells. Cell. Mol. Neurobiol. 2000, 20:781-786.
6. Dohgu S., Yamauchi A., Nakagawa S., Takata F., Kai M., Egawa T., Naito M., Tsuruo T., Sawada Y., Niwa M., Kataoka Y. Nitric oxide mediates cyclosporine-induced impairment of the blood-brain barrier in cocultures of mouse brain endothelial cells and rat astrocytes. Eur. J. Pharmacol. 2004, 505:51-59.
7. Dohgu S., Takata F., Yamauchi A., Nakagawa S., Egawa T., Naito M., Tsuruo T., Sawada Y., Niwa M., Kataoka Y. Brain pericytes contribute to the up-regulation and maintenance of blood-brain barrier functions through transforming growth factor-β production. Brain Res. 2005, 1038:208-215.
8. Geny B., Brandenberger G., Lonsdorfer J., Chakfé N., Habery P., Piquard F. Circulating adrenomedullun is increased after heart transplantation. Cardiovasc. Res. 1999, 41:731-736.
9. Gijtenbeek J.M.M., van den Bent M.J., Vecht C.J. Cyclosporine neurotoxicity: a review. J. Neurol. 1999, 246:339-346.
10. Hofbauer K.H., Schoof E., Kurtz A., Sandner P. Inflammatory cytokines stimulate adrenomedullin expression through nitric oxide-dependent and -independent pathway. Hypertension 2002, 39:161-167.
11. Honda M., Nakagawa S., Hayashi K., Kitagawa N., Tsutsumi K., Nagata I., Niwa M. Adrenomedullin improves the blood-brain barrier function through the expression of claudin-5. Cell. Mol. Neurobiol. 2006, 26:109-118.
12. Ishizaki T., Chiba H., Kojima T., Fujibe M., Soma T., Miyajima H., Nagasawa K., Wada I., Sawada N. Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways. Exp. Cell Res. 2003, 290:275-288.
13. Kis B., Deli M.A., Kobayashi H., Abraham C.S., Yanagita T., Kaiya H., Isse T., Nishi R., Gotoh S., Kangawa K., Wada A., Greenwood J., Niwa M., Yamashita H., Ueta Y. Adrenomedullin regulates blood-brain barrier functions in vitro. NeuroReport 2001, 12:4139-4142.
14. Kis B., Kaiya H., Nishi R., Deli M.A., Abraham C.S., Yanagita T., Isse T., Gotoh S., Kobayashi H., Wada A., Niwa M., Kangawa K., Greenwood J., Yamashita H., Ueta Y. Cerebral endothelial cells are a major source of adrenomedullin. J. Neuroendocrinol. 2002, 14:283-293.
15. Kis B., Chen L., Ueta Y., Busija D.W. Autocrine peptide mediators of cerebral endothelial cells and their role in the regulation of blood-brain barrier. Peptide 2006, 27:211-222.
16. Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Nakamura S., Matsuo H., Eto T. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem. Biophys. Res. Commun. 1993, 192:553-560.
17. Kochi S., Takanaga H., Matsuo H., Naito M., Tsuruo T., Sawada Y. Effect of cyclosporine A or tacrolimus on the function of blood-brain barrier cells. Eur. J. Pharmacol. 1999, 372:287-295.
18. Shuto H., Takanaga H., Kanaya A., Matsunaga K., Sueyasu M., Oishi R. Enhancement of serotonergic neural activity contributes to cyclosporine-induced tremors in mice. Eur. J. Pharmacol. 1998, 341:33-37.
19. Shuto H., Kataoka Y., Fujisaki K., Nakao T., Sueyasu M., Miura I., Watanabe Y., Fujiwara M., Oishi R. Inhibition of GABA system involved in cyclosporine-induced convulsions. Life Sci. 1999, 65:879-887.
20. Takata F., Dohgu S., Yamauchi A., Sumi N., Nakagawa S., Naito M., Tsuruo T., Shuto H., Kataoka Y. Inhibition of transforming growth factor-β production in brain pericytes contributes to cyclosporin A-induced dysfunction of the blood-brain barrier. Cell. Mol. Neurobiol. 2007, 27:317-328.
21. Takata F., Sumi N., Nishioku T., Harada E., Wakigawa T., Shuto H., Yamauchi A., Kataoka Y. Oncostatin M induces functional and structural impairment of blood-brain barriers comprised of rat brain capillary endothelial cells. Neurosci. Lett. 2008, 441:163-166.
22. Takata F., Dohgu S., Nishioku T., Takahashi H., Harada E., Makino I., Nakashima M., Yamauchi A., Kataoka Y. Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway. Neurosci. Lett. 2009, 449:71-75.
23. Tatsuta T., Naito M., Oh-hara T., Sugawara I., Tsuruo T. Functional involvement of P-glycoprotein in blood-brain barrier. J. Biol. Chem. 1992, 267:20383-20391.
24. Temmesfeld-Wollbrück B., Hocke A.C., Suttorp N., Hippenstiel S. Adrenomedullin and endothelial barrier function. Thromb. Haemost. 2007, 98:944-951.
25. Tsuji A., Tamai I., Sakata A., Tenda Y., Terasaki T. Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter P-glycoprotein. Biochem. Pharmacol. 1993, 46:1096-1099.