Nitric oxide mediates cyclosporine-induced impairment of the blood-brain barrier in cocultures of mouse brain endothelial cells and rat astrocytes

European Journal of Pharmacology

Volumn 505, Issue 1-3, 2004, Pages 51-59

  Dohgu, Shinya ^a   Yamauchi, Atsushi ^a   Nakagawa, Shinsuke ^b   Takata, Fuyuko ^a   Kai, Mamiko ^a   Egawa, Takashi ^a   Naito, Mikihiko ^c   Tsuruo, Takashi ^c   Sawada, Yasufumi ^d   Niwa, Masami ^b   Kataoka, Yasufumi ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

Blood brain barrier; Cyclosporine; Neurotoxicity; NO (nitric oxide); P glycoprotein; Permeability

Indexed keywords

CYCLOSPORIN; FLUORESCEIN SODIUM; GLYCOPROTEIN P; HISTAMINE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENYLEPHRINE; RHODAMINE 123;

ANIMAL CELL; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; COCULTURE; CONTROLLED STUDY; DOSE RESPONSE; ELECTROCHEMICAL ANALYSIS; ENDOTHELIUM CELL; GLIOMA CELL; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BLOOD-BRAIN BARRIER; BRAIN; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; COCULTURE TECHNIQUES; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENZYME INHIBITORS; FLUORESCEIN; MICE; MICE, INBRED BALB C; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; P-GLYCOPROTEINS; RATS; RATS, WISTAR; RHODAMINE 123;

EID: 8844237616     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.10.027     Document Type: Article

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