Aloe-emodin, an anthraquinone, in vitro inhibits proliferation and induces apoptosis in human colon carcinoma cells

Oncology Letters

Volumn 1, Issue 3, 2010, Pages 541-547

  Lin, Kai Yuan ^a,b   Uen, Yih Huei ^a,c  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^c SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Aloe emodin; Apoptosis; Colon carcinoma cells

Indexed keywords

ALOE EMODIN; APOPTOSIS INDUCING FACTOR; CASEIN KINASE II; CASPASE 3; CYTOCHROME C; PROTEIN BID;

AGAR GEL ELECTROPHORESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; COLON CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; MITOCHONDRION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

EID: 77955752587     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol_00000096     Document Type: Article

References (35)

1. Reynolds T: The compounds in Aloe leaf exudates: a review. Bot J Linn Soc 90: 157-177, 1985.
2. Eshun K and He Q: Aloe vera: a valuable ingredient for the food, pharmaceutical and cosmetic industries - a review. Crit Rev Food Sci Nutr 44: 91-96, 2004.
3. Pecere T, Gazzola MV, Mucignat C, Parolin C, Vecchia FD, Cavaggioni A, Basso G, Diaspro A, Salvato B, Carli M and Palu G: Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res 60: 2800-2804, 2000.
4. Lee HZ, Hsu SL, Liu MC and Wu CH: Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma. Eur J Pharmacol 431: 287-295, 2001.
5. Kuo PL, Lin TC and Lin CC: The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines. Life Sci 71: 1879-1892, 2002.
6. MAcevedo-Duncan M, Russell C, Patel S and Patel R: Aloe-emodin modulates PKC isoenzymes, inhibits proliferation and induces apoptosis in U-373MG glioma cells. Int Immunopharmacol 4: 1775-1784, 2004.
7. Yi J, Yang J, He R, Gao F, Sang H, Tang X and Ye RD: Emodin enhances arsenic trioxide-induced apoptosis via generation of reactive oxygen species and inhibition of survival signaling. Cancer Res 64: 108-116, 2004.
8. Mijatovic S, Maksimovic-Ivanic D, Radovic J, Miljkovic D, Kaludjerovic GN, Sabo TJ and Trajkovic V: Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin. Cell Mol Life Sci 62: 1275-1282, 2005.
9. Penninger JM and Kroemer G: Mitochondria, AIF and caspases - rivaling for cell death execution. Nat Cell Biol 5: 97-99, 2003.
10. Kim R, Emi M and Tanabe K: Role of mitochondria as the gardens of cell death. Cancer Chemother Pharmacol 57: 545-553, 2006.
11. Susin SA, Lorenzo HK, ZamZami N, et al: Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397: 441-446, 1999.
12. Kikkawa U, Mann SK, Firtel RA and Hunter T: Molecular cloning of casein kinase II alpha subunit from Dictyostelium discoideum and its expression in the life cycle. Mol Cell Biol 12: 5711-5723, 1992.
13. Ahmad KA, Wang G, Slaton J, Unger G and Agmed K: Targeting CK2 for cancer therapy. Anti-Cancer Drugs 16: 1037-1043, 2005.
14. Ahmed K, Gerber DA and Cochet C: Joining the cell survival squad: an emerging role for protein kinase CK2. Trends Cell Biol 12: 226-230, 2002.
15. Desagher S, Osen-Sand A, Montessuit A, Magnenat E, Vibois F, Hochmann A, Journot L, Antonsson B and Martinou JC: Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8. Mol Cell 8: 601-611, 2001.
16. Unger GM, Davis AT, Slaton JW and Ahmed K: Protein kinase CK2 as regulator of cell survival: implications for cancer therapy. Curr Cancer Drug Targets 4: 77-84, 2004.
17. 2-glycoprotein I protects J774A.1 macrophages and human coronary artery smooth muscle cells against apoptosis. J Cell Biochem 94: 485-496, 2005.
18. Chatterjee PK, Todorovic Z, Sivarajah A, Mota-Filipe H, Brown PAJ, Stewart KN, Cuzzocrea S and Thiemermann C: Differential effects of caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney. Eur J Pharmacol 503: 173-183, 2004.
19. Martin RM, Leonhardt H and Cardoso MC: DNA labeling in living cells. Cytometry Part A 67A: 45-52, 2005.
20. Sharma S, Dube A and Bose B: Pharmacokinetics and photo-toxicity of purpurin-18 in human colon carcinoma cells using liposomes as delivery vehicles. Cancer Chemother Pharmacol 57: 500-506, 2006.
21. Lee HZ: Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell. Br J Pharmacol 134: 1093-1103, 2001.
22. Sarno S, Moro S, Meggio F, Zagotto G, Ben DD, Ghisellini P, Battistutta R, Zanotti G and Pinna LA: Toward the rational design of protein kinase casein kinase-2 inhibitors. Pharmacol Ther 93: 159-168, 2002.
23. Litchfield DW: Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem J 369: 1-15, 2003.
24. Chau DHW, Yuan J, Zhang H, Cheung P, Lim T, Liu Z, Sall A and Yang D: Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondria injury and cleavage of eIL4GI but not DAP5/p97/NAT 1. Apoptosis 12: 513-524, 2007.
25. Shulga N and Pastorino JG: Acyl coenzyme A-binding protein augments Bid-induced mitochondrial damage and cell death by activating μ-calpain. J Biol Chem 281: 30824-30833, 2006.
26. Garrido C, Galluzzi L, Brunet M, Puig PE, Didelot C and Kroemer G: Mechanisms of cytochrome c release from mitochondria. Cell Death Differ 13: 1423-1433, 2006.
27. Kwon KB, Kim EK, Han MJ, et al: Induction of apoptosis by Radix Paeoniae Alba extract through cytochrome c release and the activations of caspase-9 and caspase-3 in HL-60 cells. Biol Pharm Bull 29: 1082-1086, 2006.
28. Zhang XM, Chen J, Xia YG and Xu Q: Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-α and translocating PKC-δ. Cancer Chemother Pharmacol 55: 251-262, 2005.
29. Ahmad KA, Wang G and Ahmed K: Intracellular hydrogen peroxide production is an upstream event in apoptosis induced by down-regulation of casein kinase 2 in prostate cancer cells. Mol Cancer Res 4: 331-338, 2006.
30. Morris RJ, Fischer SM, Klein-Szanto AJ and Slaga TJ: Subpopulations of primary adult murine epidermal basal cells sedimented on density gradients. Cell Tissue Kinet 23: 587-602, 1990.
31. Tiberio R, Marconi A, Fila C, et al: Keratinocytes enriched for stem cells are protected from anoikis via an integrin signaling pathway in a Bcl-2 dependent manner. FEBS Lett 524: 139-144, 2002.
32. Teplova V, Jaaskelainen E, Salkinoja-Salonen M, Saris NE, Serlachius M, Li FY and Andersson LC: Differentiated Paju cells have increased resistance to toxic effects of potassium ionophores. Acta Biochim Pol 51: 539-544, 2004.
33. Zuliani T, Denis V, Nobless E, Schnebert S, Andre P, Dumas M and Ratinaud MH: Hydrogen peroxide-induced cell death in normal human keratinocytes is differentiation dependent. Free Radic Biol Med 38: 307-316, 2005.
34. Jansen BJ, van Ruissen F, Cerneus S, Cloin W, Bergers M, van Erp PE and Schalkwijk J: Tumor necrosis factor related apoptosis inducing ligand triggers apoptosis in dividing but not in differentiating human epidermal keratinocytes. J Invest Dermatol 121: 1433-1439, 2003.
35. Pecere T, Sarinella F, Salata C, et al: Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin. Int J Cancer 106: 836-847, 2003.