Involvement of vascular endothelial growth factor signaling in CLR/RAMP1 and CLR/RAMP2-mediated pro-angiogenic effect of intermedin on human vascular endothelial cells

International Journal of Molecular Medicine

Volumn 26, Issue 2, 2010, Pages 289-294

  Albertin, Giovanna ^a   Sorato, Elisa ^a   Oselladore, Barbara ^a   Mascarin, Alessandra ^a   Tortorella, Cinzia ^a   Guidolin, Diego ^a  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

Author keywords

Angiogenesis; Calcitonin like receptor RAMP; Intermedin; Transactivation; Vascular endothelial growth factor

Indexed keywords

CALCITONIN RECEPTOR; INTERMEDIN; MATRIGEL; MESSENGER RNA; RECEPTOR ACTIVITY MODIFYING PROTEIN 1; RECEPTOR ACTIVITY MODIFYING PROTEIN 2; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; ADM2 PROTEIN, HUMAN; BIOLOGICAL MARKER; CALCITONIN RECEPTOR LIKE RECEPTOR; CALCRL PROTEIN, HUMAN; COLLAGEN; DRUG COMBINATION; LAMININ; MEMBRANE PROTEIN; PEPTIDE HORMONE; PROTEOGLYCAN; RAMP1 PROTEIN, HUMAN; RAMP2 PROTEIN, HUMAN; RAMP3 PROTEIN, HUMAN; RECEPTOR ACTIVITY MODIFYING PROTEIN; RECEPTOR ACTIVITY MODIFYING PROTEIN 3; SIGNAL PEPTIDE; VASCULOTROPIN A;

ANGIOGENESIS; ARTICLE; DIMERIZATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; WESTERN BLOTTING; ANALYSIS OF VARIANCE; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; DRUG COMBINATION; GENE SILENCING; GENETICS; METABOLISM; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; CALCITONIN RECEPTOR-LIKE PROTEIN; CELLS, CULTURED; COLLAGEN; DRUG COMBINATIONS; ENDOTHELIAL CELLS; GENE SILENCING; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LAMININ; MEMBRANE PROTEINS; NEOVASCULARIZATION, PHYSIOLOGIC; PEPTIDE HORMONES; PHOSPHORYLATION; PROTEOGLYCANS; RECEPTOR ACTIVITY-MODIFYING PROTEIN 1; RECEPTOR ACTIVITY-MODIFYING PROTEIN 2; RECEPTOR ACTIVITY-MODIFYING PROTEIN 3; RECEPTOR ACTIVITY-MODIFYING PROTEINS; RECEPTORS, CALCITONIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 77955747726     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000464     Document Type: Article

References (35)

1. Roh J, Chang CL, Bhalla A, Klein C and Hsu SYT: Intermedin is a calcitonin/CGRP family peptide acting through the calcitonin receptor-like receptor activity modifying protein receptor complexes. J Biol Chem 279: 7264-7274, 2004.
2. Takey Y, Hyodo S, Katafuchi T and Minamino N: Novel fish-derived adrenomedullin in mammals: structure and possible function. Peptides 25: 1643-1656, 2004.
3. Bell D and McDermott BJ: Intermedin (adrenomedullin-2): a novel counter-regulatory peptide in the cardiovascular and renal systems. Br J Pharmacol 153: S247-S262, 2008.
4. Taylor MM, Bagley SL and Samson WK: Intermedin/ adrenomedullin-2 inhibits growth hormone release from cultured, primary anterior pituitary cells. Endocrinology 147: 859-864, 2005.
5. Morimoto R, Satoh F, Murakami O, Totsune K, Suzuki T, Sasano H, Ito S and Takahashi K: Expression of adrenomedullin2/ intermedin in human brain, heart and kidney. Peptides 28: 1095-1103, 2007.
6. Pearson LJ, Yandle TG, Nicholls MG and Evans JJ: Intermedin (Adrenomedullin-2): a potential protective role in human aortic endothelial cells. Cell Physiol Biochem 23: 97-108, 2009.
7. Pan CS, Yang JH, Cai DY, Zhao J, Gerns H, Yang J, Chang JK, Tang CS and Qi YF: Cardiovascular effects of newly discovered peptide intermedin/ adrenomedullin 2. Peptides 26: 1640-1646, 2005. (Pubitemid 41169759)
8. Fujisawa Y, Nagai Y, Miyatake A, Miura K, Shokoji T, Nishiyama A, Kimura S and Abe Y: Roles of adrenomedullin 2 in regulating the cardiovascular and sympathetic nervous system in conscious rats. Am J Physiol Heart Circ Physiol 290: H1120-H1127, 2006.
9. Hashimoto H, Hyodo S, Kawasaki M, Shibata M, Saito T, Suzuki H, Otsubo H, Yokoyama T, Fujihara H, Higuchi T, Takey Y and Ueta Y: Adrenomedullin 2 (AM2)/Intermedin is a more potent activator of hypothalamic ocytocin-secreting neurons than AM possibly through an unidentified receptor in rats. Peptides 28: 1104-1112, 2007.
10. Cui H, Kohsaka A, Waki H, Gouraud S, Nakamura T, Yukawa K, Hatada A, Bhuiyan MER and Maeda M: Adrenomedullin 2 microinjection into the nucleus tractus solitarius elevates arterial pressure and heart rate in rats. Auton Neurosci 142: 45-50, 2008.
11. Toda M, Suzuki T, Hosono K, Kurihara Y, Kurihara H, Hayashi I, Kitasato H, Hoka S and Majima M: Roles of calcitonin generelated peptide in facilitation of wound healing and angiogenesis. Biomed Pharmacother 62: 352-359, 2008.
12. Toda M, Suzuki T, Hosono K Hayashi I, Hashiba S, Onuma Y, Amano H, Kurihara Y, Kurihara H, Okamoto H, Hoka S and Majima M: Neural system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide. Proc Natl Acad Sci USA 105: 13550-13555, 2008.
13. Ribatti D, Guidolin D, Conconi MT, Nico B, Baiguera S, Parnigotto PP and Vacca A: Vinblastine inhibits the angiogenic response induced by adrenomedullin in vitro and in vivo. Oncogene 22: 6458-6461, 2003. (Pubitemid 37281693)
14. Fernandez-Sauze S, Delfino C, Mabrouk K, Dussert C, Chinot O, Martin PM, Grisoli F, Ouafik L and Boudouresque F: Effects of adrenomedullin on endothelial cells in the multistep process of angiogenesis: involvement of CRLR/RAMP2 and CRLR/RAMP3 receptors. Int J Cancer 108: 797-804, 2004. (Pubitemid 38112605)
15. Guidolin D, Albertin G, Spinazzi R, Sorato E, Mascarin A, Cavallo D, Antonello M and Ribatti D: Adrenomedullin stimulates angiogenic response in cultured human vascular endothelial cells: involvement of the vascular endothelial growth factor receptor 2. Peptides 29: 2013-2023, 2008.
16. Smith RS, Gao L, Bledsoe G, Chao L and Chao J: Intermedin is a new angiogenic growth factor. Am J Physiol Heart Circ Physiol 297: H1040-H1047, 2009.
17. Poyner DR, Sexton PM, Marshall J, Smith DM, Quiron R, Born W, Muff R, Fischer JA and Foord SM: International Union of Pharmacology. XXXII. 2002. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin and calcitonin receptors. Pharmacol Rev 54: 233-246, 2002.
18. Lawley TJ and Kubota Y: Induction of morphologic differentiation of endothelial cells in culture. J Invest Dermatol 93: 598-618, 1989.
19. Arnaoutova I, George J, Kleinman HK and Benton G: The endothelial cell tube formation assay on basement membrane turns 20: state of the science and the art. Angiogenesis 12: 267-274, 2009.
20. Conconi MT, Lora S, Baiguera S, Boscolo E, Folin M, Scienza R, Rebuffat P, Parnigotto PP and Nussdorfer GG: In vitro culture of rat neuromicrovascular endothelial cells on polymeric scaffolds. J Biomed Mater Res A 71: 669-674, 2004.
21. Albertin G, Guidolin D, Sorato E, Spinazzi R, Mascarin A, Oselladore B, Montopoli M, Antonello M and Ribatti D: Proangiogenic activity of Urotensin-II on different human vascular endothelial cell populations. Regul Pept 157: 64-71, 2009.
22. Albertin G, Carraro G and Nussdorfer GG: Human adrenomedullin gene silencing by short interfering RNAs: a preliminary study. Int J Mol Med 15: 579-583, 2005.
23. Albertin G, Rucinski M, Carraro G, Forneris M, Andreis PG, Malendowicz LK and Nussdorfer GG: Adrenomedullin and vascular endothelium growth factor genes are overexpressed in the regenerating rat adrenal cortex and AM and VEGF reciprocally enhance their mRNA expression in cultured rat adrenocortical cells. Int J Mol Med 16: 431-435, 2005.
24. Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acid Res 29: E45, 2001.
25. Pfaffl MW, Horgan GW and Dempfle L: Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acid Res 30: E36, 2002.
26. Guidolin D, Vacca A, Nussdorfer GG and Ribatti D: A new image-analysis method based on topological and fractal parameters to evaluate the angiostatic activity of docetaxel by using the Matrigel assay in vitro. Microvasc Res 67: 117-124, 2004. (Pubitemid 38326997)
27. Eguchi S, Hirata Y, Iwasaki H, Sato K, Watanabe TX, Inui T, Nakajima K, Sakakibara S and Marumo F: Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells. Endocrinology 135: 2454-2458, 1994.
28. Chiba T, Yamaguchi A, Yamatani T, Nakamura A, Morishita T, Inui T, Fukase M, Noda T and Fujita T: Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37). Am J Physiol 256: E331-E335, 1989.
29. Fong T, Shawver LK, Sun L, Tang C, App H, Powell TJ, Kim YH, Schreck R, Wang X, Risau W, Ullrich A, Hirth KP and McMahon G: SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization and growth of multiple tumor types. Cancer Res 59: 99-106, 1999.
30. Ribatti D, Conconi MT and Nussdorfer GG: Nonclassic endogenous novel regulators of angiogenesis. Pharmacol Rev 59: 185-205, 2007. (Pubitemid 46855439)
31. Dong YL, Reddy DM, Green RE, Chauhan MS, Wang HQ, Nagamani M, Hankins GD and Yallampalli C: Calcitonin gene-related peptide (CALCA) is a proangiogenic growth factor in the human placental development. Biol Reprod 76: 892-899, 2007.
32. Lowes VL, Ip NY and Wong YH: Integration of signals from receptor tyrosine kinases and G protein-coupled receptors. Neurosignals 11: 5-19, 2002. (Pubitemid 37499845)
33. Linseman DA, Benjamin CW and Jones DA: Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cells. J Biol Chem 270: 12563-12568, 1995.
34. Daub H, Weiss FU, Wallasch C and Ullrich A: Role of transactivation of the EGF receptor in signalling by G protein-coupled receptors. Nature 379: 557-560, 1996. (Pubitemid 26049585)
35. Rao GN, Delafontaine P and Runge MS: Thrombin stimulates phosphorilation of insulin-like growth factor-1 receptor, insulin receptor substrate-1 and phospholipase C-gamma 1 in rat aortic smooth muscle cells. J Biol Chem 270: 27871-27875, 1995.