Monoclonal autoantibodies to the TSH receptor, one with stimulating activity and one with blocking activity, obtained from the same blood sample

Clinical Endocrinology

Volumn 73, Issue 3, 2010, Pages 404-412

  Evans, Michele ^a   Sanders, Jane ^a   Tagami, Tetsuya ^b   Sanders, Paul ^a   Young, Stuart ^a   Roberts, Emma ^a   Wilmot, Jane ^a   Hu, Xiaoling ^a   Kabelis, Katarzyna ^a   Clark, Jill ^a   Holl, Sabrina ^a   Richards, Tonya ^a   Collyer, Alastair ^a   Furmaniak, Jadwiga ^a   Smith, Bernard Rees ^a  

^a RSR LTD   (United Kingdom)

^b NATIONAL HOSPITAL ORGANIZATION KYOTO MEDICAL CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; MONOCLONAL ANTIBODY; THYROTROPIN RECEPTOR ANTIBODY;

ADULT; ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; BLOOD SAMPLING; CELL CLONING; CHO CELL; CONTROLLED STUDY; GENETIC ANALYSIS; HEAVY CHAIN; HUMAN; HUMAN CELL; HYPOTHYROIDISM; LIGHT CHAIN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; STANDARD; THYROTROPIN BLOOD LEVEL;

ADENOSINE MONOPHOSPHATE; ANIMALS; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; BINDING, COMPETITIVE; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; HUMANS; HYBRIDOMAS; HYPOTHYROIDISM; IMMUNOGLOBULIN JOINING REGION; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IODINE RADIOISOTOPES; MIDDLE AGED; PROTEIN BINDING; RECEPTORS, THYROTROPIN; THYROTROPIN;

EID: 77955739738     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2010.03831.x     Document Type: Article

References (32)

1. Rees Smith, B., McLachlan, S.M. Furmaniak, J. (1988) Autoantibodies to the thyrotropin receptor. Endocrine Reviews, 9, 106 121.
2. Rees Smith, B., Sanders, J. Furmaniak, J. (2007) TSH receptor antibodies. Thyroid, 17, 923 938.
3. Rapoport, B., Chazenbalk, G.D., Jaume, J.C. et al. (1998) The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies. Endocrine Reviews, 19, 673 716.
4. Takasu, N., Yamada, T., Sato, A. et al. (1990) Graves' disease following hypothyroidism due to Hashimoto's disease: studies of eight cases. Clinical Endocrinology, 33, 687 698.
5. Michelangeli, V.P., Poon, C., Topliss, D.J. et al. (1995) Specific effects of radioiodine treatment on TSAb and TBAb levels in patients with Graves' disease. Thyroid, 5, 171 176.
6. Ochi, Y., Inui, T., Kouki, T. et al. (1998) Thyroid stimulating immunoglobulin (TSI) in Graves' disease. Endocrine Journal, 45, 701 708.
7. Zakarija, M. McKenzie, J.M. (1983) Immunoglobulin G inhibitor of thyroid-stimulating antibody is a cause of delay in the onset of neonatal Graves' disease. Journal of Clinical Investigation, 72, 1352 1356.
8. Zakarija, M., McKenzie, J.M. Eidson, M.S. (1990) Transient neonatal hypothyroidism: characterization of maternal antibodies to the thyrotropin receptor. Journal of Clinical Endocrinology and Metabolism, 70, 1239 1246.
9. Sanders, J., Evans, M., Premawardhana, L.D.K.E. et al. (2003) Human monoclonal thyroid stimulating autoantibody. Lancet, 362, 126 128.
10. Sanders, J., Jeffreys, J., Depraetere, H. et al. (2004) Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function. Thyroid, 14, 560 570.
11. Sanders, J., Evans, M., Betterle, C. et al. (2008) A human monoclonal autoantibody to the thyrotropin receptor with thyroid-stimulating blocking activity. Thyroid, 18, 735 746.
12. 125I-labelled TSH receptor. Journal of Clinical Endocrinology and Metabolism, 84, 3797 3802.
13. Bolton, J., Sanders, J., Oda, Y. et al. (1999) Measurement of thyroid-stimulating hormone receptor autoantibodies by ELISA. Clinical Chemistry, 45, 2285 2287.
14. Sanders, J., Allen, F., Jeffreys, J. et al. (2005) Characteristics of a monoclonal antibody to the thyrotropin receptor that acts as a powerful thyroid-stimulating autoantibody antagonist. Thyroid, 15, 672 682.
15. Sanders, J., Jeffreys, J., Depraetere, H. et al. (2002) Thyroid-stimulating monoclonal antibodies. Thyroid, 12, 1043 1050.
16. Hayakawa, N., Premawardhana, L.D.K.E., Powell, M. et al. (2002) Isolation and characterization of human monoclonal autoantibodies to glutamic acid decarboxylase. Autoimmunity, 35, 343 355.
17. Rees Smith, B., Bolton, J., Young, S. et al. (2004) A new assay for thyrotropin receptor autoantibodies. Thyroid, 14, 830 835.
18. Scatchard, G. (1949) The attraction of proteins for small molecules and ions. Annals of the New York Academy of Sciences, 51, 660 672.
19. Oda, Y., Sanders, J., Roberts, S. et al. (1998) Binding characteristics of antibodies to the TSH receptor. Journal of Molecular Endocrinology, 20, 233 244.
20. Nakatake, N., Sanders, J., Richards, T. et al. (2006) Estimation of serum TSH receptor autoantibody concentration and affinity. Thyroid, 16, 1077 1084.
21. Ando, T., Latif, R., Pritsker, A. et al. (2002) A monoclonal thyroid-stimulating antibody. Journal of Clinical Investigation, 110, 1667 1674.
22. McLachlan, S.M. Rapoport, B. (2004) Thyroid stimulating monoclonal antibodies: overcoming the road blocks and the way forward. Clinical Endocrinology, 61, 10 18.
23. Valente, W., Vitti, P., Yavin, Z. et al. (1982) Monoclonal antibodies derived from the lymphocytes of patients with Graves' disease. Proceedings of the National Academy of Sciences of the United States of America, 79, 6680 6684.
24. Kohn, L., Suzuki, K., Hoffman, W. et al. (1997) Characterisation of monoclonal thyroid stimulating and thyrotropin binding inhibiting autoantibodies from a Hashimoto's patient whose children had intrauterine and neonatal thyroid disease. Journal of Clinical Endocrinology and Metabolism, 82, 3998 4009.
25. Yoshida, T., Ichikawa, Y., Ito, K. et al. (1986) Monoclonal antibodies to the thyrotropin receptor bind to a 56-kDa subunit of the thyrotropin receptor and show heterogeneous bioactivities. Journal of Biological Chemistry, 31, 16341 16347.
26. McLachlan, S.M. Rapoport, B. (1996) Monoclonal, human autoantibodies to the TSH receptor - the Holy Grail and why are we looking for it? Journal of Clinical Endocrinology and Metabolism, 81, 3152 3153.
27. Akamizu, T., Matsuda, F., Okuda, J. et al. (1996) Molecular analysis of stimulatory anti thyrotropin receptor antibodies (TSAbs) involved in Graves' disease. Journal of Immunology, 157, 3148 3152.
28. Akamizu, T., Moriyama, K., Miura, M. et al. (1999) Characterisation of recombinant monoclonal antithyrotropin receptor antibodies (TSHRAbs) derived from lymphocytes of patients with Graves' disease: Epitope and binding study of two stimulatory TSHRAbs. Endocrinology, 140, 1594 1601.
29. Rees Smith, B., Sanders, J. Furmaniak, J. (2008) Implications of new monoclonal antibodies and the crystal structure of the TSH receptor for the treatments and management of thyroid diseases. Biomarkers in Medicine, 2, 567 576.
30. Kumar, S., Schiefer, R., Coenen, M.K. et al. (2010) A stimulatory thyrotropin receptor antibody (M22) and thyrotropin increase interleukin-6. Thyroid, 20, 59 65.
31. Pacini, F., Ladenson, P.W., Schlumberger, M. et al. (2006) Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin in differentiated thyroid carcinoma: results of an international, randomized, controlled study. Journal of Clinical Endocrinology and Metabolism, 91, 926 932.
32. Schroeder, P.R., Haugen, B.R., Pacini, F. et al. (2006) A comparison of short-term changes in health-related quality of life in thyroid carcinoma patients undergoing diagnostic evaluation with recombinant human thyrotropin compared with thyroid hormone withdrawal. Journal of Clinical Endocrinology and Metabolism, 91, 878 884.