Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1

Brain Research

Volumn 1348, Issue , 2010, Pages 114-119

  Walsh, J ^a   Tighe, O ^a   Lai, D ^c   Harvey, R ^c   Karayiorgou, M ^b   Gogos, J A ^b   Waddington, J L ^a   O'Tuathaigh, C M P ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

9 tetrahydrocannabinol; COMT; DISC1; Knockout mice; Nociception; NRG1; Phenotype; Schizophrenia; Thermal pain

Indexed keywords

CATECHOL METHYLTRANSFERASE; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; DRONABINOL; NEU DIFFERENTIATION FACTOR; ANALGESIC AGENT; DISC1 PROTEIN, MOUSE; NERVE PROTEIN; NRG1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE DELETION; GENETIC ASSOCIATION; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SCHIZOPHRENIA; SENSITIVITY ANALYSIS; ANALYSIS OF VARIANCE; ANIMAL; ANIMAL BEHAVIOR; DEFICIENCY; DRUG EFFECTS; FEMALE; GENETICS; HYPERALGESIA; KNOCKOUT MOUSE; MALE; MUTAGENESIS; PAIN MEASUREMENT; PAIN THRESHOLD; PATHOPHYSIOLOGY; PHYSIOLOGY; REACTION TIME; SEX DIFFERENCE;

ANALGESICS, NON-NARCOTIC; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CATECHOL O-METHYLTRANSFERASE; FEMALE; HYPERALGESIA; MALE; MICE; MICE, KNOCKOUT; MUTAGENESIS; NERVE TISSUE PROTEINS; NEUREGULIN-1; PAIN MEASUREMENT; PAIN THRESHOLD; REACTION TIME; SEX FACTORS; TETRAHYDROCANNABINOL; DRONABINOL;

MUS;

EID: 77955715348     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.06.027     Document Type: Article

References (38)

1. N.C. Allen, S. Bagade, M.B. McQueen, J.P.A. Ioannidis, F.K. Kavvoura, M.J. Khoury, R.E. Tanzi, and L. Bertram Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database Nat. Genet. 40 2008 827 834
2. D. Babovic, C.M. O'Tuathaigh, A.M. O'Connor, G.J. O'Sullivan, O. Tighe, D.T. Croke, M. Karayiorgou, J.A. Gogos, D. Cotter, and J.L. Waddington Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase Neuroscience 155 2008 1021 1029
3. D. Babovic, C.M. O'Tuathaigh, G.J. O'Sullivan, J.J. Clifford, O. Tighe, D.T. Croke, M. Karayiorgou, J.A. Gogos, D. Cotter, and J.L. Waddington Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice Behav. Brain Res. 183 2007 236 239
4. J.H. Barnett, L. Scoriels, and M.R. Munafò Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism Biol. Psychiatry 64 2008 137 144
5. A. Becker, G. Grecksch, and H. Schroder Pain sensitivity is altered in animals after subchronic ketamine treatment Psychopharmacology 189 2006 237 247
6. A.A. Boucher, G.E. Hunt, T. Karl, J. Micheau, I.S. McGregor, and J.C. Arnold Heterozygous neuregulin 1 mice display greater baseline and [Delta]9-tetrahydrocannabinol-induced c-Fos expression Neuroscience 149 2007 861 870
7. M. Calvo, N. Zhu, C. Tsantoulas, Z. Ma, J. Grist, J.A. Loeb, and D.L. Bennett Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury J. Neurosci. 30 2010 5437 5450
8. A. Caspi, T.E. Moffitt, M. Cannon, J. McClay, J. Murray, H. Harrington, A. Taylor, L. Arseneault, B. Williams, A. Braithwaite, R. Poulton, and I.W. Craig Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction Biol. Psychiatry 57 2005 1117 1127
9. S. Chen, M.O. Velardez, X. Warot, Z.X. Yu, S.J. Miller, D. Cros, and G. Corfas Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function J. Neurosci. 26 2006 3079 3086
10. J.E. Chubb, N.J. Bradshaw, D.C. Soares, D.J. Porteous, and J.K. Millar The DISC locus in psychiatric illness Mol. Psychiatry 13 2008 36 64
11. S.J. Clapcote, T.V. Lipina, J.K. Millar, S. Mackie, S. Christie, F. Ogawa, J.P. Lerch, K. Trimble, M. Uchiyama, Y. Sakuraba, H. Kaneda, T. Shiroishi, M.D. Houslay, R.M. Henkelman, J.G. Sled, Y. Gondo, D.J. Porteous, and J.C. Roder Behavioral phenotypes of Disc1 missense mutations in mice Neuron 54 2007 387 402
12. L. Desbonnet, J.L. Waddington, and C.M. O'Tuathaigh Mice mutant for genes associated with schizophrenia: common phenotype or distinct endophenotypes? Behav Brain Res. 204 2009 258 273
13. R.H. Dworkin Pain insensitivity in schizophrenia: a neglected phenomenon and some implications Schizophr. Bull. 20 1994 235 248
14. F.R. Fricker, N. Zhu, C. Tsantoulas, B. Abrahamsen, M.A. Nassar, M. Thakur, A.N. Garatt, C. Birchmeier, S.B. McMahon, J.N. Wood, and D.L. Bennett Sensory axon-derived neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance J. Neurosci. 29 2009 7667 7678
15. S.Z. George, M.R. Wallace, T.W. Wright, M.W. Moser, W.H. Greenfield III, B.K. Sack, D.M. Herbstman, and R.B. Fillingim Evidence for a biopsychosocial influence on shoulder pain: pain catastrophizing and catechol-O- methyltransferase (COMT) diplotype predict clinical pain ratings Pain 136 2008 53 61
16. J.A. Gogos, M. Morgan, V. Luine, M. Santha, S. Ogawa, D. Pfaff, and M. Karayiorgou Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior Proc. Natl. Acad. Sci. U. S. A. 95 1998 9991 9996
17. Y.G. Gong, C.N. Wu, Q.H. Xing, X.Z. Zhao, J. Zhu, and L. He A two-method meta-analysis of Neuregulin 1 (NRG1) association and heterogeneity in schizophrenia Schizophr. Res. 111 2009 109 114
18. O. Kambur, P.T. Mannisto, K. Viljakka, I. Reenila, K. Lemberg, V.K. Kontinen, M. Karayiorgou, J.A. Gogos, and E. Kalso Stress-induced analgesia and morphine responses are changed in catechol-O-methyltransferase-deficient male mice Basic Clin. Pharmacol. Toxicol. 103 2008 367 373
19. M. Karst, and S. Wippermann Cannabinoids against pain. Efficacy and strategies to reduce psychoactivity: a clinical perspective Expert Opin. Investig. Drugs 18 2009 125 133
20. Kirby, B., Waddington, J.L., O'Tuathaigh, C.M.P., 2009. Advancing a functional genomics for schizophrenia: psychopathological and cognitive phenotypes in mutants with gene disruption. Brain Res. Bull. doi:10.1016/j.brainresbull.2009.09.010.
21. G. Kunos, D. Osei-Hyiaman, S. Batkai, K.A. Sharkey, and A. Makriyannis Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain? Trends Pharmacol. Sci. 30 2009 1 7
22. M.L. Lacroix-Fralish, V.L. Tawfik, N. Nutile-McMenemy, and J.A. Deleo Neuregulin 1 is a pronociceptive cytokine that is regulated by progesterone in the spinal cord: implications for sex specific pain modulation Eur. J. Pain 12 2008 94 103
23. L. Mei, and W.C. Xiong Neuregulin 1 in neural development, synaptic plasticity and schizophrenia Nat. Rev. Neurosci. 9 2008 437 452
24. W.J. Muir, B.S. Pickard, and D.H. Blackwood Disrupted-in-schizophrenia-1 Curr. Psychiatry Rep. 10 2008 140 147
25. M.R. Munafo, A.S. Attwood, and J. Flint Neuregulin 1 genotype and schizophrenia Schizophr. Bull. 34 2008 9 12
26. A.G. Nackley, K.S. Tan, K. Fecho, P. Flood, L. Diatchenko, and W. Maixner Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2-and beta3-adrenergic receptors Pain 128 2007 199 208
27. T. Okochi, M. Ikeda, T. Kishi, K. Kawashima, Y. Kinoshita, T. Kitajima, Y. Yamanouchi, M. Tomita, T. Inada, N. Ozaki, and N. Iwata Meta-analysis of association between genetic variants in COMT and schizophrenia: an update Schizophr. Res. 110 2009 140 148
28. C.M. O'Tuathaigh, D. Babovic, G.J. O'Sullivan, J.J. Clifford, O. Tighe, D.T. Croke, R. Harvey, and J.L. Waddington Phenotypic characterization of spatial cognition and social behavior in mice with 'knockout' of the schizophrenia risk gene neuregulin 1 Neuroscience 147 2007 18 27
29. C.M. O'Tuathaigh, G.J. O'Sullivan, A. Kinsella, R.P. Harvey, O. Tighe, D.T. Croke, and J.L. Waddington Sexually dimorphic changes in the exploratory and habituation profiles of heterozygous neuregulin-1 knockout mice NeuroReport 17 2006 79 83
30. F. Papaleo, J.N. Crawley, J. Song, B.K. Lipska, J. Pickel, D.R. Weinberger, and J. Chen Genetic dissection of the role of catechol-O- methyltransferase in cognition and stress reactivity in mice J. Neurosci. 28 2008 8709 8723
31. T. Sato, S. Sakurada, N. Takahashi, T. Sakurada, K. Tan-No, K. Wako, and K. Kisara Contribution of spinal [mu]1-opioid receptors to morphine-induced antinociception Eur. J. Pharm. 369 1999 183 187
32. J. Shi, E.S. Gershon, and C. Liu Genetic associations with schizophrenia: meta-analyses of 12 candidate genes Schizophr. Res. 104 2008 96 107
33. M.K. Singh, L.L. Giles, and H.A. Nasrallah Pain insensitivity in schizophrenia: trait or state marker? J. Psychiatr. Pract. 12 2006 90 102
34. H. Stefansson, E. Sigurdsson, V. Steinthorsdottir, S. Bjornsdottir, T. Sigmundsson, S. Ghosh, J. Brynjolfsson, S. Gunnarsdottir, O. Ivarsson, T.T. Chou, O. Hjaltason, B. Birgisdottir, H. Jonsson, V.G. Gudnadottir, E. Gudmundsdottir, A. Bjornsson, B. Ingvarsson, A. Ingason, S. Sigfusson, H. Hardardottir, R.P. Harvey, D. Lai, M. Zhou, D. Brunner, V. Mutel, A. Gonzalo, G. Lemke, J. Sainz, G. Johannesson, T. Andresson, D. Gudbjartsson, A. Manolescu, M.L. Frigge, M.E. Gurney, A. Kong, J.R. Gulcher, H. Petursson, and K. Stefansson Neuregulin 1 and susceptibility to schizophrenia Am. J. Hum. Genet. 71 2002 877 892
35. G. Tuboly, G. Benedek, and G. Horvath Selective disturbance of pain sensitivity after social isolation Physiol. Behav. 96 2009 18 22
36. E.M. Tunbridge, D.R. Weinberger, and P.J. Harrison A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder and effect of Val158Met genotype Mol. Psychiatry 11 2006 116 117
37. J.L. Waddington, A.P. Corvin, G. Donohoe, C.M.P. O'Tuathaigh, K.J. Mitchell, and M. Gill Functional genomics and schizophrenia: endophenotypes and mutant models Psychiat. Clin. N. Am. 30 2007 365 399
38. J.K. Zubieta, M.M. Heitzeg, Y.R. Smith, J.A. Bueller, K. Xu, Y. Xu, R.A. Koeppe, C.S. Stohler, and D. Goldman COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor Science 299 2003 1240 1243