Identification of potential HLA class i and class II epitope precursors associated with heat shock protein 70 (HSPA)

Cell Stress and Chaperones

Volumn 15, Issue 5, 2010, Pages 729-741

  Stocki, Pawel ^a   Morris, Nicholas J ^b   Preisinger, Christian ^c   Wang, Xiao N ^a   Kolch, Walter ^c   Multhoff, Gabriele ^d,e   Dickinson, Anne M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Antigen presentation; Heat shock protein 70 (HSPA); Human leukocyte antigen (HLA); Molecular chaperone

Indexed keywords

HEAT SHOCK PROTEIN 1A; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 8; HLA A ANTIGEN; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HLA B ANTIGEN; HLA DR ANTIGEN; HLA DR BETA ANTIGEN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIGEN PRESENTATION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EPITOPE MAPPING; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MISMATCH REPAIR; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN ISOLATION; PROTEIN MICROARRAY; PROTEIN PURIFICATION;

BLOTTING, WESTERN; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPITOPES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MASS SPECTROMETRY;

EID: 77955712821     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-010-0184-z     Document Type: Article

References (56)

1. S Adams FM Robbins D Chen D Wagage SL Holbeck HC Morse 3rd D Stroncek FM Marincola 2005 HLA class I and II genotype of the NCI-60 cell lines J Transl Med 3 11 10.1186/1479-5876-3-11 15748285
2. I Alvarez M Carrascal F Canals L Muixí J Abián D Jaraquemada 2007 The analysis of the HLA class I associated peptide repertoire in a hepatocellular carcinoma cell line reveals tumor-specific peptides as putative targets for immunotherapy Proteomics Clin Appl 1 286 298 10.1002/prca.200600388 1:CAS:528:DC%2BD2sXjs1KlsbY%3D
3. + T cells Nat Immunol 6 593 599 10.1038/ni1201 1:CAS:528:DC%2BD2MXktlWitrc%3D 15864309
4. RJ Binder NE Blachere PK Srivastava 2001 Heat shock protein-chaperoned peptides but not free peptides introduced into the cytosol are presented efficiently by major histocompatibility complex I molecules J Biol Chem 276 17163 17171 10.1074/jbc.M011547200 1:CAS:528:DC%2BD3MXjvFGit70%3D 11278929
5. F Boisgerault J Mounier V Tieng MC Stolzenberg I Khalil-Daher M Schmid P Sansonetti D Charron A Toubert 1998 Alteration of HLA-B27 peptide presentation after infection of transfected murine L cells by Shigella flexneri Infect Immun 66 4484 4490 1:CAS:528:DyaK1cXlslCru7o%3D 9712804
6. MK Callahan M Garg PK Srivastava 2008 Heat-shock protein 90 associates with N-terminal extended peptides and is required for direct and indirect antigen presentation Proc Natl Acad Sci USA 105 1662 1667 10.1073/pnas. 0711365105 1:CAS:528:DC%2BD1cXhvFaju7Y%3D 18216248
7. P Cascio C Hilton AF Kisselev KL Rock AL Goldberg 2001 26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide Embo J 20 2357 2366 10.1093/emboj/20.10.2357 1:CAS:528:DC%2BD3MXktFegurw%3D 11350924
8. ME Cheetham AJ Caplan 1998 Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function Cell Stress Chaperones 3 28 36 10.1379/1466-1268(1998)003<0028:SFAEOD>2.3.CO;2 1:CAS:528: DyaK1cXislCjsLw%3D 9585179
9. JM den Haan SM Lehar MJ Bevan 2000 CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo J Exp Med 192 1685 1696 10.1084/jem.192.12.1685
10. JK Eng AL McCormack JR Yates 1994 An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database J Am Soc Mass Spectrom 5 976 989 10.1016/1044-0305(94)80016-2 1:CAS:528: DyaK2MXhvF2htLw%3D
11. AM Fourie JF Sambrook MJ Gething 1994 Common and divergent peptide binding specificities of Hsp70 molecular chaperones J Biol Chem 269 30470 30478 1:STN:280:DyaK2M%2FnsVSmsQ%3D%3D 7982963
12. D Fruci G Lauvau L Saveanu M Amicosante RH Butler A Polack F Ginhoux F Lemonnier H Firat PM van Endert 2003 Quantifying recruitment of cytosolic peptides for HLA class I presentation: impact of TAP transport J Immunol 170 2977 2984 1:CAS:528:DC%2BD3sXhslOrsrk%3D 12626550
13. E Geier G Pfeifer M Wilm M Lucchiari-Hartz W Baumeister K Eichmann G Niedermann 1999 A giant protease with potential to substitute for some functions of the proteasome Science 283 978 981 10.1126/science.283.5404.978 1:CAS:528:DyaK1MXht1ehu7c%3D 9974389
14. ME Grossmann BJ Madden F Gao YP Pang JE Carpenter D McCormick CY Young 2004 Proteomics shows Hsp70 does not bind peptide sequences indiscriminately in vivo Exp Cell Res 297 108 117 10.1016/j.yexcr.2004.02.030 1:CAS:528: DC%2BD2cXkvVKmsLc%3D 15194429
15. PE Jensen 2007 Recent advances in antigen processing and presentation Nat Immunol 8 1041 1048 10.1038/ni1516 1:CAS:528:DC%2BD2sXhtVCkurjF 17878914
16. JL Johnson EA Craig 2001 An essential role for the substrate-binding region of Hsp40s in Saccharomyces cerevisiae J Cell Biol 152 851 856 10.1083/jcb.152.4.851 1:CAS:528:DC%2BD3MXhtlGmtLs%3D 11266475
17. K Kamiguchi T Torigoe O Fujiwara S Ohshima Y Hirohashi H Sahara I Hirai Y Kohgo N Sato 2008 Disruption of the association of 73 kDa heat shock cognate protein with transporters associated with antigen processing (TAP) decreases TAP-dependent translocation of antigenic peptides into the endoplasmic reticulum Microbiol Immunol 52 94 106 10.1111/j.1348-0421.2008.00017.x 1:CAS:528:DC%2BD1cXot1OrsLs%3D 18380807
18. DA Kirschmann KL Duffin CE Smith JK Welply SC Howard BD Schwartz SL Woulfe 1995 Naturally processed peptides from rheumatoid arthritis associated and non-associated HLA-DR alleles J Immunol 155 5655 5662 1:CAS:528: DyaK2MXpvVeqsr8%3D 7499850
19. MJ Kleijmeer A Kelly HJ Geuze JW Slot A Townsend J Trowsdale 1992 Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi Nature 357 342 344 10.1038/357342a0 1:STN:280:DyaK383mvF2lsg%3D%3D 1589036
20. M Kovacsovics-Bankowski KL Rock 1995 A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules Science 267 243 246 10.1126/science.7809629 1:CAS:528:DyaK2MXjt1ensb0%3D 7809629
21. T Kruger O Schoor C Lemmel B Kraemer C Reichle J Dengjel T Weinschenk M Muller J Hennenlotter A Stenzl HG Rammensee S Stevanovic 2005 Lessons to be learned from primary renal cell carcinomas: novel tumor antigens and HLA ligands for immunotherapy Cancer Immunol Immunother 54 826 836 10.1007/s00262-004-0650- 5 15627209
22. J Kunisawa N Shastri 2003 The group II chaperonin TRiC protects proteolytic intermediates from degradation in the MHC class I antigen processing pathway Mol Cell 12 565 576 10.1016/j.molcel.2003.08.009 1:CAS:528: DC%2BD3sXnvFGrtr8%3D 14527404
23. J Kunisawa N Shastri 2006 Hsp90alpha chaperones large C-terminally extended proteolytic intermediates in the MHC class I antigen processing pathway Immunity 24 523 534 10.1016/j.immuni.2006.03.015 1:CAS:528:DC%2BD28XlsFWqtrw%3D 16713971
24. J Kyte RF Doolittle 1982 A simple method for displaying the hydropathic character of a protein J Mol Biol 157 105 132 10.1016/0022-2836(82)90515-0 1:CAS:528:DyaL38Xks1yjtro%3D 7108955
25. A Liu M Takahashi K Toba Z Zheng S Hashimoto K Nikkuni T Furukawa T Koike Y Aizawa 1999 Regulation of the expression of MHC class I and II by class II transactivator (CIITA) in hematopoietic cells Hematol Oncol 17 149 160 10.1002/(SICI)1099-1069(199912)17:4<149::AID-HON645>3.0.CO;2-F 10725870
26. H Maeda H Sahara Y Mori T Torigo K Kamiguchi Y Tamura Y Tamura K Hirata N Sato 2007 Biological heterogeneity of the peptide-binding motif of the 70-kDa heat shock protein by surface plasmon resonance analysis J Biol Chem 282 26956 26962 10.1074/jbc.M703436200 1:CAS:528:DC%2BD2sXhtVWjsLjI 17626008
27. K Masuda A Hiraki N Fujii T Watanabe M Tanaka K Matsue Y Ogama M Ouchida K Shimizu K Ikeda M Tanimoto 2007 Loss or down-regulation of HLA class I expression at the allelic level in freshly isolated leukemic blasts Cancer Sci 98 102 108 10.1111/j.1349-7006.2006.00356.x 1:CAS:528:DC%2BD2sXht1Gisbc%3D 17083564
28. P Mukherjee A Dani S Bhatia N Singh AY Rudensky A George V Bal S Mayor S Rath 2001 Efficient presentation of both cytosolic and endogenous transmembrane protein antigens on MHC class II is dependent on cytoplasmic proteolysis J Immunol 167 2632 2641 1:CAS:528:DC%2BD3MXmtlSjt7w%3D 11509605
29. MP Mycko H Cwiklinska J Szymanski B Szymanska G Kudla L Kilianek A Odyniec CF Brosnan KW Selmaj 2004 Inducible heat shock protein 70 promotes myelin autoantigen presentation by the HLA class II J Immunol 172 202 213 1:CAS:528:DC%2BD3sXpvFehtLo%3D 14688327
30. JJ Neefjes V Stollorz PJ Peters HJ Geuze HL Ploegh 1990 The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route Cell 61 171 183 10.1016/0092-8674(90)90224-3 1:CAS:528:DyaK3cXitlelsbg%3D 2156628
31. + T cell cross-priming via transfer of proteasome substrates Science 304 1318 1321 10.1126/science.1096378 1:CAS:528:DC%2BD2cXkt1Ggu7g%3D 15166379
32. N Panjwani O Akbari S Garcia M Brazil B Stockinger 1999 The HSC73 molecular chaperone: involvement in MHC class II antigen presentation J Immunol 163 1936 1942 1:CAS:528:DyaK1MXltFagsrw%3D 10438929
33. P Peng A Menoret PK Srivastava 1997 Purification of immunogenic heat shock protein 70-peptide complexes by ADP-affinity chromatography J Immunol Methods 204 13 21 10.1016/S0022-1759(97)00017-3 1:CAS:528:DyaK2sXisFKlsbg%3D 9202705
34. DN Perkins DJ Pappin DM Creasy JS Cottrell 1999 Probability-based protein identification by searching sequence databases using mass spectrometry data Electrophoresis 20 3551 3567 10.1002/(SICI)1522-2683(19991201)20:18<3551:: AID-ELPS3551>3.0.CO;2-2 1:CAS:528:DC%2BD3cXhtF2ntw%3D%3D 10612281
35. B Peters J Sidney P Bourne HH Bui S Buus G Doh W Fleri M Kronenberg R Kubo O Lund D Nemazee JV Ponomarenko M Sathiamurthy S Schoenberger S Stewart P Surko S Way S Wilson A Sette 2005 The immune epitope database and analysis resource: from vision to blueprint PLoS Biol 3 e91 10.1371/journal.pbio.0030091 15760272
36. MF Princiotta D Finzi SB Qian J Gibbs S Schuchmann F Buttgereit JR Bennink JW Yewdell 2003 Quantitating protein synthesis, degradation, and endogenous antigen processing Immunity 18 343 354 10.1016/S1074-7613(03)00051-7 1:CAS:528:DC%2BD3sXisFKhu7k%3D 12648452
37. HG Rammensee K Falk O Rotzschke 1993 Peptides naturally presented by MHC class I molecules Annu Rev Immunol 11 213 244 10.1146/annurev.iy.11.040193. 001241 1:CAS:528:DyaK3sXktVKmu7g%3D 8476560
38. E Reits J Neijssen C Herberts W Benckhuijsen L Janssen JW Drijfhout J Neefjes 2004 A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation Immunity 20 495 506 10.1016/S1074-7613(04) 00074-3 1:CAS:528:DC%2BD2cXjs1Gksbc%3D 15084277
39. SR Ress J Rousseau B Ratanjee K Eidne RP Millar M Keraan 1991 HLA class II induction by interferon-gamma in K562 variant cell line: inhibition by serum lipid Hum Immunol 31 57 66 10.1016/0198-8859(91)90049-F 1:CAS:528: DyaK3MXktVKlsr8%3D 1908841
40. C Sahi EA Craig 2007 Network of general and specialty J protein chaperones of the yeast cytosol Proc Natl Acad Sci USA 104 7163 7168 10.1073/pnas.0702357104 1:CAS:528:DC%2BD2sXls1Cqur0%3D 17438278
41. K Sato Y Torimoto Y Tamura M Shindo H Shinzaki K Hirai Y Kohgo 2001 Immunotherapy using heat-shock protein preparations of leukemia cells after syngeneic bone marrow transplantation in mice Blood 98 1852 1857 10.1182/blood.V98.6.1852 1:CAS:528:DC%2BD3MXntFWgtrc%3D 11535521
42. L Saveanu O Carroll V Lindo M Del Val D Lopez Y Lepelletier F Greer L Schomburg D Fruci G Niedermann PM van Endert 2005 Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum Nat Immunol 6 689 697 10.1038/ni1208 1:CAS:528:DC%2BD2MXltlynsro%3D 15908954
43. U Seifert C Maranon A Shmueli JF Desoutter L Wesoloski K Janek P Henklein S Diescher M Andrieu H de la Salle T Weinschenk H Schild D Laderach A Galy G Haas PM Kloetzel Y Reiss A Hosmalin 2003 An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope Nat Immunol 4 375 379 10.1038/ni905 1:CAS:528:DC%2BD3sXitlyqs78%3D 12598896
44. A Serna MC Ramirez A Soukhanova LJ Sigal 2003 Cutting edge: efficient MHC class I cross-presentation during early vaccinia infection requires the transfer of proteasomal intermediates between antigen donor and presenting cells J Immunol 171 5668 5672 1:CAS:528:DC%2BD3sXptFOlurs%3D 14634072
45. L Shen KL Rock 2004 Cellular protein is the source of cross-priming antigen in vivo Proc Natl Acad Sci USA 101 3035 3040 10.1073/pnas.0308345101 1:CAS:528:DC%2BD2cXitlWhtrk%3D 14978273
46. LJ Sigal S Crotty R Andino KL Rock 1999 Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen Nature 398 77 80 10.1038/18038 1:CAS:528:DyaK1MXhvFaksL0%3D 10078533
47. P Srivastava 2002 Roles of heat-shock proteins in innate and adaptive immunity Nat Rev Immunol 2 185 194 10.1038/nri749 1:CAS:528:DC%2BD38XisFaktbs%3D 11913069
48. PK Srivastava AB DeLeo LJ Old 1986 Tumor rejection antigens of chemically induced sarcomas of inbred mice Proc Natl Acad Sci USA 83 3407 3411 10.1073/pnas.83.10.3407 1:CAS:528:DyaL28XktVCktr0%3D 3458189
49. IM Takenaka SM Leung SJ McAndrew JP Brown LE Hightower 1995 Hsc70-binding peptides selected from a phage display peptide library that resemble organellar targeting sequences J Biol Chem 270 19839 19844 10.1074/jbc.270.34.19839 1:CAS:528:DyaK2MXnvVCmur8%3D 7649995
50. MK Tewari G Sinnathamby D Rajagopal LC Eisenlohr 2005 A cytosolic pathway for MHC class II-restricted antigen processing that is proteasome and TAP dependent Nat Immunol 6 287 294 10.1038/ni1171 1:CAS:528:DC%2BD2MXhtleqt7Y%3D 15711549
51. SJ Ullrich EA Robinson LW Law M Willingham E Appella 1986 A mouse tumor-specific transplantation antigen is a heat shock-related protein Proc Natl Acad Sci USA 83 3121 3125 10.1073/pnas.83.10.3121 1:CAS:528:DyaL28XktVCktrw%3D 3458168
52. J Wahlstrom J Dengjel B Persson H Duyar HG Rammensee S Stevanovic A Eklund R Weissert J Grunewald 2007 Identification of HLA-DR-bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis J Clin Invest 117 3576 3582 10.1172/JCI32401 17975675
53. J Yague J Vazquez JA Lopez de Castro 1998 A single amino acid change makes the peptide specificity of B 3910 unrelated to B 3901 and closer to a group of HLA-B proteins including the malaria-protecting allotype HLA-B53 Tissue Antigens 52 416 421 10.1111/j.1399-0039.1998.tb03067.x 1:CAS:528: DyaK1cXnvFShu7k%3D 9864030
54. IA York SC Chang T Saric JA Keys JM Favreau AL Goldberg KL Rock 2002 The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues Nat Immunol 3 1177 1184 10.1038/ni860 1:CAS:528:DC%2BD38XovFChtr4%3D 12436110
55. X Zhang C Glendening H Linke CL Parks C Brooks SA Udem M Oglesbee 2002 Identification and characterization of a regulatory domain on the carboxyl terminus of the measles virus nucleocapsid protein J Virol 76 8737 8746 10.1128/JVI.76.17.8737-8746.2002 1:CAS:528:DC%2BD38Xmt1erurk%3D 12163594
56. D Zhou P Li Y Lin JM Lott AD Hislop DH Canaday RR Brutkiewicz JS Blum 2005 Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens Immunity 22 571 581 10.1016/j.immuni.2005.03.009 1:CAS:528:DC%2BD2MXkslOqsb0%3D 15894275