A potential regulatory role for mRNA secondary structures within the prothrombin 3'UTR

Thrombosis Research

Volumn 126, Issue 2, 2010, Pages 130-136

  Liu, Xingge ^a   Jiang, Yong ^a   Russell, J Eric ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE

Author keywords

3'UTR; mRNA; mRNA processing; Prothrombin

Indexed keywords

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; MESSENGER RNA; POLYPYRIMIDINE TRACT BINDING PROTEIN; PROTHROMBIN; PROTHROMBIN A; PROTHROMBIN G; PROTHROMBIN G+2; TRANS ACTING FACTOR; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ARTICLE; CELL STRAIN HEPG2; CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; PROTEIN SECONDARY STRUCTURE; RNA PROCESSING; SINGLE NUCLEOTIDE POLYMORPHISM;

3' UNTRANSLATED REGIONS; BASE SEQUENCE; HEP G2 CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; NUCLEIC ACID CONFORMATION; POLYPYRIMIDINE TRACT-BINDING PROTEIN; PROTEIN BINDING; PROTHROMBIN; RNA, MESSENGER;

EID: 77955708758     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2010.04.010     Document Type: Article

References (50)

1. T.K. Vu, D.T. Hung, V.I. Wheaton, and S.R. Coughlin Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation Cell 64 1991 1057 1068
2. N.H. Gehring, U. Frede, G. Neu-Yilik, P. Hundsdoerfer, B. Vetter, and M.W. Hentze Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia Nat Genet 28 2001 389 392
3. H. Ceelie Spaargaren-van Riel CC, Bertina RM, and Vos HL. G20210A is a functional mutation in the prothrombin gene; effect on protein levels and 3'-end formation J Thromb Haemost 2 2004 119 127
4. A.M. Carter, M. Sachchithananthan, S. Stasinopoulos, F. Maurer, and R.L. Medcalf Prothrombin G20210A is a bifunctional gene polymorphism Thromb Haemost 87 2002 846 853
5. S.R. Poort, F.R. Rosendaal, P.H. Reitsma, and R.M. Bertina A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis Blood 88 1996 3698 3703
6. R.F. Franco, M.D. Trip, H. ten Cate, A. van den Ende, M.H. Prins, and J.J. Kastelein The 20210 G->A mutation in the 3'-untranslated region of the prothrombin gene and the risk for arterial thrombotic disease Brit J Heme 104 1999 50 54
7. J.M. Soria, L. Almasy, J.C. Souto, I. Tirado, M. Borell, and J. Mateo Linkage analysis demonstrates that the prothrombotic G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis Blood 95 2000 2780 2785
8. A. Hillarp, B. Zoller, P.J. Svensson, and B. Dahlback The 20210 A allele of the prothrombin gene is a common risk factor among Swedish outpatients with verified deep venous thrombosis Thromb Haemost 78 1997 990 992
9. K.H. Reuner, A. Ruf, A. Grau, H. Rickmann, E. Stolz, and E. Juttler Prothrombin gene G20210->A transition is a risk factor for cerebral venous thrombosis Stroke 29 1998 1765 1769
10. I. Martinelli, E. Sacchi, G. Landi, E. Taioli, F. Duca, and P.M. Mannucci High risk of cerebral-vein thrombosis in carriers of a prothrombin-gene mutation and in users of oral contraceptives N Engl J Med 338 1998 1793 1797
11. E. Mercier, I. Quere, C. Campello, P. Mares, and J.C. Gris The 20210A allele of the prothrombin gene is frequent in young women with unexplained spinal cord infarction Blood 92 1998 1840 1841
12. M.J. Kupferminc, H. Peri, E. Zwang, Y. Yaron, I. Wolman, and A. Eldor High prevalence of the prothrombin gene mutation in women with intrauterine growth retardation, abruptio placentae, and second trimester loss Acta Obstet Gynecol Scand 79 2000 963 967
13. B. Zoller, P. Garcia de Frutos, A. Hillarp, and B. Dahlback Thrombophilia as a multigenic disease Haematologica 84 1999 59 70
14. E.S. Pollak, H.-S. Lam, and J.E. Russell The G20210A mutation does not affect the stability of prothrombin mRNA in vivo Blood 100 2002 359 362
15. N. von Ahsen, and M. Oellerich The intronic prothrombin 19911A>G polymorphism influences splicing efficiency and modulates effects of the 20210G>A polymorphism on mRNA amount and expression in a stable reporter gene assay system Blood 103 2004 586 593
16. R. Sandberg, J.R. Neilson, A. Sarma, P.A. Sharp, and C.G. Burge Proliferating cells express mRNAs with shortened 3'UTRs and fewer microRNA target sites Science 320 2008 1643 1647
17. S.A. Shell, C. Hesse, S.M. Morris, and C. Milcarek Elevated levels of 64-kDa cleavage stimulatory factor (CstF-64) in lipopolysaccharide-stimulated macrophages influence gene expression and induce alternative poly(A) site selection J Biol Chem 280 2005 39950 39961
18. M. Gossen, and H. Bujard Tight control of gene expression in mammalian cells by tetracycline responsive promoters Proc Natl Acad Sci USA 89 1992 5547 5551
19. Y. Jiang, X.-S. Xu, and J.E. Russell A nucleolin-binding 3'UTR element stabilizes [beta]-globin mRNA in vivo Mol Cell Biol 26 2006 2419 2429
20. J.E. Russell, and S.A. Liebhaber The stability of human beta-globin mRNA is dependent on structural determinants positioned within its 3' untranslated region Blood 87 1996 5314 5323
21. J. Yu, and J.E. Russell Structural and functional analysis of an mRNP complex that mediates the high stability of human [beta]-globin mRNA Mol Cell Biol 21 2001 5879 5888
22. J. Kong, X. Ji, and S.A. Liebhaber Mechanistic analysis of human [alpha]-globin mRNA stabilization Blood 98 2001 437a
23. I.M. Weiss, and S.A. Liebhaber Erythroid cell-specific determinants of alpha-globin mRNA stability Mol Cell Biol 14 1994 8123 8132
24. D.S. Fair, and B.R. Bahnak Human hepatoma cells secrete single chain factor X, prothrombin, and antithrombin III Blood 64 1984 194 204
25. M.N. Huang, H.L. Hung, S.A. Stanfield-Oakley, and K.A. High Characterization of the human blood coagulation factor X promoter J Biol Chem 267 1992 15440 15446
26. D.H. Mathews, J. Sabina, M. Zucker, and D.H. Turner Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure J Mol Biol 288 1999 911 940
27. M. Zucker Mfold web server for nucleic acid folding and hybridization prediction Nucleic Acids Res 31 2003 3406 3415
28. T.K. Sengupta, S. Bandyopadhyay, D.J. Fernandes, and E.K. Spicer Identification of nucleolin as an AU-rich element binding protein involved in bcl-2 mRNA stabilization J Biol Chem 279 2004 10855 10863
29. K. Singh, J. Laughlin, P.A. Kosinski, and L.R. Covey Nucleolin is a second component of the CD154 mRNA stability complex that regulates mRNA turnover in activated T cells J Immunol 173 2004 976 985
30. A. Ostareck-Lederer, D.H. Ostareck, C. Vans, G. Neubauer, K. Bomsztyk, and G. Superti-Furga c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs Mol Cell Biol 22 2002 4535 4543
31. M. Yano, H.J. Okano, and H. Okano Involvement of Hu and heterogeneous nuclear riboprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation J Biol Chem 280 2005 12690 12699
32. F.C. Oberstrass, S.D. Auweter, M. Erat, Y. Hargous, A. Henning, and P. Wenter Structure of PTB bound to RNA: specific binding and implications for splicing regulation Science 309 2005 2054 2057
33. I. Perez, C.-H. Lin, J.G. McAffee, and J.G. Patton Mutation of PTB-1 binding sites causes misregulation of alternative 3' splice site selection in vivo RNA 3 1997 764 768
34. S. Danckwardt, I. Kaufmann, M. Gentzel, K.U. Foerstner, A.-S. Gantzert, and N.H. Gehring Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals EMBO J 26 2007 2658 2669
35. S. Danckwardt, N.H. Gehring, G. Neu-Yilik, P. Hundsdoerfer, M. Pforsich, and U. Frede The prothrombin 3'-end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations Blood 104 2004 428 435
36. N.B. Pandey, and W.F. Marzluff The stem-loop structure at the 3' end of histone mRNA is necessary and sufficient for regulation of histone mRNA stability Mol Cell Biol 7 1987 4557 4559
37. R.D. Klausner, T.A. Rouault, and J.B. Harford Regulating the fate of mRNA: the control of cellular iron metabolism Cell 72 1993 19 28
38. A. Zilka, S. Garlapati, E. Dahan, V. Yaolsky, and M. Shapira Developmental regulation of heat shock protein 83 in Leishmania. 3' processing and mRNA stability control transcript abundance, and translation is directed by a determinant in the 3'-untranslated region J Biol Chem 276 2001 47922 47929
39. D.F. Colgan, and J.L. Manley Mechanism and regulation of mRNA polyadenylation Genes Dev 11 1997 2755 2766
40. O. Bilenoglu, A.N. Basak, and J.E. Russell A 3'UTR mutation affects [beta]-globin expression without altering the stability of its fully-processed mRNA Br J Haematol 119 2002 1106 1114
41. G. Shaw, and R. Kamen A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation Cell 46 1986 659 667
42. M. Holcik, and S.A. Liebhaber Four highly stable eukaryotic mRNAs assemble 3'UTR RNA-protein complexes sharing cis- and trans-components Proc Natl Acad Sci USA 94 1997 2410 2414
43. E. Pauws, A.H.C. van Kampen, S.A.R. van de Graaf, J.J.M. de Vijlder, and C. Ris-Stalpers Heterogeneity in polyadenylation cleavage sites in mammalian mRNA sequences: implications for SAGE analysis Nucleic Acids Res 29 2001 1690 1694
44. B. Tian, J. Hu, H. Zhang, and C. Lutz A large-scale analysis of mRNA polyadenylation of human and mouse genes Nucleic Acids Res 33 2005 201 212
45. E. Beaudoing, and D. Gautheret Identification of alternate polyadenylation sites and analysis of their tissue distribution using EST data Genome Res 11 2001 1520 1526
46. P.A. Kosinski, J. Laughlin, K. Singh, and L.R. Covey A complex containing polypyrimidine tract-binding protein is involved in regulating the stability of CD40 ligand (CD154) mRNA J Immunol 170 2003 979 988
47. M. De Nova-Ocampo, N. Villegas-Sepulveda, and R.M. del Angel Translation elongation factor-1 alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA Virology 295 2002 337 347
48. C. Le Sommer, M. Lesimple, A. Mereau, S. Menoret, M.-R. Allo, and S. Hardy PTB regulates the processing of a 3'-terminal exon by repressing both splicing and polyadenylation Mol Cell Biol 25 2005 9595 9607
49. P. Castelo-Branco, A. Furger, M. Wollerton, C. Smith, A. Moreira, and N. Proodfoot Polypyrimidine tract binding protein modulates efficiency of polyadenylation Mol Cell Biol 24 2004 4174 4183
50. C.U. Hellen, and P. Sarnow Internal ribosome entry sites in eukaryotic mRNA molecules Genes Dev 15 2001 1593 1612