Epstein-Barr virus antibodies in serum and cerebrospinal fluid from Multiple sclerosis, Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Amyotrophic Lateral Sclerosis

Journal of Neuroimmunology

Volumn 225, Issue 1-2, 2010, Pages 149-152

  Nociti, V ^a,b   Frisullo, G ^a   Marti, A ^a   Luigetti, M ^a   Iorio, R ^a   Patanella, A K ^a,b   Bianco, A ^a   Tonali, P A ^a,b   Grillo, R L ^a   Sabatelli, M ^a   Batocchi, A P ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

Amyotrophic Lateral Sclerosis; Chronic Inflammatory Demyelinating Polyradiculoneuropathy; Cytomegalovirus; Epstein Barr virus; Multiple sclerosis

Indexed keywords

CYTOMEGALOVIRUS ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; VIRUS ANTIBODY;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ANTIBODY BLOOD LEVEL; ANTIBODY TITER; ARTICLE; CEREBROSPINAL FLUID LEVEL; CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY; CONTROLLED STUDY; EPSTEIN BARR VIRUS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ANTIBODIES; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING;

EID: 77955660115     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2010.04.007     Document Type: Article

References (25)

1. Ascherio A., Munger K.L., Lennette E.T., Spiegelman D., Hernán M.A., Olek M.J., Hankinson S.E., Hunter D.J. Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study. JAMA 2001, 286:3083-3088.
2. Brettschneider J., Tumani H., Kiechle U., Muche R., Richards G., Lehmensiek V., Ludolph A.C., Otto M. IgG antibodies against measles, rubella, and varicella zoster virus predict conversion to multiple sclerosis in clinically isolated syndrome. PLoS One 2009, 4(11):e7638.
3. Brooks B.R., Miller R.G., Swash M., Munsat T.L. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph. Lateral. Scler. Other Motor Neuron Disord. 2000, 1:293-299. World Federation of Neurology Research Group on Motor Neuron Diseases.
4. Cepok S., Zhou D., Srivastava R., Nessler S., Stei S., Büssow K., Sommer N., Hemmer B. Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis. J. Clin. Invest. 2005, 115(5):1352-1360.
5. Eisen A. Amyotrophic lateral sclerosis: a 40-year personal perspective. J. Clin. Neurosci. 2009, 16:505-512.
6. Farrell R.A., Antony D., Wall G.R., Clark D.A., Fisniku L., Swanton J., Khaleeli Z., Schmierer K., Miller D.H., Giovannoni G. Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI. Neurology 2009, 73:32-38.
7. Glaser R., Strain E.C., Tarr K.L., Holliday J.E., Donnerberg R.L., Kiecolt-Glaser J.K. Changes in Epstein-Barr virus antibody titers associated with aging. Proc. Soc. Exp. Biol. Med. 1985, 179:352-355.
8. Hughes R.A., Bouche P., Cornblath D.R., Evers E., Hadden R.D., Hahn A., Illa I., Koski C.L., Léger J.M., Nobile-Orazio E., Pollard J., Sommer C., Van den Bergh P., van Doorn P.A., van Schaik I.N. European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. 1. Eur. J. Neurol. 2006, 13:326-332.
9. Lünemann J.D., Kamradt T., Martin R., Münz C. Epstein-Barr virus: environmental trigger of multiple sclerosis?. J Virol. 2007, 8:6777-6784.
10. Lünemann J.D., Huppke P., Roberts S., Lutterotti A., Tackenberg B., Martin R., Münz C. EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2. Neurology 2008, 71:1033-1035.
11. Lünemann J.D., Tackenberg B., Stein A., Wandinger K.P., Oertel W.H., Wagner H.J., Münz C., Meisel H., Sommer N., Zipp F. Dysregulated Epstein-Barr virus infection in patients with CIDP. J. Neuroimmunol. 2010, 218:107-111.
12. Musiani M., Zerbini M., Zauli D., Cometti G., La Placa M. Impairment of cytomegalovirus and host balance in elderly subjects. J. Clin. Pathol. 1988, 41:722-725.
13. Nielsen T.R., Rostgaard K., Nielsen N.M., Koch-Henriksen N., Haahr S., Sørensen P.S., Hjalgrim H. Multiple sclerosis after infectious mononucleosis. Arch. Neurol. 2007, 64:72-75.
14. Peferoen L.A., Lamers F., Lodder L.N., Gerritsen W.H., Huitinga I., Melief J., Giovannoni G., Meier U., Hintzen R.Q., Verjans G.M., van Nierop G.P., Vos W., Peferoen-Baert R.M., Middeldorp J.M., van der Valk P., Amor S. Epstein Barr virus is not a characteristic feature in the central nervous system in established multiple sclerosis. Brain 2009, Electronic publication ahead of print.
15. Pender M.P. Does Epstein-Barr virus infection in the brain drive the development of multiple sclerosis. Brain 2009, 132(Pt 12):3196-3198.
16. Pohl D., Rostasy K., Jacobi C., Lange P., Nau R., Krone B., Hanefeld F. Intrathecal antibody production against Epstein-Barr and other neurotropic viruses in pediatric and adult onset multiple sclerosis. J. Neurol. 2010, 257:212-216.
17. Poser C.M., Paty D.W., Scheinberg L., McDonald W.I., Davis F.A., Ebers G.C., Johnson K.P., Sibley W.A., Silberberg D.H., Tourtellotte W.W. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 1983, 13(3):227-231.
18. Provinciali L., Laurenzi M.A., Vesprini L., Giovagnoli A.R., Bartocci C., Montroni M., Bagnarelli P., Clementi M., Varaldo P.E. Immunity assessment in the early stages of amyotrophic lateral sclerosis: a study of virus antibodies and lymphocyte subsets. Acta Neurol. Scand. 1988, 78(6):449-454.
19. Reiber H., Lange P. Quantification of virus-specific antibodies in cerebrospinal fluid and serum: sensitive and specific detection of antibody synthesis in the brain. Clin Chem 1991, 37:1153-1160.
20. Sargsyan S.A., Shearer A.J., Ritchie A.M., Burgoon M.P., Anderson S., Hemmer B., Stadelmann C., Gattenlöhner S., Owens G.P., Gilden D., Bennett J.L. Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis. Neurology 2010, 74:1127-1135.
21. Serafini B., Rosicarelli B., Franciotta D., Magliozzi R., Reynolds R., Cinque P., Andreoni L., Trivedi P., Salvetti M., Faggioni A., Aloisi F. Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain. J. Exp. Med. 2007, 204:2899-2912.
22. Toyka K.V., Gold R. The pathogenesis of CIDP: rationale for treatment with immunomodulatory agents. Neurology 2003, 60(Suppl 3):S2-7.
23. Weiner H.L. Multiple sclerosis is an inflammatory T-cell-mediated autoimmune disease. Arch. Neurol. 2004, 61:1613-1615.
24. Willis S.N., Stadelmann C., Rodig S.J., Caron T., Gattenloehner S., Mallozzi S.S., Roughan J.E., Almendinger S.E., Blewett M.M., Brück W., Hafler D.A., O'Connor K.C. Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain. 2009, 132(Pt 12):3318-3328.
25. Zivadinov R., Weinstock-Guttman B., Zorzon M., Serafin M., Bosco A., Bratina A., Maggiore C., Grop A., Tommasi M.A., Srinivasaraghavan B., Ramanathan M. Epstein-Barr virus is associated with grey matter atrophy in multiple sclerosis. J Neurol. Neurosurg. Psychiatry 2009, 80(6):620-625.