Oxidative stimuli-responsive nanoprodrug of camptothecin kills glioblastoma cells

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 17, 2010, Pages 5262-5268

  Lee, Bong Seop ^a   Nalla, Aruna K ^a   Stock, Ilana R ^a   Shear, Talia C ^a   Black, Keith L ^a   Yu, John S ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Anticancer therapy; Camptothecin; Camptothecin nanoprodrug; Camptothecin prodrug; Glioblastoma multiforme (GBM); Nanomaterials

Indexed keywords

ALPHA TOCOPHEROL; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; CARBONIC ACID; ESTERASE; ETHYLENE GLYCOL; NANOPARTICLE; PRODRUG; THIOCTIC ACID;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CHEMICAL BOND; DRUG DEGRADATION; DRUG EFFICACY; DRUG OXIDATION; DRUG STABILITY; DRUG STORAGE; DRUG STRUCTURE; DRUG SYNTHESIS; EMULSION; GLIOBLASTOMA; GLIOMA CELL; HYDROLYSIS; IC 50; STORAGE TEMPERATURE;

ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL LINE, TUMOR; GLIOBLASTOMA; HUMANS; NANOTECHNOLOGY; OXIDATIVE STRESS; PRODRUGS;

SUS;

EID: 77955657628     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.144     Document Type: Article

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23. 2O (5 mL) was added to the clear acetone solution and the precipitate was collected and dried under vacuum. The precipitate was dissolved in acetone (2 mL). The solution was stored at -20 °C overnight and the insoluble matter was removed by filtration. The solvent was evaporated to dryness to yield the camptothecin prodrug as a light brown colored thick oil (136 mg, 45%). The purity of the camptothecin prodrug was assessed by HPLC to be >99.5%.
24. 2 > 0.99). Within this concentration range the amount of the prodrug and camptothecin could be determined reproducibly. To determine the concentration of the prodrugs or camptothecin from the nanoprodrugs, the aqueous nanoprodrugs suspension (100 μL) was added to acetonitrile (400 μL) and analyzed using RP-HPLC. The separation was performed under isocratic condition with a 60:40 mixture of acetonitrile/water at a flow rate of 1 mL/min. The detection was carried out at 360 nm.
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32. control is the number of cells of control culture which was incubated with culture medium only. The cells were also treated with nanospheres prepared from α-tocopherol only.