Flavonoid combinations cause synergistic inhibition of proinflammatory mediator secretion from lipopolysaccharide-induced RAW 264.7 cells

Inflammation Research

Volumn 59, Issue 9, 2010, Pages 711-721

  Harasstani, Omar A ^a   Moin, Saidi ^a   Tham, Chau Ling ^a   Liew, Choi Yi ^a   Ismail, Norazren ^a   Rajajendram, Revathee ^a   Harith, Hanis H ^a   Zakaria, Zainul A ^a   Mohamad, Azam S ^a   Sulaiman, Mohamad R ^a   Israf, Daud A ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Flavonoid; Isobologram; Nitric oxide; Prostaglandin E 2; RAW 264.7; Synergy; Tumour necrosis factor

Indexed keywords

CHRYSIN; DIOSMIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; FLAVONOID; HESPERIDIN; KAEMPFEROL; MORIN; NITRIC OXIDE; PROSTAGLANDIN E2; QUERCETIN; SILIBININ; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; IC 50; INFLAMMATION; MACROPHAGE; MEDIATOR RELEASE; MONOCYTE; MOUSE; NONHUMAN; PROSTAGLANDIN RELEASE;

ANIMALS; CELL LINE; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FLAVONOIDS; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77955654133     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-010-0182-8     Document Type: Article

References (29)

1. HP Kim KH Son HW Chang SS Kang 2004 Anti-inflammatory plant flavonoids and cellular action mechanisms J Pharmacol Sci 96 229 245 10.1254/jphs.CRJ04003X 1:CAS:528:DC%2BD2cXhtVequ7jL 15539763
2. EM Williamson 2001 Synergy and other interactions in phytomedicines Phytomed 8 401 409 10.1078/0944-7113-00060 1:STN:280:DC%2BD3MnktlOhsw%3D%3D
3. Chou Ting-Chao 2006 Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies Pharmacol Rev 58 621 681 10.1124/pr.58.3.10
4. EN Scott AJ Gescher WP Steward K Brown 2009 Development of dietary phytochemical chemopreventive agents: biomarkers and choice of dose for early clinical trials Cancer Prev Res (Phila Pa) 2 525 530 1:CAS:528: DC%2BC3cXptVSqu7o%3D
5. J Duarte F Perez-vizcaino J Jimenez J Tamargo A Zarzuelo 2001 Flavonoids and cardiovascular diseases Stud Nat Prod Chem 25 565 605 10.1016/S1572-5995(01) 80018-1 1:CAS:528:DC%2BD38XhsVOiurY%3D
6. J Galvez F De Sanchez Medina J Jimenez A Zarzuelo 2001 Effects of flavonoids on gastrointestinal disorders Stud Nat Prod Chem 25 607 649 10.1016/S1572-5995(01)80019-3 1:CAS:528:DC%2BD38XhsVOiurc%3D
7. H Schroeter C Boyd JPE Spencer RJ Williams E Cadenas C Rice-Evans 2002 MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide Neurobiol Aging 23 861 880 10.1016/S0197-4580(02)00075-1 1:CAS:528:DC%2BD38XotVChsrw%3D 12392791
8. MS Gohel AH Davies 2009 Pharmacological agents in the treatment of venous disease: an update of the available evidence Curr Vasc Pharmacol 7 303 308 10.2174/157016109788340758 1:CAS:528:DC%2BD1MXotlWktrg%3D 19601855
9. Y Sato H Shibata T Arai A Yamamoto Y Okimura N Arakaki T Higuti 2004 Variation in synergistic activity by flavone and its related compounds on the increased susceptibility of various strains of methicillin-resistant Staphylococcus aureus to β-lactam antibiotics Int J Antimicro Ag 24 28 35 10.1016/j.ijantimicag.2004.02.001
10. G Scambia R De Vincenzo FO Ranelletti P Benedetti Panici G Ferrandina G D'Agostino A Fattorossi E Bombardelli S Mancuso 1996 Antiproliferative effect of silybin on gynaecological malignancies: synergism with cisplatin and doxorubicin Eur J Canc 32A 877 882 10.1016/0959-8049(96)00011-1 1:CAS:528:DyaK28XjvFyntL8%3D
11. J Milde EF Elstner J Gramann 2004 Synergistic inhibition of low-density lipoprotein oxidation by rutin, γ-terpinene, and ascorbic acid Phytomed 11 105 113 10.1078/0944-7113-00380 1:CAS:528:DC%2BD2cXjsFyksL4%3D
12. A receptor benzodiazepine binding site CNS Drug Rev 5 124 144
13. JH Medina H Viola C Wolfman M Marder C Wasowski D Calvo AC Paladini 1997 Overview Flavonoids: a new family of benzodiazepine receptor ligands. Neurochem Res 22 419 425 1:CAS:528:DyaK2sXislymtrg%3D
14. A-receptor ligands of flavonoid structure Curr Top Med Chem 2 853 867 10.2174/1568026023393462 1:CAS:528:DC%2BD38XltF2kur0%3D 12171576
15. SP Fernandez C Wasowski AC Paladini M Marder 2005 Synergistic interaction between hesperidin, a natural flavonoid, and diazepam Eur J Pharmacol 512 189 198 10.1016/j.ejphar.2005.02.039 1:CAS:528:DC%2BD2MXjsVGksLY%3D 15840404
16. 2 and tumour necrosis factor-α in RAW 264.7 murine macrophages Biosci Biotechnol Biochem 67 1056 1062 10.1271/bbb.67.1056 1:CAS:528:DC%2BD3sXktlygtbg%3D 12834283
17. RJ Tallarida F Porreca A Cowan 1989 Statistical analysis of drug-drug and site-site interactions with isobolograms Life Sci 45 947 961 10.1016/0024-3205(89)90148-3 1:CAS:528:DyaL1MXls1Klt78%3D 2677570
18. G Pinardi F Sierralta HF Miranda 2001 Interaction between the antinociceptive effect of ketoprofen and adrenergic modulatory systems Inflamm 25 233 239 10.1023/A:1010923820109 1:CAS:528:DC%2BD3MXnsFWns7Y%3D
19. RJ Tallarida 2001 Drug synergism: its detection and applications J Pharmacol Exp Ther 298 865 872 1:CAS:528:DC%2BD3MXmtFKmsLg%3D 11504778
20. C Dehmlow N Murawski H De Groot 1996 Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells Life Sci 58 l591 l1600 10.1016/0024-3205(96)00134-8
21. TL Wadsworth TL McDonald DR Koop 2001 Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-α Biochem Pharmacol 62 963 974 10.1016/S0006-2952(01)00734-1 1:CAS:528:DC%2BD3MXmsFeksL4%3D 11543732
22. SY Cho SJ Park MJ Kwon TS Jeong SH Bok WY Choi WI Jeong SY Ryu SH Do CS Lee JC Song KS Jeong 2003 Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-κB pathway in lipopolysaccharide- stimulated macrophage Mol Cell Biochem 243 153 160 10.1023/A:1021624520740 1:CAS:528:DC%2BD38XpsFyjtLg%3D 12619901
23. Y Takano-Ishikawa M Goto K Yamaki 2006 Structure-activity relations of inhibitory effects of various flavonoids on lipopolysaccharide-induced prostaglandin E2 production in rat peritoneal macrophages: Comparison between subclasses of flavonoids Phytomed 13 310 317 10.1016/j.phymed.2005.01.016 1:CAS:528:DC%2BD28XmtFKksrY%3D
24. Hamalainen M, Nieminen R, Vuorela P, Heinonen M, Moilanen E. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm 2007;45673-45683.
25. HH Park S Lee HY Son SB Park MS Kim EJ Choi TSK Singh JH Ha MG Lee JE Kim MC Hyun TK Kwon YH Kim SH Kim 2008 Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells Arch Pharm Res 31 1303 1311 10.1007/s12272-001-2110-5 1:CAS:528:DC%2BD1cXht12lsLrJ 18958421
26. I Crespo MV García-Mediavilla B Gutiérrez S Sánchez-Campos MJ Tuñón J González-Gallego 2008 A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells Br J Nutr 100 968 976 10.1017/S0007114508966083 1:CAS:528:DC%2BD1cXhtlehtrrP 18394220
27. M Hecker C Priess P Klemm R Brusse 1996 Inhibition by antioxidants of nitric oxide synthase expression in murine macrophages; role of nuclear factor kappa B and interferon regulatory factor 1 Br J Pharmacol 118 21178 21184
28. CC Chen MP Chow WC Huang YC Lin YJ Chang 2004 Flavonoids inhibit tumor necrosis factor-α-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-κB: structure-activity relationships Mol Pharmacol 66 683 693 10.1124/mol.104.001206 1:CAS:528:DC%2BD2cXntlCksbY%3D 15322261
29. A Bowie LAJ O'Neill 2000 Oxidative stress and nuclear factor-κB activation: a reassessment of the evidence in the light of recent discoveries Biochem Pharmacol 59 13 23 10.1016/S0006-2952(99)00296-8 1:CAS:528: DC%2BD3cXhtV2hsw%3D%3D 10605930