When doors of perception open: Visual contrast sensitivity in never-medicated, first-episode schizophrenia

Journal of Abnormal Psychology

Volumn 119, Issue 3, 2010, Pages 586-593

  Kiss, Imre ^a   Fábián, Ágnes ^a   Benedek, György ^b   Kéri, Szabolcs ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Contrast sensitivity; First episode; Magnocellular pathways; Schizophrenia; Vision

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTRAST SENSITIVITY; CONTROLLED STUDY; FEMALE; HUMAN; INFORMATION PROCESSING; MAGNOCELLULAR NUCLEUS; MALE; SCHIZOPHRENIA; SCORING SYSTEM; SPATIAL FREQUENCY DISCRIMINATION; STRUCTURED INTERVIEW; STRUCTURED INTERVIEW FOR ASSESSING PERCEPTUAL ANOMALIES; VISUAL IMPAIRMENT;

EID: 77955635422     PISSN: 0021843X     EISSN: 19391846     Source Type: Journal    
DOI: 10.1037/a0019610     Document Type: Article

References (61)

1. Alexander K.R., Barnes C.S., Fishman G.A., Pokorny J., Smith V.C. Contrast sensitivity deficits in inferred magnocellular and parvocellular pathways in retinitis pigmentosa. Investigative Ophthalmology and Visual Science 2005, 45:4510-4519.
2. Balogh D.W., Merritt R.D. Visual masking and the schizophrenia spectrum: Interfacing clinical and experimental methods. Schizophrenia Bulletin 1987, 13:679-698.
3. Bedwell J.S., Brown J.M., Miller L.S. The magnocellular visual system and schizophrenia: What can the color red tell us?. Schizophrenia Research 2003, 63:273-284.
4. Bodis-Wollner I. Visual deficits related to dopamine deficiency in experimental animals and Parkinson's disease patients. Trends in Neurosciences 1990, 13:296-302.
5. Braff B.L., Geyer M.A. Sensorimotor gating and schizophrenia. Archives of General Psychiatry 1990, 47:181-188.
6. Bulens C., Meerwaldt J.D., van der Wildt G.J., Keemink C.J. Visual contrast sensitivity in drug-induced Parkinsonism. Journal of Neurology, Neurosurgery & Psychiatry 1989, 52:341-345.
7. Bunney W.E., Hetrick W.P., Bunney B.G., Patterson J.V., Jin Y., Potkin S.G., Sandman C.A. Structured Interview for Assessing Perceptual Anomalies (SIAPA). Schizophrenia Bulletin 1999, 25:577-592.
8. Butler P.D., Abeles I.Y., Weiskopf N.G., Tambini A., Jalbrzikowski M., Legatt M.E., Javitt D.C. Sensory contributions to impaired emotion processing in schizophrenia. Schizophrenia Bulletin 2009, 35:1095-1107.
9. Butler P.D., Martinez A., Foxe J.J., Kim D., Zemon V., Silipo G., Javitt D.C. Subcortical visual dysfunction in schizophrenia drives secondary cortical impairments. Brain 2007, 130:417-430.
10. Butler P.D., Schechter I., Zemon V., Schwartz S.G., Greenstein V.C., Gordon J., Javitt D.C. Dysfunction of early-stage visual processing in schizophrenia. American Journal of Psychiatry 2001, 158:1126-1133.
11. Butler P.D., Silverstein S.M., Dakin S.C. Visual perception and its impairment in schizophrenia. Biological Psychiatry 2008, 64:40-47.
12. Butler P.D., Tambini A., Yovel G., Jalbrzikowski M., Ziwich R., Silipo G., Javitt D.C. What's in a face? Effects of stimulus duration and inversion on face processing in schizophrenia. Schizophrenia Research 2008, 103:283-292.
13. Chen Y., Levy D.L., Sheremata S., Nakayama K., Matthysse S., Holzman P.S. Effects of typical, atypical, and no antipsychotic drugs on visual contrast detection in schizophrenia. American Journal of Psychiatry 2003, 160:1795-1801.
14. Chen Y., Norton D., Ongur D. Altered center-surround motion inhibition in schizophrenia. Biological Psychiatry 2008, 64:74-77.
15. Chen Y., Palafox G.P., Nakayama K., Levy D.L., Matthysse S., Holzman P.S. Motion perception in schizophrenia. Archives of General Psychiatry 1999, 56:149-154.
16. Delord S., Ducato M.G., Pins D., Devinck F., Thomas P., Boucart M., Knoblauch K. Psychophysical assessment of magno- and parvocellular function in schizophrenia. Visual Neuroscience 2006, 23:645-650.
17. Dorph-Petersen K.A., Caric D., Saghafi R., Zhang W., Sampson A.R., Lewis D.A. Volume and neuron number of the lateral geniculate nucleus in schizophrenia and mood disorders. Acta Neuropathologica 2009, 117:369-384.
18. Dorph-Petersen K.A., Pierri J.N., Wu Q., Sampson A.R., Lewis D.A. Primary visual cortex volume and total neuron number are reduced in schizophrenia. Journal of Comparative Neurology 2007, 501:290-301.
19. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV) 1996, American Psychiatric Association, Washington, DC.
20. Freedman R., Adler L.E., Gerhardt G.A., Waldo M., Baker N., Rose G.M., Franks R. Neurobiological studies of sensory gating in schizophrenia. Schizophrenia Bulletin 1987, 13:669-678.
21. Green M.F., Butler P.D., Chen Y., Geyer M.A., Silverstein S., Wynn J.K., Zemon V. Perception measurement in clinical trials of schizophrenia: Promising paradigms from CNTRICS. Schizophrenia Bulletin 2009, 35:163-181.
22. Green M.F., Nuechterlein K.H., Mintz J. Backward masking in schizophrenia and mania: II. Specifying the visual channels. Archives of General Psychiatry 1994, 51:945-951.
23. Harris J.P., Calvert J.E., Leendertz J.A., Phillipson O.T. The influence of dopamine on spatial vision. Eye 1990, 4:806-812.
24. Javitt D.C. When doors of perception close: Bottom-up models of disrupted cognition in schizophrenia. Annual Review of Clinical Psychology 2009, 5:249-275.
25. Kay S.R., Fiszbein A., Opler L.A. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin 1987, 13:261-276.
26. Kelly D.H. Visual contrast sensitivity. Optica Acta 1977, 24:107-129.
27. Kéri S., Antal A., Benedek G., Janka Z. Contrast detection in schizophrenia. Archives of General Psychiatry 2000, 57:995-996.
28. Kéri S., Antal A., Szekeres G., Benedek G., Janka Z. Spatiotemporal visual processing in schizophrenia. Journal of Neuropsychiatry and Clinical Neurosciences 2002, 14:190-196.
29. Kéri S., Benedek G. Visual contrast sensitivity alterations in inferred magnocellular pathways and anomalous perceptual experiences in people at high risk for psychosis. Visual Neuroscience 2007, 24:183-189.
30. Kéri S., Kelemen O., Benedek G., Janka Z. Vernier threshold in patients with schizophrenia and in their unaffected siblings. Neuropsychology 2004, 18:537-542.
31. Klosterkötter J., Hellmich M., Steinmeyer E.M., Schultze-Lutter F. Diagnosing schizophrenia in the initial prodromal phase. Archives of General Psychiatry 2001, 58:158-164.
32. Kogan C.S., Boutet I., Cornish K., Zangenehpour S., Mullen K.T., Holden J.J., Chaudhuri A. Differential impact of the FMR1 gene on visual processing in Fragile X syndrome. Brain 2004, 127:591-601.
33. Lalor E.C., Yeap S., Reilly R.B., Pearlmutter B.A., Foxe J.J. Dissecting the cellular contributions to early visual sensory processing deficits in schizophrenia using the VESPA evoked response. Schizophrenia Research 2008, 98:256-264.
34. Laycock R., Crewther S.G., Crewther D.P. A role for the "magnocellular advantage" in visual impairments in neurodevelopmental and psychiatric disorders. Neuroscience & Biobehavioral Reviews 2007, 31:363-376.
35. Legge G.E. Sustained and transient mechanisms in human vision: Temporal and spatial properties. Vision Research 1978, 18:69-81.
36. Leonova A., Pokorny J., Smith V.C. Spatial frequency processing in inferred PC- and MC-pathways. Vision Research 2003, 43:2133-2139.
37. Martínez A., Hillyard S.A., Dias E.C., Hagler D.J., Butler P.D., Guilfoyle D.N., Javitt D.C. Magnocellular pathway impairment in schizophrenia: Evidence from functional magnetic resonance imaging. Journal of Neuroscience 2008, 28:7492-7500.
38. McGhie A., Chapman J. Disorders of attention and perception in early schizophrenia. British Journal of Medical Psychology 1961, 34:103-116.
39. Mendoza Quiñones R., Martín Reyes M., Díaz de Villalvilla T., Bravo D.T., Caballero Moreno A., Lomba P., Padrón Fernández A. Scale for assessing perceptual anomalies: Validation of a Spanish version of the SIAPA scale in a sample of Cuban schizophrenic patients. Actas Españolas de Psiquiatría 2007, 35:15-19.
40. Nassi J.J., Callaway E.M. Parallel processing strategies of the primate visual system. Nature Reviews Neuroscience 2009, 10:360-372.
41. O'Donnell B.F., Bismark A., Hetrick W.P., Bodkins M., Vohs J.L., Shekhar A. Early stage vision in schizophrenia and schizotypal personality disorder. Schizophrenia Research 2006, 86:89-98.
42. Phillipson O.T., Harris J.P. Perceptual changes in schizophrenia: A questionnaire survey. Psychological Medicine 1985, 15:859-866.
43. Pokorny J., Smith V.C. Psychophysical signatures associated with magnocellular and parvocellular pathway contrast gain. Journal of Optical Society of America 1997, 14:2477-2486.
44. Renshaw P.F., Yurgelun-Todd D.A., Cohen B.M. Greater hemodynamic response to photic stimulation in schizophrenic patients: An echo planar MRI study. American Journal of Psychiatry 1994, 151:1493-1495.
45. Revheim N., Butler P.D., Schechter I., Jalbrzikowski M., Silipo G., Javitt D.C. Reading impairment and visual processing deficits in schizophrenia. Schizophrenia Research 2006, 87:238-245.
46. Sawatari A., Callaway E.M. Convergence of magno- and parvocellular pathways in layer 4B of macaque primary visual cortex. Nature 1996, April 4, 380:442-446.
47. Schiller P.H., Logothetis N.K., Charles E.R. Functions of the colour-opponent and broad-band channels of the visual system. Nature 1990, January 4, 343:68-70.
48. Schwartz B.D., Maron B.A., Evans W.J., Winstead D.K. High velocity transient visual processing deficits diminish ability of patients with schizophrenia to recognize objects. Neuropsychiatry, Neuropsychology and Behavioral Neurology 1999, 12:170-177.
49. Selemon L.D., Begovic A. Stereologic analysis of the lateral geniculate nucleus of the thalamus in normal and schizophrenic subjects. Psychiatry Research 2007, 151:1-10.
50. Skottun B.C., Skoyles J.R. Contrast sensitivity and magnocellular functioning in schizophrenia. Vision Research 2007, 47:2923-2933.
51. Slaghuis W.L. Contrast sensitivity for stationary and drifting spatial frequency gratings in positive- and negative-symptom schizophrenia. Journal of Abnormal Psychology 1998, 107:49-62.
52. Slaghuis W.L. Spatio-temporal luminance contrast sensitivity and visual backward masking in schizophrenia. Experimental Brain Research 2004, 156:196-211.
53. Slaghuis W.L., Curran C.E. Spatial frequency masking in positive- and negative-symptom schizophrenia. Journal of Abnormal Psychology 1999, 108:42-50.
54. Tadin D., Kim J., Doop M.L., Gibson C., Lappin J.S., Blake R., Park S. Weakened center-surround interactions in visual motion processing in schizophrenia. Journal of Neuroscience 2006, 26:11403-11412.
55. Tolhurst D.J. Reaction times in the detection of gratings by human observers: A probabilistic mechanism. Vision Research 1975, 15:1143-1149.
56. Treutwein B. Adaptive psychophysical procedures. Vision Research 1995, 35:2503-2522.
57. Van Essen D.C., Gallant J.L. Neural mechanisms of form and motion processing in the primate visual system. Neuron 1994, 13:1-10.
58. Venables P. Input dysfunction in schizophrenia. Progress in experimental personality research 1964, 1-47. Academic Press, New York, NY. B.A. Maher (Ed.).
59. Vidyasagar T.R., Kulikowski J.J., Lipnicki D.M., Dreher B. Convergence of parvocellular and magnocellular information channels in the primary visual cortex of the macaque. European Journal of Neuroscience 2002, 16:945-956.
60. Vohs J.L., Hetrick W.P., Kieffaber P.D., Bodkins M., Bismark A., Shekhar A., O'Donnell B.F. Visual event-related potentials in schizotypal personality disorder and schizophrenia. Journal of Abnormal Psychology 2008, 117:119-131.
61. Yeap S., Kelly S.P., Sehatpour P., Magno E., Javitt D.C., Garavan H., Foxe J.J. Early visual sensory deficits as endophenotypes for schizophrenia: High-density electrical mapping in clinically unaffected first-degree relatives. Archives of General Psychiatry 2006, 63:1180-1188.