-
2
-
-
72949119124
-
Integrins in cancer: Biological implications and therapeutic opportunities
-
J. S. Desgrosellier, D. A. Cheresh, Integrins in cancer: Biological implications and therapeutic opportunities. Nat. Rev. Cancer 10, 9-22 (2010).
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 922
-
-
Desgrosellier, J.S.1
Cheresh, D.A.2
-
4
-
-
0005306564
-
Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor
-
D. A. Cheresh, Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proc. Natl. Acad. Sci. U.S.A. 84, 6471-6475 (1987).
-
(1987)
Proc. Natl. Acad. Sci. U.S.A.
, vol.84
, pp. 6471-6475
-
-
Cheresh, D.A.1
-
5
-
-
0023609864
-
Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion
-
M. D. Pierschbacher, E. Ruoslahti, Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion. J. Biol. Chem. 262, 17294-17298 (1987).
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 17294-17298
-
-
Pierschbacher, M.D.1
Ruoslahti, E.2
-
6
-
-
70749103751
-
Tissue-penetrating delivery of compounds and nanoparticles into tumors
-
K. N. Sugahara, T. Teesalu, P. P. Karmali, V. R. Kotamraju, L. Agemy, O. M. Girard, D. Hanahan, R. F. Mattrey, E. Ruoslahti, Tissue-penetrating delivery of compounds and nanoparticles into tumors. Cancer Cell 16, 510-520 (2009).
-
(2009)
Cancer Cell
, vol.16
, pp. 510-520
-
-
Sugahara, K.N.1
Teesalu, T.2
Karmali, P.P.3
Kotamraju, V.R.4
Agemy, L.5
Girard, O.M.6
Hanahan, D.7
Mattrey, R.F.8
Ruoslahti, E.9
-
7
-
-
77952901022
-
Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs
-
K. N. Sugahara, T. Teesalu, P. P. Karmali, V. R. Kotamraju, L. Agemy, D. R. Greenwald, E. Ruoslahti, Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science 328, 1031-1035 (2010).
-
(2010)
Science
, vol.328
, pp. 1031-1035
-
-
Sugahara, K.N.1
Teesalu, T.2
Karmali, P.P.3
Kotamraju, V.R.4
Agemy, L.5
Greenwald, D.R.6
Ruoslahti, E.7
-
8
-
-
70349482671
-
C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration
-
T. Teesalu, K. N. Sugahara, V. R. Kotamraju, E. Ruoslahti, C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration. Proc. Natl. Acad. Sci. U.S.A. 106, 16157-16162 (2009).
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 16157-16162
-
-
Teesalu, T.1
Sugahara, K.N.2
Kotamraju, V.R.3
Ruoslahti, E.4
-
9
-
-
0032549799
-
Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
-
S. Soker, S. Takashima, H. Q. Miao, G. Neufeld, M. Klagsbrun, Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92, 735-745 (1998).
-
(1998)
Cell
, vol.92
, pp. 735-745
-
-
Soker, S.1
Takashima, S.2
Miao, H.Q.3
Neufeld, G.4
Klagsbrun, M.5
-
10
-
-
0034678343
-
Semaphorin3A enhances endocytosis at sites of receptor-F-actin colocalization during growth cone collapse
-
A. E. Fournier, F. Nakamura, S. Kawamoto, Y. Goshima, R. G. Kalb, S. M. Strittmatter, Semaphorin3A enhances endocytosis at sites of receptor-F-actin colocalization during growth cone collapse. J. Cell Biol. 149, 411-422 (2000).
-
(2000)
J. Cell Biol.
, vol.149
, pp. 411-422
-
-
Fournier, A.E.1
Nakamura, F.2
Kawamoto, S.3
Goshima, Y.4
Kalb, R.G.5
Strittmatter, S.M.6
-
11
-
-
33646552427
-
Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A
-
M. Narazaki, G. Tosato, Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A. Blood 107, 3892-3901 (2006).
-
(2006)
Blood
, vol.107
, pp. 3892-3901
-
-
Narazaki, M.1
Tosato, G.2
-
12
-
-
53249096017
-
Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways
-
A. Salikhova, L. Wang, A. A. Lanahan, M. Liu, M. Simons, W. P. Leenders, D. Mukhopadhyay, A. Horowitz, Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways. Circ. Res. 103, e71-e79 (2008).
-
(2008)
Circ. Res.
, vol.103
-
-
Salikhova, A.1
Wang, L.2
Lanahan, A.A.3
Liu, M.4
Simons, M.5
Leenders, W.P.6
Mukhopadhyay, D.7
Horowitz, A.8
-
13
-
-
77955610033
-
-
note
-
Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; G, Gly; K, Lys; P, Pro; R, Arg.
-
-
-
-
14
-
-
65949101737
-
HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165
-
S. Lambert, M. Bouttier, R. Vassy, M. Seigneuret, C. Petrow-Sadowski, S. Janvier, N. Heveker, F. W. Ruscetti, G. Perret, K. S. Jones, C. Pique, HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165. Blood 113, 5176-5185 (2009).
-
(2009)
Blood
, vol.113
, pp. 5176-5185
-
-
Lambert, S.1
Bouttier, M.2
Vassy, R.3
Seigneuret, M.4
Petrow-Sadowski, C.5
Janvier, S.6
Heveker, N.7
Ruscetti, F.W.8
Perret, G.9
Jones, K.S.10
Pique, C.11
-
15
-
-
0022858683
-
A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
-
Y. Matsumura, H. Maeda, A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46, 6387-6392 (1986).
-
(1986)
Cancer Res.
, vol.46
, pp. 6387-6392
-
-
Matsumura, Y.1
Maeda, H.2
-
16
-
-
34447103275
-
Targeting tumor stroma and exploiting mature tumor vasculature to improve anti-cancer drug delivery
-
C. Bouzin, O. Feron, Targeting tumor stroma and exploiting mature tumor vasculature to improve anti-cancer drug delivery. Drug Resist. Updat. 10, 109-120 (2007).
-
(2007)
Drug Resist. Updat.
, vol.10
, pp. 109-120
-
-
Bouzin, C.1
Feron, O.2
-
17
-
-
65049091113
-
Nitric oxide delivery to cancer: Why and how?
-
P. Sonveaux, B. F. Jordan, B. Gallez, O. Feron, Nitric oxide delivery to cancer: Why and how? Eur. J. Cancer 45, 1352-1369 (2009).
-
(2009)
Eur. J. Cancer
, vol.45
, pp. 1352-1369
-
-
Sonveaux, P.1
Jordan, B.F.2
Gallez, B.3
Feron, O.4
-
18
-
-
33746086723
-
Reversal of temporal and spatial heterogeneities in tumor perfusion identifies the tumor vascular tone as a tunable variable to improve drug delivery
-
P. Martinive, J. De Wever, C. Bouzin, C. Baudelet, P. Sonveaux, V. Grégoire, B. Gallez, O. Feron, Reversal of temporal and spatial heterogeneities in tumor perfusion identifies the tumor vascular tone as a tunable variable to improve drug delivery. Mol. Cancer Ther. 5, 1620-1627 (2006).
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 1620-1627
-
-
Martinive, P.1
De Wever, J.2
Bouzin, C.3
Baudelet, C.4
Sonveaux, P.5
Grégoire, V.6
Gallez, B.7
Feron, O.8
-
19
-
-
0035141292
-
Bradykinin modulation of tumor vasculature: I. Activation of B2 receptors increases delivery of chemotherapeutic agents into solid peripheral tumors, enhancing their efficacy
-
D. F. Emerich, P. Snodgrass, R. L. Dean, D. Lafreniere, M. Agostino, T. Wiens, H. Xiong, B. Hasler, J. Marsh, M. Pink, B. S. Kim, R. T. Bartus, Bradykinin modulation of tumor vasculature: I. Activation of B2 receptors increases delivery of chemotherapeutic agents into solid peripheral tumors, enhancing their efficacy. J. Pharmacol. Exp. Ther. 296, 623-631 (2001).
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.296
, pp. 623-631
-
-
Emerich, D.F.1
Snodgrass, P.2
Dean, R.L.3
Lafreniere, D.4
Agostino, M.5
Wiens, T.6
Xiong, H.7
Hasler, B.8
Marsh, J.9
Pink, M.10
Kim, B.S.11
Bartus, R.T.12
-
20
-
-
0035146475
-
Bradykinin modulation of tumor vasculature: II. activation of nitric oxide and phospholipase A2/prostaglandin signaling pathways synergistically modifies vascular physiology and morphology to enhance delivery of chemotherapeutic agents to tumors
-
D. F. Emerich, R. L. Dean, P. Snodgrass, D. Lafreniere, M. Agostino, T. Wiens, H. Xiong, B. Hasler, J. Marsh, M. Pink, B. S. Kim, B. Perdomo, R. T. Bartus, Bradykinin modulation of tumor vasculature: II. activation of nitric oxide and phospholipase A2/prostaglandin signaling pathways synergistically modifies vascular physiology and morphology to enhance delivery of chemotherapeutic agents to tumors. J. Pharmacol. Exp. Ther. 296, 632-641 (2001).
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.296
, pp. 632-641
-
-
Emerich, D.F.1
Dean, R.L.2
Snodgrass, P.3
Lafreniere, D.4
Agostino, M.5
Wiens, T.6
Xiong, H.7
Hasler, B.8
Marsh, J.9
Pink, M.10
Kim, B.S.11
Perdomo, B.12
Bartus, R.T.13
-
21
-
-
0027299899
-
Augmentation of tumour delivery of macromolecular drugs with reduced bone marrow delivery by elevating blood pressure
-
C. J. Li, Y. Miyamoto, Y. Kojima, H. Maeda, Augmentation of tumour delivery of macromolecular drugs with reduced bone marrow delivery by elevating blood pressure. Br. J. Cancer 67, 975-980 (1993).
-
(1993)
Br. J. Cancer
, vol.67
, pp. 975-980
-
-
Li, C.J.1
Miyamoto, Y.2
Kojima, Y.3
Maeda, H.4
-
22
-
-
0019478990
-
A new approach to cancer chemotherapy: Selective enhancement of tumor blood flow with angiotensin II
-
M. Suzuki, K. Hori, I. Abe, S. Saito, H. Sato, A new approach to cancer chemotherapy: Selective enhancement of tumor blood flow with angiotensin II. J. Natl. Cancer Inst. 67, 663-669 (1981).
-
(1981)
J. Natl. Cancer Inst.
, vol.67
, pp. 663-669
-
-
Suzuki, M.1
Hori, K.2
Abe, I.3
Saito, S.4
Sato, H.5
-
23
-
-
21844449129
-
Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability
-
P. M. Becker, J. Waltenberger, R. Yachechko, T. Mirzapoiazova, J. S. Sham, C. G. Lee, J. A. Elias, A. D. Verin, Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability. Circ. Res. 96, 1257-1265 (2005).
-
(2005)
Circ. Res.
, vol.96
, pp. 1257-1265
-
-
Becker, P.M.1
Waltenberger, J.2
Yachechko, R.3
Mirzapoiazova, T.4
Sham, J.S.5
Lee, C.G.6
Elias, J.A.7
Verin, A.D.8
-
24
-
-
33744965754
-
Characterization of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of vascular endothelial growth factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling
-
H. Jia, A. Bagherzadeh, B. Hartzoulakis, A. Jarvis, M. Löhr, S. Shaikh, R. Aqil, L. Cheng, M. Tickner, D. Esposito, R. Harris, P. C. Driscoll, D. L. Selwood, I. C. Zachary, Characterization of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of vascular endothelial growth factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling. J. Biol. Chem. 281, 13493-13502 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 13493-13502
-
-
Jia, H.1
Bagherzadeh, A.2
Hartzoulakis, B.3
Jarvis, A.4
Löhr, M.5
Shaikh, S.6
Aqil, R.7
Cheng, L.8
Tickner, M.9
Esposito, D.10
Harris, R.11
Driscoll, P.C.12
Selwood, D.L.13
Zachary, I.C.14
-
25
-
-
0032487348
-
Control of tumour vascular permeability
-
D. F. Baban, L. W. Seymour, Control of tumour vascular permeability. Adv. Drug Deliv. Rev. 34, 109-119 (1998).
-
(1998)
Adv. Drug Deliv. Rev.
, vol.34
, pp. 109-119
-
-
Baban, D.F.1
Seymour, L.W.2
-
26
-
-
0021111648
-
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
-
D. R. Senger, S. J. Galli, A. M. Dvorak, C. A. Perruzzi, V. S. Harvey, H. F. Dvorak, Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219, 983-985 (1983).
-
(1983)
Science
, vol.219
, pp. 983-985
-
-
Senger, D.R.1
Galli, S.J.2
Dvorak, A.M.3
Perruzzi, C.A.4
Harvey, V.S.5
Dvorak, H.F.6
-
27
-
-
0035074497
-
The vesiculo-vacuolar organelle (VVO). A new endothelial cell permeability organelle
-
A. M. Dvorak, D. Feng, The vesiculo-vacuolar organelle (VVO). A new endothelial cell permeability organelle. J. Histochem. Cytochem. 49, 419-432 (2001).
-
(2001)
J. Histochem. Cytochem.
, vol.49
, pp. 419-432
-
-
Dvorak, A.M.1
Feng, D.2
-
28
-
-
41949129114
-
Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor
-
L. M. Acevedo, S. Barillas, S. M. Weis, J. R. Göthert, D. A. Cheresh, Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor. Blood 111, 2674-2680 (2008).
-
(2008)
Blood
, vol.111
, pp. 2674-2680
-
-
Acevedo, L.M.1
Barillas, S.2
Weis, S.M.3
Göthert, J.R.4
Cheresh, D.A.5
-
29
-
-
64149106522
-
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
-
A. R. Reynolds, I. R. Hart, A. R. Watson, J. C. Welti, R. G. Silva, S. D. Robinson, G. Da Violante, M. Gourlaouen, M. Salih, M. C. Jones, D. T. Jones, G. Saunders, V. Kostourou, F. Perron-Sierra, J. C. Norman, G. C. Tucker, K. M. Hodivala-Dilke, Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat. Med. 15, 392-400 (2009).
-
(2009)
Nat. Med.
, vol.15
, pp. 392-400
-
-
Reynolds, A.R.1
Hart, I.R.2
Watson, A.R.3
Welti, J.C.4
Silva, R.G.5
Robinson, S.D.6
Da Violante, G.7
Gourlaouen, M.8
Salih, M.9
Jones, M.C.10
Jones, D.T.11
Saunders, G.12
Kostourou, V.13
Perron-Sierra, F.14
Norman, J.C.15
Tucker, G.C.16
Hodivala-Dilke, K.M.17
-
30
-
-
0026334978
-
Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells
-
C. L. Gladson, D. A. Cheresh, Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells. J. Clin. Invest. 88, 1924-1932 (1991).
-
(1991)
J. Clin. Invest.
, vol.88
, pp. 1924-1932
-
-
Gladson, C.L.1
Cheresh, D.A.2
-
31
-
-
40249108222
-
Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition
-
M. Sarris, K. G. Andersen, F. Randow, L. Mayr, A. G. Betz, Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition. Immunity 28, 402-413 (2008).
-
(2008)
Immunity
, vol.28
, pp. 402-413
-
-
Sarris, M.1
Andersen, K.G.2
Randow, F.3
Mayr, L.4
Betz, A.G.5
-
32
-
-
71749099202
-
Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis
-
S. D. Robinson, L. E. Reynolds, V. Kostourou, A. R. Reynolds, R. G. da Silva, B. Tavora, M. Baker, J. F. Marshall, K. M. Hodivala-Dilke, Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis. J. Biol. Chem. 284, 33966-33981 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 33966-33981
-
-
Robinson, S.D.1
Reynolds, L.E.2
Kostourou, V.3
Reynolds, A.R.4
Da Silva, R.G.5
Tavora, B.6
Baker, M.7
Marshall, J.F.8
Hodivala-Dilke, K.M.9
-
33
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
R. K. Jain, Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 307, 58-62 (2005).
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
34
-
-
4544333732
-
Targeting the tumor vascular compartment to improve conventional cancer therapy
-
O. Feron, Targeting the tumor vascular compartment to improve conventional cancer therapy. Trends Pharmacol. Sci. 25, 536-542 (2004).
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 536-542
-
-
Feron, O.1
-
35
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
M. Pàez-Ribes, E. Allen, J. Hudock, T. Takeda, H. Okuyama, F. Viñals, M. Inoue, G. Bergers, D. Hanahan, O. Casanovas, Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15, 220-231 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Pàez-Ribes, M.1
Allen, E.2
Hudock, J.3
Takeda, T.4
Okuyama, H.5
Viñals, F.6
Inoue, M.7
Bergers, G.8
Hanahan, D.9
Casanovas, O.10
-
36
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
-
J. M. Ebos, C. R. Lee, W. Cruz-Munoz, G. A. Bjarnason, J. G. Christensen, R. S. Kerbel, Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15, 232-239 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 232-239
-
-
Ebos, J.M.1
Lee, C.R.2
Cruz-Munoz, W.3
Bjarnason, G.A.4
Christensen, J.G.5
Kerbel, R.S.6
-
37
-
-
77955643345
-
-
note
-
Funding: O.F. is professor at the Université catholique de Louvain and Research Director of the Fonds de la Recherche Scientifi que (FRS-FNRS). His work is supported by grants from the FRS-FNRS, the Télévie, the Belgian Fundation Against Cancer, the J. Maisin Foundation, an Action de Recherche Concertée (ARC 09/14-020) from the Communauté Française de Belgique, the Région Bruxelles-Capitale, and the Région Wallonne. Competing interests: The author has no competing interests.
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