Quantifying a pathway: Kinetic analysis of actin dendritic nucleation

Biophysical Journal

Volumn 99, Issue 3, 2010, Pages 708-715

  Kraikivski, Pavel ^a   Slepchenko, Boris M ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ACTIN RELATED PROTEIN 2-3 COMPLEX; PYRENE; PYRENE DERIVATIVE;

BIOLOGICAL MODEL; COMPUTER SIMULATION; DENDRITE; KINETICS; METABOLISM; STAINING; STATISTICS; TIME;

ACTIN-RELATED PROTEIN 2-3 COMPLEX; ACTINS; COMPUTER SIMULATION; DENDRITES; KINETICS; MODELS, BIOLOGICAL; PYRENES; STAINING AND LABELING; STOCHASTIC PROCESSES; TIME FACTORS;

EID: 77955612501     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2010.05.007     Document Type: Article

References (23)

1. Alberts, B., A. Jonson, P. Walter. 2002. Molecular Biology of the Cell. Garland Science, New York.
2. Insall, R. H., and L. M. Machesky. 2009. Actin dynamics at the leading edge: from simple machinery to complex networks. Dev. Cell. 17: 310-322.
3. Svitkina, T. M., and G. G. Borisy. 1999. Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia. J. Cell Biol. 145:1009-1026.
4. Goley, E. D., and M. D. Welch. 2006. The ARP2/3 complex: an actin nucleator comes of age. Nat. Rev. Mol. Cell Biol. 7:713-726.
5. Mullins, R. D., J. A. Heuser, and T. D. Pollard. 1998. The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments. Proc. Natl. Acad. Sci. USA. 95:6181-6186.
6. Pollard, T. D. 2007. Regulation of actin filament assembly by Arp2/3 complex and formins. Annu. Rev. Biophys. Biomol. Struct. 36:451-477.
7. Marchand, J. B., D. A. Kaiser, T. D. Pollard, and H. N. Higgs. 2001. Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex. Nat. Cell Biol. 3:76-82.
8. Cai, L., and J. E. Bear. 2008. Peering deeply inside the branch. J. Cell Biol. 180:853-855.
9. Rouiller, I., X. P. Xu, D. Hanein. 2008. The structural basis of actin filament branching by the Arp2/3 complex. J. Cell Biol. 180:887-895.
10. Beltzner, C. C., and T. D. Pollard. 2008. Pathway of actin filament branch formation by Arp2/3 complex. J. Biol. Chem. 283:7135-7144.
11. Pantaloni, D., R. Boujemaa, M. F. Carlier. 2000. The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins. Nat. Cell Biol. 2:385-391.
12. Machesky, L. M., and R. H. Insall. 1998. Scar1 and the related Wiskott- Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. Curr. Biol. 8:1347-1356.
13. Carlsson, A. E., M. A. Wear, and J. A. Cooper. 2004. End versus side branching by Arp2/3 complex. Biophys. J. 86:1074-1081.
14. Ditlev, J. A., N. M. Vacanti, I. L. Novak, and L. M. Loew. 2009. An open model of actin dendritic nucleation. Biophys. J. 96:3529-3542.
15. Mogilner, A. 2009. Mathematics of cell motility: have we got its number? J. Math. Biol. 58:105-134.
16. Haviv, L., Y. Brill-Karniely, A. Bernheim-Groswasser. 2006. Reconstitution of the transition from lamellipodium to filopodium in a membrane-free system. Proc. Natl. Acad. Sci. USA. 103:4906-4911.
17. Ideses, Y., Y. Brill-Karniely, A. Bernheim-Groswasser. 2008. Arp2/3 branched actin network mediates filopodia-like bundles formation in vitro. PLoS One. 3:e3297.
18. Kraikivski, P., B. M. Slepchenko, and I. L. Novak. 2008. Actin bundling: initiation mechanisms and kinetics. Phys. Rev. Lett. 101:128102.
19. Dueber, J. E., E. A. Mirsky, and W. A. Lim. 2007. Engineering synthetic signaling proteins with ultrasensitive input/output control. Nat. Biotechnol. 25:660-662.
20. Pollard, T. D. 1986. Rate constants for the reactions of ATP- and ADP-actin with the ends of actin filaments. J. Cell Biol. 103:2747-2754.
21. Pollard, T. D., and J. A. Cooper. 1986. Actin and actin-binding proteins. A critical evaluation of mechanisms and functions. Annu. Rev. Biochem. 55:987-1035.
22. Moraru, I. I., J. C. Schaff, L. M. Loew. 2008. Virtual cell modelling and simulation software environment. IET Syst. Biol. 2:352-362.
23. Slepchenko, B. M., J. C. Schaff, I. Macara, and L. M. Loew. 2003. Quantitative cell biology with the virtual cell. Trends Cell Biol. 13:570-576.