HSV usurps eukaryotic initiation factor 3 subunit M for viral protein translation: Novel prevention target

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Cheshenko, Natalia ^a   Trepanier, Janie B ^a   Segarra, Theodore J ^a   Fuller, A Oveta ^b   Herold, Betsy C ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; CALCIUM; CELL PROTEIN; GOLGIN 97; HISTONE H1; IMMEDIATE EARLY PROTEIN; INITIATION FACTOR 3; INITIATION FACTOR 3 SUBUNIT M; MESSENGER RNA; NECTIN 1; POLYADENYLIC ACID BINDING PROTEIN; PROTEIN ICP0; PROTEIN ICP27; PROTEIN ICP4; PROTEIN VP16; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRAL TEGUMENT PROTEIN; VIRUS PROTEIN; CELL ADHESION MOLECULE; NECTINS; PROTEIN SUBUNIT;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE; CELL NUCLEUS; CONTROLLED STUDY; CROSS LINKING; CYTOPLASM; CYTOTOXICITY; DRUG TARGETING; GENE SILENCING; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HOST CELL; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; INTRACELLULAR TRANSPORT; NONHUMAN; POLYADENYLATION; POLYSOME; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN RNA BINDING; PROTEIN SYNTHESIS; PROTEIN TARGETING; PROTEIN TRANSPORT; RIBOSOME; VIRUS CAPSID; VIRUS ENTRY; VIRUS ENVELOPE; VIRUS TRANSCRIPTION; ANIMAL; CELL LINE; CERCOPITHECUS; CHEMISTRY; CONFOCAL MICROSCOPY; GENETIC TRANSCRIPTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOPRECIPITATION; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIMPLEXVIRUS; VERO CELL; WESTERN BLOTTING;

EUKARYOTA; HERPES; MIRIDAE; SIMPLEXVIRUS;

ANIMALS; BLOTTING, WESTERN; CELL ADHESION MOLECULES; CELL LINE; CERCOPITHECUS AETHIOPS; EUKARYOTIC INITIATION FACTOR-3; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HUMANS; IMMUNOPRECIPITATION; MICROSCOPY, CONFOCAL; PROTEIN SUBUNITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIMPLEXVIRUS; TRANSCRIPTION, GENETIC; VERO CELLS; VIRAL PROTEINS;

EID: 77955610172     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011829     Document Type: Article

References (33)

1. Wilson SS, Fakioglu E, Herold BC (2009) Novel approaches in fighting herpes simplex virus infections. Expert Rev Anti Infect Ther 7: 559-568.
2. Roberts C (2005) Genital herpes in young adults: changing sexual behaviours, epidemiology and management. Herpes 12: 10-14.
3. Roberts CM, Pfister JR, Spear SJ (2003) Increasing proportion of herpes simplex virus type 1 as a cause of genital herpes infection in college students. Sex Transm Dis 30: 797-800.
4. Cheshenko N, Liu W, Satlin LM, Herold BC (2007) Multiple receptor interactions trigger release of membrane and intracellular calcium stores critical for herpes simplex virus entry. Mol Biol Cell 18: 3119-3130.
5. WuDunn D, Spear PG (1989) Initial interaction of herpes simplex virus with cells is binding to heparan sulfate. J Virol 63: 52-58.
6. Herold BC, WuDunn D, Soltys N, Spear PG (1991) Glycoprotein C of herpes simplex virus type 1 plays a principal role in the adsorption of virus to cells and in infectivity. J Virol 65: 1090-1098.
7. Cheshenko N, Herold BC (2002) Glycoprotein B plays a predominant role in mediating herpes simplex virus type 2 attachment and is required for entry and cell-to-cell spread. J Gen Virol 83: 2247-2255.
8. Montgomery RI, Warner MS, Lum BJ, Spear PG (1996) Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 87: 427-436.
9. Geraghty RJ, Krummenacher C, Cohen GH, Eisenberg RJ, Spear PG (1998) Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science 280: 1618-1620.
10. Cheshenko N, Del Rosario B, Woda C, Marcellino D, Satlin LM, et al. (2003) Herpes simplex virus triggers activation of calcium-signaling pathways. J Cell Biol 163: 283-293.
11. Perez A, Li QX, Perez-Romero P, Delassus G, Lopez SR, et al. (2005) A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins. J Virol 79: 7419-7430.
12. Subramanian G, LeBlanc RA, Wardley RC, Fuller AO (1995) Defective entry of herpes simplex virus types 1 and 2 into porcine cells and lack of infection in infant pigs indicate species tropism. J Gen Virol 76(Pt 9): 2375-2379.
13. Perez A, Fuller AO (1998) Stable attachment for herpes simplex virus penetration into human cells requires glycoprotein D in the virion and cell receptors that are missing for entry-defective porcine cells. Virus Res 58: 21-34.
14. Perez-Romero P, Fuller AO (2005) The C terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection. J Virol 79: 7431-7437.
15. Damoc E, Fraser CS, Zhou M, Videler H, Mayeur GL, et al. (2007) Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Mol Cell Proteomics 6: 1135-1146.
16. Desai P, Person S (1998) Incorporation of the green fluorescent protein into the herpes simplex virus type 1 capsid. J Virol 72: 7563-7568.
17. Cheshenko N, Liu W, Satlin LM, Herold BC (2005) Focal adhesion kinase plays a pivotal role in herpes simplex virus entry. J Biol Chem 280: 31116-31125.
18. Gelman IH, Silverstein S (1985) Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene. Proc Natl Acad Sci USA 82: 5265-5269.
19. Kutluay SB, DeVos SL, Klomp JE, Triezenberg SJ (2009) Transcriptional coactivators are not required for herpes simplex virus type 1 immediate-early gene expression in vitro. J Virol 83: 3436-3449.
20. Larralde O, Smith RW, Wilkie GS, Malik P, Gray NK, et al. (2006) Direct stimulation of translation by the multifunctional herpesvirus ICP27 protein. J Virol 80: 1588-1591.
21. Mohr I (2004) Neutralizing innate host defenses to control viral translation in HSV-1 infected cells. Int Rev Immunol 23: 199-220.
22. Cheshenko N, Keller MJ, MasCasullo V, Jarvis GA, Cheng H, et al. (2004) Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread. Antimicrob Agents Chemother 48: 2025-2036.
23. Hinnebusch AG (2006) eIF3: a versatile scaffold for translation initiation complexes. Trends Biochem Sci 31: 553-562.
24. Zhou C, Arslan F, Wee S, Krishnan S, Ivanov AR, et al. (2005) PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes. BMC Biol 3: 14.
25. Brown OJ, Lopez SA, Fuller AO, Goodson T 3rd (2007) Formation and reversible dissociation of coiled coil of peptide to the C-terminus of the HSV B5 protein: a time-resolved spectroscopic analysis. Biophys J 93: 1068-1078.
26. Chew SK, Chen P, Link N, Galindo KA, Pogue K, et al. (2009) Genome-wide silencing in Drosophila captures conserved apoptotic effectors. Nature 460: 123-127.
27. Walsh D, Mohr I (2004) Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells. Genes Dev 18: 660-672.
28. Walsh D, Mohr I (2006) Assembly of an active translation initiation factor complex by a viral protein. Genes Dev 20: 461-472.
29. Celum C, Wald A, Hughes J, Sanchez J, Reid S, et al. (2008) Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. Lancet 371: 2109-2119.
30. Zhu J, Hladik F, Woodward A, Klock A, Peng T, et al. (2009) Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition. Nat Med 15: 886-892.
31. Mesquita PM, Wilson SS, Manlow P, Fischetti L, Keller MJ, et al. (2008) Candidate microbicide PPCM blocks human immunodeficiency virus type 1 infection in cell and tissue cultures and prevents genital herpes in a murine model. J Virol 82: 6576-6584.
32. Herold BC, Siston A, Bremer J, Kirkpatrick R, Wilbanks G, et al. (1997) Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens. Antimicrob Agents Chemother 41: 2776-2780.
33. Conrad NK (2008) Chapter 15. Co-immunoprecipitation techniques for assessing RNA-protein interactions in vivo. Methods Enzymol 449: 317-342.