μ-Opioid receptor stimulation in the medial subnucleus of the tractus solitarius inhibits gastric tone and motility by reducing local GABA activity

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 299, Issue 2, 2010, Pages

  Herman, Melissa A ^a   Alayan, Alisa ^b   Sahibzada, Niaz ^b   Bayer, Barbara ^c   Verbalis, Joseph ^c   Dretchen, Kenneth L ^b   Gillis, Richard A ^b  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain stem; Opioids; Vagovagal reflexes; Vagus

Indexed keywords

4 AMINOBUTYRIC ACID; ENDOMORPHIN 1; ENDOMORPHIN 2; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; IONOTROPIC RECEPTOR; MU OPIATE RECEPTOR; NALTREXONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; NARCOTIC ANTAGONIST; OLIGOPEPTIDE; OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; ELECTROENCEPHALOGRAM; EXPERIMENTAL STUDY; MALE; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SOLITARY TRACT NUCLEUS; STOMACH FUNCTION; STOMACH MOTILITY; STOMACH PRESSURE; VAGOTOMY; VAGUS NERVE DORSAL NUCLEUS; ANIMAL; DOWN REGULATION; DRUG ANTAGONISM; EFFERENT NERVE; GASTROINTESTINAL MOTILITY; METABOLISM; MUSCLE TONE; PHYSIOLOGY; RADIATION EXPOSURE; SPRAGUE DAWLEY RAT; STOMACH; STOMACH FUNDUS; VAGUS NERVE;

ANIMALS; DOWN-REGULATION; EFFERENT PATHWAYS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GASTRIC FUNDUS; GASTROINTESTINAL MOTILITY; MALE; MICROINJECTIONS; MUSCLE TONUS; NALTREXONE; NARCOTIC ANTAGONISTS; NEUROTRANSMITTER AGENTS; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RECEPTORS, OPIOID; SOLITARY NUCLEUS; STOMACH; VAGUS NERVE;

EID: 77955608269     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00038.2010     Document Type: Article

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