Use of benzodiazepines, hypnotics, and anxiolytics in major depressive disorder: Association with chronic pain diseases

Journal of Nervous and Mental Disease

Volumn 198, Issue 8, 2010, Pages 544-550

  Liu, Xianchen ^a,b   Ye, Wenyu ^a   Watson, Peter ^a   Tepper, Ping ^c  

^a ELI LILLY AND COMPANY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

benzodiazepines; chronic pain; hypnotics; Major depression; managed care patients

Indexed keywords

ALPRAZOLAM; ANXIOLYTIC AGENT; BENZODIAZEPINE; BUSPIRONE; CHLORDIAZEPOXIDE; CLONAZEPAM; CLORAZEPATE; DIAZEPAM; ESZOPICLONE; FLURAZEPAM; HYDROXYZINE; HYPNOTIC AGENT; LORAZEPAM; OXAZEPAM; RAMELTEON; TEMAZEPAM; TRIAZOLAM; ZALEPLON; ZOLPIDEM;

ADULT; ANXIETY DISORDER; ARTICLE; CHRONIC PAIN; COMORBIDITY; DRUG USE; FEMALE; FIBROMYALGIA; GROUPS BY AGE; HEADACHE; HEALTH INSURANCE; HUMAN; LOW BACK PAIN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; NEUROPATHIC PAIN; OSTEOARTHRITIS; PRESCRIPTION; PREVALENCE; RETROSPECTIVE STUDY; RHEUMATOID ARTHRITIS; SEX DIFFERENCE; SLEEP DISORDER; UNITED STATES;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGE FACTORS; ANTI-ANXIETY AGENTS; BENZODIAZEPINES; CHRONIC DISEASE; COMORBIDITY; DEPRESSIVE DISORDER, MAJOR; DRUG UTILIZATION; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; INSURANCE, HEALTH; INTERNATIONAL CLASSIFICATION OF DISEASES; MALE; MANAGED CARE PROGRAMS; MIDDLE AGED; PAIN; SEX FACTORS; TREATMENT OUTCOME;

EID: 77955600964     PISSN: 00223018     EISSN: None     Source Type: Journal    
DOI: 10.1097/NMD.0b013e3181e9daf7     Document Type: Article

References (51)

1. Adrien J (2002) Neurobiological bases for the relation between sleep and depression. Sleep Med Rev. 6:341-351. (Pubitemid 36529358)
2. Arnold LM (2008) Management of fibromyalgia and comorbid psychiatric disorders. J Clin Psychiatry. 69(suppl 2):14-19.
3. Bair MJ, Robinson RL, Katon W, Kroenke K (2003) Depression and pain comorbidity: A literature review. Arch Intern Med. 163:2433-2445.
4. Banks E, Reeves GK, Beral V, Balkwill A, Liu B, Roddam A; Million Women Study Collaborators (2009) Hip fracture incidence in relation to age, menopausal status and age at menopause: Prospective analysis. PLoS Med. 6:e1000181.
5. Barbone F, McMahon AD, Davey PG, Morris AD, Reid IC, McDevitt DG, MacDonald TM (1998) Association of road-traffic accidents with benzodiaz-epine use. Lancet. 352:1331-1336.
6. Benca RM (2005) Diagnosis and treatment of chronic insomnia: A review. Psychiatr Serv. 56:332-343.
7. Brennan MJ, Lieberman JA III (2009) Sleep disturbances in patients with chronic pain: Effectively managing opioid analgesia to improve outcomes. Curr Med Res Opin. 25:1045-1055.
8. Colman I, Croudace TJ, Wadsworth ME, Jones PB (2008) Factors associated with antidepressant, anxiolytic and hypnotic use over 17 years in a national cohort. J Affect Disord. 110:234-240.
9. Demyttenaere K, Bonnewyn A, Bruffaerts R, De Girolamo G, Gasquet I, Kovess V, Haro JM, Alonso J (2008) Clinical factors influencing the prescription of antidepressants and benzodiazepines: Results from the European study of the epidemiology of mental disorders (ESEMeD). J Affect Disord. 110:84-93.
10. Demyttenaere K, Desaiah D, Petit C, Croenlein J, Brecht S (2009) Patient-assessed versus physician-assessed disease severity and outcome in patients with nonspecific pain associated with major depressive disorder. Prim Care Companion J Clin Psychiatry. 11:8-15.
11. Dersh J, Polatin PB, Gatchel RJ (2002) Chronic pain and psychopathology: Research findings and theoretical considerations. Psychosom Med. 64:773-786.
12. Dunlop BW, Davis PG (2008) Combination treatment with benzodiazepines and SSRIs for comorbid anxiety and depression: A review. Prim Care Companion J Clin Psychiatry. 10:222-228.
13. Ebert B, Wafford KA, Deacon S (2006) Treating insomnia: Current and investigational pharmacological approaches. Pharmacol Ther. 112:612-629.
14. Fava M, Mallinckrodt CH, Detke MJ, Watkin JG, Wohlreich MM (2004) The effect of duloxetine on painful physical symptoms in depressed patients: Do improvements in these symptoms result in higher remission rates? J Clin Psychiatry. 65:521-530.
15. Fishbain DA, Hall J, Meyers AL, Gonzales J, Mallinckrodt C (2008) Does pain mediate the pain interference with sleep problem in chronic pain? Findings from studies for management of diabetic peripheral neuropathic pain with duloxetine. J Pain Symptom Manage. 36:639-647.
16. Furukawa TA, Streiner DL, Young LT (2001) Is antidepressant- benzodiazepine combination therapy clinically more useful? A meta-analytic study. J Affect Disord. 65:173-177.
17. Greden JF (2003) Physical symptoms of depression: Unmet needs. J Clin Psychiatry. 64(suppl 7):5-11.
18. Gureje O, Von Korff M, Kola L, Demyttenaere K, He Y, Posada-Villa J, Lepine JP, Angermeyer MC, Levinson D, de Girolamo G, Iwata N, Karam A, Guimaraes Borges GL, de Graaf R, Browne MO, Stein DJ, Haro JM, Bromet EJ, Kessler RC, Alonso J (2008) The relation between multiple pains and mental disorders: Results from the World Mental Health Surveys. Pain. 135:82-91.
19. Hemmelgarn B, Suissa S, Huang A, Boivin JF, Pinard G (1997) Benzodiazepine use and the risk of motor vehicle crash in the elderly. JAMA. 278:27-31.
20. Holshoe JM (2009) Antidepressants and sleep: A review. Perspect Psychiatr Care. 45:191-197.
21. Joukamaa M, Sohlman B, Lehtinen V (1995) The prescription of psychotropic drugs in primary health care. Acta Psychiatr Scand. 92:359-364.
22. Karp JF, Scott J, Houck P, Reynolds CF III, Kupfer DJ, Frank E (2005) Pain predicts longer time to remission during treatment of recurrent depression. J Clin Psychiatry. 66:591-597.
23. Karp JF, Weiner DK, Dew MA, Begley A, Miller MD, Reynolds CF III (2010) Duloxetine and care management treatment of older adults with comorbid major depressive disorder and chronic low back pain: Results of an open-label pilot study. Int JGeriatr Psychiatry. 25:633-642.
24. Kroenke K, Bair MJ, Damush TM, Wu J, Hoke S, Sutherland J, Tu W (2009a) Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: A randomized controlled trial. JAMA. 301:2099-2110.
25. Kroenke K, Krebs EE, Bair MJ (2009b) Pharmacotherapy of chronic pain: A synthesis of recommendations from systematic reviews. Gen Hosp Psychiatry. 31:206-219.
26. Leveille SG, Buchner DM, Koepsell TD, McCloskey LW, Wolf ME, Wagner EH (1994) Psychoactive medications and injurious motor vehicle collisions involving older drivers. Epidemiology. 5:591-598.
27. Liu X, Ye WY, Wohlreich MM Dube S (2009) Sleep disorders among patients with major depressive disorder in a large managed-care population. In: The Association Professional Sleep Societies (APSS) 23rd annual meeting; June 6-11, 2009; Seattle, WA.
28. Magni G, Moreschi C, Rigatti-Luchini S, Mersky H (1994) Prospective study on the relationship between depressive symptoms and chronic musculoskeletal pain. Pain. 56:289-297.
29. McWilliams LA, Goodwin RD, Cox BJ (2004) Depression and anxiety associated with three pain conditions: Results from a nationally representative sample. Pain. 111:77-83.
30. Menefee LA, Cohen MJ, Anderson WR, Doghramji K, Frank ED, Lee H (2000) Sleep disturbance and nonmalignant chronic pain: A comprehensive review of the literature. Pain Med. 1:156-172.
31. Mojtabai R, Olfson M (2008) National patterns in antidepressant treatment by psychiatrists and general medical providers: Results from the national comor-bidity survey replication. J Clin Psychiatry. 69:1064-1074.
32. Ohayon MM, Caulet M, Priest RG, Guilleminault C (1998) Psychotropic medication consumption patterns in the UK general population. J Clin Epidemiol. 51:273-283.
33. Ohayon MM, Lader MH (2002) Use of psychotropic medication in the general population of France, Germany, Italy, and the United Kingdom. J Clin Psychiatry. 63:817-825.
34. Ohayon MM, Schatzberg AF (2003) Using chronic pain to predict depressive morbidity in the general population. Arch Gen Psychiatry. 60:39-47.
35. Otte C (2008) Incomplete remission in depression: Role of psychiatric and somatic comorbidity. Dialogues Clin Neurosci. 10:453-460.
36. Perahia DG, Pritchett YL, Desaiah D, Raskin J (2006) Efficacy of duloxetine in painful symptoms: An analgesic or antidepressant effect? Int Clin Psychophar-macol. 21:311-317.
37. Polatin PB, Kinney RK, Gatchel RJ, Lillo E, Mayer TG (1993) Psychiatric illness and chronic low-back pain. The mind and the spine-which goes first? Spine. 18:66-71.
38. Pollack MH (2005) Comorbid anxiety and depression. JClin Psychiatry. 66(suppl 8):22-29.
39. Pollack MH, Marzol PC (2000) Pharmacotherapeutic options in the treatment of comorbid depression and anxiety. CNS Spectr. 5:23-30.
40. Ryynanen OP, Kivela SL, Honkanen R, Laippala P, Saano V (1993) Medications and chronic diseases as risk factors for falling injuries in the elderly. Scand J Soc Med. 21:264-271.
41. Simon GE, VonKorff M, Barlow W, Pabiniak C, Wagner E (1996) Predictors of chronic benzodiazepine use in a health maintenance organization sample. JClin Epidemiol. 49:1067-1073.
42. Smith WT, Londborg PD, Glaudin V, Painter JR (1998) Short-term augmentation of fluoxetine with clonazepam in the treatment of depression: A double-blind study. Am J Psychiatry. 155:1339-1345.
43. Smith WT, Londborg PD, Glaudin V, Painter JR, Summit Research Network (2002) Is extended clonazepam cotherapy offluoxetine effective for outpatients with major depression? J Affect Disord. 70:251-259.
44. Stahl SM (2002) Don't ask, don't tell, but benzodiazepines are still the leading treatments for anxiety disorder. J Clin Psychiatry. 63:756-757.
45. Stevens JC, Pollack MH (2005) Benzodiazepines in clinical practice: Consideration of their long-term use and alternative agents. J Clin Psychiatry. 66(suppl 2):21-27.
46. Tsang A, Von KorffM, Lee S, Alonso J, Karam E, Angermeyer MC, Borges GL, Bromet EJ, Demytteneare K, de Girolamo G, de Graaf R, Gureje O, Lepine JP, Haro JM, Levinson D, Oakley Browne MA, Posada-Villa J, Seedat S, Wa-tanabe M (2008) Common chronic pain conditions in developed and developing countries: Gender and age differences and comorbidity with depression-anxiety disorders. J Pain. 9:883-891.
47. Tsuno N, Besset A, Ritchie K (2005) Sleep and depression. J Clin Psychiatry. 66:1254-1269.
48. Valenstein M, Taylor KK, Austin K, Kales HC, McCarthy JF, Blow FC (2004) Benzodiazepine use among depressed patients treated in mental health settings. Am J Psychiatry. 161:654-661.
49. Wang PS, Bohn RL, Glynn RJ, Mogun H, Avorn J (2001) Zolpidem use and hip fractures in older people. J Am Geriatr Soc. 49:1685-1690.
50. Wells KB, Kamberg C, Brook R, Camp P, Rogers W (1985) Health status, sociodemographic factors and the use of prescribed psychotropic drugs. Med Care. 23:1295-1306.
51. Ye WY, Watson PR, Liu XC (2009) Age and gender differences of chronic pain among patients with MDD in a large managed-care population. In: Society of Biological Psychiatry, 64th Annual Convention & Scientific Program; May 14 -16, 2009; Vancouver, BC.