The growth hormone-releasing hormone (GHRH) antagonist JV-1-36 inhibits proliferation and survival of human ectopic endometriotic stromal cells (ESCs) and the T HESC cell line

Fertility and Sterility

Volumn 94, Issue 3, 2010, Pages 841-849

  Annunziata, Marta ^a   Grande, Cristina ^a   Scarlatti, Francesca ^a   Deltetto, Francesco ^b   Delpiano, Elena ^b   Camanni, Marco ^b   Ghigo, Ezio ^a   Granata, Riccarda ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b Ginteam   (Italy)

Author keywords

Endometriosis; GHRH antagonists; GHRH receptor (GHRH R); growth hormone releasing hormone (GHRH)

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BETA ACTIN; BROXURIDINE; CYCLIC AMP; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING FACTOR RECEPTOR; HORMONE ANTAGONIST; JV 1 36; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SOMATOMEDIN B; TRYPAN BLUE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL ASSAY; CELL DEATH; CELL ISOLATION; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ECTOPIC TISSUE; ENDOMETRIOSIS; ENDOMETRIOTIC STROMAL CELLS; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMORTALIZED HUMAN ENDOMETRIAL STROMAL CELL; LAPAROSCOPIC SURGERY; MEDIATOR; NITROBLUE TETRAZOLIUM TEST; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; STROMA CELL; UNIVERSITY HOSPITAL; WESTERN BLOTTING;

ADULT; CELL LINE, TRANSFORMED; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CHORISTOMA; DRUG EVALUATION, PRECLINICAL; ENDOMETRIOSIS; ENDOMETRIUM; FEMALE; GROWTH HORMONE-RELEASING HORMONE; HORMONE ANTAGONISTS; HUMANS; PROTEIN ISOFORMS; RECEPTORS, NEUROPEPTIDE; RECEPTORS, PITUITARY HORMONE-REGULATING HORMONE; STROMAL CELLS; UTERINE DISEASES;

EID: 77955587658     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2009.03.093     Document Type: Article

References (45)

1. L.C. Giudice, and L.C. Kao Endometriosis. Lancet 364 2004 1789 1799
2. H.M. Gebel, D.P. Braun, A. Tambur, D. Frame, N. Rana, and W.P. Dmowski Spontaneous apoptosis of endometrial tissue is impaired in women with endometriosis Fertil Steril 69 1998 1042 1047
3. L.S. Noble, E.R. Simpson, A. Johns, and S.E. Bulun Aromatase expression in endometriosis J Clin Endocrinol Metab 81 1996 174 179
4. R.K. Jones, J.N. Bulmer, and R.F. Searle Immunohistochemical characterization of proliferation, oestrogen receptor and progesterone receptor expression in endometriosis: comparison of eutopic and ectopic endometrium with normal cycling endometrium Hum Reprod 10 1995 3272 3279
5. R. Guillemin, P. Brazeau, P. Bohlen, F. Esch, N. Ling, and W.B. Wehrenberg Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly Science 218 1982 585 587
6. T. Shibasaki, Y. Kiyosawa, A. Masuda, M. Nakahara, T. Imaki, and I. Wakabayashi Distribution of growth hormone-releasing hormone-like immunoreactivity in human tissue extracts J Clin Endocrinol Metab 59 1984 263 268
7. N.D. Christofides, A. Stephanou, H. Suzuki, Y. Yiangou, and S.R. Bloom Distribution of immunoreactive growth hormone-releasing hormone in the human brain and intestine and its production by tumors J Clin Endocrinol Metab 59 1984 747 751
8. I. Chatzistamou, A.V. Schally, A. Pafiti, H. Kiaris, and H. Koutselini Expression of growth hormone-releasing hormone in human primary endometrial carcinomas Eur J Endocrinol 147 2002 381 386
9. Fu L, Osuga Y, Yano T, Takemura Y, Morimoto C, Hirota Y, et al. Expression and possible implication of growth hormone-releasing hormone receptor splice variant 1 in endometriosis. Fertil Steril. Published online August 5, 2008 [Epub ahead of print].
10. Z. Kahan, J.M. Arencibia, V.J. Csernus, K. Groot, R.D. Kineman, and W.R. Robinson Expression of growth hormone-releasing hormone (GHRH) messenger ribonucleic acid and the presence of biologically active GHRH in human breast, endometrial, and ovarian cancers J Clin Endocrinol Metab 84 1999 582 589
11. O. Khorram, M. Garthwaite, E. Grosen, and T. Golos Human uterine and ovarian expression of growth hormone-releasing hormone messenger RNA in benign and malignant gynecologic conditions Fertil Steril 75 2001 174 179
12. A. Havt, A.V. Schally, G. Halmos, J.L. Varga, G.L. Toller, and J.E. Horvath The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissues Proc Natl Acad Sci U S A 102 2005 17424 17429
13. Z. Rekasi, T. Czompoly, A.V. Schally, and G. Halmos Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers Proc Natl Acad Sci U S A 97 2000 10561 10566
14. N. Barabutis, and A.V. Schally Knocking down gene expression for growth hormone-releasing hormone inhibits proliferation of human cancer cell lines Br J Cancer 98 2008 1790 1796
15. A.V. Schally, J.L. Varga, and J.B. Engel Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancer Nat Clin Pract Endocrinol Metab 4 2008 33 43
16. H. Kiaris, I. Chatzistamou, A.V. Schally, G. Halmos, J.L. Varga, and H. Koutselini Ligand-dependent and -independent effects of splice variant 1 of growth hormone-releasing hormone receptor Proc Natl Acad Sci U S A 100 2003 9512 9517
17. M.O. Garcia-Fernandez, A.V. Schally, J.L. Varga, K. Groot, and R. Busto The expression of growth hormone-releasing hormone (GHRH) and its receptor splice variants in human breast cancer lines; the evaluation of signaling mechanisms in the stimulation of cell proliferation Breast Cancer Res Treat 77 2003 15 26
18. Z. Rekasi, T. Czompoly, A.V. Schally, F. Boldizsar, J.L. Varga, and M. Zarandi Antagonist of growth hormone-releasing hormone induces apoptosis in LNCaP human prostate cancer cells through a Ca2+-dependent pathway Proc Natl Acad Sci U S A 102 2005 3435 3440
19. C.A. Kanashiro, A.V. Schally, M. Zarandi, B.D. Hammann, and J.L. Varga Suppression of growth of H-69 small cell lung carcinoma by antagonists of growth hormone releasing hormone and bombesin is associated with an inhibition of protein kinase C signaling Int J Cancer 112 2004 570 576
20. A. Stangelberger, A.V. Schally, J.L. Varga, M. Zarandi, R.Z. Cai, and B. Baker Inhibition of human androgen-independent PC-3 and DU-145 prostate cancers by antagonists of bombesin and growth hormone releasing hormone is linked to PKC, MAPK and c-Jun intracellular signalling Eur J Cancer 41 2005 2735 2744 (Pubitemid 41607567)
21. J.B. Engel, G. Keller, A.V. Schally, G.L. Toller, K. Groot, and A. Havt Inhibition of growth of experimental human endometrial cancer by an antagonist of growth hormone-releasing hormone J Clin Endocrinol Metab 90 2005 3614 3621 (Pubitemid 41014334)
22. G. Keller, A.V. Schally, K. Groot, G.L. Toller, A. Havt, and F. Koster Effective treatment of experimental human non-Hodgkin's lymphomas with antagonists of growth hormone-releasing hormone Proc Natl Acad Sci U S A 102 2005 10628 10633
23. K. Szepeshazi, A.V. Schally, K. Groot, P. Armatis, F. Hebert, and G. Halmos Antagonists of growth hormone-releasing hormone (GH-RH) inhibit in vivo proliferation of experimental pancreatic cancers and decrease IGF-II levels in tumours Eur J Cancer 36 2000 128 136
24. G. Krikun, G. Mor, A. Alvero, S. Guller, F. Schatz, and E. Sapi A novel immortalized human endometrial stromal cell line with normal progestational response Endocrinology 145 2004 2291 2296
25. D.K. Hapangama, M.A. Turner, J.A. Drury, S. Quenby, G. Saretzki, and C. Martin-Ruiz Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length Hum Reprod 23 2008 1511 1519
26. R. Granata, F. Settanni, D. Gallo, L. Trovato, L. Biancone, and V. Cantaluppi Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function Diabetes 57 2008 967 979
27. K.E. Mayo Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone Mol Endocrinol 6 1992 1734 1744
28. C.M. Pombo, J. Zalvide, B.D. Gaylinn, and C. Dieguez Growth hormone-releasing hormone stimulates mitogen-activated protein kinase Endocrinology 141 2000 2113 2119
29. F. Koster, J.B. Engel, A.V. Schally, A. Honig, A. Schroer, and S. Seitz Triple-negative breast cancers express receptors for growth hormone-releasing hormone (GHRH) and respond to GHRH antagonists with growth inhibition Breast Cancer Res Treat 2008
30. A. Lania, M. Filopanti, S. Corbetta, M. Losa, E. Ballare, and P. Beck-Peccoz Effects of hypothalamic neuropeptides on extracellular signal-regulated kinase (ERK1 and ERK2) cascade in human tumoral pituitary cells J Clin Endocrinol Metab 88 2003 1692 1696
31. V.J. Csernus, A.V. Schally, H. Kiaris, and P. Armatis Inhibition of growth, production of insulin-like growth factor-II (IGF-II), and expression of IGF-II mRNA of human cancer cell lines by antagonistic analogs of growth hormone-releasing hormone in vitro Proc Natl Acad Sci U S A 96 1999 3098 3103
32. K. Szepeshazi, A.V. Schally, K. Groot, P. Armatis, G. Halmos, and F. Herbert Antagonists of growth hormone-releasing hormone (GH-RH) inhibit IGF-II production and growth of HT-29 human colon cancers Br J Cancer 82 2000 1724 1731
33. R. Gallego, E. Pintos, T. Garcia-Caballero, K. Raghay, L. Boulanger, and A. Beiras Cellular distribution of growth hormone-releasing hormone receptor in human reproductive system and breast and prostate cancers Histol Histopathol 20 2005 697 706
34. M.C. Johnson, M. Torres, A. Alves, K. Bacallao, A. Fuentes, and M. Vega Augmented cell survival in eutopic endometrium from women with endometriosis: expression of c-Myc, TGF-beta1 and Bax genes Reprod Biol Endocrinol 3 2005 45
35. Z. Rekasi, J.L. Varga, A.V. Schally, G. Halmos, P. Armatis, and K. Groot Antagonists of growth hormone-releasing hormone and vasoactive intestinal peptide inhibit tumor proliferation by different mechanisms: evidence from in vitro studies on human prostatic and pancreatic cancers Endocrinology 141 2000 2120 2128
36. Z. Rekasi, J.L. Varga, A.V. Schally, A. Plonowski, G. Halmos, and B. Csernus Antiproliferative actions of growth hormone-releasing hormone antagonists on MiaPaCa-2 human pancreatic cancer cells involve cAMP independent pathways Peptides 22 2001 879 886
37. N. Barabutis, E. Tsellou, A.V. Schally, S. Kouloheri, A. Kalofoutis, and H. Kiaris Stimulation of proliferation of MCF-7 breast cancer cells by a transfected splice variant of growth hormone-releasing hormone receptor Proc Natl Acad Sci U S A 104 2007 5575 5579
38. M. Kovacs, A.V. Schally, E.J. Lee, R. Busto, P. Armatis, and K. Groot Inhibitory effects of antagonistic analogs of GHRH on GH3 pituitary cells overexpressing the human GHRH receptor J Endocrinol 175 2002 425 434
39. V. Csernus, A.V. Schally, and K. Groot Antagonistic analogs of growth hormone releasing hormone (GHRH) inhibit cyclic AMP production of human cancer cell lines in vitro Peptides 20 1999 843 850
40. R. Busto, A.V. Schally, J.L. Varga, M.O. Garcia-Fernandez, K. Groot, and P. Armatis The expression of growth hormone-releasing hormone (GHRH) and splice variants of its receptor in human gastroenteropancreatic carcinomas Proc Natl Acad Sci U S A 99 2002 11866 11871 (Pubitemid 34994490)
41. P.J. Stork, and J.M. Schmitt Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation Trends Cell Biol 12 2002 258 266
42. O. Yoshino, Y. Osuga, Y. Hirota, K. Koga, T. Hirata, and M. Harada Possible pathophysiological roles of mitogen-activated protein kinases (MAPKs) in endometriosis Am J Reprod Immunol 52 2004 306 311
43. D. Gentilini, M. Busacca, S. Di Francesco, M. Vignali, P. Vigano, and A.M. Di Blasio PI3K/Akt and ERK1/2 signalling pathways are involved in endometrial cell migration induced by 17beta-estradiol and growth factors Mol Hum Reprod 13 2007 317 322
44. W. Murk, C.S. Atabekoglu, H. Cakmak, A. Heper, A. Ensari, and U.A. Kayisli Extracellularly signal-regulated kinase activity in the human endometrium: possible roles in the pathogenesis of endometriosis J Clin Endocrinol Metab 93 2008 3532 3540
45. H. Kiaris, A.V. Schally, and J.L. Varga Suppression of tumor growth by growth hormone-releasing hormone antagonist JV-1-36 does not involve the inhibition of autocrine production of insulin-like growth factor II in H-69 small cell lung carcinoma Cancer Lett 161 2000 149 155