Comparison of two dose regimens of misoprostol for second-trimester pregnancy termination

Contraception

Volumn 82, Issue 3, 2010, Pages 266-275

  Brouns, Joseph Franciscus Gertrudis Maria ^a   Van Wely, Madelon ^b   Burger, Mattheus Petrus Maria ^b   Van Wijngaarden, Willem Jacobus ^c  

^a ZAANS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c MEDICAL CENTER HAAGLANDEN   (Netherlands)

Author keywords

Medical abortion; Mifepristone; Misoprostol; Randomized controlled trial; Second trimester; Termination of pregnancy

Indexed keywords

HEMOGLOBIN; MIFEPRISTONE; MISOPROSTOL;

ABORTION; ADOLESCENT; ADULT; ARTICLE; BLEEDING; CLINICAL TRIAL; CONGENITAL DISORDER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOSAGE SCHEDULE COMPARISON; DOUBLE BLIND PROCEDURE; DRUG CHOICE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG FEVER; DRUG INDUCED HEADACHE; FEMALE; FETUS DEATH; FETUS DISEASE; GENETIC DISORDER; HEMOGLOBIN BLOOD LEVEL; HUMAN; LIVE BIRTH; NAUSEA; NETHERLANDS; OUTCOME ASSESSMENT; PLACENTA; PREGNANCY; PREGNANCY TERMINATION; PSYCHOSOCIAL ADJUSTMENT TO ILLNESS SCALE; RANDOMIZED CONTROLLED TRIAL; RETCHING; SECOND TRIMESTER PREGNANCY; SURGICAL ABORTION; VOMITING;

ABORTIFACIENT AGENTS, NONSTEROIDAL; ABORTION, INDUCED; ADMINISTRATION, INTRAVAGINAL; ADMINISTRATION, ORAL; ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; MIFEPRISTONE; MISOPROSTOL; PREGNANCY; PREGNANCY TRIMESTER, SECOND; QUESTIONNAIRES;

EID: 77955573491     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.contraception.2010.03.006     Document Type: Article

References (25)

1. The Royal College of Obstetricians and Gynaecologists The care of women requesting induced abortion 2004 RCOG Press London
2. Ashok P.W., and Templeton A. Nonsurgical mid-trimester termination of pregnancy: a review of 500 consecutive cases Br J Obstet Gynaecol 106 1999 706 710
3. Hamoda H., Ashok P.W., Flett G.M., and Templeton A. A randomized trial of mifepristone in combination with misoprostol administered sublingually or vaginally for medical abortion at 13-20 weeks gestation Hum Reprod 20 2005 2348 2354 (Pubitemid 41418530)
4. Danielsson K.G., Marions L., Rodriguez A., Spur B.W., Wong P.Y., and Bygdeman M. Comparison between oral and vaginal administration of misoprostol on uterine contractility Obstet Gynecol 93 1999 275 280
5. Dickinson J.E., and Evans S.F. A comparison of oral misoprostol with vaginal misoprostol administration in second-trimester pregnancy termination for fetal abnormality Obstet Gynecol 101 2003 1294 1299
6. Gilbert A., and Reid R. A randomised trial of oral versus vaginal administration of misoprostol for the purpose of mid-trimester termination of pregnancy Aust N Z J Obstet Gynaecol 41 2001 407 410
7. Tang O.S., Lau W.N., Chan C.C., and Ho P.C. A prospective randomised comparison of sublingual and vaginal misoprostol in second trimester termination of pregnancy BJOG 111 2004 1001 1005
8. Tang O.S., Schweer H., Seyberth H.W., Lee S.W., and Ho P.C. Pharmacokinetics of different routes of administration of misoprostol Hum Reprod 17 2002 332 336
9. Tang O.S., and Ho P.C. The pharmacokinetics and different regimens of misoprostol in early first-trimester medical abortion Contraception 74 2006 26 30
10. Tang O.S., Gemzell-Danielsson K., and Ho P.C. Misoprostol: pharmacokinetic profiles, effects on the uterus and side-effects Int J Gynaecol Obstet 99 Suppl 2 2007 S160 S167
11. Herabutya Y., and Prasertsawat P. Second trimester abortion using intravaginal misoprostol Int J Gynaecol Obstet 60 1998 161 165
12. Ho P.C., Ngai S.W., Liu K.L., Wong G.C., and Lee S.W. Vaginal misoprostol compared with oral misoprostol in termination of second-trimester pregnancy Obstet Gynecol 90 1997 735 738
13. Chai J., Tang O.S., and Hong Q.Q. A randomized trial to compare two dosing intervals of misoprostol following mifepristone administration in second trimester medical abortion Hum Reprod 24 2009 320 324
14. Kapp N., Borgatta L., Stubblefield P., Vragovic O., and Moreno N. Mifepristone in second-trimester medical abortion: a randomized controlled trial Obstet Gynecol 110 2007 1304 1310
15. Webster D., Penney G.C., and Templeton A. A comparison of 600 and 200 mg mifepristone prior to second trimester abortion with the prostaglandin misoprostol Br J Obstet Gynaecol 103 1996 706 709
16. Ashok P.W., Templeton A., Wagaarachchi P.T., and Flett G.M. Midtrimester medical termination of pregnancy: a review of 1002 consecutive cases Contraception 69 2004 51 58
17. Ngai S.W., Tang O.S., and Ho P.C. Randomized comparison of vaginal (200 microg every 3 h) and oral (400 microg every 3 h) misoprostol when combined with mifepristone in termination of second trimester pregnancy Hum Reprod 15 2000 2205 2208
18. Suhonen S., Heikinheimo O., Tikka M., and Haukkamaa M. The learning curve is rapid in medical termination of pregnancy - first-year results from the Helsinki area Contraception 67 2003 223 227
19. Dickinson J.E., and Evans S.F. The optimization of intravaginal misoprostol dosing schedules in second-trimester pregnancy termination Am J Obstet Gynecol 186 2002 470 474
20. Jain J.K., and Mishell D.R. Jr A comparison of misoprostol with and without laminaria tents for induction of second-trimester abortion Am J Obstet Gynecol 175 1996 173 177
21. Bhattacharyya S.K., Mukherji J., Kamilya G.S., Ray S., and Hazra A. Two regimens of vaginal misoprostol in second trimester termination of pregnancy: a prospective randomised trial Acta Obstet Gynecol Scand 85 2006 1458 1462
22. Tang O.S., Chan C.C., Kan A.S., and Ho P.C. A prospective randomized comparison of sublingual and oral misoprostol when combined with mifepristone for medical abortion at 12-20 weeks gestation Hum Reprod 20 2005 3062 3066
23. Vadeyar S., Johnston T.A., Sidebotham M., and Sands J. Neonatal death following termination of pregnancy BJOG 112 2005 1159 1162
24. Goldberg A.B., Greenberg M.B., and Darney P.D. Misoprostol and pregnancy 4 N Engl J Med 344 2001 38 47
25. Lydon-Rochelle M., Holt V.L., Easterling T.R., and Martin D.P. Risk of uterine rupture during labor among women with a prior cesarean delivery1 N Engl J Med 345 2001 3 8