The pharmacokinetics and different regimens of misoprostol in early first-trimester medical abortion

Contraception

Volumn 74, Issue 1, 2006, Pages 26-30

  Tang, Oi Shan ^a   Ho, Pak Chung ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Medical abortion; Misoprostol; Pharmacokinetics

Indexed keywords

MIFEPRISTONE; MISOPROSTOL; PROSTAGLANDIN E1;

AREA UNDER THE CURVE; CLINICAL TRIAL; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; FIRST TRIMESTER PREGNANCY; GASTROINTESTINAL SYMPTOM; HUMAN; PEPTIC ULCER; REVIEW; SYSTEMATIC REVIEW; TABLET FORMULATION; THERAPEUTIC ABORTION; UNSPECIFIED SIDE EFFECT;

ABORTIFACIENT AGENTS, NONSTEROIDAL; ABORTION, INDUCED; ADMINISTRATION, INTRAVAGINAL; ADMINISTRATION, ORAL; ADMINISTRATION, SUBLINGUAL; FEMALE; GESTATIONAL AGE; HUMANS; MISOPROSTOL; PREGNANCY; PREGNANCY TRIMESTER, FIRST;

EID: 33745012138     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.contraception.2006.03.005     Document Type: Review

References (23)

1. Watkinson G., Hopkins A., and Akbar F.A. The therapeutic efficacy of misoprostol in peptic ulcer disease. Postgrad Med J 64 Suppl 1 (1998) 60-77
2. Robert A., Nezamis J.E., and Phillips H. Inhibition of gastric secretion by prostaglandins. Am J Dig Dis 12 (1967) 1073-1076
3. 1 prostaglandin analog. Prostaglandins 10 (1975) 733-745
4. 1 and its methyl ester in animals. Prostaglandins 10 (1975) 205-215
5. El-Refaey H., Rajasekar D., Abdalla M., et al. Induction of abortion with mifepristone (RU 486) and oral or vaginal misoprostol. N Engl J Med 332 (1995) 983-987
6. Ho P.C., Ngai S.W., Liu K.L., et al. Vaginal misoprostol compared with oral misoprostol in termination of second trimester pregnancy. Obstet Gynecol 90 (1997) 735-738
7. Zieman M., Fong S.K., Benowitz N.L., et al. Absorption kinetics of misoprostol with oral or vaginal administration. Obstet Gynecol 90 (1997) 88-92
8. Tang O.S., Schweer H., Seyberth N.W., et al. Pharmacokinetics of different routes of administration of misoprostol. Hum Reprod 17 (2002) 332-336
9. Cicinelli E., Schonauer L.M., Galantino P., et al. Mechanisms of uterine specificity of vaginal progesterone. Hum Reprod 15 Suppl 1 (2000) 159-165
10. Cicinelli E., de Ziegler D., Bulletti C., et al. Direct transport of progesterone from vagina to uterus. Obstet Gynecol 95 (2000) 403-406
11. McKinley C., Thong K.J., and Baird D.T. The effect of dose of mifepristone and gestation on the efficacy of medical abortion with mifepristone and misoprostol. Hum Reprod 8 (1993) 1502-1505
12. World Health Organization Task Force on Post-Ovulatory Methods for Fertility Regulation. Termination of pregnancy with reduced doses of mifepristone. BMJ 307 (1993) 532-537
13. Spitz I.M., Bardin C.W., Benton L., et al. Early termination of pregnancy with mifepristone (RU 486) and the orally active prostaglandin misoprostol. N Engl J Med 21 (1998) 1509-1513
14. El-Refaey H., Rajasekar D., Abdalla M., et al. Induction of abortion with mifepristone (RU 486) and oral or vaginal misoprostol. N Engl J Med 332 (1995) 983-987
15. Bartley J., Brown A., Elton R., et al. A double blind randomized control trial between vaginal gemeprost and misoprostol in combination with mifepristone for induction of abortion in early pregnancy. Hum Reprod 16 (2001) 2098-2102
16. Ashok P.W., Penney G.C., Flett G.M., et al. An effective regimen for early medical abortion: a report of 2000 consecutive cases. Hum Reprod 13 (1998) 2962-2965
17. Tang O.S., Chan C.C.W., Ng E.H.Y., et al. A prospective, randomized, placebo-controlled trial on the use of mifepristone with sublingual or vaginal misoprostol for medical abortions of less than 9 weeks gestation. Hum Reprod 18 (2003) 2315-2318
18. Baird D.T. Mode of action of medical methods of abortion. J Am Med Women's Assoc 55 3 (2000) 121-126 [Supplement]
19. Hamoda H., Ashok P.W., Dow J., et al. A pilot study of mifepristone in combination with sublingual or vaginal misoprostol for medical termination of pregnancy up to 63 days gestation. Contraception 68 (2003) 335-338
20. Jain J.K., Dutton C., Harwood B., et al. A prospective randomized, double-blinded, placebo-controlled trial comparing mifepristone and vaginal misoprostol to vaginal misoprostol alone for elective termination of early pregnancy. Hum Reprod 17 (2002) 1477-1482
21. Zikopoulos K.A., Papanikolaou E.G., Kalantaridou S.N., et al. Early pregnancy termination with vaginal misoprostol before and after 42 days gestation. Hum Reprod 17 (2002) 3079-3083
22. Singh K., Fong Y.F., and Dong F. A viable alternative to surgical vacuum aspiration: repeated doses of intravaginal misoprostol over 9 hours for medical termination of pregnancies up to eight weeks. Br J Obstet Gynaecol 110 (2003) 175-180
23. Tang O.S., Wong K.S., Tang L.C.H., et al. Pilot study on the use of repeated doses of misoprostol in termination of pregnancy at less than 8 weeks of gestation. Adv Contracept 15 (1999) 211-216