Effects of activated protein c on ventilator-induced lung injury in rats

Respiration

Volumn 80, Issue 3, 2010, Pages 246-253

  Jiang, Jiunn Song ^a   Chou, Hsiu Chu ^b   Wang, Leng Fang ^c   Lang, Yaw Dong ^d   Chen, Chung Ming ^e  

^a SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^b Departments of Anatomyd   (Taiwan)

^c School of Medicine   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Bronchoalveolar lavage; Dimers; Macrophage inflammatory protein 2; Plasminogen activator inhibitor 1; Ventilator induced lung injury

Indexed keywords

ACTIVATED PROTEIN C; FIBRIN; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN C;

ANIMAL EXPERIMENT; ARTERIAL OXYGEN TENSION; ARTICLE; ARTIFICIAL VENTILATION; BREATHING RATE; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME BLOOD LEVEL; FIBRIN DEPOSITION; FIBRINOLYSIS; IMMUNOHISTOCHEMISTRY; LUNG FUNCTION; LUNG LAVAGE; LUNG PARENCHYMA; NONHUMAN; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; TIDAL VOLUME; VENTILATOR INDUCED LUNG INJURY;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CXCL2; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOLYSIS; IMMUNOHISTOCHEMISTRY; LUNG; MALE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN C; PULMONARY GAS EXCHANGE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIDAL VOLUME; VENTILATOR-INDUCED LUNG INJURY;

EID: 77955564519     PISSN: 00257931     EISSN: None     Source Type: Journal    
DOI: 10.1159/000279438     Document Type: Article

References (32)

1. Sandur S, Stoller JK: Pulmonary complications of mechanical ventilation. Clin Chest Med 1999; 20: 223-247.
2. Dos Santos CC, Slutsky AS: Invited review: mechanisms of ventilator-induced lung injury: a perspective. J Appl Physiol 2000; 89: 16 45-1655.
3. Slutsky AS: Lung injury caused by mechani-ca l venti lation. Chest 1999; 116 : 9S-15S.
4. Tremblay LN, Slutsky AS: Ventilator-induced injury: from barotrauma to biotrau-ma. Proc Assoc Am Physicians 1998; 110: 482-488.
5. Lionetti V, Recchia FA, Ranieri VM: Overview of ventilator-induced lung injury mechanisms. Curr Opin Crit Care 2005; 11:82-86.
6. Ren Y, Zhan Q, Hu Q, Sun B, Yang C, Wang C: Static stretch induces active morphological remodeling and functional impairment of alveolar epithelial cells. Respiration 2009; 78: 301-311.
7. Abraham E: Coagulation abnormalities in acute lung injury and sepsis. Am J Respir Cell Mol Biol 2000; 22:401-404.
8. Dahlem P, Bos AP, Haitsma JJ, Schultz MJ, Meijers JC, Lachmann B: Alveolar fibrino-lytic capacity suppressed by injurious mechanical ventilation. Intensive Care Med 2005; 31:724-732.
9. Dahlem P, Bos AP, Haitsma JJ, et al: Mechanical ventilation affects alveolar fibrinolysis in LPS-induced lung injury. Eur Respir J 2006; 28:992-998.
10. Idell S: Coagulation, fibrinolysis, and fibrin deposition in acute lung injury. Crit Care Med 2003; 31(4suppl):S213-S220.
11. Marshall R, Bellingan G, Laurent G: The acute respiratory distress syndrome: fibrosis in t he fast lane. Thorax 1998; 53: 815-817. (Pubitemid 28459534)
12. Choi G, Schultz MJ, Levi M, Van Der Poll T, Millo JL, Garrard CS: Protein C in pneumonia. Thorax 2005; 60: 705-706.
13. Vassalli JD, Sappino AP, Belin D: The plas-minogen activator/plasmin system. J Clin Invest 1991; 88: 1067-1072.
14. Chen CM, Chou HC, Wang LF, Lang YD: Captopril decreases plasminogen activator inhibitor-1 in rats with ventilator-induced lung injury. Crit Care Med 2008; 36:1880-1885.
15. Van Hinsbergh VW, Bertina RM, Van Wijn-gaarden A, Van Tilburg NH, Emeis JJ, Haver-kate F: Activated protein C decreases plas-minogen activator-inhibitor activity in en-dothelial cell-conditioned medium. Blood 1985; 65: 444-451.
16. Sakata Y, Loskutoff DJ, Gladson CL, Hek-man CM, Griffin JH: Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor. Blood 1986; 68: 1218-1223.
17. Sakamoto T, Ogawa H, Takazoe K, et al: Effect of activated protein C on plasma plas-minogen activator inhibitor activity in patients with acute myocardial infarction treated with alteplase: comparison with un-fractionated heparin. J Am Coll Cardiol 2003; 42:1389-1394.
18. Finigan JH, Boueiz A, Wilkinson E, et al: Activated protein C protects against ventilator-induced pulmonary capillary leak. Am J Physiol 2009; 296:L1002-L1011.
19. Moriondo A, Pelosi P, Passi A, et al: Proteo-glycan fragmentation and respiratory mechanics in mechanically ventilated healthy rats. J Appl Physiol 2007; 103:747-756.
20. Villar J, Herrera-Abreu MT, Valladares F, Muros M, Pérez- Méndez L, Flores C, Kac-marek RM: Experimental ventilator-induced lung injury: exacerbation by positive end-expiratory pressure. Anesthesiology 2009; 110: 1341-1347.
21. Ware LB, Matthay MA, Parsons PE, Thompson BT, Januzzi JL, Eisner MD, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network:. Pathogenetic and prognostic significance of altered coagulation and fibrino-lysis in acute lung injury/acute respiratory distress syndrome. Crit Care Med 2007; 35: 1821-1828.
22. Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA: Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Am J Physiol Lung Lung Cell Mol Physiol 2006; 291:L307-L311.
23. Dahlbäck B, Villoutreix BO: Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition. Arterioscler Thromb Vasc Biol 2005; 25: 1311-1320.
24. Bernard GR, Vincent JL, Laterre PF, et al: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344:699-709.
25. Esmon CT: Interactions between the innate immune and blood coagulation systems. Trends Immunol 2004; 25:536-542.
26. Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W: Activation of endothelial cell protease activated receptor 1 by the protein C pat hway. Science 2002; 296: 1880-1882.
27. Huether S, McCance K (ed): Understanding Pathophysiology, ed 2. St. Louis, Mosby, 2000.
28. Esmon CT: Cell mediated events that control blood coagulation and vascular injury (review). Annu Rev Cell Biol 1993; 9:1-26.
29. Esmon CT, Gu JM, Xu J, Qu D, Stearns-Ku-rosawa DJ, Kurosawa S: Regulation and functions of the protein C anticoagulant pathway. Haematologica 1999; 84: 363-368.
30. Bonville C, Bennett N, Koehnlein M, et al: Respiratory dysfunction and proinflamma-tory chemokines in the pneumonia virus of mice (PVM) model of viral bronchiolitis. Virology 2006; 349:87-95.
31. Jiang JS, Wang LF, Chou HC, Chen CM: An-giotensin-converting enzyme inhibitor cap-topril attenuates ventilation-induced lung injury in rats. J Appl Physiol 2007; 102:2098-2103.
32. Tanaka A, Minoguchi K, Chen X, et al: Activated protein C attenuates leukocyte elas-tase-induced lung injury in mice. Shock 2008; 30: 153-158.