Synthesis and cytotoxic activity of N-((2-methyl-4(3H)-quinazolinon-6-yl) methyl)dithiocarbamates

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 3850-3857

  Cao, Sheng Li ^a   Wang, Yao ^a   Zhu, Lin ^a   Liao, Ji ^a   Guo, Yan Wen ^b   Chen, Lin Lin ^b   Liu, Hong Qin ^b   Xu, Xingzhi ^a  

^a CAPITAL NORMAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF TECHNOLOGY   (China)

Author keywords

4(3H) quinazolinone; Cell cycle; Cytotoxic activity; Dithiocarbamate; Synthesis

Indexed keywords

2,3,4,5,6 PENTAFLUOROBENZYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; 2,4 DIFLUOROBENZYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; 3 CYANO 3,3 DIPHENYLPROPYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; 4 BROMOBENZYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; 4 CARBOXYBENZYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; 4 CHLOROBENZYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; 4 CYANOBENZYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; 4 ETHOXYCARBONYLBENZYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; 4 FLUOROBENZYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; 4 METHYLBENZYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; 4 NITROBENZYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; ALLYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; ANTINEOPLASTIC AGENT; BENZHYDRYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; BENZYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; BUTYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; CYCLOHEXYLMETHYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; DITHIOCARBAMIC ACID DERIVATIVE; ETHYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; FLUOROURACIL; HEXYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; ISOPROPYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; METHYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; N [[2 METHYL 4 (3H) QUINAZOLINON 6 YL]METHYL]DITHIOCARBAMATE DERIVATIVE; PENTYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; PROP 2 YNYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; PROPYL N [[2 METHYL 4 (3H)QUINAZOLIN 6 YL]METHYL]DITHIOCARBAMATE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN HCT116; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; IC 50;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; THIOCARBAMATES;

EID: 77955555432     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.05.038     Document Type: Article

References (16)

1. S. Webber, C.A. Bartlett, T.J. Boritzki, J.A. Hilliard, E.F. Howland, A.L. Johnston, M. Kosa, S.A. Margosiak, C.A. Morse, and B.V. Shetty Cancer Chemother. Pharmacol. 37 1996 509 517
2. A.N. Hughes, I. Rafi, M.J. Griffin, A.H. Calvert, D.R. Newell, J.A. Calvete, A. Johnston, N. Clendeninn, and A.V. Boddy Clin. Cancer Res. 5 1999 111 118
3. J.J. McGuire Curr. Pharm. Des. 9 2003 2593 2613
4. I.M. Kompis, K. Islam, and R.L. Then Chem. Rev. 105 2005 593 620
5. E. Bram, I. Ifergan, A. Shafran, B. Berman, G. Jansen, and Y.G. Assaraf Cancer Chemother. Pharmacol. 58 2006 826 834
6. A. Gangjee, H.D. Jain, and S. Kurup Anti-cancer Agents Med. Chem. 7 2007 524 542
7. A. Gangjee, H.D. Jain, and S. Kurup Anti-cancer Agents Med. Chem. 8 2008 205 231
8. R.G. Metha, J. Liu, A. Constantinou, C.F. Thomas, M. Hawthorne, M. You, C. Gerhauser, J.M. Pezutto, R.C. Moon, and M.R. Moriarty Carcinogenesis 16 1995 399 404
9. M. Sabol, P. Kutschy, L. Siegfried, A. Mirossay, M. Suchy, H. Hrbkova, M. Dzurilla, R. Maruskova, J. Starkova, and E. Paulikova Biologia 55 2000 701 707
10. M. Pilatova, M. Sarissky, P. Kutschy, A. Mirossay, R. Mezencev, Z. Curillova, M. Suchy, K. Monde, L. Mirossay, and J. Mojzis Leuk. Res. 29 2005 415 421
11. P. Gaspari, T. Banerjee, W.P. Malachowski, A.J. Muller, G.C. Prendergast, J. DuHadaway, S. Bennett, and A.M. Donovan J. Med. Chem. 49 2006 684 692
12. T. Banerjee, J.B. DuHadaway, P. Gaspari, E. Sutanto-Ward, D.H. Munn, A.L. Mellor, W.P. Malachowski, G.C. Prendergast, and A.J. Muller Oncogene 27 2008 2851 2857
13. S.L. Cao, Y.P. Feng, Y.Y. Jiang, S.Y. Liu, G.Y. Ding, and R.T. Li Bioorg. Med. Chem. Lett. 15 2005 1915 1917
14. S.L. Cao, Y.Y. Jiang, Y.P. Feng, S.Y. Liu, M. Zhang, and R. Wan Yaoxue Xuebao 42 2007 741 746
15. S.L. Cao, Y.P. Feng, X.L. Zheng, Y.Y. Jiang, M. Zhang, Y. Wang, and M. Xu Arch. Pharm. Chem. Life Sci. 339 2006 250 254
16. S.L. Cao, Y.W. Guo, X.B. Wang, M. Zhang, Y.P. Feng, Y.Y. Jiang, Y. Wang, Q. Gao, and J. Ren Arch. Pharm. Chem. Life Sci. 342 2009 182 189