Fragments of antigen-loaded dendritic cells (DC) and DC-derived exosomes induce protective immunity against Leishmania major

Vaccine

Volumn 28, Issue 36, 2010, Pages 5785-5793

  Schnitzer, Johannes K ^a   Berzel, Simon ^a   Fajardo Moser, Marcela ^a   Remer, Katharina A ^a   Moll, Heidrun ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Dendritic cells; Leishmania major; T cells

Indexed keywords

DENDRITIC CELL VACCINE; INTERLEUKIN 12; PARAFORMALDEHYDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; CELL DISRUPTION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; ENDOCYTOSIS; EXOSOME; FEMALE; LEISHMANIA MAJOR; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN LEISHMANIASIS; SPLEEN CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; ULTRAVIOLET IRRADIATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, PROTOZOAN; CELLS, CULTURED; DENDRITIC CELLS; EXOSOMES; FEMALE; INTERLEUKIN-12; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; PROTOZOAN VACCINES; SPLEEN; T-LYMPHOCYTES;

EID: 77955553260     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2010.06.077     Document Type: Article

References (36)

1. Banchereau J., Palucka A.K. Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol 2005, 5(4):296-306.
2. Flohé S.B., Bauer C., Flohé S., Moll H. Antigen-pulsed epidermal Langerhans cells protect susceptible mice from infection with the intracellular parasite Leishmania major. Eur J Immunol 1998, 28(11):3800-3811.
3. Ludewig B., Ehl S., Karrer U., Odermatt B., Hengartner H., Zinkernagel R.M. Dendritic cells efficiently induce protective antiviral immunity. J Virol 1998, 72(5):3812-3818.
4. Mbow M.L., Zeidner N., Panella N., Titus R.G., Piesman J. Borrelia burgdorferi-pulsed dendritic cells induce a protective immune response against tick-transmitted spirochetes. Infect Immun 1997, 65(8):3386-3390.
5. Moll H. Antigen delivery by dendritic cells. Int J Med Microbiol 2004, 294(5):337-344.
6. Su H., Messer R., Whitmire W., Fischer E., Portis J.C., Caldwell H.D. Vaccination against chlamydial genital tract infection after immunization with dendritic cells pulsed ex vivo with nonviable Chlamydiae. J Exp Med 1998, 188(5):809-818.
7. Sacks D., Noben-Trauth N. The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol 2002, 2(11):845-858.
8. Berberich C., Ramírez-Pineda J.R., Hambrecht C., Alber G., Skeiky Y.A., Moll H. Dendritic cell (DC)-based protection against an intracellular pathogen is dependent upon DC-derived IL-12 and can be induced by molecularly defined antigens. J Immunol 2003, 170(6):3171-3179.
9. von Stebut E., Belkaid Y., Nguyen B.V., Cushing M., Sacks D.L., Udey M.C. Leishmania major-infected murine langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous Leishmaniasis. Eur J Immunol 2000, 30(12):3498-3506.
10. Ramírez-Pineda J.R., Fröhlich A., Berberich C., Moll H. Dendritic cells (DC) activated by CpG DNA ex vivo are potent inducers of host resistance to an intracellular pathogen that is independent of IL-12 derived from the immunizing DC. J Immunol 2004, 172(10):6281-6289.
11. Alferink J., Lieberam I., Reindl W., Behrens A., Weiss S., Hüser N., et al. Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen. J Exp Med 2003, 197(5):585-599.
12. Lutz M.B., Kukutsch N., Ogilvie A.L., Rössner S., Koch F., Romani N., et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 1999, 223(1):77-92.
13. Aline F., Bout D., Amigorena S., Roingeard P., Dimier-Poisson I. Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T. gondii infection. Infect Immun 2004, 72(7):4127-4137.
14. Titus R.G., Ceredig R., Cerottini J.C., Louis J.A. Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice. J Immunol 1985, 135(3):2108-2114.
15. Théry C., Duban L., Segura E., Véron P., Lantz O., Amigorena S. Indirect activation of naïve CD4+ T cells by dendritic cell-derived exosomes. Nat Immunol 2002, 3(12):1156-1162.
16. Zitvogel L., Regnault A., Lozier A., Wolfers J., Flament C., Tenza D., et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med 1998, 4(5):594-600.
17. Remer K.A., Apetrei C., Schwarz T., Linden C., Moll H. Vaccination with plasmacytoid dendritic cells induces protection against infection with Leishmania major in mice. Eur J Immunol 2007, 37(9):2463-2473.
18. Kovar M., Boyman O., Shen X., Hwang I., Kohler R., Sprent J. Direct stimulation of T cells by membrane vesicles from antigen-presenting cells. Proc Natl Acad Sci USA 2006, 103(31):11671-11676.
19. Lasic D.D. The mechanism of vesicle formation. Biochem J 1988, 256(1):1-11.
20. Inaba K., Turley S., Yamaide F., Iyoda T., Mahnke K., Inaba M., et al. Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J Exp Med 1998, 188(11):2163-2173.
21. Kang T.H., Lee J.H., Bae H.C., Noh K.H., Kim J.H., Song C.K., et al. Enhancement of dendritic cell-based vaccine potency by targeting antigen to endosomal/lysosomal compartments. Immunol Lett 2006, 106(2):126-134.
22. + T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major. J Immunol 2002, 168(8):3992-4000.
23. Chakkalath H.R., Theodos C.M., Markowitz J.S., Grusby M.J., Glimcher L.H., Titus R.G. Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease. J Infect Dis 1995, 171(5):1302-1308.
24. O'Garra A., Vieira P. T(H)1 cells control themselves by producing interleukin-10. Nat Rev Immunol 2007, 7(6):425-428.
25. Gallucci S., Lolkema M., Matzinger P. Natural adjuvants: endogenous activators of dendritic cells. Nat Med 1999, 5(11):1249-1255.
26. Messmer D., Yang H., Telusma G., Knoll F., Li J., Messmer B., et al. High mobility group box protein 1: an endogenous signal for dendritic cell maturation and Th1 polarization. J Immunol 2004, 173(1):307-313.
27. Asea A., Kraeft S.K., Kurt-Jones E.A., Stevenson M.A., Chen L.B., Finberg R.W., et al. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 2000, 6(4):435-442.
28. Wang Y., Kelly C.G., Singh M., McGowan E.G., Carrara A.S., Bergmeier L.A., et al. Stimulation of Th1-polarizing cytokines, C-C chemokines, maturation of dendritic cells, and adjuvant function by the peptide binding fragment of heat shock protein 70. J Immunol 2002, 169(5):2422-2429.
29. Shi Y., Evans J.E., Rock K.L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 2003, 425(6957):516-521.
30. Théry C., Boussac M., Véron P., Ricciardi-Castagnoli P., Raposo G., Garin J., et al. Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J Immunol 2001, 166(12):7309-7318.
31. Hanayama R., Tanaka M., Miwa K., Shinohara A., Iwamatsu A., Nagata S. Identification of a factor that links apoptotic cells to phagocytes. Nature 2002, 417(6885):182-187.
32. Véron P., Segura E., Sugano G., Amigorena S., Théry C. Accumulation of MFG-E8/lactadherin on exosomes from immature dendritic cells. Blood Cells Mol Dis 2005, 35(2):81-88.
33. Diamond M.S., Staunton D.E., de Fougerolles A.R., Stacker S.A., Garcia-Aguilar J., Hibbs M.L., et al. ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18). J Cell Biol 1990, 111(6 Pt 2):3129-3139.
34. Kaji K., Oda S., Shikano T., Ohnuki T., Uematsu Y., Sakagami J., et al. The gamete fusion process is defective in eggs of Cd9-deficient mice. Nat Genet 2000, 24(3):279-282.
35. Tachibana I., Hemler M.E. Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance. J Cell Biol 1999, 146(4):893-904.
36. Shortman K., Lahoud M.H., Caminschi I. Improving vaccines by targeting antigens to dendritic cells. Exp Mol Med 2009, 41(2):61-66.