메뉴 건너뛰기




Volumn 1, Issue 3, 2010, Pages 117-126

2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells

Author keywords

2 Methoxyestradiol; Breast cancer; Progesterone receptor; STAT5; Tissue factor

Indexed keywords

2 METHOXYESTRADIOL; BETA ACTIN; ESTRADIOL; ESTROGEN RECEPTOR; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROGESTERONE; PROGESTERONE RECEPTOR; STAT5 PROTEIN; THROMBOPLASTIN;

EID: 77955550727     PISSN: 18688497     EISSN: 18688500     Source Type: Journal    
DOI: 10.1007/s12672-010-0019-5     Document Type: Article
Times cited : (10)

References (51)
  • 1
    • 0031848636 scopus 로고    scopus 로고
    • Functional role of estrogen metabolism in target cells: Review and perspectives
    • Zhu B, Conney AH (1998) Functional role of estrogen metabolism in target cells: review and perspectives. Carcinogenesis 19(1): 1-27.
    • (1998) Carcinogenesis , vol.19 , Issue.1 , pp. 1-27
    • Zhu, B.1    Conney, A.H.2
  • 3
    • 48249145841 scopus 로고    scopus 로고
    • In vitro effects of 2-methoxyestradiol on MCF-12A and MCF-7 cell growth, morphology and mitotic spindle formation
    • van Zijl C, Lottering ML, Steffens F, Joubert A (2008) In vitro effects of 2-methoxyestradiol on MCF-12A and MCF-7 cell growth, morphology and mitotic spindle formation. Cell Biochem Funct 26(5): 632-642.
    • (2008) Cell Biochem Funct , vol.26 , Issue.5 , pp. 632-642
    • van Zijl, C.1    Lottering, M.L.2    Steffens, F.3    Joubert, A.4
  • 4
    • 0742269867 scopus 로고    scopus 로고
    • New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent
    • Mooberry SL (2003) New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent. Curr Opin Oncol 15(6): 425-430.
    • (2003) Curr Opin Oncol , vol.15 , Issue.6 , pp. 425-430
    • Mooberry, S.L.1
  • 6
    • 69249212263 scopus 로고    scopus 로고
    • Activity of 2 methoxyestradiol (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: A Hoosier Oncology Group trial
    • Matei D, Schilder J, Sutton G, Perkins S, Breen T, Quon C, Sidor C (2009) Activity of 2 methoxyestradiol (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: a Hoosier Oncology Group trial. Gynecol Oncol 115(1): 90-96.
    • (2009) Gynecol Oncol , vol.115 , Issue.1 , pp. 90-96
    • Matei, D.1    Schilder, J.2    Sutton, G.3    Perkins, S.4    Breen, T.5    Quon, C.6    Sidor, C.7
  • 7
    • 77955552654 scopus 로고    scopus 로고
    • Zhou Q, Gustafson D, Nallapareddy S, Diab S, Leong S, Lewis K, Gore L, Messersmith WA, Treston AM, Eckhardt SG, Sidor C, Camidge DR (2010) "A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer". Invest New Drugs.
  • 11
    • 57649097524 scopus 로고    scopus 로고
    • Kato S, Sadarangani A, Lange S, Delpiano AM, Vargas M, Brañes J, Carvajal J, Lipkowitz S, Owen GI y Cuello MA (2008) "2-methoxyestradiol mediates apoptosis through caspase-dependent and independent mechanisms in ovarian cancer cells but not in normal counterparts". Reprod Sci (9): 878-894.
  • 12
    • 13944271914 scopus 로고    scopus 로고
    • Mulac-Jericevic B, Conneely OM (2005) "Reproductive tissue-selective actions of progesterone receptors". Ernst Schering Res Found Workshop (52): 19-37.
  • 13
    • 0034086140 scopus 로고    scopus 로고
    • Origins and evolutionary diversification of the nuclear receptor superfamily
    • Owen GI, Zelent A (2000) Origins and evolutionary diversification of the nuclear receptor superfamily. Cell Mol Life Sci 57(5): 809-827.
    • (2000) Cell Mol Life Sci , vol.57 , Issue.5 , pp. 809-827
    • Owen, G.I.1    Zelent, A.2
  • 14
    • 44549083120 scopus 로고    scopus 로고
    • The role and mechanism of progesterone receptor activation of extra-nuclear signaling pathways in regulating gene transcription and cell cycle progression
    • Boonyaratanakornkit V, Bi Y, Rudd M, Edwards DP (2008) The role and mechanism of progesterone receptor activation of extra-nuclear signaling pathways in regulating gene transcription and cell cycle progression. Steroids 73(9-10): 922-928.
    • (2008) Steroids , vol.73 , Issue.9-10 , pp. 922-928
    • Boonyaratanakornkit, V.1    Bi, Y.2    Rudd, M.3    Edwards, D.P.4
  • 15
    • 0032562712 scopus 로고    scopus 로고
    • Progesterone regulates transcription of the p21(WAF1) cyclin-dependent kinase inhibitor gene through Sp1 and CBP/p300
    • Owen GI, Richer JK, Tung L, Takimoto G, Horwitz KB (1998) Progesterone regulates transcription of the p21(WAF1) cyclin-dependent kinase inhibitor gene through Sp1 and CBP/p300. J Biol Chem 273(17): 10696-10701.
    • (1998) J Biol Chem , vol.273 , Issue.17 , pp. 10696-10701
    • Owen, G.I.1    Richer, J.K.2    Tung, L.3    Takimoto, G.4    Horwitz, K.B.5
  • 16
    • 0032553553 scopus 로고    scopus 로고
    • Convergence of progesterone with growth factor and cytokine signaling in breast cancer. Progesterone receptors regulate signal transducers and activators of transcription expression and activity
    • Richer JK, Lange CA, Manning NG, Owen G, Powell R, Horwitz KB (1998) Convergence of progesterone with growth factor and cytokine signaling in breast cancer. Progesterone receptors regulate signal transducers and activators of transcription expression and activity. J Biol Chem 273(47): 31317-31326.
    • (1998) J Biol Chem , vol.273 , Issue.47 , pp. 31317-31326
    • Richer, J.K.1    Lange, C.A.2    Manning, N.G.3    Owen, G.4    Powell, R.5    Horwitz, K.B.6
  • 17
    • 38749140218 scopus 로고    scopus 로고
    • Integration of progesterone receptor action with rapid signaling events in breast cancer models
    • Lange CA (2008) Integration of progesterone receptor action with rapid signaling events in breast cancer models. J Steroid Biochem Mol Biol 108: 203-212.
    • (2008) J Steroid Biochem Mol Biol , vol.108 , pp. 203-212
    • Lange, C.A.1
  • 18
    • 58049218988 scopus 로고    scopus 로고
    • Non-genomic progesterone actions in female reproduction
    • Epub 2008 Oct 19
    • Gellersen B, Fernandes MS, Brosens JJ (2009) Non-genomic progesterone actions in female reproduction. Hum Reprod Updat 15(1): 119-138, Epub 2008 Oct 19.
    • (2009) Hum Reprod Updat , vol.15 , Issue.1 , pp. 119-138
    • Gellersen, B.1    Fernandes, M.S.2    Brosens, J.J.3
  • 19
    • 0042978662 scopus 로고    scopus 로고
    • MAP kinases couple multiple functions of human progesterone receptors: Degradation, transcriptional synergy, and nuclear association
    • Qiu M, Lange CA (2003) MAP kinases couple multiple functions of human progesterone receptors: degradation, transcriptional synergy, and nuclear association. J Steroid Biochem Mol Biol 85(2-5): 147-157.
    • (2003) J Steroid Biochem Mol Biol , vol.85 , Issue.2-5 , pp. 147-157
    • Qiu, M.1    Lange, C.A.2
  • 20
    • 0042018741 scopus 로고    scopus 로고
    • Breast cancer and hormone-replacement therapy in the Million Women Study
    • Million Women Study Collaborators
    • Beral V, Million Women Study Collaborators (2003) Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 362(9382): 419-27.
    • (2003) Lancet , vol.362 , Issue.9382 , pp. 419-427
    • Beral, V.1
  • 26
    • 0037085303 scopus 로고    scopus 로고
    • Richer JK, Jacobsen BM, Manning NG, Abel MG, Wolf DM, Horwitz KB (2002) "Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells". J Biol Chem 15; 277(7): 5209-18.
  • 28
    • 33746092472 scopus 로고    scopus 로고
    • Ex vivo and in vivo delivery of anti-tissue factor short interfering RNA inhibits mouse pulmonary metastasis of B16 melanoma cells
    • Amarzguioui M, Peng Q, Wiiger MT, Vasovic V, Babaie E, Holen T, Nesland JM, Prydz H (2006) Ex vivo and in vivo delivery of anti-tissue factor short interfering RNA inhibits mouse pulmonary metastasis of B16 melanoma cells. Clin Cancer Res 12(13): 4055-4061.
    • (2006) Clin Cancer Res , vol.12 , Issue.13 , pp. 4055-4061
    • Amarzguioui, M.1    Peng, Q.2    Wiiger, M.T.3    Vasovic, V.4    Babaie, E.5    Holen, T.6    Nesland, J.M.7    Prydz, H.8
  • 30
    • 0028007430 scopus 로고
    • Procoagulant activity in cancer cells is dependent on tissue factor expression
    • Hu T, Bach RR, Horton R, Konigsberg WH, Todd MB (1994) Procoagulant activity in cancer cells is dependent on tissue factor expression. Oncol Res 6(7): 321-327.
    • (1994) Oncol Res , vol.6 , Issue.7 , pp. 321-327
    • Hu, T.1    Bach, R.R.2    Horton, R.3    Konigsberg, W.H.4    Todd, M.B.5
  • 33
    • 16344381892 scopus 로고    scopus 로고
    • 2-methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer
    • Sutherland TE, Schuliga M, Harris T, Eckhardt BL, Anderson RL, Quan L, Stewart AG (2005) 2-methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer. Clin Cancer Res 11(5): 1722-1732.
    • (2005) Clin Cancer Res , vol.11 , Issue.5 , pp. 1722-1732
    • Sutherland, T.E.1    Schuliga, M.2    Harris, T.3    Eckhardt, B.L.4    Anderson, R.L.5    Quan, L.6    Stewart, A.G.7
  • 34
    • 0034638620 scopus 로고    scopus 로고
    • Methoxyestradiols mediate the antimitogenic effects of estradiol on vascular smooth muscle cells via estrogen receptor-independent mechanisms
    • Dubey RK, Gillespie DG, Zacharia LC, Rosselli M, Korzekwa KR, Fingerle J, Jackson EK (2000) Methoxyestradiols mediate the antimitogenic effects of estradiol on vascular smooth muscle cells via estrogen receptor-independent mechanisms. Biochem Biophys Res Commun 278(1): 27-33.
    • (2000) Biochem Biophys Res Commun , vol.278 , Issue.1 , pp. 27-33
    • Dubey, R.K.1    Gillespie, D.G.2    Zacharia, L.C.3    Rosselli, M.4    Korzekwa, K.R.5    Fingerle, J.6    Jackson, E.K.7
  • 35
    • 0028026693 scopus 로고    scopus 로고
    • Sartorius CA, Groshong SD, Miller LA, Powell RL, Tung L, Takimoto GS, Horwitz KB (1994) "New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP". Cancer Res, 15; 54(14): 3868-77.
  • 37
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger R, Krebs EG (1995) The MAPK signaling cascade. FASEB J 9(9): 726-735.
    • (1995) FASEB J , vol.9 , Issue.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 38
    • 0033305372 scopus 로고    scopus 로고
    • Hypothesis: Progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals
    • Lange CA, Richer JK, Horwitz KB (1999) Hypothesis: Progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals. Mol Endocrinol 13(6): 829-836.
    • (1999) Mol Endocrinol , vol.13 , Issue.6 , pp. 829-836
    • Lange, C.A.1    Richer, J.K.2    Horwitz, K.B.3
  • 39
    • 10044257416 scopus 로고    scopus 로고
    • Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2
    • Pierson-Mullany LK, Lange CA (2004) Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2. Mol Cell Biol 24(24): 10542-10557.
    • (2004) Mol Cell Biol , vol.24 , Issue.24 , pp. 10542-10557
    • Pierson-Mullany, L.K.1    Lange, C.A.2
  • 40
    • 73349137944 scopus 로고    scopus 로고
    • A semi-quantitative assay to screen for angiogenic compounds and compounds with angiogenic potential using the EA.hy926 endothelial cell line
    • Aranda E, Owen GI (2009) A semi-quantitative assay to screen for angiogenic compounds and compounds with angiogenic potential using the EA. hy926 endothelial cell line. Biol Res 42: 377-389.
    • (2009) Biol Res , vol.42 , pp. 377-389
    • Aranda, E.1    Owen, G.I.2
  • 41
    • 77950224904 scopus 로고    scopus 로고
    • In vitro effects of 2-methoxyestradiol on morphology, cell cycle progression, cell death and gene expression changes in the tumorigenic MCF-7 breast epithelial cell line
    • Stander BA, Marais S, Vorster CJ, Joubert AM (2010) In vitro effects of 2-methoxyestradiol on morphology, cell cycle progression, cell death and gene expression changes in the tumorigenic MCF-7 breast epithelial cell line. J Steroid Biochem Mol Biol 119(3-5): 149-160.
    • (2010) J Steroid Biochem Mol Biol , vol.119 , Issue.3-5 , pp. 149-160
    • Stander, B.A.1    Marais, S.2    Vorster, C.J.3    Joubert, A.M.4
  • 42
    • 58849135484 scopus 로고    scopus 로고
    • Mechanism of 2-methoxyestradiol-induced apoptosis and growth arrest in human breast cancer cells
    • Fukui M, Zhu B-T (2009) Mechanism of 2-methoxyestradiol-induced apoptosis and growth arrest in human breast cancer cells. Mol Carcinog 48: 66-78.
    • (2009) Mol Carcinog , vol.48 , pp. 66-78
    • Fukui, M.1    Zhu, B.-T.2
  • 44
    • 77955555066 scopus 로고    scopus 로고
    • Ting CM, Lee YM, Wong CK, Wong AS, Lung HL, Lung ML, Lo KW, Wong RN, Mak NK. "2-Methoxyestradiol induces endoreduplication through the induction of mitochondrial oxidative stress and the activation of MAPK signaling pathways". Biochem Pharmacol. 2009 Oct 31.
  • 45
    • 33645462175 scopus 로고    scopus 로고
    • 2-methoxyestradiol induces apoptosis in cultured human anaplastic thyroid carcinoma cells
    • Roswall P, Bu S, Rubin K, Landström M, Heldin NE (2006) 2-methoxyestradiol induces apoptosis in cultured human anaplastic thyroid carcinoma cells. Thyroid 16(2): 143-150.
    • (2006) Thyroid , vol.16 , Issue.2 , pp. 143-150
    • Roswall, P.1    Bu, S.2    Rubin, K.3    Landström, M.4    Heldin, N.E.5
  • 46
    • 33645222234 scopus 로고    scopus 로고
    • Modulation of cell-cycle regulatory signaling network by 2-methoxyestradiol in prostate cancer cells is mediated through multiple signal transduction pathways
    • Ray G, Dhar G, van Veldhuizen PJ, Banerjee S, Saxena NK, Sengupta K, Banerjee SK (2006) Modulation of cell-cycle regulatory signaling network by 2-methoxyestradiol in prostate cancer cells is mediated through multiple signal transduction pathways. Biochemistry 45(11): 3703-3713.
    • (2006) Biochemistry , vol.45 , Issue.11 , pp. 3703-3713
    • Ray, G.1    Dhar, G.2    van Veldhuizen, P.J.3    Banerjee, S.4    Saxena, N.K.5    Sengupta, K.6    Banerjee, S.K.7
  • 47
    • 48949087080 scopus 로고    scopus 로고
    • ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma (HCC) cells, and inhibits growth and vascularization in vivo
    • Moser C, Lang SA, Mori A, Hellerbrand C, Schlitt HJ, Geissler EK, Fogler WE, Stoeltzing O (2008) ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma (HCC) cells, and inhibits growth and vascularization in vivo. BMC Cancer 8: 206.
    • (2008) BMC Cancer , vol.8 , pp. 206
    • Moser, C.1    Lang, S.A.2    Mori, A.3    Hellerbrand, C.4    Schlitt, H.J.5    Geissler, E.K.6    Fogler, W.E.7    Stoeltzing, O.8
  • 48
    • 49749142056 scopus 로고    scopus 로고
    • 2-Methoxyestradiol inhibits hepatocellular carcinoma cell growth by inhibiting Cdc25 and inducing cell cycle arrest and apoptosis
    • Kar S, Wang M, Carr BI (2008) 2-Methoxyestradiol inhibits hepatocellular carcinoma cell growth by inhibiting Cdc25 and inducing cell cycle arrest and apoptosis. Cancer Chemother Pharmacol 62(5): 831-840.
    • (2008) Cancer Chemother Pharmacol , vol.62 , Issue.5 , pp. 831-840
    • Kar, S.1    Wang, M.2    Carr, B.I.3
  • 50
    • 41649119043 scopus 로고    scopus 로고
    • Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors
    • Faivre EJ, Daniel AR, Hillard CJ, Lange CA (2008) Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors. Mol Endocrinol 22(4): 823-837.
    • (2008) Mol Endocrinol , vol.22 , Issue.4 , pp. 823-837
    • Faivre, E.J.1    Daniel, A.R.2    Hillard, C.J.3    Lange, C.A.4
  • 51
    • 0020626267 scopus 로고
    • Concentrations of 2-methoxyoestrogens in human serum measured by a heterologous immunoassay with an 125I-labelled ligand
    • Berg D, Sonsalla R, Kuss E (1983) Concentrations of 2-methoxyoestrogens in human serum measured by a heterologous immunoassay with an 125I-labelled ligand. Acta Endocrinol (Copenh) 103(2): 282-288.
    • (1983) Acta Endocrinol (Copenh) , vol.103 , Issue.2 , pp. 282-288
    • Berg, D.1    Sonsalla, R.2    Kuss, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.