Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-κB activation in vascular smooth muscle cells

Atherosclerosis

Volumn 201, Issue 2, 2008, Pages 248-257

  Cifarelli, Vincenza ^a   Luppi, Patrizia ^a   Tse, Hubert M ^a   He, Jing ^a   Piganelli, Jon ^a   Trucco, Massimo ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

C Peptide; Diabetes; NF B; Proliferation; Smooth muscle cells

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; BETA ACTIN; C PEPTIDE; GLUCOSE; I KAPPA B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR FACTOR KAPPA B P50; PYRROLIDINE DITHIOCARBAMATE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ARTICLE; ATHEROSCLEROSIS; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

AORTA; C-PEPTIDE; CELL PROLIFERATION; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; ENDOTHELIUM, VASCULAR; GLUCOSE; HUMANS; KI-67 ANTIGEN; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTOR RELA;

EID: 48149106096     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2007.12.060     Document Type: Article

References (31)

1. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352 (1998) 837-853
2. Diabetes Control, Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329 (1993) 977-986
3. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 340 (1999) 115-126
4. Natarajan R., Gonzales N., Xu L., and Nadler J.L. Vascular smooth muscle cells exhibit increased growth in response to elevated glucose. Biochem Biophys Res Commun 187 (1992) 552-560
5. Nakamura J., Kasuya Y., Hamada Y., et al. Glucose-induced hyperproliferation of cultured rat aortic smooth muscle cells through polyol pathway hyperactivity. Diabetologia 44 (2001) 480-487
6. Yamamoto M., Acevedo-Duncan M., Chalfant C.E., et al. Acute glucose-induced downregulation of PKC-beta II accelerates cultured VSMC proliferation. Am J Physiol Cell Physiol 279 (2000) C587-C595
7. Kumar K., Yerneni V., Bai W., et al. Hyperglycemia-induced activation of nuclear transcription factor κB in vascular smooth muscle cells. Diabetes 48 (1999) 855-864
8. Bellas R.E., Lee J.S., and Sonenshein G. Expression of a constitutive NF-κB like activity is essential for proliferation of cultured bovine vascular smooth muscle cells. J Clin Invest 96 (1995) 2521-2527
9. Brand K., Page S., Walli A.K., Neumeier D., and Baeuerle P.A. Role of nuclear factor-kappa B in atherogenesis. Exp Physiol 82 (1997) 297-303
10. Autieri M.V., Yue T.L., Ferstein G.Z., and Ohlestein E. Antisense oligonucleotides to the p65 subunit of NF-κB inhibit human vascular smooth muscle cell adherence and proliferation and prevent neointima formation in rat carotid arteries. Biochem Biophys Res Commun 213 (1995) 827-836
11. Merhof F.B., Schmidt-Ullrich R., Dietz R., and Scheidereit C. Regulation of vascular smooth muscle cell proliferation. Role of NF-κB revisited. Circ Res 96 (2005) 958-964
12. Zuckerbraun B.S., McCloskey C.A., Mahidhara R.S., et al. Overexpression of mutated IκBα inhibits vascular smooth muscle cell proliferation and intimal hyperplasia formation. J Vasc Surg 38 (2003) 812-819
13. Morishita R., Sugimoto T., Aoki M., et al. In vivo transfection of cis element "decoy" against nuclear factor-κB binding site prevents myocardial infarction. Nat Med 8 (1997) 894-899
14. Marques R.G., Fontaine M.J., and Rogers J. C-peptide much more than a byproduct of insulin biosynthesis. Pancreas 29 (2004) 231-238
15. Johansson B.L., Borg K., Fernqvist-Forbes E., et al. Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with type 1 diabetes: a three-month study. Diabet Med 17 (2000) 181-189
16. Johansson B.L., Wahren J., and Pernow J. C-peptide increases forearm blood flow in patients with type 1 diabetes via a nitric oxide-dependent mechanism. Am J Physiol Endocrinol Metab 285 (2003) E864-E870
17. Ekberg K., Brismar T., Johansson B.L., et al. C-peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy. Diabetes Care 30 (2007) 71-76
18. Lee T.C., Barshes N.R., Agee E.E., et al. The effect of whole organ pancreas transplantation and PIT on diabetic complications. Curr Diab Rep 6 (2006) 323-327
19. Shapiro A.M., Ricordi C., Hering B.J., et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med 355 (2006) 1318-1330
20. Lindstrom K., Johansson C., Johansson E., and Haraldsson B. Acute effects of C-peptide on the microvasculature of isolated perfused skeletal muscle and kidneys in rat. Acta Physiol Scand 156 (1996) 19-25
21. Walcher D., Aleksie M., Jerg V., et al. C-peptide induces chemotaxis of human CD4-positive cells: involvement of pertussis toxin-sensitive G-proteins and phosphoinositide 3-kinase. Diabetes 53 7 (2004) 1664-1670
22. Kobayashi Y., Naruse K., Hamada Y., et al. Human proinsulin C-pepide prevents proliferation of rat aortic smooth muscle cells cultured in high-glucose conditions. Diabetologia 48 (2005) 2396-2401
23. Scalia R., Coyle K.M., Levin B.L., Booth G., and Lefer A.M. C-peptide inhibits leukocyte endothelium interaction in the microcirculation during acute endothelial dysfunction. FASEB J 14 (2000) 2357-2364
24. Rigler R., Pramanik A., Jonasson P., et al. Specific binding of proinsulin C-peptide to human cell membranes. Proc Natl Acad Sci 96 (1999) 13318-13323
25. Graier W.F., Grubenthal I., Dittrich P., Wascher T.C., and Kostner G.M. Intracellular mechanism of high d-glucose-induced modulation of vascular cell proliferation. Eur J Pharm 294 (1995) 221-229
26. Tse H.M., Milton M.J., and Piganelli J.D. Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: implication for their use in targeting oxidation-reduction reactions in innate immunity. Free Radic Biol Med 36 (2004) 233-247
27. Clarke M.C., Figg N., Maguire J.J., et al. Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis. Nat Med 12 (2006) 1075-1080
28. Walcher D., Babiak C., Poletek P., et al. C-peptide induces vascular smooth muscle cell proliferation. Circ Res 99 (2006) 1181-1187
29. Steffes M.W., Sibley S., Jackson M., and Thomas W. Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial. Diabetes Care 26 3 (2003) 832-836
30. Kitazawa M., Shibata Y., Hashimoto S., Ohizumi Y., and Yamakuni T. Proinsulin C-peptide stimulates a PKC/IκB/NF-κB signaling pathway to activate COX-2 gene transcription in swiss 3T3 fibroblasts. J Biochem 139 (2006) 1083-1086
31. Cifarelli V., Libman I.M., DeLuca A., et al. Increased expression of monocyte CD11b (Mac-1) in overweight recent-onset type 1 diabetic children. Rev Diabet Stud 4 2 (2007) 112-117