Cytokine combination therapy with long-acting erythropoietin and granulocyte colony stimulating factor improves cardiac function but is not superior than monotherapy in a mouse model of acute myocardial infarction

Journal of Cardiac Failure

Volumn 16, Issue 8, 2010, Pages 669-678

  Yeghiazarians, Yerem ^a   Khan, Muhammad ^a   Angeli, Franca S ^a   Zhang, Yan ^a   Jahn, Sarah ^a   Prasad, Megha ^a   Mirsky, Rachel ^a   Shih, Henry ^a   Minasi, Petros ^a   Boyle, Andrew ^a   Grossman, William ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

acute myocardial infarction; Cytokine; erythropoietin; granulocyte colony stimulating factor

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; ERYTHROPOIETIN; GRANULOCYTE COLONY STIMULATING FACTOR; LONG ACTING DRUG; LONG ACTING ERYTHROPOIETIN; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTERIOLE; ARTICLE; CAPILLARY; CELL MOTILITY; CHIMERA; CONTROLLED STUDY; DRUG EFFICACY; ENGRAFTMENT; HEART FUNCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HISTOLOGY; MALE; MONOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ANIMALS; CYTOKINES; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; ERYTHROPOIETIN; GRANULOCYTE COLONY-STIMULATING FACTOR; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; RADIATION CHIMERA; RANDOM ALLOCATION; VENTRICULAR FUNCTION, LEFT;

EID: 77955510715     PISSN: 10719164     EISSN: 15328414     Source Type: Journal    
DOI: 10.1016/j.cardfail.2010.03.008     Document Type: Article

References (37)

1. P. Anderlini, M. Donato, K.W. Chan, Y.O. Huh, A.P. Gee, and M.J. Lauppe Allogeneic blood progenitor cell collection in normal donors after mobilization with filgrastim: the M.D. Anderson Cancer Center experience Transfusion 39 1999 555 560
2. L. Sterin-Borda, A.C. Barcelo, and C.E. Bozzini Erythropoietin improves cardiac contractility in post-hypoxic mice Br J Haematol 121 2003 180 186
3. M. Harada, Y. Qin, H. Takano, T. Minamino, Y. Zou, and H. Toko G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes Nat Med 11 2005 305 311
4. H. Hasegawa, H. Takano, K. Iwanaga, M. Ohtsuka, Y. Qin, and Y. Niitsuma Cardioprotective effects of granulocyte colony-stimulating factor in swine with chronic myocardial ischemia J Am Coll Cardiol 47 2006 842 849
5. D. Orlic, J. Kajstura, S. Chimenti, F. Limana, I. Jakoniuk, and F. Quaini Mobilized bone marrow cells repair the infarcted heart, improving function and survival Proc Natl Acad Sci U S A 98 2001 10344 10349
6. S. Minatoguchi, G. Takemura, X.H. Chen, N. Wang, Y. Uno, and M. Koda Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment Circulation 109 2004 2572 2580
7. Y. Sugano, T. Anzai, T. Yoshikawa, Y. Maekawa, T. Kohno, and K. Mahara Granulocyte colony-stimulating factor attenuates early ventricular expansion after experimental myocardial infarction Cardiovasc Res 65 2005 446 456
8. K. Iwanaga, H. Takano, M. Ohtsuka, H. Hasegawa, Y. Zou, and Y. Qin Effects of G-CSF on cardiac remodeling after acute myocardial infarction in swine Biochem Biophys Res Commun 325 2004 1353 1359
9. H. Okada, G. Takemura, Y. Li, T. Ohno, L. Li, and R. Maruyama Effect of a long-term treatment with a low-dose granulocyte colony-stimulating factor on post-infarction process in the heart J Cell Mol Med 12 2008 1272 1283
10. P. van der Meer, E. Lipsic, R.H. Henning, R.A. de Boer, A.J. Suurmeijer, and D.J. van Veldhuisen Erythropoietin improves left ventricular function and coronary flow in an experimental model of ischemia-reperfusion injury Eur J Heart Fail 6 2004 853 859
11. L. Calvillo, R. Latini, J. Kajstura, A. Leri, P. Anversa, and P. Ghezzi Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling Proc Natl Acad Sci U S A 100 2003 4802 4806
12. P. van der Meer, E. Lipsic, R.H. Henning, K. Boddeus, J. van der Velden, and A.A. Voors Erythropoietin induces neovascularization and improves cardiac function in rats with heart failure after myocardial infarction J Am Coll Cardiol 46 2005 125 133
13. F. Prunier, O. Pfister, L. Hadri, L. Liang, F. Del Monte, and R. Liao Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cells Am J Physiol Heart Circ Physiol 292 2007 H522 H529
14. H.J. Kang, H.S. Kim, S.Y. Zhang, K.W. Park, H.J. Cho, and B.K. Koo Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial Lancet 363 2004 751 756
15. H. Ince, M. Petzsch, H.D. Kleine, H. Eckard, T. Rehders, and D. Burska Prevention of left ventricular remodeling with granulocyte colony-stimulating factor after acute myocardial infarction: final 1-year results of the Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Granulocyte Colony-Stimulating Factor (FIRSTLINE-AMI) Trial Circulation 112 9 Suppl 2005 I73 I80
16. R.S. Ripa, E. Jorgensen, Y. Wang, J.J. Thune, J.C. Nilsson, and L. Sondergaard Stem cell mobilization induced by subcutaneous granulocyte-colony stimulating factor to improve cardiac regeneration after acute ST-elevation myocardial infarction: result of the double-blind, randomized, placebo-controlled stem cells in myocardial infarction (STEMMI) trial Circulation 113 2006 1983 1992
17. D. Zohlnhofer, I. Ott, J. Mehilli, K. Schomig, F. Michalk, and T. Ibrahim Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial JAMA 295 2006 1003 1010
18. B.D. Westenbrink, E. Lipsic, P. van der Meer, P. van der Harst, H. Oeseburg, and G.J. Du Marchie Sarvaas Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization Eur Heart J 28 2007 2018 2027
19. Y.L. Colson, S.M. Wren, M.J. Schuchert, K.D. Patrene, P.C. Johnson, and S.S. Boggs A nonlethal conditioning approach to achieve durable multilineage mixed chimerism and tolerance across major, minor, and hematopoietic histocompatibility barriers J Immunol 155 1995 4179 4188
20. M. Neipp, T. Zorina, M.A. Domenick, B.G. Exner, and S.T. Ildstad Effect of FLT3 ligand and granulocyte colony-stimulating factor on expansion and mobilization of facilitating cells and hematopoietic stem cells in mice: kinetics and repopulating potential Blood 92 1998 3177 3188
21. M.L. Springer, R.E. Sievers, M.N. Viswanathan, M.S. Yee, E. Foster, and W. Grossman Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography Am J Physiol Heart Circ Physiol 289 2005 H1307 H1314
22. Y. Zhang, J. Takagawa, R.E. Sievers, M.F. Khan, M.N. Viswanathan, and M.L. Springer Validation of the wall motion score and myocardial performance indexes as novel techniques to assess cardiac function in mice after myocardial infarction Am J Physiol Heart Circ Physiol 292 2007 H1187 H1192
23. E. Lipsic, B.D. Westenbrink, P. van der Meer, P. van der Harst, A.A. Voors, and D.J. van Veldhuisen Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit Eur J Heart Fail 10 2008 22 29
24. F.H. Bahlmann, R. Song, S.M. Boehm, M. Mengel, R. von Wasielewski, and C. Lindschau Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial Akt and attenuates progressive organ failure Circulation 110 2004 1006 1012
25. E. Gao, M. Boucher, J.K. Chuprun, R.H. Zhou, A.D. Eckhart, and W.J. Koch Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart Am J Physiol Heart Circ Physiol 293 2007 H60 H68
26. D. Nishiya, T. Omura, K. Shimada, R. Matsumoto, T. Kusuyama, and S. Enomoto Effects of erythropoietin on cardiac remodeling after myocardial infarction J Pharmacol Sci 101 2006 31 39
27. C.J. Parsa, A. Matsumoto, J. Kim, R.U. Riel, L.S. Pascal, and G.B. Walton A novel protective effect of erythropoietin in the infarcted heart J Clin Invest 112 2003 999 1007
28. K.T. Krause, K. Jaquet, S. Geidel, C. Schneider, C. Mandel, and H.P. Stoll Percutaneous endocardial injection of erythropoietin: assessment of cardioprotection by electromechanical mapping Eur J Heart Fail 8 2006 443 450
29. C. James, V. Ugo, J.P. Le Couedic, J. Staerk, F. Delhommeau, and C. Lacout A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera Nature 434 2005 1144 1148 (Pubitemid 40663494)
30. C. Lacombe, and P. Mayeux Biology of erythropoietin Haematologica 83 1998 724 732
31. S. Brunner, J. Winogradow, B.C. Huber, M.M. Zaruba, R. Fischer, and R. David Erythropoietin administration after myocardial infarction in mice attenuates ischemic cardiomyopathy associated with enhanced homing of bone marrow-derived progenitor cells via the CXCR-4/SDF-1 axis FASEB J 23 2009 351 361
32. E. Lipsic, P. van der Meer, A.A. Voors, B.D. Westenbrink, A.F. van den Heuvel, and H.C. de Boer A single bolus of a long-acting erythropoietin analogue darbepoetin alfa in patients with acute myocardial infarction: a randomized feasibility and safety study Cardiovasc Drugs Ther 20 2006 135 141
33. K. Jaquet, K. Krause, M. Tawakol-Khodai, S. Geidel, and K.H. Kuck Erythropoietin and VEGF exhibit equal angiogenic potential Microvasc Res 64 2002 326 333
34. C. Toma, D.P. Letts, M. Tanabe, J. Gorcsan 3rd, and P.J. Counihan Positive effect of darbepoetin on peri-infarction remodeling in a porcine model of myocardial ischemia-reperfusion J Mol Cell Cardiol 43 2007 130 136
35. D. Ribatti, M. Presta, A. Vacca, R. Ria, R. Giuliani, and P. Dell'Era Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo Blood 93 1999 2627 2636
36. K.H. Schuleri, L.C. Amado, A.J. Boyle, M. Centola, A.P. Saliaris, and M.R. Gutman Early improvement in cardiac tissue perfusion due to mesenchymal stem cells Am J Physiol Heart Circ Physiol 294 2008 H2002 H2011
37. Y. Yeghiazarians, Y. Zhang, M. Prasad, H. Shih, S.A. Saini, and J. Takagawa Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy Mol Ther 17 2009 1250 1256