Mitofusin-2 protects against cold stress-induced cell injury in HEK293 cells

Biochemical and Biophysical Research Communications

Volumn 397, Issue 2, 2010, Pages 270-276

  Zhang, Wenbin ^a   Chen, Yaomin ^a   Yang, Qun ^a   Che, Honglei ^a   Chen, Xiangjun ^a   Yao, Ting ^a   Zhao, Fang ^a   Liu, Mingchao ^a   Ke, Tao ^a   Chen, Jingyuan ^a   Luo, Wenjing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

ATP; Cold stress; Drp1; Mfn2; Mitochondria

Indexed keywords

ADENOSINE TRIPHOSPHATE; DYNAMIN I; MITOFUSIN 1; MITOFUSIN 2; SMALL INTERFERING RNA; CARRIER PROTEIN; GUANOSINE TRIPHOSPHATASE; MEMBRANE PROTEIN; MFN1 PROTEIN, HUMAN; MFN2 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN;

ARTICLE; CELL CULTURE; CELL DAMAGE; CELL DEATH; CELL FUSION; CELL PROTECTION; CELL STRAIN HEK293; CELL SURVIVAL; COLD STRESS; ELECTRON MICROSCOPY; ENVIRONMENT; MITOCHONDRION; MORPHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TEMPERATURE; WESTERN BLOTTING; APOPTOSIS; CELL LINE; COLD; GENETICS; HUMAN; MEMBRANE FUSION; MITOCHONDRIAL MEMBRANE; PHYSIOLOGICAL STRESS; PHYSIOLOGY; ULTRASTRUCTURE;

APOPTOSIS; CELL LINE; CELL SURVIVAL; COLD TEMPERATURE; GTP PHOSPHOHYDROLASES; HUMANS; MEMBRANE FUSION; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL PROTEINS; RNA, SMALL INTERFERING; STRESS, PHYSIOLOGICAL;

EID: 77955493825     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.05.099     Document Type: Article

References (32)

1. T.R. Doeppner, T. Grune, H. de Groot, U. Rauen, Cold-induced apoptosis of rat liver endothelial cells: involvement of the proteasome, Transplantation 75 (2003) 1946-1953.
2. U. Rauen, B. Polzar, H. Stephan, H.G. Mannherz, H. De Groot, Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species, FASEB J. 13 (1999) 155-168.
3. U. Kerkweg, M. Jacob, H. De Groot, H.G. Mannherz, U. Rauen, Cold-induced apoptosis of rat liver endothelial cells: contribution of mitochondrial alterations, Transplantation 76 (2003) 501-508.
4. H. Yuan, A.A. Gerencser, G. Liot, S.A. Lipton, M. Ellisman, G.A. Perkins, E. Bossy-Wetzel, Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons, Cell Death Differ. 14 (2007) 462-471.
5. A. Nechushtan, C.L. Smith, Y.T. Hsu, R.J. Youle, Conformation of the Bax C-terminus regulates subcellular location and cell death, EMBO J. 18 (1999) 2330-2341.
6. S.Y. Choi, P. Huang, G.M. Jenkins, D.C. Chan, J. Schiller, M.A. Frohman, A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis, Nat. Cell Biol. 8 (2006) 1255-1262.
7. H. Chen, S.A. Detmer, A.J. Ewald, E.E. Griffin, S.E. Fraser, D.C. Chan, Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development, J. Cell Biol. 160 (2003) 189-200.
8. P. Pawlikowska, A. Orzechowski, Role of transmembrane GTPases in mitochondrial morphology and activity, Postepy Biochem. 53 (2007) 53-59.
9. V. Parra, V. Eisner, M. Chiong, A. Criollo, F. Moraga, A. Garcia, S. Hartel, E. Jaimovich, A. Zorzano, C. Hidalgo, S. Lavandero, Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis, Cardiovasc. Res. 77 (2008) 387-397.
10. R. Sugioka, S. Shimizu, Y. Tsujimoto, Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis, J. Biol. Chem. 279 (2004) 52726-52734.
11. R. Cartoni, B. Leger, M.B. Hock, M. Praz, A. Crettenand, S. Pich, J.L. Ziltener, F. Luthi, O. Deriaz, A. Zorzano, C. Gobelet, A. Kralli, A.P. Russell, Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise, J. Physiol. 567 (2005) 349-358.
12. R.H. Baloh, R.E. Schmidt, A. Pestronk, J. Milbrandt, Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations, J. Neurosci. 27 (2007) 422-430.
13. T. Tatsuta, T. Langer, Quality control of mitochondria: protection against neurodegeneration and ageing, EMBO J. 27 (2008) 306-314.
14. D. Bach, D. Naon, S. Pich, F.X. Soriano, N. Vega, J. Rieusset, M. Laville, C. Guillet, Y. Boirie, H. Wallberg-Henriksson, M. Manco, M. Calvani, M. Castagneto, M. Palacin, G. Mingrone, J.R. Zierath, H. Vidal, A. Zorzano, Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6, Diabetes 54 (2005) 2685-2693.
15. M. Neuspiel, R. Zunino, S. Gangaraju, P. Rippstein, H. McBride, Activated mitofusin 2 signals mitochondrial fusion interferes with Bax activation, and reduces susceptibility to radical induced depolarization, J. Biol. Chem. 280 (2005) 25060-25070.
16. A. Santel, S. Frank, B. Gaume, M. Herrler, R.J. Youle, M.T. Fuller, Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells, J. Cell Sci. 116 (2003) 2763-2774.
17. K.S. Kordas, B. Sperlagh, T. Tihanyi, L. Topa, M.C. Steward, G. Varga, A. Kittel, ATP and ATPase secretion by exocrine pancreas in rat, guinea pig, and human, Pancreas 29 (2004) 53-60.
18. M. Vairetti, P. Griffini, G. Pietrocola, P. Richelmi, I. Freitas, Cold-induced apoptosis in isolated rat hepatocytes: protective role of glutathione, Free Radic. Biol. Med. 31 (2001) 954-961.
19. T. Sakurai, K. Itoh, Y. Liu, H. Higashitsuji, Y. Sumitomo, K. Sakamaki, J. Fujita, Low temperature protects mammalian cells from apoptosis initiated by various stimuli in vitro, Exp. Cell Res. 309 (2005) 264-272.
20. U. Rauen, H. De Groot, Cold-induced release of reactive oxygen species as a decisive mediator of hypothermia injury to cultured liver cells, Free Radic. Biol. Med. 24 (1998) 1316-1323.
21. M.P. Mollica, L. Lionetti, R. Crescenzo, R. Tasso, A. Barletta, G. Liverini, S. Iossa, Cold exposure differently influences mitochondrial energy efficiency in rat liver and skeletal muscle, FEBS Lett. 579 (2005) 1978-1982.
22. H. Chen, D.C. Chan, Emerging functions of mammalian mitochondrial fusion and fission, Hum. Mol. Genet. 14 (2005) R283-R289 (Spec. No. 2).
23. H. Chen, A. Chomyn, D.C. Chan, Disruption of fusion results in mitochondrial heterogeneity and dysfunction, J. Biol. Chem. 280 (2005) 26185-26192.
24. R.J. Youle, M. Karbowski, Mitochondrial fission in apoptosis, Nat. Rev. Mol. Cell Biol. 6 (2005) 657-663.
25. S. Frank, Dysregulation of mitochondrial fusion and fission: an emerging concept in neurodegeneration, Acta Neuropathol. (Berl.) 111 (2006) 93-100.
26. E.E. Griffin, S.A. Detmer, D.C. Chan, Molecular mechanism of mitochondrial membrane fusion, Biochim. Biophys. Acta 1763 (2006) 482-489.
27. L.P. Kravchenko, B.J. Fuller, Energy status of isolated hepatocytes after longterm cold storage in various types of media, Ukr. Biokhim. Zh. 73 (2001) 55- 60.
28. P. Amati-Bonneau, A. Guichet, A. Olichon, A. Chevrollier, F. Viala, S. Miot, C. Ayuso, S. Odent, C. Arrouet, C. Verny, M.N. Calmels, G. Simard, P. Belenguer, J. Wang, J.L. Puel, C. Hamel, Y. Malthiery, D. Bonneau, G. Lenaers, P. Reynier, OPA1 R445H mutation in optic atrophy associated with sensorineural deafness, Ann. Neurol. 58 (2005) 958-963.
29. S. Pich, D. Bach, P. Briones, M. Liesa, M. Camps, X. Testar, M. Palacin, A. Zorzano, The Charcot-Marie-Tooth type 2A gene product, Mfn2 up-regulates fuel oxidation through expression of OXPHOS system, Hum. Mol. Genet. 14 (2005) 1405-1415.
30. H. Chen, J.M. McCaffery, D.C. Chan, Mitochondrial fusion protects against neurodegeneration in the cerebellum, Cell 130 (2007) 548-562.
31. C. Brooks, Q. Wei, L. Feng, G. Dong, Y. Tao, L. Mei, Z.J. Xie, Z. Dong, Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins, Proc. Natl. Acad. Sci. USA 104 (2007) 11649-11654.
32. M. Karbowski, K.L. Norris, M.M. Cleland, S.Y. Jeong, R.J. Youle, Role of Bax and Bak in mitochondrial morphogenesis, Nature 443 (2006) 658-662.