-
1
-
-
0025219280
-
Evaluation of new drugs in untreated patients with small-cell lung cancer: Its time has come
-
Ettinger DS: Evaluation of new drugs in untreated patients with small-cell lung cancer: Its time has come. J Clin Oncol 8:374-377, 1990
-
(1990)
J Clin Oncol
, vol.8
, pp. 374-377
-
-
Ettinger, D.S.1
-
3
-
-
0024536437
-
Optimal two-stage designs for phase II clinical trials
-
Simon R: Optimal two-stage designs for phase II clinical trials. Control Clin Trials 10:1-10, 1989
-
(1989)
Control Clin Trials
, vol.10
, pp. 1-10
-
-
Simon, R.1
-
4
-
-
0034848308
-
Phase II window studies: 10 Years of experience and counting
-
DOI 10.1097/00043426-200108000-00002
-
Smith MA, Anderson B: Phase II window studies: 10 years of experience and counting. J Pediatr Hematol Oncol 23:334-337, 2001 (Pubitemid 32845657)
-
(2001)
Journal of Pediatric Hematology/Oncology
, vol.23
, Issue.6
, pp. 334-337
-
-
Smith, M.A.1
Anderson, B.2
-
5
-
-
0021026574
-
High-dose etoposide as single-agent chemotherapy for small cell carcinoma of the lung
-
Wolff SN, Johnson DH, Hande KR, et al: High-dose etoposide as single-agent chemotherapy for small-cell carcinoma of the lung. Cancer Treat Rep 67:957-958, 1983 (Pubitemid 14231394)
-
(1983)
Cancer Treatment Reports
, vol.67
, Issue.10
, pp. 957-958
-
-
Wolff, S.N.1
Johnson, D.H.2
Hande, K.R.3
-
6
-
-
0022007273
-
Multicenter phase II trial of etoposide in refractory small cell lung cancer
-
Issell BF, Einhorn LH, Comis RL, et al: Multicenter Phase II trial of etoposide in refractory small-cell lung cancer. Cancer Treat Rep 69:127-128, 1985 (Pubitemid 15197092)
-
(1985)
Cancer Treatment Reports
, vol.69
, Issue.1
, pp. 127-128
-
-
Issell, B.F.1
Einhorn, L.H.2
Comis, R.L.3
-
7
-
-
0024417601
-
A randomized trial to evaluate the effect of schedule on the activity of etoposide in small-cell lung cancer
-
Slevin ML, Clark PI, Joel SP, et al: A randomized trial to evaluate the effect of schedule on the activity of etoposide in small-cell lung cancer. J Clin Oncol 7:1333-1340, 1989 (Pubitemid 19220137)
-
(1989)
Journal of Clinical Oncology
, vol.7
, Issue.9
, pp. 1333-1340
-
-
Slevin, M.L.1
Clark, P.I.2
Joel, S.P.3
Malik, S.4
Osborne, R.J.5
Gregory, W.M.6
Lowe, D.G.7
Reznek, R.H.8
Wrigley, P.F.M.9
-
8
-
-
0018746271
-
Phase II evaluation of ftorafur in previously untreated colorectal cancer. A Southwest Oncology Group study
-
DOI 10.1002/1097-0142(197907)44:1<48::AID-CNCR2820440109>3.0.CO;2-C
-
Buroker T, Padilla F, Groppe C, et al: Phase II evaluation of ftorafur in previously untreated colorectal cancer: A Southwest Oncology Group Study. Cancer 44:48-51, 1979 (Pubitemid 9234908)
-
(1979)
Cancer
, vol.44
, Issue.1
, pp. 48-51
-
-
Buroker, T.1
Padilla, F.2
Groppe, C.3
-
9
-
-
0019924472
-
Phase II trial of mitoxantrone in previously untreated patients with colorectal adenocarcinoma: A Southwest Oncology Group study
-
Cowan JD, Von Hoff DD, McDonald B, et al: Phase II trial of mitoxantrone in previously untreated patients with colorectal adenocarcinoma: A Southwest Oncology Group Study. Cancer Treat Rep 66:1779-1780, 1982 (Pubitemid 12000639)
-
(1982)
Cancer Treatment Reports
, vol.66
, Issue.9
, pp. 1779-1780
-
-
Cowan, J.D.1
Von, H.D.D.2
McDonald, B.3
-
10
-
-
0023497776
-
Identification of new drugs in small-cell lung cancer: Phase II agents first?
-
Aisner J: Identification of new drugs in small-cell lung cancer: Phase II agents first? Cancer Treat Rep 71:1131-1133, 1987
-
(1987)
Cancer Treat Rep
, vol.71
, pp. 1131-1133
-
-
Aisner, J.1
-
11
-
-
0025241726
-
Epirubicin in extensive small-cell lung cancer: A phase II study in previously untreated patients: A National Cancer Institute of Canada Clinical Trials Group Study
-
Blackstein M, Eisenhauer EA, Wierzbicki R, et al: Epirubicin in extensive small-cell lung cancer: A phase II study in previously untreated patients - A National Cancer Institute of Canada Clinical Trials Group Study. J Clin Oncol 8:385-389, 1990 (Pubitemid 20087537)
-
(1990)
Journal of Clinical Oncology
, vol.8
, Issue.3
, pp. 385-389
-
-
Blackstein, M.1
Eisenhauer, E.A.2
Wierzbicki, R.3
Yoshida, S.4
-
12
-
-
10244265842
-
Prospective randomised phase III trial of etoposide/cisplatin versus high-dose epirubicin/cisplatin in small-cell lung cancer
-
Artal-Cortés A, Gomez-Codina J, Gonzalez-Larriba JL, et al: Prospective randomized phase III trial of etoposide/cisplatin versus high-dose epirubicin/ cisplatin in small-cell lung cancer. Clin Lung Cancer 6:175-183, 2004 (Pubitemid 39618642)
-
(2004)
Clinical Lung Cancer
, vol.6
, Issue.3
, pp. 175-183
-
-
Artal-Cortes, A.1
Gomez-Codina, J.2
Gonzales-Larriba, J.L.3
Barneto, I.4
Carrato, A.5
Isla, D.6
Camps, C.7
Garcia-Giron, C.8
Font, A.9
Meana, A.10
Lomas, M.11
Vadell, C.12
Arrivi, A.13
Alonso, C.14
Maestu, I.15
Cambell, J.16
Rosell, R.17
-
13
-
-
0032954658
-
Safety and efficacy of using a single agent or a phase II agent before instituting standard combination chemotherapy in previously untreated metastatic breast cancer patients: Report of a randomized study - Cancer and Leukemia Group B 8642
-
Costanza ME, Weiss RB, Henderson IC, et al: Safety and efficacy of using a single agent or a phase II agent before instituting standard combination chemotherapy in previously untreated metastatic breast cancer patients: Report of a randomized study - Cancer and Leukemia Group B 8642. J Clin Oncol 17:1397-1406, 1999 (Pubitemid 29220845)
-
(1999)
Journal of Clinical Oncology
, vol.17
, Issue.5
, pp. 1397-1406
-
-
Costanza, M.E.1
Weiss, R.B.2
Henderson, I.C.3
Norton, L.4
Berry, D.A.5
Cirrincione, C.6
Winer, E.7
Wood, W.C.8
Frei III, E.9
McIntyre, O.R.10
Schilsky, R.L.11
-
14
-
-
77955504706
-
Phase II window study on rituximab in newly diagnosed pediatric mature B-cell non-Hodgkin's lymphoma and Burkitt leukemia
-
Meinhardt A, Burkhardt B, Zimmermann M, et al: Phase II window study on rituximab in newly diagnosed pediatric mature B-cell non-Hodgkin's lymphoma and Burkitt leukemia. J Clin Oncol 28:3115-3121, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 3115-3121
-
-
Meinhardt, A.1
Burkhardt, B.2
Zimmermann, M.3
-
15
-
-
77955503066
-
Phase II proof-of-concept study of pazopanib monotherapy in treatment-naive patients with stage I/II resectable non - Small-cell lung cancer
-
Altorki N, Lane ME, Bauer T, et al: Phase II proof-of-concept study of pazopanib monotherapy in treatment-naive patients with stage I/II resectable non - small-cell lung cancer. J Clin Oncol 28:3131-3137, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 3131-3137
-
-
Altorki, N.1
Lane, M.E.2
Bauer, T.3
-
16
-
-
27744462595
-
The impact of age and gender on biology, clinical features and treatment outcome of non-Hodgkin lymphoma in childhood and adolescence
-
DOI 10.1111/j.1365-2141.2005.05735.x
-
Burkhardt B, Zimmermann M, Oschlies I, et al: The impact of age and gender on biology, clinical features, and treatment outcome of non-Hodgkin lymphoma in childhood and adolescence. Br J Haematol 131:39-49, 2005 (Pubitemid 43899706)
-
(2005)
British Journal of Haematology
, vol.131
, Issue.1
, pp. 39-49
-
-
Burkhardt, B.1
Zimmermann, M.2
Oschlies, I.3
Niggli, F.4
Mann, G.5
Parwaresch, R.6
Riehm, H.7
Schrappe, M.8
Reiter, A.9
-
17
-
-
77951479165
-
Use of the proposals of the international association for the study of lung cancer in the forthcoming edition of lung cancer staging system to predict long-term prognosis of operated patients
-
Rena O, Massera F, Robustellini M, et al: Use of the proposals of the international association for the study of lung cancer in the forthcoming edition of lung cancer staging system to predict long-term prognosis of operated patients. Cancer J 16:176-181, 2010
-
(2010)
Cancer J
, vol.16
, pp. 176-181
-
-
Rena, O.1
Massera, F.2
Robustellini, M.3
-
18
-
-
33847359111
-
Setting the bar in phase II trials: The use of historical data for determining "go/no go" decision for definitive phase III testing
-
Vickers AJ, Ballen V, Scher HI: Setting the bar in phase II trials: The use of historical data for determining "go/no go" decision for definitive phase III testing. Clin Cancer Res 13:972-976, 2007
-
(2007)
Clin Cancer Res
, vol.13
, pp. 972-976
-
-
Vickers, A.J.1
Ballen, V.2
Scher, H.I.3
-
19
-
-
0036210050
-
Non-randomised phase II trials of drug combinations: Often meaningless, sometimes misleading - Are there alternative strategies?
-
Van Glabbeke M, Steward W, Armand JP: Non-randomised phase II trials of drug combinations: Often meaningless, sometimes misleading - Are there alternative strategies? Eur J Cancer 38:635-638, 2002
-
(2002)
Eur J Cancer
, vol.38
, pp. 635-638
-
-
Van Glabbeke, M.1
Steward, W.2
Armand, J.P.3
-
20
-
-
16544380415
-
Phase II studies of modern drugs directed against new targets: If you are fazed, too, then resist RECIST
-
DOI 10.1200/JCO.2004.07.960
-
Ratain MJ, Eckhardt SG: Phase II studies of modern drugs directed against new targets: If you are fazed, too, then resist RECIST. J Clin Oncol 22:4442-4445, 2004 (Pubitemid 41185107)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.22
, pp. 4442-4445
-
-
Ratain, M.J.1
Eckhardt, S.G.2
-
21
-
-
23844469804
-
Phase II oncology trials: Let's be positive
-
Ratain MJ: Phase II oncology trials: Let's be positive. Clin Cancer Res 11:5661-5662, 2005
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5661-5662
-
-
Ratain, M.J.1
-
22
-
-
27244436755
-
Design issues of randomized phase II trials and a proposal for phase II screening trials
-
Rubinstein LV, Korn EL, Freidlin B, et al: Design issues of randomized phase II trials and a proposal for phase II screening trials. J Clin Oncol 23:7199-7206, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 7199-7206
-
-
Rubinstein, L.V.1
Korn, E.L.2
Freidlin, B.3
-
23
-
-
34247860864
-
Phase II trials published in 2002: A cross-specialty comparison showing significant design differences between oncology trials and other medical specialties
-
Michaelis LC, Ratain MJ: Phase II trials published in 2002: A cross-specialty comparison showing significant design differences between oncology trials and other medical specialties. Clin Cancer Res 13:2400-2405, 2007
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2400-2405
-
-
Michaelis, L.C.1
Ratain, M.J.2
-
24
-
-
33847415407
-
Testing the wrong hypothesis in phase II oncology trials: There is a better alternative. Commentary on Vickers et al., p. 972
-
DOI 10.1158/1078-0432.CCR-06-2533
-
Ratain MJ, Karrison TG: Testing the wrong hypothesis in phase II oncology trials: There is a better alternative. Clin Cancer Res 13:781-782, 2007 (Pubitemid 46340347)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.3
, pp. 781-782
-
-
Ratain, M.J.1
Karrison, T.G.2
-
25
-
-
33845588585
-
Improving the design of phase II trials of cytostatic anticancer agents
-
DOI 10.1016/j.cct.2006.05.009, PII S1551714406000656
-
Stone A, Wheeler C, Barge A: Improving the design of phase II trials of cytostatic anticancer agents. Contemp Clin Trials 28:138-145, 2007 (Pubitemid 44937880)
-
(2007)
Contemporary Clinical Trials
, vol.28
, Issue.2
, pp. 138-145
-
-
Stone, A.1
Wheeler, C.2
Barge, A.3
-
26
-
-
37149042854
-
Recommended changes to oncology clinical trial design: Revolution or evolution?
-
DOI 10.1016/j.ejca.2007.09.011, PII S095980490700737X
-
Ratain MJ, Humphrey RW, Gordon GB, et al: Recommended changes to oncology clinical trial design: Revolution or evolution? Eur J Cancer 44:8-11, 2008 (Pubitemid 350258715)
-
(2008)
European Journal of Cancer
, vol.44
, Issue.1
, pp. 8-11
-
-
Ratain, M.J.1
Humphrey, R.W.2
Gordon, G.B.3
Fyfe, G.4
Adamson, P.C.5
Fleming, T.R.6
Stadler, W.M.7
Berry, D.A.8
Peck, C.C.9
-
27
-
-
63449089608
-
Novel designs and end points for phase II clinical trials
-
Adjei AA, Christian M, Ivy P: Novel designs and end points for phase II clinical trials. Clin Cancer Res 15:1866-1872, 2009
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1866-1872
-
-
Adjei, A.A.1
Christian, M.2
Ivy, P.3
-
28
-
-
67650302854
-
Phase II trials in Journal of Clinical Oncology
-
Cannistra SA: Phase II trials in Journal of Clinical Oncology. J Clin Oncol 27:3073-3076, 2009
-
(2009)
J Clin Oncol
, vol.27
, pp. 3073-3076
-
-
Cannistra, S.A.1
-
29
-
-
57849154374
-
Optimising the design of phase II oncology trials: The importance of randomisation
-
Ratain MJ, Sargent DJ: Optimising the design of phase II oncology trials: The importance of randomisation. Eur J Cancer 45:275-280, 2009
-
(2009)
Eur J Cancer
, vol.45
, pp. 275-280
-
-
Ratain, M.J.1
Sargent, D.J.2
-
30
-
-
70350156609
-
Other paradigms: Better treatments are identified by better trials - The value of randomized phase II studies
-
Sharma MR, Maitland ML, Ratain MJ: Other paradigms: Better treatments are identified by better trials - The value of randomized phase II studies. Cancer J 15:426-430, 2009
-
(2009)
Cancer J
, vol.15
, pp. 426-430
-
-
Sharma, M.R.1
Maitland, M.L.2
Ratain, M.J.3
-
31
-
-
77949673913
-
The design of phase II clinical trials testing cancer therapeutics: Consensus recommendations from the Clinical Trial Design Task Force of the National Cancer Institute Investigational Drug Steering Committee
-
Seymour L, Ivy SP, Sargent D, et al: The design of phase II clinical trials testing cancer therapeutics: Consensus recommendations from the Clinical Trial Design Task Force of the National Cancer Institute Investigational Drug Steering Committee. Clin Cancer Res 16:1764-1769, 2010
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1764-1769
-
-
Seymour, L.1
Ivy, S.P.2
Sargent, D.3
-
32
-
-
77951639219
-
Comparison of error rates in single-arm versus randomized phase II cancer clinical trials
-
Tang H, Foster NR, Grothey A, et al: Comparison of error rates in single-arm versus randomized phase II cancer clinical trials. J Clin Oncol 28:1936-1941, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 1936-1941
-
-
Tang, H.1
Foster, N.R.2
Grothey, A.3
-
33
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
DOI 10.1056/NEJM200104053441401
-
Druker BJ, Talpaz M, Resta DJ, et al: Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344:1031-1037, 2001 (Pubitemid 32267972)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.14
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
34
-
-
33644847440
-
Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
-
DOI 10.1200/JCO.2005.02.2194
-
Faivre S, Delbaldo C, Vera K, et al: Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol 24:25-35, 2006 (Pubitemid 46630490)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.1
, pp. 25-35
-
-
Faivre, S.1
Delbaldo, C.2
Vera, K.3
Robert, C.4
Lozahic, S.5
Lassau, N.6
Bello, C.7
Deprimo, S.8
Brega, N.9
Massimini, G.10
Armand, J.-P.11
Scigalla, P.12
Raymond, E.13
-
35
-
-
0037111832
-
Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
-
DOI 10.1200/JCO.2002.01.133
-
Orlowski RZ, Stinchcombe TE, Mitchell BS, et al: Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 20:4420-4427, 2002 (Pubitemid 35334752)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.22
, pp. 4420-4427
-
-
Orlowski, R.Z.1
Stinchcombe, T.E.2
Mitchell, B.S.3
Shea, T.C.4
Baldwin, A.S.5
Stahl, S.6
Adams, J.7
Esseltine, D.-L.8
Elliott, P.J.9
Pien, C.S.10
Guerciolini, R.11
Anderson, J.K.12
Depcik-Smith, N.D.13
Bhagat, R.14
Lehman, M.J.15
Novick, S.C.16
O'Connor, O.A.17
Soignet, S.L.18
-
36
-
-
4344646459
-
Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer
-
DOI 10.1200/JCO.2004.11.057
-
Péréz-Soler R, Chachoua A, Hammond LA, et al: Determinants of tumor response and survival with erlotinib in patients with non - small-cell lung cancer. J Clin Oncol 22:3238-3247, 2004 (Pubitemid 41103678)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.16
, pp. 3238-3247
-
-
Perez-Soler, R.1
Chachoua, A.2
Hammond, L.A.3
Rowinsky, E.K.4
Huberman, M.5
Karp, D.6
Rigas, J.7
Clark, G.M.8
Santabarbara, P.9
Bonomi, P.10
-
37
-
-
57849117384
-
New response evaluation criteria in solid tumours: Revised RECIST guideline
-
version 1.1.
-
Eisenhauer EA, Therasse P, Bogaerts J, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer 45:228-247, 2009
-
(2009)
Eur J Cancer
, vol.45
, pp. 228-247
-
-
Eisenhauer, E.A.1
Therasse, P.2
Bogaerts, J.3
-
38
-
-
77149155968
-
Trends in risks associated with new drug development: Success rates for investigational drugs
-
DiMasi JA, Feldman L, Seckler A, et al: Trends in risks associated with new drug development: Success rates for investigational drugs. Clin Pharmacol Ther 87:272-277, 2010
-
(2010)
Clin Pharmacol Ther
, vol.87
, pp. 272-277
-
-
DiMasi, J.A.1
Feldman, L.2
Seckler, A.3
-
39
-
-
77949667760
-
Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents
-
Dancey JE, Dobbin KK, Groshen S, et al: Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents. Clin Cancer Res 16:1745-1755, 2010
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1745-1755
-
-
Dancey, J.E.1
Dobbin, K.K.2
Groshen, S.3
-
40
-
-
35649023163
-
Effects of isoflurane exposure on oncogene and tumour suppressor gene expressions in vital organs of CBA/CA mice
-
Kádár B, Gombos K, Szele E, et al: Effects of isoflurane exposure on oncogene and tumour suppressor gene expressions in vital organs of CBA/CA mice. In Vivo 21:861-865, 2007
-
(2007)
In Vivo
, vol.21
, pp. 861-865
-
-
Kádár, B.1
Gombos, K.2
Szele, E.3
-
41
-
-
58149233834
-
Morphine induces apoptosis of human endothelial cells through nitric oxide and reactive oxygen species pathways
-
Hsiao PN, Chang MC, Cheng WF, et al: Morphine induces apoptosis of human endothelial cells through nitric oxide and reactive oxygen species pathways. Toxicology 256:83-91, 2009
-
(2009)
Toxicology
, vol.256
, pp. 83-91
-
-
Hsiao, P.N.1
Chang, M.C.2
Cheng, W.F.3
-
42
-
-
39749085432
-
Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers
-
DOI 10.1200/JCO.2007.13.5939
-
Guix M, Granja Nde M, Meszoely I, et al: Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers. J Clin Oncol 26:897-906, 2008 (Pubitemid 351398082)
-
(2008)
Journal of Clinical Oncology
, vol.26
, Issue.6
, pp. 897-906
-
-
Guix, M.1
Granja, N.D.M.2
Meszoely, I.3
Adkins, T.B.4
Wieman, B.M.5
Frierson, K.E.6
Sanchez, V.7
Sanders, M.E.8
Grau, A.M.9
Mayer, I.A.10
Pestano, G.11
Shyr, Y.12
Muthuswamy, S.13
Calvo, B.14
Krontiras, H.15
Krop, I.E.16
Kelley, M.C.17
Arteaga, C.L.18
-
43
-
-
58449087275
-
From darkness to light with biomarkers in early clinical trials of cancer drugs
-
Carden CP, Banerji U, Kaye SB, et al: From darkness to light with biomarkers in early clinical trials of cancer drugs. Clin Pharmacol Ther 85:131-133, 2009
-
(2009)
Clin Pharmacol Ther
, vol.85
, pp. 131-133
-
-
Carden, C.P.1
Banerji, U.2
Kaye, S.B.3
-
44
-
-
58449108534
-
Biomarkers in early cancer drug development: Limited utility
-
Glassman RH, Ratain MJ: Biomarkers in early cancer drug development: Limited utility. Clin Pharmacol Ther 85:134-135, 2009
-
(2009)
Clin Pharmacol Ther
, vol.85
, pp. 134-135
-
-
Glassman, R.H.1
Ratain, M.J.2
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45
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79951841983
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Unknown/unknown
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Wikipedia: Unknown/unknown. http://en.wikipedia.org/wiki/Unknown-unknown
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