Regulation of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes

Arthritis Research and Therapy

Volumn 12, Issue 1, 2010, Pages

  Chen, Shu Huang ^a   Fahmi, Hassan ^a   Shi, Qin ^a   Benderdour, Mohamed ^a  

^a HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; ALDEHYDE; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; CYCLOOXYGENASE 2; LEUKOTRIENE B4; MESSENGER RNA; NAPROXEN; PROSTAGLANDIN E2; PROSTAGLANDIN E2 SYNTHASE 1; PROSTAGLANDIN SYNTHASE; TRANSCRIPTION FACTOR EGR 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; 4-HYDROXY-2-NONENAL; 5-LIPOXYGENASE-ACTIVATING PROTEIN; CARRIER PROTEIN; CYSTEINE PROTEINASE INHIBITOR; ISOMERASE; MEMBRANE PROTEIN; PROSTAGLANDIN E SYNTHASE; TGFB1 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; CARTILAGE CELL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROSOME; OSTEOARTHRITIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; AGED; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM;

AGED; ALDEHYDES; ARACHIDONATE 5-LIPOXYGENASE; BLOTTING, WESTERN; CARRIER PROTEINS; CELLS, CULTURED; CHONDROCYTES; CYCLOOXYGENASE 2; CYSTEINE PROTEINASE INHIBITORS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LEUKOTRIENE B4; MEMBRANE PROTEINS; MICROSOMES; OSTEOARTHRITIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77955474381     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2926     Document Type: Article

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