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Volumn 25, Issue 5, 2010, Pages 513-517

Vitamin D and cardiovascular disease risk: Emerging evidence

Author keywords

blood pressure; cardiovascular disease; diabetes mellitus; metabolic syndrome; supplementation; vitamin D

Indexed keywords

1,25 DIHYDROXY VITAMIN D; CALCIFEDIOL; COLECALCIFEROL; ERGOCALCIFEROL; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D DERIVATIVE;

EID: 77955466842     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/HCO.0b013e32833cd491     Document Type: Review
Times cited : (22)

References (66)
  • 1
    • 41049096380 scopus 로고    scopus 로고
    • Vitamin D deficiency and risk of cardiovascular disease
    • Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008; 117:503-511.
    • (2008) Circulation , vol.117 , pp. 503-511
    • Wang, T.J.1    Pencina, M.J.2    Booth, S.L.3
  • 2
    • 53749092973 scopus 로고    scopus 로고
    • Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography
    • Pilz S, Marz W, Wellnitz B, et al. Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography. J Clin Endocrinol Metab 2008; 93:3927-3935.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3927-3935
    • Pilz, S.1    Marz, W.2    Wellnitz, B.3
  • 3
    • 67349254810 scopus 로고    scopus 로고
    • 25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey
    • This large, cross-sectional study provides further evidence that low vitamin D levels are associated with cardiovascular disease, even after accounting for potential confounders
    • Kendrick J, Targher G, Smits G, Chonchol M. 25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey. Atherosclerosis 2009; 205:255-260. This large, cross-sectional study provides further evidence that low vitamin D levels are associated with cardiovascular disease, even after accounting for potential confounders.
    • (2009) Atherosclerosis , vol.205 , pp. 255-260
    • Kendrick, J.1    Targher, G.2    Smits, G.3    Chonchol, M.4
  • 4
    • 46449131684 scopus 로고    scopus 로고
    • Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with allcause and cardiovascular mortality
    • Dobnig H, Pilz S, Scharnagl H, et al. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with allcause and cardiovascular mortality. Arch Intern Med 2008; 168:1340-1349.
    • (2008) Arch Intern Med , vol.168 , pp. 1340-1349
    • Dobnig, H.1    Pilz, S.2    Scharnagl, H.3
  • 5
    • 45149090726 scopus 로고    scopus 로고
    • 25-Hydroxyvitamin D and risk of myocardial infarction in men: A prospective study
    • Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-Hydroxyvitamin D and risk of myocardial infarction in men: A prospective study. Arch Intern Med 2008; 168:1174-1180.
    • (2008) Arch Intern Med , vol.168 , pp. 1174-1180
    • Giovannucci, E.1    Liu, Y.2    Hollis, B.W.3    Rimm, E.B.4
  • 7
    • 63849098416 scopus 로고    scopus 로고
    • Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004
    • Ginde AA, Liu MC, Camargo CA Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med 2009; 169:626-632.
    • (2009) Arch Intern Med , vol.169 , pp. 626-632
    • Ginde, A.A.1    Liu, M.C.2    Camargo Jr., C.A.3
  • 8
    • 0029916947 scopus 로고    scopus 로고
    • 1,25(OH)2 Vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes
    • Wu J, Garami M, Cheng T, Gardner DG. 1,25(OH)2 Vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes. J Clin Invest 1996; 97:1577-1588.
    • (1996) J Clin Invest , vol.97 , pp. 1577-1588
    • Wu, J.1    Garami, M.2    Cheng, T.3    Gardner, D.G.4
  • 9
    • 33745343132 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy
    • O'Connell TD, Berry JE, Jarvis AK, et al. 1,25-Dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy. Am J Physiol 1997; 272:H1751-H1758.
    • (1997) Am J Physiol , vol.272
    • O'Connell, T.D.1    Berry, J.E.2    Jarvis, A.K.3
  • 10
    • 35648976022 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter
    • Yuan W, Pan W, Kong J, et al. 1,25-Dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter. J Biol Chem 2007; 282:29821-29830.
    • (2007) J Biol Chem , vol.282 , pp. 29821-29830
    • Yuan, W.1    Pan, W.2    Kong, J.3
  • 11
    • 0036073755 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system
    • Li YC, Kong J, Wei M, et al. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002; 110:229-238.
    • (2002) J Clin Invest , vol.110 , pp. 229-238
    • Li, Y.C.1    Kong, J.2    Wei, M.3
  • 12
    • 38549151870 scopus 로고    scopus 로고
    • Functional vitamin D receptor (VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility
    • Tishkoff DX, Nibbelink KA, Holmberg KH, et al. Functional vitamin D receptor (VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility. Endocrinology 2008; 149:558-564.
    • (2008) Endocrinology , vol.149 , pp. 558-564
    • Tishkoff, D.X.1    Nibbelink, K.A.2    Holmberg, K.H.3
  • 13
    • 33947230704 scopus 로고    scopus 로고
    • Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse
    • Simpson RU, Hershey SH, Nibbelink KA. Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse. J Steroid Biochem Mol Biol 2007; 103:521-524.
    • (2007) J Steroid Biochem Mol Biol , vol.103 , pp. 521-524
    • Simpson, R.U.1    Hershey, S.H.2    Nibbelink, K.A.3
  • 14
    • 46249115642 scopus 로고    scopus 로고
    • Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice
    • Zhou C, Lu F, Cao K, et al. Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice. Kidney Int 2008; 74:170-179.
    • (2008) Kidney Int , vol.74 , pp. 170-179
    • Zhou, C.1    Lu, F.2    Cao, K.3
  • 15
    • 34247158555 scopus 로고    scopus 로고
    • Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 125-Dihydroxyvitamin D(3) works as anti-inflammatory
    • Giulietti A, van Etten E, Overbergh L, et al. Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1,25-Dihydroxyvitamin D(3) works as anti-inflammatory. Diabetes Res Clin Pract 2007; 77:47-57.
    • (2007) Diabetes Res Clin Pract , vol.77 , pp. 47-57
    • Giulietti, A.1    Van Etten, E.2    Overbergh, L.3
  • 16
    • 0023267970 scopus 로고
    • Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA
    • Rigby WF, Denome S, Fanger MW. Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA. J Clin Invest 1987; 79:1659-1664.
    • (1987) J Clin Invest , vol.79 , pp. 1659-1664
    • Rigby, W.F.1    Denome, S.2    Fanger, M.W.3
  • 17
    • 69549116323 scopus 로고    scopus 로고
    • 1,25(OH)2 Vitamin D inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus
    • This study provides further experimental evidence that vitamin D influences lipid metabolism and modulates atherogenesis
    • Oh J, Weng S, Felton SK, et al. 1,25(OH)2 Vitamin D inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus. Circulation 2009; 120:687-698. This study provides further experimental evidence that vitamin D influences lipid metabolism and modulates atherogenesis.
    • (2009) Circulation , vol.120 , pp. 687-698
    • Oh, J.1    Weng, S.2    Felton, S.K.3
  • 18
    • 0036402888 scopus 로고    scopus 로고
    • Characterization of transgenic rats constitutively expressing vitamin D-24-hydroxylase gene
    • Kasuga H, Hosogane N, Matsuoka K, et al. Characterization of transgenic rats constitutively expressing vitamin D-24-hydroxylase gene. Biochem Biophys Res Commun 2002; 297:1332-1338.
    • (2002) Biochem Biophys Res Commun , vol.297 , pp. 1332-1338
    • Kasuga, H.1    Hosogane, N.2    Matsuoka, K.3
  • 19
    • 0026042297 scopus 로고
    • 1,25-Dihydroxyvitamin D3 modulates growth of vascular smooth muscle cells
    • Mitsuhashi T, Morris RC Jr, Ives HE. 1,25-Dihydroxyvitamin D3 modulates growth of vascular smooth muscle cells. J Clin Invest 1991; 87:1889-1895.
    • (1991) J Clin Invest , vol.87 , pp. 1889-1895
    • Mitsuhashi, T.1    Morris Jr., R.C.2    Ives, H.E.3
  • 20
    • 33645871291 scopus 로고    scopus 로고
    • Effects of Vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells
    • Wu-Wong JR, Nakane M, Ma J, et al. Effects of Vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells. Atherosclerosis 2006; 186:20-28.
    • (2006) Atherosclerosis , vol.186 , pp. 20-28
    • Wu-Wong, J.R.1    Nakane, M.2    Ma, J.3
  • 21
    • 33646156641 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 stimulates vascular smooth muscle cell proliferation through a VEGF-mediated pathway
    • Cardus A, Parisi E, Gallego C, et al. 1,25-Dihydroxyvitamin D3 stimulates vascular smooth muscle cell proliferation through a VEGF-mediated pathway.Kidney Int 2006; 69:1377-1384.
    • (2006) Kidney Int , vol.69 , pp. 1377-1384
    • Cardus, A.1    Parisi, E.2    Gallego, C.3
  • 22
    • 0033870768 scopus 로고    scopus 로고
    • 1 alpha,25-Dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivo
    • Mantell DJ, Owens PE, Bundred NJ, et al. 1 alpha,25-Dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivo. Circ Res 2000; 87:214-220.
    • (2000) Circ Res , vol.87 , pp. 214-220
    • Mantell, D.J.1    Owens, P.E.2    Bundred, N.J.3
  • 23
    • 17144398824 scopus 로고    scopus 로고
    • 25-Hydroxyvitamin D3-1alpha-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds
    • Somjen D, Weisman Y, Kohen F, et al. 25-Hydroxyvitamin D3-1alpha-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds. Circulation 2005; 111:1666-1671.
    • (2005) Circulation , vol.111 , pp. 1666-1671
    • Somjen, D.1    Weisman, Y.2    Kohen, F.3
  • 24
    • 4143096123 scopus 로고    scopus 로고
    • Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice
    • Aihara K, Azuma H, Akaike M, et al. Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice. J Biol Chem 2004; 279:35798-35802.
    • (2004) J Biol Chem , vol.279 , pp. 35798-35802
    • Aihara, K.1    Azuma, H.2    Akaike, M.3
  • 25
    • 17344390844 scopus 로고
    • Involvement of vitamin D3 with cardiovascular function. II. Direct and indirect effects
    • Weishaar RE, Simpson RU. Involvement of vitamin D3 with cardiovascular function. II. Direct and indirect effects. Am J Physiol 1987; 253:E675-E683.
    • (1987) Am J Physiol , vol.253
    • Weishaar, R.E.1    Simpson, R.U.2
  • 26
    • 75649122588 scopus 로고    scopus 로고
    • Association of low serum 25-hydroxyvitamin D levels and high arterial blood pressure in the elderly
    • Almirall J, Vaqueiro M, Bare ML, Anton E. Association of low serum 25-hydroxyvitamin D levels and high arterial blood pressure in the elderly.Nephrol Dial Transplant 2010; 25:503-509.
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 503-509
    • Almirall, J.1    Vaqueiro, M.2    Bare, M.L.3    Anton, E.4
  • 27
    • 68149096822 scopus 로고    scopus 로고
    • Association of 25-hydroxyvitamin D with blood pressure in predominantly 25-hydroxyvitamin D deficient Hispanic and African Americans
    • Schmitz KJ, Skinner HG, Bautista LE, et al. Association of 25-hydroxyvitamin D with blood pressure in predominantly 25-hydroxyvitamin D deficient Hispanic and African Americans. Am J Hypertens 2009; 22:867-870.
    • (2009) Am J Hypertens , vol.22 , pp. 867-870
    • Schmitz, K.J.1    Skinner, H.G.2    Bautista, L.E.3
  • 28
    • 72049090362 scopus 로고    scopus 로고
    • Relation of serum 25-hydroxyvitamin D to heart rate and cardiac work (from the National Health and Nutrition Examination Surveys)
    • Based on an analysis of the National Health and Nutrition Survey database, this report explores hemodynamic correlates of vitamin D insufficiency
    • Scragg RK, Camargo CA Jr, Simpson RU. Relation of serum 25-hydroxyvitamin D to heart rate and cardiac work (from the National Health and Nutrition Examination Surveys). Am J Cardiol 2010; 105:122-128. Based on an analysis of the National Health and Nutrition Survey database, this report explores hemodynamic correlates of vitamin D insufficiency.
    • (2010) Am J Cardiol , vol.105 , pp. 122-128
    • Scragg, R.K.1    Camargo Jr., C.A.2    Simpson, R.U.3
  • 29
    • 34247893803 scopus 로고    scopus 로고
    • Plasma 25-hydroxyvitamin D levels and risk of incident hypertension
    • Forman JP, Giovannucci E, Holmes MD, et al. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension 2007; 49:1063-1069.
    • (2007) Hypertension , vol.49 , pp. 1063-1069
    • Forman, J.P.1    Giovannucci, E.2    Holmes, M.D.3
  • 30
    • 77955172440 scopus 로고    scopus 로고
    • The association of serum vitamin D level with presence of metabolic syndrome and hypertension in middle-aged Korean subjects
    • [Epub ahead of print]
    • Kim MK, Kang MI, Oh KW, et al. The association of serum vitamin D level with presence of metabolic syndrome and hypertension in middle-aged Korean subjects. Clin Endocrinol (Oxf) 2010. [Epub ahead of print]
    • (2010) Clin Endocrinol (Oxf)
    • Kim, M.K.1    Kang, M.I.2    Oh, K.W.3
  • 31
    • 77149135590 scopus 로고    scopus 로고
    • Serum 25-hydroxyvitamin D levels are strongly related to systolic blood pressure but do not predict future hypertension
    • This Norwegian study confirms the cross-sectional association of low vitamin D levels with elevated BP, but fails to find an association with incident hypertension
    • Jorde R, Figenschau Y, Emaus N, et al. Serum 25-hydroxyvitamin D levels are strongly related to systolic blood pressure but do not predict future hypertension. Hypertension 2010; 55:792-798. This Norwegian study confirms the cross-sectional association of low vitamin D levels with elevated BP, but fails to find an association with incident hypertension.
    • (2010) Hypertension , vol.55 , pp. 792-798
    • Jorde, R.1    Figenschau, Y.2    Emaus, N.3
  • 32
    • 55949102601 scopus 로고    scopus 로고
    • Effect of calcium and vitamin D supplementation on blood pressure: The Women's Health Initiative Randomized Trial
    • Margolis KL, Ray RM, Van Horn L, et al. Effect of calcium and vitamin D supplementation on blood pressure: The Women's Health Initiative Randomized Trial. Hypertension 2008; 52:847-855.
    • (2008) Hypertension , vol.52 , pp. 847-855
    • Margolis, K.L.1    Ray, R.M.2    Van Horn, L.3
  • 33
    • 70350463868 scopus 로고    scopus 로고
    • Effect of vitamin D on blood pressure: A systematic review and meta-analysis
    • This is the first meta-analysis of clinical trials of vitamin D supplementation and BP
    • Witham MD, Nadir MA, Struthers AD. Effect of vitamin D on blood pressure: A systematic review and meta-analysis. J Hypertens 2009; 27:1948-1954. This is the first meta-analysis of clinical trials of vitamin D supplementation and BP.
    • (2009) J Hypertens , vol.27 , pp. 1948-1954
    • Witham, M.D.1    Nadir, M.A.2    Struthers, A.D.3
  • 34
    • 77950366532 scopus 로고    scopus 로고
    • Systematic review: Vitamin D and cardiometabolic outcomes
    • This is a comprehensive review of observational and interventional studies focused on vitamin D and cardiovascular and metabolic endpoints. The findings emphasize the need for further prospective, randomized trials in this area
    • Pittas AG, Chung M, Trikalinos T, et al. Systematic review: Vitamin D and cardiometabolic outcomes. Ann Intern Med 2010; 152:307-314. This is a comprehensive review of observational and interventional studies focused on vitamin D and cardiovascular and metabolic endpoints. The findings emphasize the need for further prospective, randomized trials in this area.
    • (2010) Ann Intern Med , vol.152 , pp. 307-314
    • Pittas, A.G.1    Chung, M.2    Trikalinos, T.3
  • 35
    • 72949121915 scopus 로고    scopus 로고
    • Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men
    • Lee DM, Rutter MK, O'Neill TW, et al. Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men. Eur J Endocrinol 2009; 161:947-954.
    • (2009) Eur J Endocrinol , vol.161 , pp. 947-954
    • Lee, D.M.1    Rutter, M.K.2    O'Neill, T.W.3
  • 36
    • 67650066856 scopus 로고    scopus 로고
    • Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals
    • Lu L, Pan A, Hu FB, et al. Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care 2009; 32:1278-1283.
    • (2009) Diabetes Care , vol.32 , pp. 1278-1283
    • Lu, L.1    Pan, A.2    Hu, F.B.3
  • 37
    • 60249087200 scopus 로고    scopus 로고
    • Plasma 25-hydroxyvitamin d is associated with markers of the insulin resistant phenotype in nondiabetic Adults
    • Liu E, Meigs JB, Pittas AG, et al. Plasma 25-hydroxyvitamin d is associated with markers of the insulin resistant phenotype in nondiabetic Adults. J Nutr 2009; 139:329-334.
    • (2009) J Nutr , vol.139 , pp. 329-334
    • Liu, E.1    Meigs, J.B.2    Pittas, A.G.3
  • 38
    • 77955468245 scopus 로고    scopus 로고
    • Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes
    • Kayaniyil S, Vieth R, Retnakaran R, et al. Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care 2010; 33:1379-1381.
    • (2010) Diabetes Care , vol.33 , pp. 1379-1381
    • Kayaniyil, S.1    Vieth, R.2    Retnakaran, R.3
  • 39
    • 77955469633 scopus 로고    scopus 로고
    • Serum 25-hydroxy vitamin D and insulin resistance, metabolic syndrome, and glucose intolerance among Arab Americans
    • Pinelli NR, Jaber LA, Brown MB, Herman WH. Serum 25-hydroxy vitamin D and insulin resistance, metabolic syndrome, and glucose intolerance among Arab Americans. Diabetes Care 2010; 33:1373-1375.
    • (2010) Diabetes Care , vol.33 , pp. 1373-1375
    • Pinelli, N.R.1    Jaber, L.A.2    Brown, M.B.3    Herman, W.H.4
  • 40
    • 77955467419 scopus 로고    scopus 로고
    • Association of A1c levels with vitamin D status in U.S. Adults: Data from the National Health and Nutrition Examination Survey
    • Kositsawat J, Freeman VL, Gerber BS, Geraci S. Association of A1c levels with vitamin D status in U.S. Adults: Data from the National Health and Nutrition Examination Survey. Diabetes Care 2010; 33:1236-1238.
    • (2010) Diabetes Care , vol.33 , pp. 1236-1238
    • Kositsawat, J.1    Freeman, V.L.2    Gerber, B.S.3    Geraci, S.4
  • 41
    • 77953057248 scopus 로고    scopus 로고
    • Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome
    • Gulseth HL, Gjelstad IM, Tierney AC, et al. Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome. Diabetes Care 2010; 33:923-925.
    • (2010) Diabetes Care , vol.33 , pp. 923-925
    • Gulseth, H.L.1    Gjelstad, I.M.2    Tierney, A.C.3
  • 42
    • 77649219884 scopus 로고    scopus 로고
    • Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient -a randomised, placebo-controlled trial
    • von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient -a randomised, placebo-controlled trial. Br J Nutr 2010; 103:549-555.
    • (2010) Br J Nutr , vol.103 , pp. 549-555
    • Von Hurst, P.R.1    Stonehouse, W.2    Coad, J.3
  • 43
    • 58149216055 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men
    • Nagpal J, Pande JN, Bhartia A. A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men. Diabet Med 2009; 26:19-27.
    • (2009) Diabet Med , vol.26 , pp. 19-27
    • Nagpal, J.1    Pande, J.N.2    Bhartia, A.3
  • 44
    • 77954586775 scopus 로고    scopus 로고
    • Hypovitaminosis D in Chinese type 2 diabetes: Lack of impact on clinical metabolic status and biomarkers of cellular inflammation
    • Luo C, Wong J, Brown M, et al. Hypovitaminosis D in Chinese type 2 diabetes: Lack of impact on clinical metabolic status and biomarkers of cellular inflammation. Diab Vasc Dis Res 2009; 6:194-199.
    • (2009) Diab Vasc Dis Res , vol.6 , pp. 194-199
    • Luo, C.1    Wong, J.2    Brown, M.3
  • 45
    • 69949159348 scopus 로고    scopus 로고
    • Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels
    • Jorde R, Figenschau Y. Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels. Eur J Nutr 2009; 48:349-354.
    • (2009) Eur J Nutr , vol.48 , pp. 349-354
    • Jorde, R.1    Figenschau, Y.2
  • 46
    • 34147190196 scopus 로고    scopus 로고
    • The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic Adults
    • Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic Adults. Diabetes Care 2007; 30:980-986.
    • (2007) Diabetes Care , vol.30 , pp. 980-986
    • Pittas, A.G.1    Harris, S.S.2    Stark, P.C.3    Dawson-Hughes, B.4
  • 47
    • 77950483852 scopus 로고    scopus 로고
    • Effect of 5 y of calcium plus vitamin D supplementation on change in circulating lipids: Results from the Women's Health Initiative
    • Rajpathak SN, Xue X, Wassertheil-Smoller S, et al. Effect of 5 y of calcium plus vitamin D supplementation on change in circulating lipids: Results from the Women's Health Initiative. Am J Clin Nutr 2010; 91:894-899.
    • (2010) Am J Clin Nutr , vol.91 , pp. 894-899
    • Rajpathak, S.N.1    Xue, X.2    Wassertheil-Smoller, S.3
  • 48
    • 65549137566 scopus 로고    scopus 로고
    • Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers
    • This moderately sized clinical trial examines the effect of vitamin D supplementation on several metabolic markers
    • Zittermann A, Frisch S, Berthold HK, et al. Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am J Clin Nutr 2009; 89:1321-1327. This moderately sized clinical trial examines the effect of vitamin D supplementation on several metabolic markers.
    • (2009) Am J Clin Nutr , vol.89 , pp. 1321-1327
    • Zittermann, A.1    Frisch, S.2    Berthold, H.K.3
  • 49
    • 77449105166 scopus 로고    scopus 로고
    • Adiposity, cardiometabolic risk, and vitamin D status: The Framingham Heart Study
    • This is one of the largest studies relating vitamin D status with detailed measures of fat distribution, obtained via computed tomography. Interestingly, vitamin D status was related to fat deposition, even among lean individuals
    • Cheng S, Massaro JM, Fox CS, et al. Adiposity, cardiometabolic risk, and vitamin D status: The Framingham Heart Study. Diabetes 2010; 59:242-248. This is one of the largest studies relating vitamin D status with detailed measures of fat distribution, obtained via computed tomography. Interestingly, vitamin D status was related to fat deposition, even among lean individuals.
    • (2010) Diabetes , vol.59 , pp. 242-248
    • Cheng, S.1    Massaro, J.M.2    Fox, C.S.3
  • 50
    • 68549135080 scopus 로고    scopus 로고
    • The dependency of vitamin D status on body mass index, gender, age and season
    • Lagunova Z, Porojnicu AC, Lindberg F, et al. The dependency of vitamin D status on body mass index, gender, age and season. Anticancer Res 2009; 29:3713-3720.
    • (2009) Anticancer Res , vol.29 , pp. 3713-3720
    • Lagunova, Z.1    Porojnicu, A.C.2    Lindberg, F.3
  • 51
    • 69949096095 scopus 로고    scopus 로고
    • Association of plasma vitamin D levels with adiposity in Hispanic and African Americans
    • Young KA, Engelman CD, Langefeld CD, et al. Association of plasma vitamin D levels with adiposity in Hispanic and African Americans. J Clin Endocrinol Metab 2009; 94:3306-3313.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 3306-3313
    • Young, K.A.1    Engelman, C.D.2    Langefeld, C.D.3
  • 52
    • 77749267620 scopus 로고    scopus 로고
    • Vitamin D, adiposity, and calcified atherosclerotic plaque in African-Americans
    • Freedman BI, Wagenknecht LE, Hairston KG, et al. Vitamin D, adiposity, and calcified atherosclerotic plaque in African-Americans. J Clin Endocrinol Metab 2010; 95:1076-1083.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1076-1083
    • Freedman, B.I.1    Wagenknecht, L.E.2    Hairston, K.G.3
  • 53
    • 67349150829 scopus 로고    scopus 로고
    • Vitamin D and mortality in older men and women
    • Pilz S, Dobnig H, Nijpels G, et al. Vitamin D and mortality in older men and women. Clin Endocrinol (Oxf) 2009; 71:666-672.
    • (2009) Clin Endocrinol (Oxf) , vol.71 , pp. 666-672
    • Pilz, S.1    Dobnig, H.2    Nijpels, G.3
  • 54
    • 69549133632 scopus 로고    scopus 로고
    • Prospective study of serum 25-hydroxyvitamin d level, cardiovascular disease mortality, and allcause mortality in older U.S. Adults
    • This analysis of longitudinal data from the National Health and Nutrition Survey shows robust association of vitamin D status with cardiovascular and all-cause mortality. The report corroborates and extends findings of earlier observational studies
    • Ginde AA, Scragg R, Schwartz RS, Camargo CA Jr. Prospective study of serum 25-hydroxyvitamin d level, cardiovascular disease mortality, and allcause mortality in older U.S. Adults. J Am Geriatr Soc 2009; 57:1595-1603. This analysis of longitudinal data from the National Health and Nutrition Survey shows robust association of vitamin D status with cardiovascular and all-cause mortality. The report corroborates and extends findings of earlier observational studies.
    • (2009) J Am Geriatr Soc , vol.57 , pp. 1595-1603
    • Ginde, A.A.1    Scragg, R.2    Schwartz, R.S.3    Camargo Jr., C.A.4
  • 55
    • 70249150759 scopus 로고    scopus 로고
    • Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community- dwelling women
    • Semba RD, Houston DK, Ferrucci L, et al. Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community- dwelling women. Nutr Res 2009; 29:525-530.
    • (2009) Nutr Res , vol.29 , pp. 525-530
    • Semba, R.D.1    Houston, D.K.2    Ferrucci, L.3
  • 56
    • 69949160060 scopus 로고    scopus 로고
    • Serum concentrations of 17beta-E2 and 25-hydroxycholecalciferol (25OHD) in relation to all-cause mortality in older men -the MINOS study
    • Szulc P, Claustrat B, Delmas PD. Serum concentrations of 17beta-E2 and 25-hydroxycholecalciferol (25OHD) in relation to all-cause mortality in older men -the MINOS study. Clin Endocrinol (Oxf) 2009; 71:594-602.
    • (2009) Clin Endocrinol (Oxf) , vol.71 , pp. 594-602
    • Szulc, P.1    Claustrat, B.2    Delmas, P.D.3
  • 57
    • 70349678964 scopus 로고    scopus 로고
    • Vitamin D status and the risk of cardiovascular disease death
    • This large Finnish study also demonstrates an association of low vitamin D status with cardiovascular death. The findings specifically highlight the association between vitamin D status and cerebrovascular death
    • Kilkkinen A, Knekt P, Aro A, et al. Vitamin D status and the risk of cardiovascular disease death. Am J Epidemiol 2009; 170:1032-1039. This large Finnish study also demonstrates an association of low vitamin D status with cardiovascular death. The findings specifically highlight the association between vitamin D status and cerebrovascular death.
    • (2009) Am J Epidemiol , vol.170 , pp. 1032-1039
    • Kilkkinen, A.1    Knekt, P.2    Aro, A.3
  • 58
    • 77950791842 scopus 로고    scopus 로고
    • Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study
    • This study examines the tracking of 25-hydroxy vitamin D levels in a large Norwegian sample. It is one of the few studies to provide longitudinal data for a vitamin D measure, and suggests that intraindividual variability is comparable with that of established cardiovascular risk factors
    • Jorde R, Sneve M, Hutchinson M, et al. Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study. Am J Epidemiol 2010; 171:903-908. This study examines the tracking of 25-hydroxy vitamin D levels in a large Norwegian sample. It is one of the few studies to provide longitudinal data for a vitamin D measure, and suggests that intraindividual variability is comparable with that of established cardiovascular risk factors.
    • (2010) Am J Epidemiol , vol.171 , pp. 903-908
    • Jorde, R.1    Sneve, M.2    Hutchinson, M.3
  • 59
    • 13244264697 scopus 로고    scopus 로고
    • Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: Implications for establishing a new effective dietary intake recommendation for vitamin D
    • Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: Implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr 2005; 135:317-322.
    • (2005) J Nutr , vol.135 , pp. 317-322
    • Hollis, B.W.1
  • 60
    • 84862512816 scopus 로고    scopus 로고
    • Benefit-risk assessment of vitamin D supplementation
    • [Epub ahead of print] This is a systematic review of prior musculoskeletal trials, which attempts to define optimal ranges for vitamin D concentration
    • Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, et al. Benefit-risk assessment of vitamin D supplementation. Osteoporos Int 2009. [Epub ahead of print] This is a systematic review of prior musculoskeletal trials, which attempts to define optimal ranges for vitamin D concentration.
    • (2009) Osteoporos Int
    • Bischoff-Ferrari, H.A.1    Shao, A.2    Dawson-Hughes, B.3
  • 62
    • 49449114001 scopus 로고    scopus 로고
    • Pharmacokinetics of vitamin D toxicity
    • Jones G. Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr 2008; 88:582S-586S.
    • (2008) Am J Clin Nutr , vol.88
    • Jones, G.1
  • 63
    • 0003788033 scopus 로고    scopus 로고
    • Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine, Washington, DC: National Academy Press
    • Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary reference intakes: Calcium, phosphorus, magnesium, vitamin D, and fluoride. Washington, DC: National Academy Press; 1997.
    • (1997) Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride
  • 64
    • 34447514029 scopus 로고    scopus 로고
    • Vitamin D deficiency
    • Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357:266-281.
    • (2007) N Engl J Med , vol.357 , pp. 266-281
    • Holick, M.F.1
  • 65
    • 40849085157 scopus 로고    scopus 로고
    • Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D
    • Holick MF, Biancuzzo RM, Chen TC, et al. Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab 2008; 93:677-681.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 677-681
    • Holick, M.F.1    Biancuzzo, R.M.2    Chen, T.C.3
  • 66
    • 71149116580 scopus 로고    scopus 로고
    • Adequacy of vitamin D replacement in severe deficiency is dependent on body mass index
    • This study emphasizes the potential importance of adiposity in determining the response to vitamin D supplementation
    • Lee P, Greenfield JR, Seibel MJ, et al. Adequacy of vitamin D replacement in severe deficiency is dependent on body mass index. Am J Med 2009; 122:1056-1060. This study emphasizes the potential importance of adiposity in determining the response to vitamin D supplementation.
    • (2009) Am J Med , vol.122 , pp. 1056-1060
    • Lee, P.1    Greenfield, J.R.2    Seibel, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.