Enhancing allograft bone healing through gene therapy

Spine

Volumn 35, Issue 17, 2010, Pages 1640-1647

  Rubery, Paul T ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

allograft; gene therapy; murine femoral intercalary graft revitalizing; stem cells

Indexed keywords

ACTIVIN RECEPTOR; ACTIVIN RECEPTOR LIKE KINASE 2; BONE MORPHOGENETIC PROTEIN 2; COMPLEMENTARY DNA; OSTEOCLAST DIFFERENTIATION FACTOR; RECOMBINANT ADENO-ASSOCIATED VIRUS; UNCLASSIFIED DRUG; VASCULOTROPIN; VIRUS VECTOR;

ALLOGRAFT; AUTOGRAFT; BONE GRAFT; DRUG DELIVERY SYSTEM; ENCHONDRAL OSSIFICATION; FRACTURE HEALING; GENE EXPRESSION; GENE INSERTION; GENE THERAPY; GENE TRANSFER; GRAFT VERSUS HOST REACTION; HISTOLOGY; HUMAN; IMMUNOGENICITY; MEDICAL LITERATURE; MORPHOMETRICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; STEM CELL; TRANSGENE; TRANSGENICS;

ANIMALS; BONE TRANSPLANTATION; GENE THERAPY; MICE; OSTEOGENESIS; TRANSPLANTATION, HOMOLOGOUS; WOUND HEALING;

EID: 77955466593     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3181ccc7bf     Document Type: Review

References (53)

1. Joyce MJ, Greenwald AS, Boden S, et al; Committee on Biological ImplantsTissue Work Group. Musculoskeletal Allograft Tissue Safety. In the 75th Annual meeting of American Academy of Orthopaedic Surgeons; March 5-9, 2008; San Francisco, CA. Available at: http://www.aatb.org/ files/tissuesafety.pdf. Accessed January 12, 2009.
2. Enneking WF, Campanacci DA. Retrieved human allografts: a clinicopathological study. J Bone Joint Surg Am 2001;83-A:971-986
3. Enneking WF, Mindell ER. Observations on massive retrieved human allografts. J Bone Joint Surg Am 1991;73:1123-1142
4. Berrey BH Jr, Lord CF, Gebhardt MC, et al. Fractures of allografts. Frequency, treatment, and end-results. J Bone Joint Surg Am 1990;72:825-33.
5. Thompson RC Jr, Pickvance EA, Garry D. Fractures in large-segment allografts. J Bone Joint Surg Am 1993;75:1663-1673
6. Wheeler DL, Enneking WF. Allograft bone decreases in strength in vivo over time. Clin Orthop Relat Res 2005:36-42.
7. Buttermann GR, Glazer PA, Bradford DS. The use of bone allografts in the spine. Clin Orthop Relat Res 1996:75-85.
8. Fernyhough JC, White JI, LaRocca H. Fusion rates in multilevel cervical spondylosis comparing allograft fibula with autograft fibula in 126 patients. Spine 1991;16:S561-4.
9. Lekovic GP, Han PP, Kenny KJ, et al. Bone dowels in anterior lumbar interbody fusion. J Spinal Disord Tech 2007;20:374-379
10. Bradford DS, Ganjavian S, Antonious D, et al. Anterior strut-grafting for the treatment of kyphosis. Review of experience with forty-eight patients. J Bone Joint Surg Am 1982;64:680-690
11. Jones J, Yoo J, Hart R. Delayed fracture of fibular strut allograft following multilevel anterior cervical spine corpectomy and fusion. Spine 2006;31: E595-9.
12. McKenna PJ, Freeman BJ, Mulholland RC, et al. A prospective, randomised controlled trial of femoral ring allograft versus a titanium cage in circumferential lumbar spinal fusion with minimum 2-year clinical results. Eur Spine J 2005;14:727-737
13. McKoy BE, Wingate JK, Poletti SC, et al. Fibular allograft after anterior cervical corpectomy: long term follow-up. Iowa Orthop J 2002;22:42-46
14. Munting E, Faundez A, Manche E. Vertebral reconstruction with cortical allograft: long-term evaluation. Eur Spine J 2001;10(suppl 2):S153-7.
15. Singh K, DeWald CJ, Hammerberg KW, et al. Long structural allografts in the treatment of anterior spinal column defects. Clin Orthop Relat Res 2002: 121-129
16. Thongtrangan I, Balabhadra RS, Kim DH. Management of strut graft failure in anterior cervical spine surgery. Neurosurg Focus 2003;15:E4.
17. Zdeblick TA, Ducker TB. The use of freeze-dried allograft bone for anterior cervical fusions. Spine 1991;16:726-729
18. Zdeblick TA, Hughes SS, Riew KD, et al. Failed anterior cervical discectomy and arthrodesis. Analysis and treatment of thirty-five patients. J Bone Joint Surg Am 1997;79:523-532
19. Lord CF, Gebhardt MC, Tomford WW, et al. Infection in bone allografts. Incidence, nature, and treatment. J Bone Joint Surg Am 1988;70:369-376
20. Burchardt H. The biology of bone graft repair. Clin Orthop Relat Res 1983: 28-42.
21. Burchardt H. Biology of bone transplantation. Orthop Clin North Am 1987; 18:187-196
22. Garbuz DS, Masri BA, Czitrom AA. Biology of allografting. Orthop Clin North Am 1998;29:199-204.
23. Stevenson S. Biology of bone grafts. Orthop Clin North Am 1999;30: 543-552
24. Bauer TW, Muschler GF. Bone graft materials. An overview of the basic science. Clin Orthop Relat Res 2000:10-27.
25. Tiyapatanaputi P, Rubery PT, Carmouche J, et al. A novel murine segmental femoral graft model. J Orthop Res 2004;22:1254-1260
26. Karaoglu S, Baktir A, Kabak S, et al. Experimental repair of segmental bone defects in rabbits by demineralized allograft covered by free autogenous periosteum. Injury 2002;33:679-683
27. Liu JY, Wang D, Cheng HH. Use of revascularized periosteal allografts for repairing bony defects: an experimental study. Microsurgery 1994;15:93-97
28. Zhang X, Xie C, Lin AS, et al. Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering. J Bone Miner Res 2005;20:2124-2137
29. Akahane M, Ohgushi H, Yoshikawa T, et al. Osteogenic phenotype expression of allogeneic rat marrow cells in porous hydroxyapatite ceramics. J Bone Miner Res 1999;14:561-568
30. Cinotti G, Patti AM, Vulcano A, et al. Experimental posterolateral spinal fusion with porous ceramics and mesenchymal stem cells. J Bone Joint Surg Br 2004;86:135-142
31. Erbe EM, Marx JG, Clineff TD, et al. Potential of an ultraporous betatricalcium phosphate synthetic cancellous bone void filler and bone marrow aspirate composite graft. Eur Spine J 2001;10(suppl 2):S141-6.
32. Hardouin P, Anselme K, Flautre B, et al. Tissue engineering and skeletal diseases. Joint Bone Spine 2000;67:419-424
33. Minamide A, Yoshida M, Kawakami M, et al. The effects of bone morphogenetic protein and basic fibroblast growth factor on cultured mesenchymal stem cells for spine fusion. Spine 2007;32:1067-1071
34. Muschler GF, Nitto H, Matsukura Y, et al. Spine fusion using cell matrix composites enriched in bone marrow-derived cells. Clin Orthop Relat Res 2003:102-118
35. Nakajima T, Iizuka H, Tsutsumi S, et al. Evaluation of posterolateral spinal fusion using mesenchymal stem cells: differences with or without osteogenic differentiation. Spine 2007;32:2432-2436
36. Neen D, Noyes D, Shaw M, et al. Healos and bone marrow aspirate used for lumbar spine fusion: a case controlled study comparing healos with autograft. Spine 2006;31:E636-40.
37. Nelson ER, Huang Z, Ma T, et al. New bone formation by murine osteoprogenitor cells cultured on corticocancellous allograft bone. J Orthop Res 2008;26:1660-1664
38. Soltan M, Smiler D, Prasad HS, et al. Bone block allograft impregnated with bone marrow aspirate. Implant Dent 2007;16:329-339
39. Xie C, Reynolds D, Awad H, et al. Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering. Tissue Eng 2007;13:435-445
40. Reynolds DG, Hock C, Shaikh S, et al. Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts. J Biomech 2007;40:3178-3186
41. Kimelman N, Pelled G, Helm GA, et al. Review: gene- and stem cell-based therapeutics for bone regeneration and repair. Tissue Eng 2007;13:1135-1150
42. Nixon AJ, Goodrich LR, Scimeca MS, et al. Gene therapy in musculoskeletal repair. Ann N Y Acad Sci 2007;1117:310-327
43. Phillips JE, Gersbach CA, Garcia AJ. Virus-based gene therapy strategies for bone regeneration. Biomaterials 2007;28:211-229
44. Yoon ST, Boden SD. Spine fusion by gene therapy. Gene Ther 2004;11:360-367
45. Baltzer AW, Lieberman JR. Regional gene therapy to enhance bone repair. Gene Ther 2004;11:344-350
46. Carofino BC, Lieberman JR. Gene therapy applications for fracture-healing. J Bone Joint Surg Am 2008;90(suppl 1):99-110.
47. Evans CH, Ghivizzani SC, Herndon JH, et al. Gene therapy for the treatment of musculoskeletal diseases. J Am Acad Orthop Surg 2005;13:230-242
48. Giannoudis PV, Tzioupis CC, Tsiridis E. Gene therapy in orthopaedics. Injury 2006;37(suppl 1):S30-40.
49. Kang R, Ghivizzani SC, Muzzonigro TS, et al. The Marshall R. Urist Young Investigator Award. Orthopaedic applications of gene therapy. From concept to clinic. Clin Orthop Relat Res 2000:324-337
50. Schwarz EM. The adeno-associated virus vector for orthopaedic gene therapy. Clin Orthop Relat Res 2000:S31-9.
51. Ito H, Koefoed M, Tiyapatanaputi P, et al. Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nat Med 2005;11:291-297
52. Shore EM, Xu M, Feldman GJ, et al. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat Genet 2006;38:525-527
53. Koefoed M, Ito H, Gromov K, et al. Biological effects of rAAV-caAlk2 coating on structural allograft healing. Mol Ther 2005;12:212-218