The marine sponge metabolite mycothiazole: A novel prototype mitochondrial complex i inhibitor

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 16, 2010, Pages 5988-5994

  Morgan, J Brian ^a   Mahdi, Fakhri ^a   Liu, Yang ^a   Coothankandaswamy, Veena ^a   Jekabsons, Mika B ^a   Johnson, Tyler A ^b   Sashidhara, Koneni V ^b   Crews, Phillip ^b   Nagle, Dale G ^a,c   Zhou, Yu Dong ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Hypoxia inducible factor 1 (HIF 1); Marine natural products; Mitochondrial complex I inhibitor; NADH ubiquinone oxidoreductase

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 4,19 DIHYDROXY 4,19 DIHYDROMYCOTHIAZOLE; 8 O ACETYLMYCOTHIAZOLE; ANNONACIN; ANTIMYCIN A1; ANTINEOPLASTIC AGENT; CAPSAICIN; FENPYROXIMATE; HYPOXIA INDUCIBLE FACTOR 1; MYCOTHIAZOLE; MYXOTHIAZOL; PHENOXAN; PIERICIDIN A; PYRIDABEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MARINE SPECIES; MOLECULAR PROBE; NEUROTOXICITY; NONHUMAN; PETROSASPONGIA MYCOFIJIENSIS; RAT; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

ANIMALS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; ELECTRON TRANSPORT COMPLEX I; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOVASCULARIZATION, PATHOLOGIC; NEURONS; PORIFERA; RATS; THIAZOLES;

EID: 77955465887     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.072     Document Type: Article

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