A cardioprotective agent of a novel calpain inhibitor, SNJ-1945, exerts β1 actions on left ventricular mechanical work and energetics

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 299, Issue 2, 2010, Pages

  Yoshikawa, Yoshiro ^a   Zhang, Guo Xing ^a   Obata, Koji ^a   Matsuyoshi, Hiroko ^a   Asada, Keiji ^a   Taniguchi, Shigeki ^a   Takaki, Miyako ^a  

^a NARA MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

1 adrenergic receptor; Cardiac function; Oxygen consumption; Systolic pressure volume area

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ION; CALPASTATIN; FODRIN; LANDIOLOL; POTASSIUM CHLORIDE; SNJ 1945; UNCLASSIFIED DRUG;

ADRENERGIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOPLEGIA; CONTROLLED STUDY; EXCITATION CONTRACTION COUPLING; HEART MUSCLE OXYGEN CONSUMPTION; HEART PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; REPERFUSION INJURY;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CALPAIN; CARBAMATES; CARDIOTONIC AGENTS; CYSTEINE PROTEINASE INHIBITORS; ENERGY METABOLISM; EXCITATION CONTRACTION COUPLING; HEART VENTRICLES; MALE; OXYGEN CONSUMPTION; PERFUSION; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA-1; STROKE VOLUME; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 77955464263     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00153.2010     Document Type: Article

References (24)

1. Abe T, Ohga Y, Tabayashi N, Kobayashi S, Sakata S, Misawa H, Tsuji T, Kohzuki H, Suga H, Taniguchi S, Takaki M. Left ventricular diastolic dysfunction in type 2 diabetes mellitus model rats. Am J Physiol Heart Circ Physiol 282: H138-H148, 2002.
2. Bennett V. Spectrin-based membrane skeleton: a multipotential adaptor between plasma membrane and cytoplasm. Physiol Rev 70: 1029-1065, 1990.
3. Galli A, DeFelice LJ. Inactivation of L-type Ca channels in embryonic chick ventricle cells: dependence on the cytoskeletal agents colchicine and taxol. Biophys J 67: 2296-2304, 1994.
4. 2+ exchange inhibition protects the rat heart from ischemic-reperfusion injury by blocking energy-wasting processes. Am J Physiol Heart Circ Physiol 288: H1699-H1707, 2005.
5. 2 use-pressure-volume area relation from curved end-systolic pressure-volume relation of the blood-perfused rat left ventricle. Jpn J Physiol 48: 197-204, 1998.
6. 2 use of the excised blood perfused rat heart. J Mol Cell Cardiol 30: 2137-2144, 1998.
7. Kawaguchi M, Takamatsu I, Masui K, Kazama T. Effect of landiolol on bispectral index and spectral entropy responses to tracheal intubation during propofol anesthesia. Br J Anaesth 101: 273-278, 2008.
8. Koumura A, Nonaka Y, Hyakkoku K, Oka T, Shimazawa M, Hozumi I, Inuzuka T, Hara H. A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl- 3-cyclopropyl-amino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice. Neuroscience 157: 309-318, 2008.
9. Lazarides E, Nelson WJ. Erythrocyte and brain forms of spectrin in cerebellum: distinct membrane-cytoskeletal domains in neurons. Science 220: 1295-1296, 1983.
10. Lee S, Ohga Y, Tachibana H, Syuu Y, Ito H, Harada M, Suga H, Takaki M. Effects of myosin isozyme shift on curvilinearity of the left ventricular end-systolic pressure-volume relation of in situ rat hearts. Jpn J Physiol 48: 445-455, 1998.
11. Miyazaki M, Kadoi Y, Saito S. Effects of landiolol, a short-actingbeta- 1blocker, on hemodynamic variables during emergence from anesthesia and tracheal extubation in elderly patients with and without hypertension. J Anesth 23: 483-488, 2009.
12. 2+ channel current in cultured vascular smooth muscle cells. Am J Physiol Cell Physiol 279: C480-C487, 2000.
13. Ohga Y, Sakata S, Takenaka C, Abe T, Tsuji T, Taniguchi S, Takaki M. Cardiac dysfunction in terms of left ventricular mechanical work and energetics in hypothyroid rats. Am J Physiol Heart Circ Physiol 283: H631-H641, 2002.
14. Oka T, Walkup RD, Tamada Y, Nakajima E, Tochigi A, Shearer TR, Azuma M. Amelioration of retinal degeneration and proteolysis in acute ocular hypertensive rats by calpain inhibitor ((1S)-1((((1S)-1-benzyl-3- cyclopropylamino- 2,3-di-oxopropyl) amino) carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester. Neuroscience 141: 2139-2145, 2006.
15. Shirasaki Y, Yamaguchi M, Miyashita H. Retinal penetration of calpain inhibitors in rats after oral administration. J Ocul Pharmacol 22: 417-424, 2006.
16. 2+ overload-induced failing hearts. Jpn J Physiol 52: 163-171, 2002.
17. Takaki M. Left ventricular mechanoenergetics in small animals. Jpn J Physiol 54: 175-207, 2004.
18. 2 use of unloaded contracting rat heart slices: thapsigargin and cyclopiazonic acid. J Mol Cell Cardiol 30: 649-659, 1998.
19. 2+ overload-induced left ventricle dysfunction by targeted ablation of phospholamban. Am J Physiol Heart Circ Physiol 296: H310-H317, 2009.
20. 2+ overload: Possible link to the proteolysis of fodrin. Am J Physiol Heart Circ Physiol 281: H1286-H1294, 2001.
21. Tsuji T, Ohga Y, Yoshikawa Y, Sakata S, Kohzuki H, Misawa H, Abe T, Tabayashi N, Kobayashi S, Kitamura S, Taniguchi S, Suga H, Takaki M. New index for oxygen cost of contractility from curved end-systolic pressure-volume relations in cross-circulated rat hearts. Jpn J Physiol 49: 513-520, 1999.
22. Yoshida K, Yamasaki Y, Kawashima S. Calpain activity alters rat myocardial subfractions after ischemia and reperfusion. Biochim Biophys Acta 1182: 215-220, 1993.
23. Yoshikawa Y, Hagihara H, Ohga Y, Nakajima-Takenaka C, Murata K, Taniguchi S, Takaki M. Calpain inhibitor-1 protects the rat heart from ischemic-reperfusion injury: analysis by mechanical work and energetics. Am J Physiol Heart Circ Physiol 288: H1690-H1698, 2005.
24. Yoshikawa Y, Zhnag GX, Obata K, Ohga Y, Matsuyoshi H, Taniguchi S, Takaki M. Cardioprotective effects of a novel calpain inhibitor, SNJ-1945 for reperfusion injury after cardioplegic cardiac arrest. Am J Physiol Heart Circ Physiol 298: H643-H651, 2010.