Rescue of Ca 2+ overload-induced left ventriclur dysfunction by targeted ablation of phospholamban

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 296, Issue 2, 2009, Pages

  Tsuji, Tsuyoshi ^a,b,c   Monte, Federica Del ^a   Yoshikawa, Yoshiro ^b,c   Abe, Takehisa ^b,c   Shimizu, Juichiro ^c   Nakajima Takenaka, Chikako ^c   Taniguchi, Shigeki ^b   Hajjar, Roger J ^a   Takaki, Miyako ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Department of Thoracic and Cardiovascular Surgery ^*  (Japan)

^c NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Cardiac function; In vivo gene transfer; Myocardial o 2 consumption per beat; Percutaneous; Systolic pres sure volume area

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; PHOSPHOLAMBAN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; ACTIN BINDING PROTEIN; CALCIUM; CALCIUM BINDING PROTEIN; CARRIER PROTEIN; COMPLEMENTARY DNA; FODRIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTISENSE THERAPY; ARTICLE; CONTROLLED STUDY; GENE DELIVERY SYSTEM; GENE TRANSFER; HEART CONTRACTION; HEART LEFT VENTRICLE FAILURE; HEART VENTRICLE OVERLOAD; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REPORTER GENE; SHAM PROCEDURE; SYSTOLIC BLOOD PRESSURE; WISTAR RAT; ANIMAL; CELL LINE; DISEASE MODEL; ENERGY METABOLISM; ENZYMOLOGY; GENE THERAPY; GENETICS; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART RATE; HEART STROKE VOLUME; HEART VENTRICLE PRESSURE; HUMAN; MALE; METABOLISM; METHODOLOGY; PATHOPHYSIOLOGY;

ANIMALS; CALCIUM; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CELL LINE; DISEASE MODELS, ANIMAL; DNA, ANTISENSE; ENERGY METABOLISM; GENE THERAPY; GENE TRANSFER TECHNIQUES; HEART RATE; HUMANS; MALE; MICROFILAMENT PROTEINS; MYOCARDIAL CONTRACTION; MYOCARDIUM; OXYGEN CONSUMPTION; RATS; RATS, WISTAR; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; STROKE VOLUME; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 61949300248     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00975.2008     Document Type: Article

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