Annulus cells from more degenerated human discs show modified gene expression in 3D culture compared with expression in cells from healthier discs

Spine Journal

Volumn 10, Issue 8, 2010, Pages 721-727

  Gruber, Helen E ^a   Hoelscher, Gretchen L ^a   Hanley Jr , Edward N ^a  

^a CAROLINAS MEDICAL CENTER   (United States)

Author keywords

Disc degeneration; Gene expression; Intervertebral disc

Indexed keywords

BIGLYCAN; CASPASE 10; CX3C CHEMOKINE; INTERLEUKIN 1ALPHA; INTERLEUKIN 26; INTERLEUKIN 7; MESSENGER RNA;

ADAMTS6 GENE; ADULT; AGED; ALPHA INDUCED PROTEIN 2 GENE; ANNULUS CELL; ARTICLE; BCL2 LIKE 11 GENE; BONE CELL; CELL CULTURE; CLINICAL ARTICLE; COLLAGEN TYPE 4 ALPHA 2 GENE; CYCLIN DEPENDENT KINASE 6 GENE; DOWN REGULATION; ELASTIN MICROFIBRIL INTERFACER 2 GENE; EXTRACELLULAR MATRIX; FADD LIKE APOPTOSIS REGULATOR GENE; FEMALE; FIBROBLAST GROWTH FACTOR 1 GENE; FIBRONECTIN TYPE III DOMAIN CONTAINING PROTEIN 1 GENE; FIBULIN 2 GENE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYALURONAN SYNTHASE 2 GENE; INTERLEUKIN 1 RECEPTOR LIKE 1 GENE; INTERVERTEBRAL DISK DEGENERATION; KERATIN ASSOCIATED PROTEIN 1 1 GENE; LAMINEN ALPHA 1 GENE; LUMBAR DISK; MALE; NEXIN GENE; NIDOGEN 1 GENE; NIDOGEN 2 GENE; NUCLEOTIDE SEQUENCE; P53 INDUCIBLE NUCLEAR PROTEIN 1 GENE; PREGNANCY ASSOCIATED PLASMA PROTEIN A GENE; PRIORITY JOURNAL; RAB24 GENE; RAS LIKE GTP BINDING 1 GENE; TGF BETA INDUCED TRANSCRIPT 1 GENE; THREE DIMENSIONAL IMAGING; THROMBOSPONDIN 3 GENE; TUMOR NECROSIS FACTOR GENE; UPREGULATION; DNA MICROARRAY; GENETICS; INTERVERTEBRAL DISK; LUMBAR VERTEBRA; MIDDLE AGED; PATHOLOGY; VERTEBRA;

ADULT; CELLS, CULTURED; FEMALE; GENE EXPRESSION; HUMANS; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; THORACIC VERTEBRAE;

EID: 77955462084     PISSN: 15299430     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.spinee.2010.05.014     Document Type: Article

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