Beneficial effect of erdosteine on methotrexate-induced testicular toxicity in mice

Toxicology and Industrial Health

Volumn 26, Issue 7, 2010, Pages 433-438

  Oktar, Süleyman ^a   Gökçe, Ahmet ^a   Aydin, Mehmet ^a   Davarci, Mürsel ^a   Meydan, Sedat ^a   Oztürk, Oktay Hasan ^a   Koç, Ahmet ^a  

^a MUSTAFA KEMAL UNIVERSITY   (Turkey)

Author keywords

antioxidant capacity; erdosteine; methotrexate; oxidative stress; testes

Indexed keywords

ERDOSTEINE; MALONALDEHYDE; METHOTREXATE; MYELOPEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INDUCED DISEASE; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; TESTIS DISEASE; TESTIS TOXICITY;

ANALYSIS OF VARIANCE; ANIMALS; DRUG INTERACTIONS; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; METHOTREXATE; MICE; OXIDATIVE STRESS; PEROXIDASE; STATISTICS, NONPARAMETRIC; TESTICULAR DISEASES; TESTIS; THIOGLYCOLATES; THIOPHENES;

ANIMALIA; MUS;

EID: 77955459120     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233710369666     Document Type: Article

References (29)

1. Armagan A., Uzar E., Uz E., Yilmaz HR, Kutluhan S., Koyuncuoglu HR, et al. (2008) Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat. Human and Experimental Toxicology 27: 547-552.
2. Aydilek N. (2007) Comparison between xylazine-tiletamine-zolazepam and fentanyl-tiletamine-zolazepam anaesthetic combinations on plasma oxidative status in sheep. Acta Veterinaria Brno 76: 573-578.
3. Basyigit I., Yildiz F., Cekmen M., Duman C., and Bulut O. (2005) Effects of erdosteine on smoking-induced lipid peroxidation in healthy smokers. Drugs in R&D 6: 83-89.
4. Bayram M., Ozogul C., Dursun A., Ercan ZS, Isik I., and Dilekoz E. (2005) Light and electron microscope examination of the effects of methotrexate on the endosalpinx. European Journal of Obstetrics & Gynecology and Reproductive Biology 120: 96-103.
5. Chan GL, Weinstein SS, and Vijayanagar RR (1995) Treatment of recalcitrant cardiac allograft rejection with methotrexate. Cardiac Transplant Team. Clinical Transplant 9: 106-114.
6. Dal Negro RW, Visconti M., Micheletto C., and Tognella S. (2005) Erdosteine 900 mg/day leads to substantial changes in blood ROS, e-NO and some chemotactic cytokines in human secretions of current smokers. American Journal of Respiratory and Critical Care Medicine Suppl 2: A89.
7. Dal Negro RW, Visconti M., Micheletto C., and Tognella S. (2008) Changes in blood ROS, e-NO, and some pro-inflammatory mediators in bronchial secretions following erdosteine or placebo: a controlled study in current smokers with mild COPD. Pulmonary Pharmacology and Therapeutics 21: 304-308.
8. Dalmarco EM, Frode TS, and Medeiros YS (2002) Effects of methotrexate upon inflammatory parameters induced by carrageenan in the mouse model of pleurisy. Mediators of Inflammation 11: 299-306.
9. Erel O. (2004) A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinical Biochemistry 37: 277-285.
10. Erel O. (2005) A new automated colorimetric method for measuring total oxidant status. Clinical Biochemistry 38: 1103-1111.
11. Esterbauer H., Cheeseman KH (1990) Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods in Enzymology 186: 407-421.
12. Gao F., Ueda S., and Horie T. (2001) Effect of a synthetic analog of prostaglandin E1 on the intestinal mucosa of methotrexate-treated rats. Anticancer Research 21: 1913-1917.
13. Hayashi K., Hosoe H., Kaise T., and Ohmori K. (2000) Protective effect of erdosteine against hypochlorous acid-induced acute lung injury and lipopolysaccharide-induced neutrophilic lung inflammation in mice. Journal of Pharmacy and Pharmacology 52: 1411-1416.
14. Jahovic N., Sener G., Cevik H., Ersoy Y., Arbak S., and Yegen BC (2004) Amelioration of methotrexate-induced enteritis by melatonin in rats. Cell Biochemistry and Function 22: 169-178.
15. Koc A., Duru M., Ciralik H., Akcan R., and Sogut S. (2005) Protective agent, erdosteine, against cisplatin-induced hepatic oxidant injury in rats. Molecular and Cellular Biochemistry 278: 79-84.
16. Koc A., Narci A., Duru M., Gergerlioglu HS, Akaydin Y., and Sogut S. (2005) The protective role of erdosteine on testicular tissue after testicular torsion and detorsion. Molecular and Cellular Biochemistry 280: 193-199.
17. Kosecik M., Erel O., Sevinc E., and Selek S. (2005) Increased oxidative stress in children exposed to passive smoking. International Journal of Cardiology 100: 61-64.
18. Koyama S., Sato E., Takamizawa A., Tsukadaira A., Haniuda M., Kurai M., et al. (2003) Methotrexate stimulates lung epithelial cells to release inflammatory cell chemotactic activities. Experimental Lung Research 29: 91-111.
19. Lowry OH, Rosebrough N., Farr AL, and Randall RJ (1951) Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 193: 265-275.
20. Mitchell MS, Wade ME, DeConti RC, Bertino JR, and Calabresi P. (1969) Immunosuppressive effects of cytosine arabinoside and methotrexate in man. Annals of Internal Medicine 70: 535-547.
21. Miyazono Y., Gao F., and Horie T. (2004) Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats. Scandinavian Journal of Gastroenterology 39: 1119-1127.
22. Moretti M., Marchioni CF (2007) An overview of erdosteine antioxidant activity in experimental research. Pharmacological Research 55: 249-254.
23. Ng C., Xiao YD, Lum BL, and Han YH (2005) Quantitative structure-activity relationships of methotrexate and methotrexate analogues transported by the rat multispecific resistance-associated protein 2 (rMrp2). European Journal of Pharmaceutical Science 26: 405-413.
24. Selcoki Y., Uz E., Bayrak R., Sahin S., Kaya A., Uz B., et al. (2007) The protective effect of erdosteine against cyclosporine A-induced cardiotoxicity in rats. Toxicology 239: 53-59.
25. Sener G., Aksoy H., Sehirli O., Yuksel M., Aral C., Gedik N., et al. (2007) Erdosteine prevents colonic inflammation through its antioxidant and free radical scavenging activities. Digestive Diseases Sciences 52, 2122-2132.
26. Uzar E., Koyuncuoglu HR, Uz E., Yilmaz HR, Kutluhan S., Kilbas S., and Gultekin F. (2006) The activities of antioxidant enzymes and the level of malondialdehyde in cerebellum of rats subjected to methotrexate: protective effect of caffeic acid phenethyl ester. Molecular and Cellular Biochemistry 291: 63-68.
27. Uzar E., Sahin O., Koyuncuoglu HR, Uz E., Bas O., Kilbas S., et al. (2006b) The activity of adenosine deaminase and the level of nitric oxide in spinal cord of methotrexate administered rats: protective effect of caffeic acid phenethyl ester. Toxicology 218: 125-133.
28. Wei H., Frenkel K. (1991) In vivo formation of oxidized DNA bases in tumor promoter-treated mouse skin. Cancer Research 51: 4443-4449.
29. Widemann BC, Adamson PC (2006) Understanding and managing methotrexate nephrotoxicity. Oncologist 11: 694-703.