Erdosteine prevents colonic inflammation through its antioxidant and free radical scavenging activities

Digestive Diseases and Sciences

Volumn 52, Issue 9, 2007, Pages 2122-2132

  Şener, Göksel ^a   Aksoy, Halil ^a   Şehirli, Özer ^a   Yüksel, Meral ^a   Aral, Cenk ^a   Gedik, Nursal ^b   Çetinel, Şule ^a   Yeǧen, Berrak Ç ^a  

^a MARMARA UNIVERSITY   (Turkey)

^b KASIMPASA MILITARY HOSPITAL   (Turkey)

Author keywords

Colitis; Erdosteine; Inflammation; Oxidative damage; TNBS

Indexed keywords

COLLAGEN; DNA FRAGMENT; ERDOSTEINE; GLUTATHIONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTATE DEHYDROGENASE; LUCIGENIN; LUMINOL; MALONALDEHYDE; MYELOPEROXIDASE; THIOL DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CHEMICAL ANALYSIS; COLITIS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACRIDINES; ANIMALS; ANTIOXIDANTS; COLITIS; COLLAGEN; COLON; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXPECTORANTS; FEMALE; FREE RADICAL SCAVENGERS; GLUTATHIONE; LUMINESCENCE; LUMINOL; MALONDIALDEHYDE; OXIDATIVE STRESS; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; SEVERITY OF ILLNESS INDEX; THIOGLYCOLATES; THIOPHENES; TRINITROBENZENESULFONIC ACID;

EID: 34547843589     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-9801-9     Document Type: Article

References (51)

1. Shanahan F (1993) Pathogenesis of ulcerative colitis. Lancet 342:407-411
2. Yoshida N, Yoshikawa T, Yamaguchi T, Naito Y, Tanigawa T, Murase H, Kondo M (1999) A novel water-soluble vitamin E derivative protects against experimental colitis in rats. Antioxid Redox Signal 1:555-562
3. Gulluoglu BM, Kurtel H, Gulluoglu MG, Yegen C, Aktan AO, Dizdaroglu F, Yalin R, Yegen BC (1999) Role of endothelins in trinitrobenzene sulfonic acid-induced colitis in rats. Digestion 60:484-492
4. Ukil A, Maity S, Karmakar S, Datta N, Vedasiromoni JR, Das PK (2003) Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. Br J Pharmacol 139:209-218
5. Babbs CF (1992) Oxygen radicals in ulcerative colitis. Free Radic Biol Med 13:169-181
6. Imlay JA, Linn S (1988) DNA damage and oxygen radical toxicity. Science 240:1302-1309
7. Sismonds NJ, Rampton DS (1994) Inflammatory bowel disease: a radical view. Gut 34:861-865
8. Shiratova A, Aoki S, Takada H, Kiriyama H, Ohto K, Hai K, Teraoka H, Matano S, Matsumoto K, Kamii K (1989) Oxygen derived free radicals generating capacity of polymorphonuclear cells in patients with ulcerative colitis. Digestion 44:163- 171
9. Suematsu M, Suzuki M, Kitahora T, Miura S, Suzuki K, Hibi T, Watanabe T, Nagata H, Asakura H, Tsuchiya M (1987) Increased respiratory burst of leukocytes in inflammatory bowel disease: The analysis of free radical generation by using chemiluminescence probe. J Clin Lab Immunol 24:125-128
10. Yoshikawa T, Yamaguchi T, Yoshida N, Yamamato H, Kitazumi S, Takahashi S, Naito Y, Kondo M (1997) Effect of Z-103 on TNB-induced colitis in rats. Digestion 58:464-468
11. Ahnfelt-Ronne I, Nielsen OH, Christensen A, Langholz E, Binder V, Riis P (1990) Clinical evidence supporting the radical scavenger mechanism of 5-aminosalicylic acid. Gastroenterology 98:1162-1169
12. Dechant KL, Noble S (1996) Erdosteine. Drugs 52:875-881
13. Moretti M, Bottrighi P, Dallari R, Da Porto R, Dolcetti A, Grandi P, Garuti G, Guffanti E, Roversi P, De Gugliemo M, Potena A; EQUALIFE Study Group (2004) The effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: the EQUALIFE Study. Drugs Exp Clin Res 30:143- 152
14. Braga PC, Dal Sasso M, Zuccotti T (2000) Assessment of the antioxidant activity of the SH metabolite I of erdosteine on human neutrophil oxidative bursts. Arzneimittelforschung. 50:739- 746
15. Inglesi M, Nicola M, Fregnan GB, Bradamante S, Pagani G (1994) Synthesis and free radical scavenging properties of the enantiomers of erdosteine. Farmaco 40:703-708
16. Boyaci H, Maral H, Turan G, Basyigit I, Dillioglugil MO, Yildiz F, Tugay M, Pala A, Ercin C (2006) Effects of erdosteine on bleomycin-induced lung fibrosis in rats. Mol Cell Biochem 281:129-137
17. Yagmurca M, Fadillioglu E, Erdogan H, Ucar M, Sogut S, Irmak MK (2003) Erdosteine prevents doxorubicin-induced cardiotoxicity in rats. Pharmacol Res 48:377-382
18. Isik B, Bayrak R, Akcay A, Sogut S (2006) Erdosteine against acetaminophen induced renal toxicity. Mol Cell Biochem 287:185-191
19. Demiralay R, Gursan N, Erdem H (2006) The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of pulmonary cells. Toxicology 219:197-207
20. Wallace JL, Braquet P, Ibbotson GC, MacNaugton WK, Cirino G (1989) Assessment of the role of platelet activating factor in an animal model of inflammatory bowel disease. J Lipid Med 1:13-23
21. Gué M, Bonbonne J, Fioramonti J, More C, Del Rio-Lacléze C, Comera C, Bueno L (1997) Stress-induced enhancement of colitis in rats: CRF and arginine vasopressin are not involved. Am J Physiol 272:G84-G91
22. Lopez De Leon A, Rojkind M (1985) A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections. J Histochem Cytochem 33:737- 743
23. Martinek RG (1972) A rapid ultraviolet spectrophotometric lactic dehydrogenase assay. Clin Chem Acta 40:91-99
24. Bradley PP, Priebat DA, Christersen RD, Rothstein G (1982) Measurement of cutaneous inflammation. Estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206-209
25. Davies GR, Simmonds NJ, Stevens TR, Sheaff MT, Banatvala N, Laurenson IF, Blake DR, Rampton DS (1994) Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut 35:179-185
26. Ohara Y, Peterson TE, Harrisorn DG (1993) Hypercholesterolemia increases endothelial superoxide anion production. J. Clin Invest 92:2546-2551
27. Haklar G, Ulukaya-Durakbaşa C, Yüksel M, DaglI T, Yalcin AS (1998) Oxygen radicals and nitric oxide in rat mesenteric ischemia-reperfusion: modulation by L-arginine and N-nitro-L-arginine methyl ester. Clin Exp Pharmacol Physiol 25:908- 912
28. Beuge JA, Aust SD (1978) Microsomal lipid peroxidation. Meth Enzymol 52:302-311
29. Beutler E (1975) Glutathione in red blood cell metabolism. In: A manual of biochemical methods. Grune & Stratton, New York; pp 112-114
30. Wyllie H (1980) Glucocorticoid induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284:555-556
31. Burton K (1956) A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 62:315-323
32. Grisham MB, Granger DN (1988) Neutrophil-mediated mucosal injury. Role of reactive oxygen metabolites. Dig Dis Sci 33(3 Suppl):6S-15S
33. Elson CO, Sartor RB, Tennyson GS, Riddell RH (1995) Experimental models of inflammatory bowel disease. Gastroenterology 109:1344-1367
34. Guo X, Wang WP, Ko JK, Cho CH (1999) Involvement of neutrophils and free radicals in the potentiating effects of passive cigarette smoking on inflammatory bowel disease in rats. Gastroenterology 117:884-892
35. Dal Sasso M, Culici M, Guffanti EE, Bianchi T, Fonti E, Braga PC (2005) A combination of budesonide and the SH-metabolite I of erdosteine acts synergistically in reducing chemiluminescence during human neutrophil respiratory burst. Pharmacology 74:127-134
36. Grisham MB (1994) Oxidants and free radicals in inflammatory bowel disease. Lancet 24;344(8926):859-861
37. Braga PC, Dal Sasso M, Culici M, Verducci P, Lo Verso R, Marabini L (2006) Effect of metabolite I of erdosteine on the release of human neutrophil elastase. Pharmacology 77:150-154
38. Siddiqui A, Ancha H, Tedesco D, Lightfoot S, Stewart CA, Harty RF (2006) Antioxidant therapy with N-acetylcysteine plus mesalamine accelerates mucosal healing in a rodent model of colitis. Dig Dis Sci 51:698-705
39. Stark G (2005) Functional consequences of oxidative membrane damage. J Membr Biol 205:1-16
40. Isozaki Y, Yoshida N, Kuroda M, Takagi T, Handa O, Kokura S, Ichikawa H, Naito Y, Okanoue T, Yoshikawa T (2006) Effect of a novel water-soluble vitamin E derivative as a cure for TNBS-induced colitis in rats. Int J Mol Med 17:497-502
41. Colon AL, Madrigal JL, Menchen LA, Moro MA, Lizasoain I, Lorenzo P, Leza JC (2004) Stress increases susceptibility to oxidative/nitrosative mucosal damage in an experimental model of colitis in rats. Dig Dis Sci 49:1713-1721
42. Jahovic N, Gedik N, Ercan F, Sirvanci S, Yuksel M, Sener G, Alican I (2006) Effects of statins on experimental colitis in normocholesterolemic rats. Scand J Gastroenterol 41:954-962
43. Peifer C, Wagner G, Laufer S (2006) New approaches to the treatment of inflammatory disorders small molecule inhibitors of p38 MAP kinase. Curr Top Med Chem 6:113-149
44. Cuzzocrea S, Mazzon E, Serraino I, Lepore V, Terranova ML, Ciccolo A, Caputi AP (2001) Melatonin reduces dinitrobenzene sulfonic acid-induced colitis. J Pineal Res 30:1- 12
45. Hosoe H, Kaise T, Ohmori K (2002) Effects on the reactive oxygen species of erdosteine and its metabolite in vitro. Arzneimittelforschung 52:435-440
46. Dal Sasso M, Culici M, Bianchi T, Fonti E, Braga PC (2004) Inhibitory effects of metabolite I of erdosteine on the generation of nitric oxide and peroxynitrite chemiluminescence by human neutrophils. Pharmacology 71:120-127
47. Jang YY, Song JH, Shin YK, Han ES, Lee CS (2003) Depressant effects of ambroxol and erdosteine on cytokine synthesis, granule enzyme release, and free radical production in rat alveolar macrophages activated by lipopolysaccharide. Pharmacol Toxicol 92:173-179
48. Ross D (1988) Glutathione, free radicals and chemotherapeutic agents. Mechanisms of free-radical induced toxicity and glutathione-dependent protection. Pharmacol Ther 37:231-249
49. Reiter RJ, Tan DX, Osuna C, Gitto E (2000) Actions of melatonin in the reduction of oxidative stress. A review. J Biomed Sci 7:444-458
50. D'Odorico A, Bortolan S, Cardin R, D'Inca' R, Martines D, Ferronato A, Sturniolo GC (2001) Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease. Scand J Gastroenterol 36:1289-1294
51. Martin AR, Villegas I, La Casa C, Alarcon de la Lastra C (2003) The cyclo-oxygenase-2 inhibitor, rofecoxib, attenuates mucosal damage due to colitis induced by trinitrobenzene sulphonic acid in rats. Eur J Pharmacol 481:281-291